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Assay Method Information

Assay Name:  Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Marek Napierala, University of Texas MD Anderson Cancer Center Network: Molecular Library Probe Production Center Network (MLPCN) Grant Proposal Number: 11R21NS064827-01 Grant Proposal PI: Marek Napierala, University of Texas MD Anderson Cancer Center External Assay ID: FXN-GAA850_ACT_LUMI_1536_3XEC50 DRUN Name: Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter. Description: The most frequently inherited early-onset ataxia in Caucasians is Friedreich's ataxia (FRDA), a severe autosomal recessive neurodegenerative disease. FRDA is associated with progressive neurological disability, hypertrophic cardiomyopathy, increased risk of diabetes mellitus, severe disruption of iron-sulfur (Fe-S) cluster biosynthesis, mitochondrial iron overload coupled to
Affinity data for this assay
 

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Last update November 1, 2007
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