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| | Dose Response Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction for Cherry Pick 1 |
| Description: | University of New Mexico Assay Overview: Assay Support: 1 R03 DA031665-01A1 Project Title: MLP Assay for Arrestin-AP2 Inhibitors Assay Provider: Eric Prossnitz Ph.D. Lead Biologist: Catherine Prudom Ph.D., post screen Peter Simons Ph.D. Screening Operations Team: Mark Carter MS, Kristine Gouveia MS, J. Jacob Strouse Ph.D., Anna Waller Ph.D., Annette Evangelisti Ph.D. Chemistry Center/ PI: Craig W. Lindsley Specialized Chemistry Center: Vanderbilt Specialized Chemistry Center For Accelerated Probe Development Assay Implementation: Keon Ahghar, Stephanie Chavez, Terry Foutz, Matthew Garcia, Travis Houston, Dominique Perez. Assay Background and Significance: G protein-coupled receptors (GPCRs) represent the largest family of proteins in the human genome with over 600 members. As such they are involved in almost every aspect of normal human physiology, in addition to a multitude of pathophysiological processes, including cancer. The protein arrestin, which binds to phosphorylated GP |
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