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Assay Method Information

Assay Name:  Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Bert O'Malley, Baylor College of Medicine Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 5U19DK062434-09 Grant Proposal PI: Bert O'Malley, Baylor College of Medicine External Assay ID: SRC3_INH_LUMI_1536_3XIC50 DRUN Name: Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3). Description: Chemotherapeutic agents that target estrogen receptor alpha (ERa and growth factor signaling systems have been extensively pursued and developed for a long time (1-4). However, one of the most pressing limitations of currently established chemotherapeutic agents for breast cancer is the fact that breast cancers frequently acquire resistance to antiestrogens (5, 6). Nuclear receptors (NR) and other hormone recep
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Last update November 1, 2007
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