Search and Browse
Download
Enter Data
|
Assay Method Information |
|
| | Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Cherry Pick2 compound set |
| Description: | UNMCMD Assay Overview: Assay Support: 1 R03 MH087406-01A1 Project Title: Identification of broad-spectrum antifungal efflux pump inhibitors PI: Richard Cannon Screening Center PI: Larry Sklar / UNMCMD Chemistry Center PI: Craig Lindsley Assay Implementation: J Jacob Strouse, Dominique Perez, Matthew Garcia, Anna Waller, Annette Evangelisti, Mark Carter, Kristine Gouveia Assay Background and Significance: Fungal infections, exemplified by oral and invasive candidiasis, cause considerable morbidity and mortality in the immunocompromised. Treatment of patients with fungal infections is severely hampered by the development of antifungal drug resistance [Cannon, et al 2009]. The goal of this project is to address this health need by discovering novel chemical compounds that reverse antifungal drug resistance by inhibiting the drug efflux pump molecules in the fungal cell membrane, overexpression of which is the major cause of resistance in clinical isolates of most Can |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |
|
Home |
| |
Search |
| |
Deposit |
| |
SiteMap |
| |
About us |
| |
Email us |
| |
Info |
|
©2000 BindingDB. All rights reserved. |
|||||||||||||