null
SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
InChI Key InChIKey=XNOPRXBHLZRZKH-DSZYJQQASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 69 hits for monomerid = 50205990
Affinity DataKi: 0.440nMAssay Description:Displacement of [3H]8-arginine-vasopressin from human oxytocin receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataKi: 0.790nMAssay Description:Displacement of [3H]OT from oxytocin receptor expressed in COS1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.790nMAssay Description:Competitive binding to oxytocin receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.790nMAssay Description:Binding affinity to OTR (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Binding affinity for human oxytocin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addi...More data for this Ligand-Target Pair
Affinity DataKi: 0.890nMAssay Description:Binding affinity against oxytocin receptor in rat uterusMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]OT from human mammary gland oxytocin receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Binding affinity against Oxytocin receptor was determined in rat uterine membrane using radioligand [3H]-oxytocinMore data for this Ligand-Target Pair
Affinity DataKi: 6.60nMAssay Description:Competitive binding to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells incubated for 1 hr at RT followed by 4 hrs at 4 degC ...More data for this Ligand-Target Pair
Affinity DataKi: 6.80nMAssay Description:Binding affinity to oxytocin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 9.5nMAssay Description:Competitive binding to SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells incubated for 1 hr at RT followed by 4 hrs at 4 degC ...More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]AVP from human liver vasopressin V1a receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Binding affinity against Vasopressin receptor in rat liverMore data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:Binding affinity against Vasopressin receptor in rat kidney medullaMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Binding affinity to V1aR (unknown origin)More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataKi: 1.54E+3nMAssay Description:Binding affinity to V2R (unknown origin)More data for this Ligand-Target Pair
TargetVasopressin V1b receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataKi: 1.78E+3nMAssay Description:Binding affinity to V1bR (unknown origin)More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataKi: 3.50E+3nMAssay Description:Binding affinity towards human Vasopressin V2 receptorMore data for this Ligand-Target Pair
TargetVasopressin V1b receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [3H]AVP from human kidney vasopressin V2 receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 10.8nMAssay Description:Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKd: 6.70nMAssay Description:Compound was evaluated for its dissociation constant (Kd) to guinea pig myometrial Oxytocin receptorMore data for this Ligand-Target Pair
Affinity DataKd: 6.70nMAssay Description:Inhibition of radioligand [3H]OT binding to oxytocin receptor (OT) in guinea pig myometrium membraneMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataEC50: 7.30nMAssay Description:Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.30nMAssay Description:Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetVasopressin V1b receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataEC50: 240nMAssay Description:Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assa...More data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Agonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by f...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Displacement of [3H]OT from human OT receptor expressed in HEK cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at recombinant human oxytocin receptor expressed in CHO-DUKX-A2 cells assessed as change in intracellular calcium level by FLIPR ass...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0400nMAssay Description:Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 d...More data for this Ligand-Target Pair
Affinity DataEC50: 5.80nMAssay Description:Agonist activity at human V1b receptor expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR as...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00800nMAssay Description:Agonist activity at human OTR expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Binding affinity against Vasopressin receptor in rat liverMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Agonist activity at C-terminal GFP-tagged V1a receptor (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human V1a receptor expressed in CHO cells assessed as calcium mobilization measured after 30 mins by Fluo-4-AM dye based FLIPR as...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mi...More data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 min...More data for this Ligand-Target Pair
TargetVasopressin V1b receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataEC50: 33nMAssay Description:Agonist activity at human vasopressin V1b receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by F...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
Affinity DataEC50: 29nMAssay Description:Agonist activity at human kidney vasopressin V2 receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 min...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at mouse OTR receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayMore data for this Ligand-Target Pair