2AZ5: Crystal Structure of TNF-alpha with a small molecule inhibitor

PDB ID: 2AZ5Download
MMDB ID: 36124
PDB Deposition Date: 2005/9/9
Updated in MMDB: 2005/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 2AZ5: tetrameric; determined by author
Molecular Components in 2AZ5
Label Count Molecule
Proteins (4 molecules)
4
Tumor Necrosis Factor (Tnf-alpha) (Tumor Necrosis Factor Ligand Superfamily Member 2) (Tnf-a) (Cachectin) [contains: Tumor Necrosis Factor, Membrane Form; Tumor Necrosis Factor, Soluble Form]
(Gene symbol: TNF)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303