Thalidomide and its analogues as cyclooxygenase inhibitors

Tomomi Noguchi; Rumiko Shimazawa; Kazuo Nagasawa; Yuichi Hashimoto

doi:10.1016/s0960-894x(02)00084-7

Thalidomide and its analogues as cyclooxygenase inhibitors

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1043-6. doi: 10.1016/s0960-894x(02)00084-7.

Authors

Tomomi Noguchi¹, Rumiko Shimazawa, Kazuo Nagasawa, Yuichi Hashimoto

Affiliation

¹ Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

PMID: 11909713
DOI: 10.1016/s0960-894x(02)00084-7

Abstract

Thalidomide showed cyclooxygenase (COX)-1/2 inhibitory activity with a potency comparable to that of aspirin. Structural development studies of thalidomide resulted in potent COX-1/2 inhibitors, and COX-1-selective and COX-2-selective inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / chemical synthesis*
Cyclooxygenase Inhibitors / chemistry
Cyclooxygenase Inhibitors / pharmacology*
Humans
Inhibitory Concentration 50
Isoenzymes / antagonists & inhibitors*
Isoenzymes / metabolism
Membrane Proteins
Molecular Structure
Prostaglandin-Endoperoxide Synthases / metabolism
Structure-Activity Relationship
Substrate Specificity
Thalidomide / analogs & derivatives*
Thalidomide / chemical synthesis
Thalidomide / pharmacology*

Substances

Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Isoenzymes
Membrane Proteins
Thalidomide
Cyclooxygenase 1
Cyclooxygenase 2
PTGS1 protein, human
PTGS2 protein, human
Prostaglandin-Endoperoxide Synthases