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Compile Data Set for Download or QSAR

Found 903 hits of affinity data for UniProtKB/TrEMBL: O75385   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		CHEMBL5280560
PNG
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n/an/a 1.60n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50111572
PNG
(CHEMBL3605057)
Show SMILES O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1
Show InChI InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)
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n/an/a 2.90n/an/an/an/an/an/a



Sichuan Universitt China Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged ULK1 (unknown origin)

J Med Chem 61: 6491-6500 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01684
BindingDB Entry DOI: 10.7270/Q2DN47KX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		CHEMBL5266681
PNG
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n/an/a 2.90n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50503137
PNG
(CHEMBL4516990)
Show SMILES CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
Show InChI InChI=1S/C25H34N6O/c1-31-13-10-19-14-21(9-8-20(19)16-31)29-25-28-15-22(17-6-7-17)23(30-25)26-11-3-12-27-24(32)18-4-2-5-18/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H,27,32)(H2,26,28,29,30)
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n/an/a 2.90n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of wild type GST-tagged ULK1 (unknown origin) after 5 mins in presence of gamma-[32]P-ATP by immunoblot analysis

J Med Chem 61: 4656-4687 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01019
BindingDB Entry DOI: 10.7270/Q2RR22GW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379404
PNG
(6-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimi...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3C(=O)CCCc3c2)nc1NC1CC1
Show InChI InChI=1S/C18H17F3N4O/c19-18(20,21)14-9-22-17(25-16(14)23-11-4-5-11)24-12-6-7-13-10(8-12)2-1-3-15(13)26/h6-9,11H,1-5H2,(H2,22,23,24,25)
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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379381
PNG
(N4-cyclopropyl-N2-(quinolin-6-yl)-5-(trifluorometh...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3ncccc3c2)nc1NC1CC1
Show InChI InChI=1S/C17H14F3N5/c18-17(19,20)13-9-22-16(25-15(13)23-11-3-4-11)24-12-5-6-14-10(8-12)2-1-7-21-14/h1-2,5-9,11H,3-4H2,(H2,22,23,24,25)
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379329
PNG
(N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(tr...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1NC1CC1
Show InChI InChI=1S/C15H13F3N6/c16-15(17,18)10-6-19-14(24-13(10)22-8-1-2-8)23-9-3-4-11-12(5-9)21-7-20-11/h3-8H,1-2H2,(H,20,21)(H2,19,22,23,24)
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50111577
PNG
(CHEMBL3605055)
Show SMILES C1CC(C1)c1cc(Nc2nc(Nc3ccc4[nH]cnc4c3)nc3ccccc23)n[nH]1
Show InChI InChI=1S/C22H20N8/c1-2-7-16-15(6-1)21(27-20-11-18(29-30-20)13-4-3-5-13)28-22(26-16)25-14-8-9-17-19(10-14)24-12-23-17/h1-2,6-13H,3-5H2,(H,23,24)(H3,25,26,27,28,29,30)
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n/an/a 5.30n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of SUMO-tagged ULK1 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...

Bioorg Med Chem 23: 5483-8 (2015)


Article DOI: 10.1016/j.bmc.2015.07.034
BindingDB Entry DOI: 10.7270/Q2CN75P8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379305
PNG
(N2-(1H-benzo[d][1,2,3]triazol-6-yl)-N4-cyclopropyl...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3nn[nH]c3c2)nc1NC1CC1
Show InChI InChI=1S/C14H12F3N7/c15-14(16,17)9-6-18-13(21-12(9)19-7-1-2-7)20-8-3-4-10-11(5-8)23-24-22-10/h3-7H,1-2H2,(H,22,23,24)(H2,18,19,20,21)
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379307
PNG
(N4-cyclopropyl-N2-(3,4-dihydro-2H-benzo[b][1,4]dio...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3OCCCOc3c2)nc1NC1CC1
Show InChI InChI=1S/C17H17F3N4O2/c18-17(19,20)12-9-21-16(24-15(12)22-10-2-3-10)23-11-4-5-13-14(8-11)26-7-1-6-25-13/h4-5,8-10H,1-3,6-7H2,(H2,21,22,23,24)
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50111577
PNG
(CHEMBL3605055)
Show SMILES C1CC(C1)c1cc(Nc2nc(Nc3ccc4[nH]cnc4c3)nc3ccccc23)n[nH]1
Show InChI InChI=1S/C22H20N8/c1-2-7-16-15(6-1)21(27-20-11-18(29-30-20)13-4-3-5-13)28-22(26-16)25-14-8-9-17-19(10-14)24-12-23-17/h1-2,6-13H,3-5H2,(H,23,24)(H3,25,26,27,28,29,30)
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n/an/a 8n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50111577
PNG
(CHEMBL3605055)
Show SMILES C1CC(C1)c1cc(Nc2nc(Nc3ccc4[nH]cnc4c3)nc3ccccc23)n[nH]1
Show InChI InChI=1S/C22H20N8/c1-2-7-16-15(6-1)21(27-20-11-18(29-30-20)13-4-3-5-13)28-22(26-16)25-14-8-9-17-19(10-14)24-12-23-17/h1-2,6-13H,3-5H2,(H,23,24)(H3,25,26,27,28,29,30)
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n/an/a 8n/an/an/an/an/an/a



Sichuan Universitt China Hospital

Curated by ChEMBL


Assay Description
Inhibition of N-terminal SUMO-tagged ULK1 kinase domain (1 to 283 residues) (unknown origin) using MBP as substrate in presence of [32P]ATP after 15 ...

J Med Chem 61: 6491-6500 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01684
BindingDB Entry DOI: 10.7270/Q2DN47KX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50111577
PNG
(CHEMBL3605055)
Show SMILES C1CC(C1)c1cc(Nc2nc(Nc3ccc4[nH]cnc4c3)nc3ccccc23)n[nH]1
Show InChI InChI=1S/C22H20N8/c1-2-7-16-15(6-1)21(27-20-11-18(29-30-20)13-4-3-5-13)28-22(26-16)25-14-8-9-17-19(10-14)24-12-23-17/h1-2,6-13H,3-5H2,(H,23,24)(H3,25,26,27,28,29,30)
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n/an/a 8n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of ULK1 (unknown origin) by 32P-ATP radio active assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112782
BindingDB Entry DOI: 10.7270/Q2PZ5DH2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		CHEMBL5269042
PNG
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n/an/a 8.30n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 9n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human ULK1 using MBP as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50520142
PNG
(CHEMBL4435393)
Show SMILES C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3)c2)c1 |r|
Show InChI InChI=1S/C28H31F3N8O/c1-18(37-8-10-38(11-9-37)26(40)14-28(29,30)31)20-6-7-32-25(13-20)36-27-34-23-5-4-21(12-24(23)35-27)22-15-33-39(17-22)16-19-2-3-19/h4-7,12-13,15,17-19H,2-3,8-11,14,16H2,1H3,(H2,32,34,35,36)/t18-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Bayer AG

Curated by ChEMBL


Assay Description
Inhibition of wild-type human partial length ULK1 (M1 to T309 residues) expressed in mammalian expression system by Kinomescan method

J Med Chem 63: 601-612 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01460
BindingDB Entry DOI: 10.7270/Q2CN7795
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 10.3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human ULK1 using MBP as substrate by [gamma-33P]-ATP assay

Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50280086
PNG
(CHEMBL4167070)
Show SMILES NC1CCCC(C1)C(=O)Nc1ccc2[nH]nc(Nc3cccc4ccccc34)c2c1
Show InChI InChI=1S/C24H25N5O/c25-17-8-3-7-16(13-17)24(30)26-18-11-12-22-20(14-18)23(29-28-22)27-21-10-4-6-15-5-1-2-9-19(15)21/h1-2,4-6,9-12,14,16-17H,3,7-8,13,25H2,(H,26,30)(H2,27,28,29)
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n/an/a 11n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ATG13 binding to full-length ULK1 (unknown origin) expressed in HEK293T cells preincubated for 15 mins followed by human C-terminal FLA...

ACS Med Chem Lett 8: 1258-1263 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00344
BindingDB Entry DOI: 10.7270/Q27S7R9H
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379414
PNG
(N-(4-((4-(cyclopropylamino)-5-(trifluoromethyl)pyr...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc(NC(=O)C3CC3)cc2)nc1NC1CC1
Show InChI InChI=1S/C18H18F3N5O/c19-18(20,21)14-9-22-17(26-15(14)23-11-3-4-11)25-13-7-5-12(6-8-13)24-16(27)10-1-2-10/h5-11H,1-4H2,(H,24,27)(H2,22,23,25,26)
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n/an/a 13n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379450
PNG
(US10266549, Example 349 | US10774092, Example 349)
Show SMILES COc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1OC
Show InChI InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)
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n/an/a 13n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379408
PNG
(N4-cyclopropyl-N2-(quinoxalin-6-yl)-5-(trifluorome...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3nccnc3c2)nc1NC1CC1
Show InChI InChI=1S/C16H13F3N6/c17-16(18,19)11-8-22-15(25-14(11)23-9-1-2-9)24-10-3-4-12-13(7-10)21-6-5-20-12/h3-9H,1-2H2,(H2,22,23,24,25)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379311
PNG
(N4-cyclopropyl-N2-(1H-indazol-5-yl)-5-(trifluorome...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3[nH]ncc3c2)nc1NC1CC1
Show InChI InChI=1S/C15H13F3N6/c16-15(17,18)11-7-19-14(23-13(11)21-9-1-2-9)22-10-3-4-12-8(5-10)6-20-24-12/h3-7,9H,1-2H2,(H,20,24)(H2,19,21,22,23)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379259
PNG
(US10266549, Example 158a | US10774092, Example 158...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3OCCOc3c2)nc1NC1CC1
Show InChI InChI=1S/C16H15F3N4O2/c17-16(18,19)11-8-20-15(23-14(11)21-9-1-2-9)22-10-3-4-12-13(7-10)25-6-5-24-12/h3-4,7-9H,1-2,5-6H2,(H2,20,21,22,23)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379352
PNG
(N4-cyclopropyl-N2-(5-methoxypyridin-3-yl)-5-(trifl...)
Show SMILES COc1cncc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)c1
Show InChI InChI=1S/C14H14F3N5O/c1-23-10-4-9(5-18-6-10)21-13-19-7-11(14(15,16)17)12(22-13)20-8-2-3-8/h4-8H,2-3H2,1H3,(H2,19,20,21,22)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379387
PNG
(N4-cyclopropyl-N2-(quinolin-3-yl)-5-(trifluorometh...)
Show SMILES FC(F)(F)c1cnc(Nc2cnc3ccccc3c2)nc1NC1CC1
Show InChI InChI=1S/C17H14F3N5/c18-17(19,20)13-9-22-16(25-15(13)23-11-5-6-11)24-12-7-10-3-1-2-4-14(10)21-8-12/h1-4,7-9,11H,5-6H2,(H2,22,23,24,25)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379264
PNG
(US10266549, Example 161a | US10774092, Example 161...)
Show SMILES FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CCC1
Show InChI InChI=1S/C16H15F3N6/c17-16(18,19)12-8-22-15(25-14(12)23-10-2-1-3-10)24-11-6-9-4-5-20-13(9)21-7-11/h4-8,10H,1-3H2,(H,20,21)(H2,22,23,24,25)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379325
PNG
(US10266549, Example 208a | US10774092, Example 208...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3ncoc3c2)nc1NC1CC1
Show InChI InChI=1S/C15H12F3N5O/c16-15(17,18)10-6-19-14(23-13(10)21-8-1-2-8)22-9-3-4-11-12(5-9)24-7-20-11/h3-8H,1-2H2,(H2,19,21,22,23)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379406
PNG
(US10266549, Example 304a | US10774092, Example 304...)
Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379332
PNG
(N2-(benzo[d][1,3]dioxol-5-yl)-N4-cyclopropyl-5-(tr...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3OCOc3c2)nc1NC1CC1
Show InChI InChI=1S/C15H13F3N4O2/c16-15(17,18)10-6-19-14(22-13(10)20-8-1-2-8)21-9-3-4-11-12(5-9)24-7-23-11/h3-6,8H,1-2,7H2,(H2,19,20,21,22)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379323
PNG
(N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1
Show InChI InChI=1S/C16H14F3N5/c17-16(18,19)12-8-21-15(24-14(12)22-10-1-2-10)23-11-3-4-13-9(7-11)5-6-20-13/h3-8,10,20H,1-2H2,(H2,21,22,23,24)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50280041
PNG
(CHEMBL4159827)
Show SMILES N[C@@H]1CCC[C@H](C1)C(=O)Nc1ccc2[nH]nc(Nc3cccc4ccccc34)c2c1 |r|
Show InChI InChI=1S/C24H25N5O/c25-17-8-3-7-16(13-17)24(30)26-18-11-12-22-20(14-18)23(29-28-22)27-21-10-4-6-15-5-1-2-9-19(15)21/h1-2,4-6,9-12,14,16-17H,3,7-8,13,25H2,(H,26,30)(H2,27,28,29)/t16-,17-/m1/s1
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ATG13 binding to full-length ULK1 (unknown origin) expressed in HEK293T cells preincubated for 15 mins followed by human C-terminal FLA...

ACS Med Chem Lett 8: 1258-1263 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00344
BindingDB Entry DOI: 10.7270/Q27S7R9H
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50520161
PNG
(CHEMBL4468020 | US10894784, Example 39.01.02)
Show SMILES FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cnn(CC4CC4)c3)c2)CC1
Show InChI InChI=1S/C27H29F3N8O/c28-27(29,30)13-25(39)37-9-7-36(8-10-37)15-19-5-6-31-24(11-19)35-26-33-22-4-3-20(12-23(22)34-26)21-14-32-38(17-21)16-18-1-2-18/h3-6,11-12,14,17-18H,1-2,7-10,13,15-16H2,(H2,31,33,34,35)
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Bayer AG

Curated by ChEMBL


Assay Description
Inhibition of wild-type human partial length ULK1 (M1 to T309 residues) expressed in mammalian expression system by Kinomescan method

J Med Chem 63: 601-612 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01460
BindingDB Entry DOI: 10.7270/Q2CN7795
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379252
PNG
(US10266549, Example 152a | US10774092, Example 152...)
Show SMILES FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CC1
Show InChI InChI=1S/C15H13F3N6/c16-15(17,18)11-7-21-14(24-13(11)22-9-1-2-9)23-10-5-8-3-4-19-12(8)20-6-10/h3-7,9H,1-2H2,(H,19,20)(H2,21,22,23,24)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379413
PNG
(N-(cyclopropanecarbonyl)-N-(4-((4-(cyclopropylamin...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc(cc2)N(C(=O)C2CC2)C(=O)C2CC2)nc1NC1CC1
Show InChI InChI=1S/C22H22F3N5O2/c23-22(24,25)17-11-26-21(29-18(17)27-14-5-6-14)28-15-7-9-16(10-8-15)30(19(31)12-1-2-12)20(32)13-3-4-13/h7-14H,1-6H2,(H2,26,27,28,29)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379445
PNG
(N4-cyclopropyl-N2-(4-ethyl-3,4-dihydro-2H-pyrido[3...)
Show SMILES CCN1CCOc2cc(Nc3ncc(c(NC4CC4)n3)C(F)(F)F)cnc12
Show InChI InChI=1S/C17H19F3N6O/c1-2-26-5-6-27-13-7-11(8-21-15(13)26)24-16-22-9-12(17(18,19)20)14(25-16)23-10-3-4-10/h7-10H,2-6H2,1H3,(H2,22,23,24,25)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		CHEMBL5279228
PNG
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		CHEMBL5276694
PNG
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379295
PNG
(US10266549, Example 182a | US10774092, Example 182...)
Show SMILES CNc1nc(Nc2cnc3[nH]ccc3c2)ncc1C(F)(F)F
Show InChI InChI=1S/C13H11F3N6/c1-17-11-9(13(14,15)16)6-20-12(22-11)21-8-4-7-2-3-18-10(7)19-5-8/h2-6H,1H3,(H,18,19)(H2,17,20,21,22)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50280098
PNG
(CHEMBL4176003)
Show SMILES NC1CCCC(C1)C(=O)Nc1ccc2[nH]nc(Nc3cccc4ncccc34)c2c1
Show InChI InChI=1S/C23H24N6O/c24-15-5-1-4-14(12-15)23(30)26-16-9-10-21-18(13-16)22(29-28-21)27-20-8-2-7-19-17(20)6-3-11-25-19/h2-3,6-11,13-15H,1,4-5,12,24H2,(H,26,30)(H2,27,28,29)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ATG13 binding to full-length ULK1 (unknown origin) expressed in HEK293T cells preincubated for 15 mins followed by human C-terminal FLA...

ACS Med Chem Lett 8: 1258-1263 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00344
BindingDB Entry DOI: 10.7270/Q27S7R9H
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379343
PNG
(US10266549, Example 221a | US10774092, Example 221...)
Show SMILES FC(F)(F)c1cnc(Nc2ccnnc2)nc1NC1CC1
Show InChI InChI=1S/C12H11F3N6/c13-12(14,15)9-6-16-11(20-8-3-4-17-18-5-8)21-10(9)19-7-1-2-7/h3-7H,1-2H2,(H2,16,17,19,20,21)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379376
PNG
(N4-cyclopropyl-N2-(2,2-difluorobenzo[d][1,3]dioxol...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3OC(F)(F)Oc3c2)nc1NC1CC1
Show InChI InChI=1S/C15H11F5N4O2/c16-14(17,18)9-6-21-13(24-12(9)22-7-1-2-7)23-8-3-4-10-11(5-8)26-15(19,20)25-10/h3-7H,1-2H2,(H2,21,22,23,24)
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TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50280093
PNG
(CHEMBL4170480)
Show SMILES N[C@H]1CCC[C@H](C1)C(=O)Nc1ccc2[nH]nc(Nc3cccc4ccccc34)c2c1 |r|
Show InChI InChI=1S/C24H25N5O/c25-17-8-3-7-16(13-17)24(30)26-18-11-12-22-20(14-18)23(29-28-22)27-21-10-4-6-15-5-1-2-9-19(15)21/h1-2,4-6,9-12,14,16-17H,3,7-8,13,25H2,(H,26,30)(H2,27,28,29)/t16-,17+/m1/s1
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ATG13 binding to full-length ULK1 (unknown origin) expressed in HEK293T cells preincubated for 15 mins followed by human C-terminal FLA...

ACS Med Chem Lett 8: 1258-1263 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00344
BindingDB Entry DOI: 10.7270/Q27S7R9H
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50556418
PNG
(CHEMBL4784530)
Show SMILES O=C(NCCCNc1nc(Cc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1
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TBA

Assay Description
Inhibition of ULK1 (unknown origin) by 32P-ATP radio active assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112782
BindingDB Entry DOI: 10.7270/Q2PZ5DH2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50111572
PNG
(CHEMBL3605057)
Show SMILES O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1
Show InChI InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)
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n/an/a 45n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of wild type GST-tagged ULK1 (unknown origin) after 5 mins in presence of gamma-[32]P-ATP by immunoblot analysis

J Med Chem 61: 4656-4687 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01019
BindingDB Entry DOI: 10.7270/Q2RR22GW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		CHEMBL5288376
PNG
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50271370
PNG
(CHEMBL4127042)
Show SMILES CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=N)C4CCC4)n3)ccc2C1
Show InChI InChI=1S/C25H35N7/c1-32-13-10-19-14-21(9-8-20(19)16-32)30-25-29-15-22(17-6-7-17)24(31-25)28-12-3-11-27-23(26)18-4-2-5-18/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H2,26,27)(H2,28,29,30,31)
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n/an/a 45n/an/an/an/an/an/a



Sichuan Universitt China Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged ULK1 (unknown origin)

J Med Chem 61: 6491-6500 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01684
BindingDB Entry DOI: 10.7270/Q2DN47KX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379374
PNG
(2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimi...)
Show SMILES Oc1ccccc1Nc1ncc(c(NC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O/c15-14(16,17)9-7-18-13(21-12(9)19-8-5-6-8)20-10-3-1-2-4-11(10)22/h1-4,7-8,22H,5-6H2,(H2,18,19,20,21)
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n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00873
BindingDB Entry DOI: 10.7270/Q2TX3K0J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50111575
PNG
(CHEMBL3603853)
Show SMILES Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)C1CC1
Show InChI InChI=1S/C22H28IN7O2/c23-18-14-26-21(29-19(18)24-9-4-10-25-20(31)15-7-8-15)27-16-5-3-6-17(13-16)28-22(32)30-11-1-2-12-30/h3,5-6,13-15H,1-2,4,7-12H2,(H,25,31)(H,28,32)(H2,24,26,27,29)
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n/an/a 67n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of SUMO-tagged ULK1 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...

Bioorg Med Chem 23: 5483-8 (2015)


Article DOI: 10.1016/j.bmc.2015.07.034
BindingDB Entry DOI: 10.7270/Q2CN75P8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM17051
PNG
(BX-795 | BX-795, 3 | N-(3-{[5-iodo-4-({3-[(thiophe...)
Show SMILES Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c1cccs1
Show InChI InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
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n/an/a 87n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of SUMO-tagged ULK1 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...

Bioorg Med Chem 23: 5483-8 (2015)


Article DOI: 10.1016/j.bmc.2015.07.034
BindingDB Entry DOI: 10.7270/Q2CN75P8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM379177
PNG
(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Show SMILES CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Show InChI InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
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n/an/a 108n/an/an/an/an/an/a



Sichuan Universitt China Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged ULK1 (unknown origin)

J Med Chem 61: 6491-6500 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01684
BindingDB Entry DOI: 10.7270/Q2DN47KX
More data for this
Ligand-Target Pair
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