Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 0.400 | 11 | n/a | n/a | n/a | 7.0 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla... | J Med Chem 52: 3915-26 (2009) Article DOI: 10.1021/jm9002928 BindingDB Entry DOI: 10.7270/Q2VT1QD3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 0.400 | 11 | n/a | n/a | n/a | n/a | n/a |
Chemical Genomics Centre of the Max Planck Society | Assay Description Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach. | Nat Chem Biol 5: 394-6 (2009) Article DOI: 10.1038/nchembio.162 BindingDB Entry DOI: 10.7270/Q20V8B46 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50322535 (3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097956 (3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase activity | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50437150 (CHEMBL2403820) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM92348 (1,4-Hybrid, 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM92347 (1,4-Hybrid, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097939 (7-Cyclopentyl-5-(3-methoxy-phenyl)-7H-pyrrolo[2,3-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase activity | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM81375 (Amine compound, 12a) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Washington | Assay Description In vitro activity assay using various kinases. | Chem Biol 17: 195-206 (2010) Article DOI: 10.1016/j.chembiol.2010.01.008 BindingDB Entry DOI: 10.7270/Q2833QG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097942 (3-(4-Amino-7-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase mediated phosphorylation of Fak in IC8.1 fibroblasts | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50532280 (CHEMBL4465847) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah Curated by ChEMBL | Assay Description Inhibition of chicken Src kinase domain using AEEEIYGEFAKKK as substrate by continuous spectrophotometric assay | J Med Chem 59: 6629-44 (2016) Article DOI: 10.1021/acs.jmedchem.5b01874 BindingDB Entry DOI: 10.7270/Q2N58QV5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50532280 (CHEMBL4465847) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah Curated by ChEMBL | Assay Description Inhibition of chicken Src kinase domain using AEEEIYGEFAKKK as substrate by continuous spectrophotometric assay | J Med Chem 59: 6629-44 (2016) Article DOI: 10.1021/acs.jmedchem.5b01874 BindingDB Entry DOI: 10.7270/Q2N58QV5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50437149 (CHEMBL2403821) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM81376 (Amine compound, 13a) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Washington | Assay Description In vitro activity assay using various kinases. | Chem Biol 17: 195-206 (2010) Article DOI: 10.1016/j.chembiol.2010.01.008 BindingDB Entry DOI: 10.7270/Q2833QG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.30 | 8 | n/a | n/a | n/a | n/a | n/a |
Chemical Genomics Centre of the Max Planck Society | Assay Description Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach. | Nat Chem Biol 5: 394-6 (2009) Article DOI: 10.1038/nchembio.162 BindingDB Entry DOI: 10.7270/Q20V8B46 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3095 (2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 62 | 6-(2,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3096 (2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3101 (2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 68 | 6-(2,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097951 (4-(4-Amino-7-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase activity | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3104 (2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H,8H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50088905 (2-(3-(4-amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation | Bioorg Med Chem Lett 10: 945-9 (2000) BindingDB Entry DOI: 10.7270/Q2R78DG4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50437153 (CHEMBL2403815) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM31829 (RL46 | quinazoline-pyrazolourea hybrid compound, 3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | 56 | n/a | n/a | n/a | 7.0 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla... | J Med Chem 52: 3915-26 (2009) Article DOI: 10.1021/jm9002928 BindingDB Entry DOI: 10.7270/Q2VT1QD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM31829 (RL46 | quinazoline-pyrazolourea hybrid compound, 3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097941 (4-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase mediated phosphorylation of Fak in IC8.1 fibroblasts | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50437154 (CHEMBL2403814) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50088909 ((4-(4-amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation | Bioorg Med Chem Lett 10: 945-9 (2000) BindingDB Entry DOI: 10.7270/Q2R78DG4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50088898 (2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation | Bioorg Med Chem Lett 10: 945-9 (2000) BindingDB Entry DOI: 10.7270/Q2R78DG4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097940 (2-({3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase activity | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097944 (3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase activity | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097938 (3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of p60 c-Src tyrosine kinase activity | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM31828 (quinazoline-pyrazolourea hybrid compound, 3b) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 21 | 73 | n/a | n/a | n/a | 7.0 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla... | J Med Chem 52: 3915-26 (2009) Article DOI: 10.1021/jm9002928 BindingDB Entry DOI: 10.7270/Q2VT1QD3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src [251-533,T338M] (Gallus gallus (Chicken)) | BDBM31829 (RL46 | quinazoline-pyrazolourea hybrid compound, 3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.0 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla... | J Med Chem 52: 3915-26 (2009) Article DOI: 10.1021/jm9002928 BindingDB Entry DOI: 10.7270/Q2VT1QD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3451 (3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50064349 (1-tert-Butyl-3-{6-(2,6-dichloro-phenyl)-2-[4-(2-di...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3071 (2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM81374 (BODIPY-labeled probe, 4a) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25.4 | 13 | n/a | n/a | n/a | 7.5 | n/a |
University of Washington | Assay Description In vitro activity assay using various kinases. | Chem Biol 17: 195-206 (2010) Article DOI: 10.1016/j.chembiol.2010.01.008 BindingDB Entry DOI: 10.7270/Q2833QG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3487 (3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src [251-533,V323S,T338C] (Gallus gallus (Chicken)) | BDBM234844 (US9353116, 13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 29 | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Regents of the University of California US Patent | Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat... | US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50097947 (CHEMBL352801 | {3-[4-Amino-5-(3-methoxy-phenyl)-py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Research Curated by ChEMBL | Assay Description Inhibition of v-Abl tyrosine kinase activity | Bioorg Med Chem Lett 11: 849-52 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3473 (1-benzyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50088903 (2-((4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation | Bioorg Med Chem Lett 10: 945-9 (2000) BindingDB Entry DOI: 10.7270/Q2R78DG4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50088912 (2-(4-(4-amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation | Bioorg Med Chem Lett 10: 945-9 (2000) BindingDB Entry DOI: 10.7270/Q2R78DG4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50088899 (2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description Tested for inhibition of protein tyrosine kinase c-Src phosphorylation | Bioorg Med Chem Lett 10: 945-9 (2000) BindingDB Entry DOI: 10.7270/Q2R78DG4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM3474 (1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of chicken c-Src tyrosine kinase | J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src [251-533,T338M] (Gallus gallus (Chicken)) | BDBM31828 (quinazoline-pyrazolourea hybrid compound, 3b) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.0 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla... | J Med Chem 52: 3915-26 (2009) Article DOI: 10.1021/jm9002928 BindingDB Entry DOI: 10.7270/Q2VT1QD3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50437155 (CHEMBL2403813) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50142887 (1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee Curated by ChEMBL | Assay Description Inhibition of Src in the presence of 50uM ATP | Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50437152 (CHEMBL2403816) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken)) | BDBM50437148 (CHEMBL2403874) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund Curated by ChEMBL | Assay Description Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein... | J Med Chem 56: 5757-72 (2014) Article DOI: 10.1021/jm4004076 BindingDB Entry DOI: 10.7270/Q2W37XPH | |||||||||||
More data for this Ligand-Target Pair |
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