Compile Data Set for Download or QSAR

Found 73 hits for UniProtKB: P03428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050697 (CHEMBL3317982) Show SMILES COCC(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C20H22ClFN6O2/c1-30-10-17(29)26-12-3-2-4-13(6-12)27-20-16(22)9-25-19(28-20)15-8-24-18-14(15)5-11(21)7-23-18/h5,7-9,12-13H,2-4,6,10H2,1H3,(H,23,24)(H,26,29)(H,25,27,28)/t12-,13+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050698 (CHEMBL3317983) Show SMILES COCC(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-30-10-17(29)26-12-3-2-4-13(6-12)27-20-16(22)9-25-19(28-20)15-8-24-18-14(15)5-11(21)7-23-18/h5,7-9,12-13H,2-4,6,10H2,1H3,(H,23,24)(H,26,29)(H,25,27,28)/t12-,13+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050699 (CHEMBL3317984) Show SMILES CC(O)C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C20H22ClFN6O2/c1-10(29)20(30)27-13-4-2-3-12(6-13)26-19-16(22)9-25-18(28-19)15-8-24-17-14(15)5-11(21)7-23-17/h5,7-10,12-13,29H,2-4,6H2,1H3,(H,23,24)(H,27,30)(H,25,26,28)/t10?,12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050700 (CHEMBL3317985) Show SMILES Fc1cnc(nc1N[C@H]1CCC[C@H](C1)NC(=O)CN1CCOCC1)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C23H27ClFN7O2/c24-14-8-17-18(11-27-21(17)26-10-14)22-28-12-19(25)23(31-22)30-16-3-1-2-15(9-16)29-20(33)13-32-4-6-34-7-5-32/h8,10-12,15-16H,1-7,9,13H2,(H,26,27)(H,29,33)(H,28,30,31)/t15-,16+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050701 (CHEMBL3317986) Show SMILES CN(C)C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r| Show InChI InChI=1S/C20H23F2N7O/c1-29(2)20(30)27-13-5-3-4-12(7-13)26-19-16(22)10-25-18(28-19)15-9-24-17-14(15)6-11(21)8-23-17/h6,8-10,12-13H,3-5,7H2,1-2H3,(H,23,24)(H,27,30)(H,25,26,28)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050702 (CHEMBL3317999) Show SMILES NC(=O)[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H18ClFN6O/c19-9-5-11-12(7-23-16(11)22-6-9)17-24-8-13(20)18(26-17)25-14-4-2-1-3-10(14)15(21)27/h5-8,10,14H,1-4H2,(H2,21,27)(H,22,23)(H,24,25,26)/t10-,14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050703 (CHEMBL3318000) Show SMILES OC(=O)[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H17ClFN5O2/c19-9-5-11-12(7-22-15(11)21-6-9)16-23-8-13(20)17(25-16)24-14-4-2-1-3-10(14)18(26)27/h5-8,10,14H,1-4H2,(H,21,22)(H,26,27)(H,23,24,25)/t10-,14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050705 (CHEMBL3318001) Show SMILES C[C@@]1(CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C19H19ClFN5O2/c1-19(18(27)28)5-3-2-4-14(19)25-17-13(21)9-24-16(26-17)12-8-23-15-11(12)6-10(20)7-22-15/h6-9,14H,2-5H2,1H3,(H,22,23)(H,27,28)(H,24,25,26)/t14-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050706 (CHEMBL3318002) Show SMILES C[C@@]1(CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12)C(O)=O |r| Show InChI InChI=1S/C19H19F2N5O2/c1-19(18(27)28)5-3-2-4-14(19)25-17-13(21)9-24-16(26-17)12-8-23-15-11(12)6-10(20)7-22-15/h6-9,14H,2-5H2,1H3,(H,22,23)(H,27,28)(H,24,25,26)/t14-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050707 (CHEMBL3318003) Show SMILES COCC[C@@]1(CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C21H23ClFN5O3/c1-31-7-6-21(20(29)30)5-3-2-4-16(21)27-19-15(23)11-26-18(28-19)14-10-25-17-13(14)8-12(22)9-24-17/h8-11,16H,2-7H2,1H3,(H,24,25)(H,29,30)(H,26,27,28)/t16-,21+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050708 (CHEMBL3318004) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@@H]([C@H]2Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C19H17ClFN5O2/c20-10-4-11-12(6-23-16(11)22-5-10)17-24-7-13(21)18(26-17)25-15-9-2-1-8(3-9)14(15)19(27)28/h4-9,14-15H,1-3H2,(H,22,23)(H,27,28)(H,24,25,26)/t8-,9+,14+,15+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050709 (CHEMBL3318005) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@@H]([C@H]2Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C19H17ClFN5O2/c20-10-4-11-12(6-23-16(11)22-5-10)17-24-7-13(21)18(26-17)25-15-9-2-1-8(3-9)14(15)19(27)28/h4-9,14-15H,1-3H2,(H,22,23)(H,27,28)(H,24,25,26)/t8-,9+,14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050710 (CHEMBL3318006) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r,wU:3.2,wD:10.12,(29.25,-16.63,;27.75,-17,;26.69,-15.88,;27.31,-18.47,;28.37,-19.59,;27.93,-21.07,;26.43,-21.42,;25.38,-20.31,;26.46,-19.21,;26.86,-20.7,;25.82,-18.84,;24.76,-17.72,;23.26,-18.08,;22.83,-19.55,;21.33,-19.91,;20.27,-18.8,;20.71,-17.32,;22.2,-16.96,;22.64,-15.49,;20.89,-21.39,;21.83,-22.61,;20.96,-23.89,;19.49,-23.45,;18.17,-24.25,;16.82,-23.52,;16.78,-21.98,;15.43,-21.24,;18.09,-21.17,;19.44,-21.91,)| Show InChI InChI=1S/C20H19ClFN5O2/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20(28)29/h5-10,15-16H,1-4H2,(H,23,24)(H,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050713 (CHEMBL3317987) Show SMILES Fc1cnc(nc1N[C@H]1CCC[C@H](C1)NC(=O)N1CCOCC1)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C22H25ClFN7O2/c23-13-8-16-17(11-26-19(16)25-10-13)20-27-12-18(24)21(30-20)28-14-2-1-3-15(9-14)29-22(32)31-4-6-33-7-5-31/h8,10-12,14-15H,1-7,9H2,(H,25,26)(H,29,32)(H,27,28,30)/t14-,15+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050714 (CHEMBL3317988) Show SMILES Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4CCC[C@H](C4)NC(=O)N4CCOCC4)n3)c2c1 |r| Show InChI InChI=1S/C22H25F2N7O2/c23-13-8-16-17(11-26-19(16)25-10-13)20-27-12-18(24)21(30-20)28-14-2-1-3-15(9-14)29-22(32)31-4-6-33-7-5-31/h8,10-12,14-15H,1-7,9H2,(H,25,26)(H,29,32)(H,27,28,30)/t14-,15+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050715 (CHEMBL3317989) Show SMILES Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4CCC[C@H](C4)NC(=O)NC4CCOCC4)n3)c2c1 |r| Show InChI InChI=1S/C23H27F2N7O2/c24-13-8-17-18(11-27-20(17)26-10-13)21-28-12-19(25)22(32-21)29-15-2-1-3-16(9-15)31-23(33)30-14-4-6-34-7-5-14/h8,10-12,14-16H,1-7,9H2,(H,26,27)(H,28,29,32)(H2,30,31,33)/t15-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050716 (CHEMBL3317990) Show SMILES Cn1cncc1C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C22H22ClFN8O/c1-32-11-25-10-18(32)22(33)30-14-4-2-3-13(6-14)29-21-17(24)9-28-20(31-21)16-8-27-19-15(16)5-12(23)7-26-19/h5,7-11,13-14H,2-4,6H2,1H3,(H,26,27)(H,30,33)(H,28,29,31)/t13-,14+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050717 (CHEMBL3317991) Show SMILES Cn1cncc1C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r| Show InChI InChI=1S/C22H22F2N8O/c1-32-11-25-10-18(32)22(33)30-14-4-2-3-13(6-14)29-21-17(24)9-28-20(31-21)16-8-27-19-15(16)5-12(23)7-26-19/h5,7-11,13-14H,2-4,6H2,1H3,(H,26,27)(H,30,33)(H,28,29,31)/t13-,14+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050718 (CHEMBL3317969) Show SMILES C[C@H](Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(=O)N(C)C |r| Show InChI InChI=1S/C16H16ClFN6O/c1-8(16(25)24(2)3)22-15-12(18)7-21-14(23-15)11-6-20-13-10(11)4-9(17)5-19-13/h4-8H,1-3H3,(H,19,20)(H,21,22,23)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair				3D Structure (crystal)
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050719 (CHEMBL3317970) Show SMILES Fc1cnc(nc1NC1CCCCC1)-c1c[nH]c2ncc(Cl)cc12 Show InChI InChI=1S/C17H17ClFN5/c18-10-6-12-13(8-21-15(12)20-7-10)16-22-9-14(19)17(24-16)23-11-4-2-1-3-5-11/h6-9,11H,1-5H2,(H,20,21)(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050720 (CHEMBL3317972) Show SMILES Fc1cnc(nc1NC1CCCC1)-c1c[nH]c2ncc(Cl)cc12 Show InChI InChI=1S/C16H15ClFN5/c17-9-5-11-12(7-20-14(11)19-6-9)15-21-8-13(18)16(23-15)22-10-3-1-2-4-10/h5-8,10H,1-4H2,(H,19,20)(H,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050721 (CHEMBL3317973) Show SMILES CC(=O)N1CCC[C@H](CNc2nc(ncc2F)-c2c[nH]c3ncc(Cl)cc23)C1 |r| Show InChI InChI=1S/C19H20ClFN6O/c1-11(28)27-4-2-3-12(10-27)6-22-19-16(21)9-25-18(26-19)15-8-24-17-14(15)5-13(20)7-23-17/h5,7-9,12H,2-4,6,10H2,1H3,(H,23,24)(H,22,25,26)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050722 (CHEMBL3317974) Show SMILES CS(=O)(=O)N1CCCC[C@@H]1CNc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H20ClFN6O2S/c1-29(27,28)26-5-3-2-4-12(26)8-22-18-15(20)10-24-17(25-18)14-9-23-16-13(14)6-11(19)7-21-16/h6-7,9-10,12H,2-5,8H2,1H3,(H,21,23)(H,22,24,25)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050750 (CHEMBL3317975) Show SMILES COCCC(=O)N1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C20H22ClFN6O2/c1-30-6-4-17(29)28-5-2-3-13(11-28)26-20-16(22)10-25-19(27-20)15-9-24-18-14(15)7-12(21)8-23-18/h7-10,13H,2-6,11H2,1H3,(H,23,24)(H,25,26,27)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050754 (CHEMBL3317976) Show SMILES OC[C@H](O)CN1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C19H22ClFN6O2/c20-11-4-14-15(6-23-17(14)22-5-11)18-24-7-16(21)19(26-18)25-12-2-1-3-27(8-12)9-13(29)10-28/h4-7,12-13,28-29H,1-3,8-10H2,(H,22,23)(H,24,25,26)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050756 (CHEMBL3317977) Show SMILES NC(=O)CN1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H19ClFN7O/c19-10-4-12-13(6-23-16(12)22-5-10)17-24-7-14(20)18(26-17)25-11-2-1-3-27(8-11)9-15(21)28/h4-7,11H,1-3,8-9H2,(H2,21,28)(H,22,23)(H,24,25,26)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050757 (CHEMBL3317978) Show SMILES N[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C17H18ClFN6/c18-9-5-10-11(7-22-15(10)21-6-9)16-23-8-12(19)17(25-16)24-14-4-2-1-3-13(14)20/h5-8,13-14H,1-4,20H2,(H,21,22)(H,23,24,25)/t13-,14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050758 (CHEMBL3317979) Show SMILES N[C@@H]1CCCC[C@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050759 (CHEMBL3317980) Show SMILES CC(=O)N[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050760 (CHEMBL3317981) Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50521200 (CHEMBL4554496) Show SMILES CC\C=C1\C=CC(=O)[C@@H](O)[C@@]11[C@@H](O)[C@](C)(OC)N(OC)C1=O |r,c:4| Show InChI InChI=1S/C15H21NO6/c1-5-6-9-7-8-10(17)11(18)15(9)12(19)14(2,21-3)16(22-4)13(15)20/h6-8,11-12,18-19H,5H2,1-4H3/b9-6-/t11-,12+,14+,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to Influenza A virus RNA polymerase PB2 by SPR assay				J Nat Prod 81: 2722-2730 (2018) Article DOI: 10.1021/acs.jnatprod.8b00656 BindingDB Entry DOI: 10.7270/Q2BG2SCR
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50521201 (CHEMBL4472996) Show SMILES Oc1cc(O)c2c(c1)oc(=O)c1ccccc21 Show InChI InChI=1S/C13H8O4/c14-7-5-10(15)12-8-3-1-2-4-9(8)13(16)17-11(12)6-7/h1-6,14-15H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to Influenza A virus RNA polymerase PB2 by SPR assay				J Nat Prod 81: 2722-2730 (2018) Article DOI: 10.1021/acs.jnatprod.8b00656 BindingDB Entry DOI: 10.7270/Q2BG2SCR
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507221 (CHEMBL4542293) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1N1CCOc2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(51.16,-2.19,;52.49,-2.95,;53.82,-2.17,;52.51,-4.49,;53.85,-5.25,;53.86,-6.79,;52.53,-7.57,;51.2,-6.81,;51.96,-5.52,;53.08,-6.43,;51.19,-5.27,;49.88,-4.51,;49.39,-3.04,;47.87,-2.74,;46.85,-3.9,;47.35,-5.36,;46.33,-6.51,;46.81,-7.97,;48.32,-8.28,;49.35,-7.13,;48.87,-5.67,;48.8,-9.73,;47.9,-10.98,;48.81,-12.23,;50.27,-11.74,;51.61,-12.51,;52.94,-11.74,;52.93,-10.19,;54.27,-9.42,;51.6,-9.43,;50.27,-10.21,)| Show InChI InChI=1S/C22H22FN5O3/c23-13-7-14-15(9-25-19(14)24-8-13)20-26-10-16-21(27-20)28(5-6-31-16)18-12-3-1-11(2-4-12)17(18)22(29)30/h7-12,17-18H,1-6H2,(H,24,25)(H,29,30)/t11?,12?,17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507222 (CHEMBL4459959) Show SMILES Cn1cc(F)c2c(N[C@H]3C4CCC(CC4)[C@@H]3C(O)=O)nc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:15.17,wD:8.7,(19.15,-35.75,;20.47,-34.99,;20.63,-33.46,;22.14,-33.14,;22.76,-31.74,;22.91,-34.47,;24.41,-34.78,;25.72,-34,;27.05,-34.75,;27.06,-36.31,;28.39,-37.06,;29.73,-36.29,;29.72,-34.74,;28.94,-35.92,;27.82,-35.01,;28.37,-33.97,;28.36,-32.43,;27.02,-31.67,;29.69,-31.65,;24.88,-36.23,;23.86,-37.37,;22.36,-37.07,;21.88,-35.62,;24.35,-38.82,;23.45,-40.08,;24.36,-41.33,;25.82,-40.84,;27.16,-41.61,;28.5,-40.84,;28.49,-39.29,;29.83,-38.51,;27.16,-38.52,;25.82,-39.3,)| Show InChI InChI=1S/C23H22F2N6O2/c1-31-9-15(25)17-21(28-18-11-4-2-10(3-5-11)16(18)23(32)33)29-20(30-22(17)31)14-8-27-19-13(14)6-12(24)7-26-19/h6-11,16,18H,2-5H2,1H3,(H,26,27)(H,32,33)(H,28,29,30)/t10?,11?,16-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9.60	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507223 (CHEMBL4470294) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2SCCc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(54.38,-44.92,;55.71,-45.68,;57.05,-44.9,;55.72,-47.22,;57.07,-47.99,;57.08,-49.54,;55.75,-50.32,;54.41,-49.56,;55.18,-48.26,;56.29,-49.17,;54.41,-48.01,;53.08,-47.26,;51.76,-48.03,;52.24,-49.48,;51.22,-50.62,;49.72,-50.32,;49.23,-48.87,;47.83,-48.24,;47.99,-46.71,;49.49,-46.39,;50.26,-47.72,;51.7,-52.07,;50.8,-53.33,;51.71,-54.58,;53.18,-54.09,;54.52,-54.86,;55.85,-54.09,;55.85,-52.54,;57.18,-51.76,;54.51,-51.77,;53.17,-52.55,)| Show InChI InChI=1S/C22H22FN5O2S/c23-12-7-14-15(9-25-18(14)24-8-12)20-27-19(13-5-6-31-21(13)28-20)26-17-11-3-1-10(2-4-11)16(17)22(29)30/h7-11,16-17H,1-6H2,(H,24,25)(H,29,30)(H,26,27,28)/t10?,11?,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507224 (CHEMBL4580408) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1cc(C#N)c2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(29.83,-2.09,;31.16,-2.85,;32.49,-2.07,;31.17,-4.39,;32.52,-5.15,;32.53,-6.69,;31.2,-7.47,;29.87,-6.71,;30.63,-5.42,;31.74,-6.33,;29.86,-5.17,;28.55,-4.41,;27.51,-3.27,;26.11,-3.91,;24.79,-3.15,;23.47,-2.4,;26.28,-5.44,;25.26,-6.59,;25.74,-8.05,;27.24,-8.37,;28.27,-7.21,;27.79,-5.75,;27.72,-9.82,;26.82,-11.07,;27.73,-12.31,;29.19,-11.83,;30.53,-12.6,;31.86,-11.83,;31.86,-10.28,;33.19,-9.5,;30.53,-9.51,;29.19,-10.29,)| Show InChI InChI=1S/C23H19FN6O2/c24-14-5-15-17(9-27-20(15)26-7-14)21-28-8-16-13(6-25)10-30(22(16)29-21)19-12-3-1-11(2-4-12)18(19)23(31)32/h5,7-12,18-19H,1-4H2,(H,26,27)(H,31,32)/t11?,12?,18-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507225 (CHEMBL4444973) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2c(csc12)C#N)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(68.54,-43.82,;69.88,-44.58,;71.22,-43.8,;69.89,-46.12,;71.24,-46.89,;71.25,-48.44,;69.92,-49.22,;68.58,-48.46,;69.35,-47.16,;70.46,-48.07,;68.58,-46.91,;67.24,-46.16,;65.93,-46.93,;66.41,-48.38,;65.39,-49.52,;63.89,-49.22,;63.4,-47.77,;61.99,-47.14,;62.16,-45.61,;63.66,-45.29,;64.43,-46.62,;60.67,-47.9,;59.35,-48.67,;65.87,-50.97,;64.97,-52.23,;65.88,-53.48,;67.35,-52.99,;68.69,-53.76,;70.02,-52.99,;70.02,-51.44,;71.35,-50.66,;68.68,-50.67,;67.34,-51.45,)| Show InChI InChI=1S/C23H19FN6O2S/c24-13-5-14-15(8-27-20(14)26-7-13)21-29-18-12(6-25)9-33-19(18)22(30-21)28-17-11-3-1-10(2-4-11)16(17)23(31)32/h5,7-11,16-17H,1-4H2,(H,26,27)(H,31,32)(H,28,29,30)/t10?,11?,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507226 (CHEMBL4538856) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CCS(=O)(=O)c12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(9.28,-2.69,;10.62,-3.45,;11.95,-2.67,;10.63,-4.99,;11.98,-5.76,;11.99,-7.31,;10.65,-8.09,;9.32,-7.33,;10.08,-6.03,;11.2,-6.94,;9.31,-5.78,;7.98,-5.03,;6.67,-5.8,;7.14,-7.25,;6.13,-8.39,;4.62,-8.09,;4.14,-6.64,;2.73,-6.01,;2.89,-4.48,;4.4,-4.15,;4.39,-2.62,;5.72,-3.38,;5.17,-5.49,;6.61,-9.84,;5.71,-11.1,;6.62,-12.35,;8.08,-11.86,;9.42,-12.63,;10.76,-11.86,;10.75,-10.31,;12.09,-9.53,;9.42,-9.54,;8.08,-10.32,)| Show InChI InChI=1S/C22H22FN5O4S/c23-12-7-13-14(9-25-19(13)24-8-12)20-26-15-5-6-33(31,32)18(15)21(28-20)27-17-11-3-1-10(2-4-11)16(17)22(29)30/h7-11,16-17H,1-6H2,(H,24,25)(H,29,30)(H,26,27,28)/t10?,11?,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507227 (CHEMBL4519832) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CS(=O)(=O)Cc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(22.98,-2.34,;24.32,-3.1,;25.65,-2.32,;24.33,-4.65,;25.68,-5.41,;25.69,-6.96,;24.35,-7.74,;23.02,-6.98,;23.78,-5.69,;24.9,-6.59,;23.02,-5.43,;21.68,-4.68,;20.37,-5.46,;20.85,-6.91,;19.83,-8.04,;18.32,-7.75,;17.84,-6.29,;16.43,-5.66,;16.59,-4.13,;15.06,-4.13,;15.82,-2.81,;18.1,-3.81,;18.87,-5.15,;20.31,-9.5,;19.41,-10.75,;20.32,-12,;21.79,-11.51,;23.13,-12.29,;24.46,-11.51,;24.46,-9.96,;25.79,-9.18,;23.12,-9.19,;21.78,-9.97,)| Show InChI InChI=1S/C22H22FN5O4S/c23-12-5-13-14(7-25-19(13)24-6-12)20-26-16-9-33(31,32)8-15(16)21(28-20)27-18-11-3-1-10(2-4-11)17(18)22(29)30/h5-7,10-11,17-18H,1-4,8-9H2,(H,24,25)(H,29,30)(H,26,27,28)/t10?,11?,17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507228 (CHEMBL4434862) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2ccsc12)-c1n[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(9.79,-17.85,;11.13,-18.61,;12.46,-17.83,;11.14,-20.16,;12.49,-20.92,;12.5,-22.47,;11.16,-23.25,;9.83,-22.49,;10.59,-21.2,;11.71,-22.1,;9.82,-20.94,;8.49,-20.19,;7.18,-20.96,;7.65,-22.41,;6.63,-23.55,;5.13,-23.25,;4.65,-21.8,;3.24,-21.17,;3.4,-19.64,;4.91,-19.32,;5.68,-20.65,;7.12,-25.01,;6.22,-26.26,;7.13,-27.51,;8.59,-27.02,;9.93,-27.79,;11.27,-27.02,;11.26,-25.47,;12.6,-24.69,;9.93,-24.7,;8.59,-25.48,)| Show InChI InChI=1S/C21H19FN6O2S/c22-11-7-12-16(27-28-18(12)23-8-11)19-24-13-5-6-31-17(13)20(26-19)25-15-10-3-1-9(2-4-10)14(15)21(29)30/h5-10,14-15H,1-4H2,(H,29,30)(H,23,27,28)(H,24,25,26)/t9?,10?,14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507229 (CHEMBL4593027) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2sccc12)-c1n[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(24.37,-19.32,;25.71,-20.08,;27.04,-19.3,;25.72,-21.62,;27.07,-22.39,;27.08,-23.94,;25.74,-24.71,;24.41,-23.95,;25.17,-22.66,;26.29,-23.57,;24.4,-22.4,;23.07,-21.65,;21.76,-22.43,;22.24,-23.88,;21.22,-25.02,;19.71,-24.72,;19.23,-23.26,;17.82,-22.64,;17.98,-21.11,;19.49,-20.79,;20.26,-22.12,;21.7,-26.47,;20.8,-27.73,;21.71,-28.97,;23.18,-28.49,;24.52,-29.26,;25.85,-28.49,;25.85,-26.93,;27.18,-26.16,;24.51,-26.17,;23.17,-26.95,)| Show InChI InChI=1S/C21H19FN6O2S/c22-11-7-13-16(27-28-17(13)23-8-11)19-25-18(12-5-6-31-20(12)26-19)24-15-10-3-1-9(2-4-10)14(15)21(29)30/h5-10,14-15H,1-4H2,(H,29,30)(H,23,27,28)(H,24,25,26)/t9?,10?,14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0600	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507230 (CHEMBL4472219) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CCSc12)-c1n[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(37.95,-18.53,;39.29,-19.29,;40.62,-18.51,;39.3,-20.84,;40.65,-21.6,;40.66,-23.15,;39.32,-23.93,;37.99,-23.17,;38.75,-21.88,;39.87,-22.78,;37.98,-21.62,;36.65,-20.87,;35.34,-21.64,;35.82,-23.09,;34.8,-24.23,;33.29,-23.93,;32.81,-22.48,;31.4,-21.85,;31.56,-20.32,;33.07,-20,;33.84,-21.33,;35.28,-25.69,;34.38,-26.94,;35.29,-28.19,;36.76,-27.7,;38.1,-28.47,;39.43,-27.7,;39.43,-26.15,;40.76,-25.37,;38.09,-25.38,;36.75,-26.16,)| Show InChI InChI=1S/C21H21FN6O2S/c22-11-7-12-16(27-28-18(12)23-8-11)19-24-13-5-6-31-17(13)20(26-19)25-15-10-3-1-9(2-4-10)14(15)21(29)30/h7-10,14-15H,1-6H2,(H,29,30)(H,23,27,28)(H,24,25,26)/t9?,10?,14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050712 (CHEMBL3318007) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(15.61,-25.66,;14.11,-26.02,;13.05,-24.9,;13.67,-27.49,;14.73,-28.62,;14.29,-30.09,;12.8,-30.45,;11.74,-29.34,;12.83,-28.23,;13.22,-29.72,;12.18,-27.86,;11.12,-26.75,;9.63,-27.1,;9.19,-28.58,;7.69,-28.94,;6.63,-27.82,;7.06,-26.35,;8.56,-25.99,;9,-24.51,;7.25,-30.41,;8.2,-31.63,;7.32,-32.91,;5.84,-32.47,;4.53,-33.27,;3.18,-32.54,;3.14,-31,;1.79,-30.27,;4.45,-30.19,;5.8,-30.93,)| Show InChI InChI=1S/C20H19F2N5O2/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20(28)29/h5-10,15-16H,1-4H2,(H,23,24)(H,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507231 (CHEMBL4453678) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-n1ccc2ncc(F)cc12 |r,wU:3.2,wD:10.12,(9.5,-36.14,;10.83,-36.9,;12.16,-36.12,;10.84,-38.44,;12.19,-39.21,;12.2,-40.75,;10.87,-41.53,;9.54,-40.77,;10.3,-39.48,;11.41,-40.38,;9.53,-39.22,;8.2,-38.47,;6.89,-39.25,;7.36,-40.7,;6.35,-41.83,;4.85,-41.54,;4.36,-40.08,;5.39,-38.94,;4.92,-37.49,;6.83,-43.28,;5.93,-44.54,;6.84,-45.78,;8.3,-45.3,;9.64,-46.07,;10.97,-45.3,;10.97,-43.75,;12.3,-42.97,;9.64,-42.98,;8.3,-43.76,)| Show InChI InChI=1S/C20H19F2N5O2/c21-12-7-15-14(23-8-12)5-6-27(15)20-24-9-13(22)18(26-20)25-17-11-3-1-10(2-4-11)16(17)19(28)29/h5-11,16-17H,1-4H2,(H,28,29)(H,24,25,26)/t10?,11?,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507232 (CHEMBL4513835) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ccc(F)cc12 |r,wU:3.2,wD:10.12,(21.38,-34.97,;22.71,-35.73,;24.04,-34.95,;22.72,-37.27,;24.07,-38.04,;24.08,-39.58,;22.75,-40.36,;21.42,-39.6,;22.18,-38.31,;23.29,-39.21,;21.41,-38.05,;20.08,-37.3,;18.77,-38.08,;19.24,-39.52,;18.23,-40.66,;16.73,-40.36,;16.24,-38.91,;17.27,-37.77,;16.8,-36.32,;18.71,-42.11,;17.81,-43.36,;18.72,-44.61,;20.18,-44.12,;21.52,-44.9,;22.85,-44.12,;22.85,-42.57,;24.18,-41.8,;21.52,-41.81,;20.18,-42.59,)| Show InChI InChI=1S/C21H20F2N4O2/c22-12-5-6-16-13(7-12)14(8-24-16)19-25-9-15(23)20(27-19)26-18-11-3-1-10(2-4-11)17(18)21(28)29/h5-11,17-18,24H,1-4H2,(H,28,29)(H,25,26,27)/t10?,11?,17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507233 (CHEMBL4589525) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1cnc2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(40.52,-2.61,;41.86,-3.37,;43.19,-2.59,;41.87,-4.91,;43.21,-5.68,;43.22,-7.22,;41.89,-7.99,;40.56,-7.24,;41.32,-5.95,;42.44,-6.85,;40.56,-5.69,;39.25,-4.93,;38.21,-3.8,;36.8,-4.43,;36.98,-5.96,;35.95,-7.12,;36.43,-8.58,;37.93,-8.89,;38.97,-7.74,;38.48,-6.27,;38.42,-10.34,;37.52,-11.59,;38.43,-12.84,;39.89,-12.35,;41.22,-13.12,;42.56,-12.35,;42.55,-10.8,;43.88,-10.03,;41.22,-10.04,;39.88,-10.81,)| Show InChI InChI=1S/C21H19FN6O2/c22-12-5-13-14(7-24-18(13)23-6-12)19-25-8-15-20(27-19)28(9-26-15)17-11-3-1-10(2-4-11)16(17)21(29)30/h5-11,16-17H,1-4H2,(H,23,24)(H,29,30)/t10?,11?,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507234 (CHEMBL4464813) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2cccc(F)c12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(63.47,-2.1,;64.8,-2.86,;66.14,-2.08,;64.82,-4.41,;66.17,-5.18,;66.18,-6.72,;64.84,-7.5,;63.5,-6.74,;64.27,-5.45,;65.39,-6.35,;63.5,-5.19,;62.16,-4.44,;60.85,-5.22,;61.32,-6.67,;60.3,-7.81,;58.8,-7.51,;58.32,-6.05,;56.82,-5.74,;56.34,-4.29,;57.37,-3.13,;58.87,-3.45,;59.89,-2.31,;59.35,-4.91,;60.79,-9.27,;59.89,-10.52,;60.8,-11.77,;62.27,-11.29,;63.61,-12.06,;64.95,-11.29,;64.94,-9.73,;66.28,-8.95,;63.61,-8.96,;62.26,-9.74,)| Show InChI InChI=1S/C24H21F2N5O2/c25-13-8-14-15(10-28-21(14)27-9-13)22-29-17-3-1-2-16(26)19(17)23(31-22)30-20-12-6-4-11(5-7-12)18(20)24(32)33/h1-3,8-12,18,20H,4-7H2,(H,27,28)(H,32,33)(H,29,30,31)/t11?,12?,18-,20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507235 (CHEMBL4514982) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2cccnc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(76.83,-1,;78.17,-1.76,;79.51,-.98,;78.18,-3.31,;79.53,-4.08,;79.54,-5.62,;78.2,-6.4,;76.87,-5.64,;77.63,-4.35,;78.76,-5.25,;76.86,-4.09,;75.53,-3.34,;74.21,-4.12,;74.69,-5.57,;73.67,-6.71,;72.17,-6.41,;71.69,-4.95,;70.19,-4.64,;69.71,-3.19,;70.74,-2.04,;72.24,-2.35,;72.72,-3.81,;74.16,-8.16,;73.26,-9.42,;74.17,-10.67,;75.63,-10.18,;76.98,-10.96,;78.31,-10.18,;78.31,-8.63,;79.65,-7.85,;76.97,-7.86,;75.63,-8.64,)| Show InChI InChI=1S/C23H21FN6O2/c24-13-8-14-15(10-27-20(14)26-9-13)21-28-16-2-1-7-25-19(16)22(30-21)29-18-12-5-3-11(4-6-12)17(18)23(31)32/h1-2,7-12,17-18H,3-6H2,(H,26,27)(H,31,32)(H,28,29,30)/t11?,12?,17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507236 (CHEMBL4530239) Show SMILES Cc1cccc2nc(nc(N[C@H]3C4CCC(CC4)[C@@H]3C(O)=O)c12)-c1c[nH]c2ncc(F)cc12 |r,wU:18.20,wD:11.10,(20.41,-17.61,;19.38,-18.76,;17.88,-18.44,;16.85,-19.59,;17.33,-21.05,;18.83,-21.36,;19.31,-22.83,;20.82,-23.13,;21.84,-21.98,;21.36,-20.53,;22.68,-19.75,;24.02,-20.5,;24.03,-22.06,;25.37,-22.82,;26.71,-22.04,;26.7,-20.49,;25.92,-21.67,;24.79,-20.76,;25.34,-19.72,;25.33,-18.16,;23.99,-17.4,;26.67,-17.38,;19.86,-20.22,;21.31,-24.59,;20.4,-25.85,;21.32,-27.1,;22.79,-26.61,;24.13,-27.39,;25.47,-26.61,;25.47,-25.05,;26.81,-24.27,;24.13,-24.28,;22.78,-25.06,)| Show InChI InChI=1S/C25H24FN5O2/c1-12-3-2-4-18-19(12)24(30-21-14-7-5-13(6-8-14)20(21)25(32)33)31-23(29-18)17-11-28-22-16(17)9-15(26)10-27-22/h2-4,9-11,13-14,20-21H,5-8H2,1H3,(H,27,28)(H,32,33)(H,29,30,31)/t13?,14?,20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507237 (CHEMBL4567152) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2nccnc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(51.29,-18.03,;52.63,-18.79,;53.97,-18.01,;52.64,-20.34,;53.99,-21.1,;54,-22.65,;52.66,-23.43,;51.33,-22.67,;52.09,-21.38,;53.21,-22.28,;51.32,-21.12,;49.99,-20.37,;48.67,-21.15,;49.15,-22.6,;48.13,-23.74,;46.63,-23.44,;46.15,-21.98,;44.66,-21.66,;44.18,-20.21,;45.2,-19.06,;46.7,-19.38,;47.18,-20.84,;48.62,-25.19,;47.72,-26.45,;48.63,-27.7,;50.09,-27.21,;51.44,-27.98,;52.77,-27.21,;52.77,-25.65,;54.1,-24.88,;51.43,-24.89,;50.09,-25.67,)| Show InChI InChI=1S/C22H20FN7O2/c23-12-7-13-14(9-27-18(13)26-8-12)19-29-20-17(24-5-6-25-20)21(30-19)28-16-11-3-1-10(2-4-11)15(16)22(31)32/h5-11,15-16H,1-4H2,(H,26,27)(H,31,32)(H,25,28,29,30)/t10?,11?,15-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair

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