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Compile Data Set for Download or QSAR

Found 635 hits for UniProtKB: P05622   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50193104
PNG
(CHEMBL3905910)
Show SMILES CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1
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 0.626n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Alpha-2 adrenergic receptor induced contractile response of rabbit vas deferens

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5275386
PNG
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cccc(OCc2ccccc2)c1)C(C)C)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C28H37N3O7/c1-17(2)13-22(26(34)30-23(15-32)28(36)37)29-27(35)24(18(3)4)31-25(33)20-11-8-12-21(14-20)38-16-19-9-6-5-7-10-19/h5-12,14,17-18,22-24,32H,13,15-16H2,1-4H3,(H,29,35)(H,30,34)(H,31,33)(H,36,37)/t22-,23-,24-/m0/s1
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 3.30n/an/an/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5272722
PNG
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CCS)C(C)C)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C17H31N3O6S/c1-9(2)7-11(15(23)19-12(8-21)17(25)26)18-16(24)14(10(3)4)20-13(22)5-6-27/h9-12,14,21,27H,5-8H2,1-4H3,(H,18,24)(H,19,23)(H,20,22)(H,25,26)/t11-,12-,14-/m0/s1
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 3.30n/an/an/an/an/an/an/an/a


TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5270747
PNG
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1ccc(OCc2ccccc2)cc1)C(C)C)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C28H37N3O7/c1-17(2)14-22(26(34)30-23(15-32)28(36)37)29-27(35)24(18(3)4)31-25(33)20-10-12-21(13-11-20)38-16-19-8-6-5-7-9-19/h5-13,17-18,22-24,32H,14-16H2,1-4H3,(H,29,35)(H,30,34)(H,31,33)(H,36,37)/t22-,23-,24-/m0/s1
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 3.30n/an/an/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5274911
PNG
Show SMILES [#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-1-[#6]-[#6@H](-[#8])-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1cccs1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@H](-[#6]-1-[#6]-[#6]-[#6]-[#6]-1)-[#6](=O)-[#7](-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O)-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C55H91N19O13S/c56-35(16-6-20-63-53(57)58)45(79)69-36(17-7-21-64-54(59)60)49(83)72-23-9-19-40(72)50(84)74-28-33(76)25-41(74)48(82)66-27-42(77)68-38(26-34-15-10-24-88-34)46(80)70-39(30-75)47(81)71-44(31-11-4-5-12-31)51(85)73(32-13-2-1-3-14-32)29-43(78)67-37(52(86)87)18-8-22-65-55(61)62/h10,15,24,31-33,35-41,44,75-76H,1-9,11-14,16-23,25-30,56H2,(H,66,82)(H,67,78)(H,68,77)(H,69,79)(H,70,80)(H,71,81)(H,86,87)(H4,57,58,63)(H4,59,60,64)(H4,61,62,65)/t33-,35+,36+,37+,38+,39+,40+,41+,44-/m1/s1
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 5.20E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity against bradykinin B2 receptor

Citation and Details
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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50014260
PNG
(3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione | 3,7...)
Show SMILES Cn1cnc2n(C)c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)9-7(13)11(5)2/h3H,1-2H3,(H,9,12,13)
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>1.00E+5n/an/an/an/an/an/an/an/a



J. Uriach & Cía, S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from chicken liver

J Med Chem 40: 547-58 (1997)


Article DOI: 10.1021/jm9604383
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5268482
PNG
Show SMILES CC(O)C(NC(C)=O)C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C2CCCCC2CC1C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C36H45N5O6/c1-22(42)33(37-23(2)43)34(45)38-29(20-28-18-26-14-8-10-16-30(26)40(28)24(3)44)35(46)41-31-17-11-9-15-27(31)19-32(41)36(47)39(4)21-25-12-6-5-7-13-25/h5-8,10,12-14,16,18,22,27,29,31-33,42H,9,11,15,17,19-21H2,1-4H3,(H,37,43)(H,38,45)/t22?,27?,29-,31?,32?,33?/m1/s1
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n/an/a 0.0400n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5268427
PNG
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n/an/a 0.140n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5286715
PNG
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n/an/a 0.210n/an/an/an/an/an/a


TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5288936
PNG
MMDB

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n/an/a 0.210n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5267724
PNG
MMDB

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n/an/a 0.210n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5271348
PNG
MMDB

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n/an/a 0.210n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5290499
PNG
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n/an/a 0.210n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50518950
PNG
(CHEMBL4468881)
Show SMILES COc1ccc2c3conc3c(=O)n(CCN3CCC(CC3)NCc3ccc4OCC(=O)Nc4n3)c2c1
Show InChI InChI=1S/C26H28N6O5/c1-35-18-3-4-19-20-14-37-30-24(20)26(34)32(21(19)12-18)11-10-31-8-6-16(7-9-31)27-13-17-2-5-22-25(28-17)29-23(33)15-36-22/h2-5,12,14,16,27H,6-11,13,15H2,1H3,(H,28,29,33)
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n/an/a 0.210n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5275288
PNG
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1ccccc1O)C(C)C)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C21H31N3O7/c1-11(2)9-14(19(28)23-15(10-25)21(30)31)22-20(29)17(12(3)4)24-18(27)13-7-5-6-8-16(13)26/h5-8,11-12,14-15,17,25-26H,9-10H2,1-4H3,(H,22,29)(H,23,28)(H,24,27)(H,30,31)/t14-,15-,17-/m0/s1
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n/an/a 0.216n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5279750
PNG
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1ccccc1OCc1ccccc1)C(C)C)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C28H37N3O7/c1-17(2)14-21(26(34)30-22(15-32)28(36)37)29-27(35)24(18(3)4)31-25(33)20-12-8-9-13-23(20)38-16-19-10-6-5-7-11-19/h5-13,17-18,21-22,24,32H,14-16H2,1-4H3,(H,29,35)(H,30,34)(H,31,33)(H,36,37)/t21-,22-,24-/m0/s1
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n/an/a 0.216n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5287343
PNG
Show SMILES CC(O)C(NC(C)=O)C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1
Show InChI InChI=1S/C37H43N5O6/c1-23(28-16-10-7-11-17-28)41(5)37(48)32(20-27-14-8-6-9-15-27)40-35(46)31(39-36(47)34(24(2)43)38-25(3)44)22-30-21-29-18-12-13-19-33(29)42(30)26(4)45/h6-19,21,23-24,31-32,34,43H,20,22H2,1-5H3,(H,38,44)(H,39,47)(H,40,46)/t23?,24?,31-,32?,34?/m1/s1
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n/an/a 0.260n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50411638
PNG
(CHEMBL404371)
Show SMILES OC(=O)CC1CCC(=O)N(CC(=O)NCc2ccc(Nc3nc4ccccc4[nH]3)cc2)c2ccccc12
Show InChI InChI=1S/C28H27N5O4/c34-25(17-33-24-8-4-1-5-21(24)19(15-27(36)37)11-14-26(33)35)29-16-18-9-12-20(13-10-18)30-28-31-22-6-2-3-7-23(22)32-28/h1-10,12-13,19H,11,14-17H2,(H,29,34)(H,36,37)(H2,30,31,32)
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n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5269793
PNG
Show SMILES CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C60H64N10O11/c1-33(2)53(70-58(78)50(28-38-32-64-46-19-11-8-16-42(38)46)67-55(75)47(24-35-20-22-39(71)23-21-35)65-54(74)43(61)29-52(72)73)59(79)68-49(27-37-31-63-45-18-10-7-15-41(37)45)56(76)66-48(26-36-30-62-44-17-9-6-14-40(36)44)57(77)69-51(60(80)81)25-34-12-4-3-5-13-34/h3-23,30-33,43,47-51,53,62-64,71H,24-29,61H2,1-2H3,(H,65,74)(H,66,76)(H,67,75)(H,68,79)(H,69,77)(H,70,78)(H,72,73)(H,80,81)/t43-,47-,48+,49+,50+,51-,53-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a


TBA

Assay Description
Activity at Histamine H2 receptor using functional H2 receptor assay on guinea pig atrium

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM21690
PNG
(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O
Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
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n/an/a 0.770n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5282942
PNG
MMDB

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n/an/a 0.950n/an/an/an/an/an/a


TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))		BDBM50446319
PNG
(CHEMBL3109343)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3(F)CCNCC3)c2n1
Show InChI InChI=1S/C25H27FN4O3/c1-31-13-14-32-19-7-12-30-21(16-28-23(30)15-19)20-6-5-18-3-2-4-22(24(18)29-20)33-17-25(26)8-10-27-11-9-25/h2-7,12,15-16,27H,8-11,13-14,17H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Array BioPharma

Curated by ChEMBL


Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...

ACS Med Chem Lett 5: 78-83 (2014)


Article DOI: 10.1021/ml4003953
BindingDB Entry DOI: 10.7270/Q23N24VQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))		BDBM50446312
PNG
(CHEMBL3109350)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3CCNC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-11-12-30-19-8-10-28-21(15-26-23(28)13-19)20-6-5-18-3-2-4-22(24(18)27-20)31-16-17-7-9-25-14-17/h2-6,8,10,13,15,17,25H,7,9,11-12,14,16H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Array BioPharma

Curated by ChEMBL


Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...

ACS Med Chem Lett 5: 78-83 (2014)


Article DOI: 10.1021/ml4003953
BindingDB Entry DOI: 10.7270/Q23N24VQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50193093
PNG
(RGB-286638)
Show SMILES COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1
Show InChI InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)
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Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50239948
PNG
(CHEMBL4071326 | US9850225, Example 1166)
Show SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3C[C@H](O)C[C@@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1 |r|
Show InChI InChI=1S/C36H33ClN2O7/c1-22-26(6-3-7-29(22)25-8-9-32-35(14-25)44-11-10-43-32)21-46-34-16-33(45-20-24-5-2-4-23(12-24)17-38)27(13-30(34)37)18-39-19-28(40)15-31(39)36(41)42/h2-9,12-14,16,28,31,40H,10-11,15,18-21H2,1H3,(H,41,42)/t28-,31-/m1/s1
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TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5286795
PNG
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cccc(OCc2ccccc2)c1O)C(C)C)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C28H37N3O8/c1-16(2)13-20(26(35)30-21(14-32)28(37)38)29-27(36)23(17(3)4)31-25(34)19-11-8-12-22(24(19)33)39-15-18-9-6-5-7-10-18/h5-12,16-17,20-21,23,32-33H,13-15H2,1-4H3,(H,29,36)(H,30,35)(H,31,34)(H,37,38)/t20-,21-,23-/m0/s1
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TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL4535844
PNG
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TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5180503
PNG
Show SMILES CN(C)C(C)(C)CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C18H22N2S/c1-18(2,19(3)4)13-20-14-9-5-7-11-16(14)21-17-12-8-6-10-15(17)20/h5-12H,13H2,1-4H3
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Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...

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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5267457
PNG
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TBA



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Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM21691
PNG
(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...)
Show SMILES CCn1cc(C(O)=O)c(=O)c2ccc(C)nc12
Show InChI InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)
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TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5283958
PNG
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C17H32N4O7/c1-8(2)5-11(15(25)20-12(7-23)17(27)28)19-16(26)13(9(3)4)21-14(24)10(18)6-22/h8-13,22-23H,5-7,18H2,1-4H3,(H,19,26)(H,20,25)(H,21,24)(H,27,28)/t10-,11-,12-,13-/m0/s1
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TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50241662
PNG
(CHEMBL4104741)
Show SMILES CN(C)[C@H]1CN(C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(C)(=O)=O)C1CCc2cccc(F)c12 |r|
Show InChI InChI=1S/C26H35FN4O2S/c1-28(2)25-18-30(24-12-9-20-5-4-6-23(27)26(20)24)17-22(25)19-7-10-21(11-8-19)29-13-15-31(16-14-29)34(3,32)33/h4-8,10-11,22,24-25H,9,12-18H2,1-3H3/t22-,24?,25+/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a


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Dissociation constant against VEGF (vascular endothelial growth factor) was determined.

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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL26159
PNG
Show SMILES Cc1ccccc1-c1nc(CCc2ccccc2)c([nH]1)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C26H23N3O3/c1-17-8-5-6-13-21(17)24-28-22(15-14-18-9-3-2-4-10-18)23(29-24)25(30)27-20-12-7-11-19(16-20)26(31)32/h2-13,16H,14-15H2,1H3,(H,27,30)(H,28,29)(H,31,32)
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n/an/a 1.80n/an/an/an/an/an/a


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Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50193093
PNG
(RGB-286638)
Show SMILES COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1
Show InChI InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)
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n/an/a 2n/an/an/an/an/an/a


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Assay Description
Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparations

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))		BDBM50384726
PNG
(CHEMBL2037208)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14-
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells

ACS Med Chem Lett 3: 140-145 (2012)


Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))		BDBM50446315
PNG
(CHEMBL3109347)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@@H]3O)c2n1 |r|
Show InChI InChI=1S/C24H26N4O4/c1-30-11-12-31-17-8-10-28-19(14-26-23(28)13-17)18-6-5-16-3-2-4-22(24(16)27-18)32-21-7-9-25-15-20(21)29/h2-6,8,10,13-14,20-21,25,29H,7,9,11-12,15H2,1H3/t20-,21+/m0/s1
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Array BioPharma

Curated by ChEMBL


Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...

ACS Med Chem Lett 5: 78-83 (2014)


Article DOI: 10.1021/ml4003953
BindingDB Entry DOI: 10.7270/Q23N24VQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor in P19 cells

J Med Chem 48: 1725-8 (2005)


Article DOI: 10.1021/jm049478u
BindingDB Entry DOI: 10.7270/Q2765DVX
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50512074
PNG
(CHEMBL4575813)
Show SMILES ONC(=O)CCCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1
Show InChI InChI=1S/C20H23Cl2N7O2/c21-14-6-8-15(9-7-14)25-19-17(22)12-23-20(27-19)26-16-11-24-29(13-16)10-4-2-1-3-5-18(30)28-31/h6-9,11-13,31H,1-5,10H2,(H,28,30)(H2,23,25,26,27)
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Assay Description
Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5271201
PNG
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TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50239946
PNG
(CHEMBL4084368)
Show SMILES Cc1cc(CN[C@H](CO)C(O)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1 |r|
Show InChI InChI=1S/C35H34N2O7/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40)/t30-/m1/s1
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TBA



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More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5273069
PNG
Show SMILES COCCN(CC(O)=O)C(=O)C(CCCNC(N)=N)NS(=O)(=O)c1ccc2ccc(C)cc2c1
Show InChI InChI=1S/C22H31N5O6S/c1-15-5-6-16-7-8-18(13-17(16)12-15)34(31,32)26-19(4-3-9-25-22(23)24)21(30)27(10-11-33-2)14-20(28)29/h5-8,12-13,19,26H,3-4,9-11,14H2,1-2H3,(H,28,29)(H4,23,24,25)
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n/an/a 2.5n/an/an/an/an/an/a


TBA

Assay Description
In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM8131
PNG
(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)
Show SMILES CC(C)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1
Show InChI InChI=1S/C19H18N6/c1-13(2)14-5-7-15(8-6-14)23-19-20-11-9-17(24-19)16-12-22-25-18(16)4-3-10-21-25/h3-13H,1-2H3,(H,20,23,24)
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n/an/a 2.70n/an/an/an/an/an/a


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Assay Description
The compound was evaluated for its relative binding affinity against mutant N131A scytalone dehydratase; Relative Ki

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM21690
PNG
(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O
Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))		BDBM50446303
PNG
(CHEMBL3109338)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CCNC[C@@H]3F)c2n1 |r|
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma

Curated by ChEMBL


Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...

ACS Med Chem Lett 5: 78-83 (2014)


Article DOI: 10.1021/ml4003953
BindingDB Entry DOI: 10.7270/Q23N24VQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM50193093
PNG
(RGB-286638)
Show SMILES COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1
Show InChI InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)
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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Blocking activity against Beta-2 adrenergic receptor in guinea pig tracheal strips

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))		BDBM50446316
PNG
(CHEMBL3109346)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C24H26N4O4/c1-30-11-12-31-17-8-10-28-19(14-26-23(28)13-17)18-6-5-16-3-2-4-22(24(16)27-18)32-21-7-9-25-15-20(21)29/h2-6,8,10,13-14,20-21,25,29H,7,9,11-12,15H2,1H3/t20-,21-/m1/s1
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Array BioPharma

Curated by ChEMBL


Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...

ACS Med Chem Lett 5: 78-83 (2014)


Article DOI: 10.1021/ml4003953
BindingDB Entry DOI: 10.7270/Q23N24VQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM289647
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CC(F)(F)c4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25F2N5O3S/c1-33-17-4-2-15(3-5-17)11-30-22-19(21-27-14-28-31(21)23(30)32)20-18(35-22)12-29(13-24(20,25)26)10-16-6-8-34-9-7-16/h2-5,14,16H,6-13H2,1H3
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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay

Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Mus musculus (mouse))		BDBM50446306
PNG
(CHEMBL3109340)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OC3CCNCC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-13-14-30-19-9-12-28-21(16-26-23(28)15-19)20-6-5-17-3-2-4-22(24(17)27-20)31-18-7-10-25-11-8-18/h2-6,9,12,15-16,18,25H,7-8,10-11,13-14H2,1H3
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma

Curated by ChEMBL


Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...

ACS Med Chem Lett 5: 78-83 (2014)


Article DOI: 10.1021/ml4003953
BindingDB Entry DOI: 10.7270/Q23N24VQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		BDBM23928
PNG
(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Show SMILES COc1ccc(\C=C\c2cc(OC)cc(OC)c2)cc1
Show InChI InChI=1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4+
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Mus musculus (mouse))		CHEMBL5287701
PNG
Show SMILES OC(=O)C(O)=O.CC(C)CCOc1ccccc1C(=O)NC(=O)NC1CC2CCC(C1)N2C |TLB:23:24:31:27.28|
Show InChI InChI=1S/C21H31N3O3.C2H2O4/c1-14(2)10-11-27-19-7-5-4-6-18(19)20(25)23-21(26)22-15-12-16-8-9-17(13-15)24(16)3;3-1(4)2(5)6/h4-7,14-17H,8-13H2,1-3H3,(H2,22,23,25,26);(H,3,4)(H,5,6)
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n/an/a 3.30n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
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