Compile Data Set for Download or QSAR

Found 1257 hits of affinity data for UniProtKB/TrEMBL: P08473   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM298285 (US10123984, Example 2A | US10744104, Example 2A | ...) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C19H18ClNO6/c20-14-3-1-2-13(9-14)12-6-4-11(5-7-12)8-15(10-16(22)18(24)25)21-17(23)19(26)27/h1-7,9,15-16,22H,8,10H2,(H,21,23)(H,24,25)(H,26,27)/t15-,16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem		0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2PR8136
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50411736 (CHEMBL271225) Show SMILES CC(C)C[C@H](S)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C21H25NO3S/c1-14(2)12-19(26)20(23)22-18(21(24)25)13-15-8-10-17(11-9-15)16-6-4-3-5-7-16/h3-11,14,18-19,26H,12-13H2,1-2H3,(H,22,23)(H,24,25)/t18-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human recombinant NEP by fluorescence assay				Bioorg Med Chem Lett 18: 732-7 (2008) Article DOI: 10.1016/j.bmcl.2007.11.048 BindingDB Entry DOI: 10.7270/Q2GT5PCB
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM582847 (US11547687, Comparative Compound I | US20230285340...) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)CC(O)=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		0.316	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2PR8136
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	CHEMBL5272269 Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM582848 (US11547687, Comparative Compound J | US20230285340...) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)CCC(O)=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		0.501	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2PR8136
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM617465 (US20230285340, Example 5A) Show SMILES COC(=O)C(O)CC(Cc1ccc(cc1)-c1cc(Cl)ccc1C)NC(=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		0.631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2PR8136
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50024101 ((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...) Show SMILES C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(O)=O Show InChI InChI=1S/C13H17NO3S/c1-9(13(16)17)14-12(15)11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,14,15)(H,16,17)/t9-,11+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France. Curated by ChEMBL					Assay Description Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry				J Med Chem 57: 5748-63 (2014) Article DOI: 10.1021/jm500602h BindingDB Entry DOI: 10.7270/Q2Q241TH
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50407297 (CHEMBL2052008) Show SMILES C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney				J Med Chem 37: 1070-83 (1994) BindingDB Entry DOI: 10.7270/Q26W995T
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50407297 (CHEMBL2052008) Show SMILES C[C@H](NC(=O)[C@H](CS)[C@@H](C)c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney				J Med Chem 37: 1070-83 (1994) BindingDB Entry DOI: 10.7270/Q26W995T
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50411731 (CHEMBL257726) Show SMILES CC[C@H](S)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C19H21NO3S/c1-2-17(24)18(21)20-16(19(22)23)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17,24H,2,12H2,1H3,(H,20,21)(H,22,23)/t16-,17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human recombinant NEP by fluorescence assay				Bioorg Med Chem Lett 18: 732-7 (2008) Article DOI: 10.1016/j.bmcl.2007.11.048 BindingDB Entry DOI: 10.7270/Q2GT5PCB
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM582844 (US11547687, Comparative Compound G | US20230285340...) Show SMILES OC[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2PR8136
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459392 (US10759813, Example 18-32) Show SMILES CC(O)c1cc([nH]n1)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C23H24ClN3O5/c1-13(28)19-12-20(27-26-19)22(30)25-18(11-21(29)23(31)32)9-14-5-7-15(8-6-14)16-3-2-4-17(24)10-16/h2-8,10,12-13,18,21,28-29H,9,11H2,1H3,(H,25,30)(H,26,27)(H,31,32)/t13?,18-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459393 (US10759813, Example 18-34) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc([nH]n1)-c1cccnc1)C(O)=O Show InChI InChI=1S/C26H23ClN4O4/c27-20-5-1-3-18(12-20)17-8-6-16(7-9-17)11-21(13-24(32)26(34)35)29-25(33)23-14-22(30-31-23)19-4-2-10-28-15-19/h1-10,12,14-15,21,24,32H,11,13H2,(H,29,33)(H,30,31)(H,34,35)/t21-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459394 (US10759813, Example 18-35) Show SMILES Cn1nc(cc1O)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C22H22ClN3O5/c1-26-20(28)12-18(25-26)21(29)24-17(11-19(27)22(30)31)9-13-5-7-14(8-6-13)15-3-2-4-16(23)10-15/h2-8,10,12,17,19,27-28H,9,11H2,1H3,(H,24,29)(H,30,31)/t17-,19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459395 (US10759813, Example 18-37) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)n(n1)-c1ccccn1)C(O)=O Show InChI InChI=1S/C26H23ClN4O5/c27-19-5-3-4-18(13-19)17-9-7-16(8-10-17)12-20(14-22(32)26(35)36)29-25(34)21-15-24(33)31(30-21)23-6-1-2-11-28-23/h1-11,13,15,20,22,32-33H,12,14H2,(H,29,34)(H,35,36)/t20-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459396 (US10759813, Example 18-38) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)n(n1)-c1ccccc1F)C(O)=O Show InChI InChI=1S/C27H23ClFN3O5/c28-19-5-3-4-18(13-19)17-10-8-16(9-11-17)12-20(14-24(33)27(36)37)30-26(35)22-15-25(34)32(31-22)23-7-2-1-6-21(23)29/h1-11,13,15,20,24,33-34H,12,14H2,(H,30,35)(H,36,37)/t20-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459397 (US10759813, Example 18-39) Show SMILES O[C@H](C[C@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)n(n1)-c1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C27H23Cl2N3O5/c28-19-4-1-3-18(12-19)17-9-7-16(8-10-17)11-21(14-24(33)27(36)37)30-26(35)23-15-25(34)32(31-23)22-6-2-5-20(29)13-22/h1-10,12-13,15,21,24,33-34H,11,14H2,(H,30,35)(H,36,37)/t21-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459398 (US10759813, Example 18-40) Show SMILES CCOc1cc(n[nH]1)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C23H24ClN3O5/c1-2-32-21-13-19(26-27-21)22(29)25-18(12-20(28)23(30)31)10-14-6-8-15(9-7-14)16-4-3-5-17(24)11-16/h3-9,11,13,18,20,28H,2,10,12H2,1H3,(H,25,29)(H,26,27)(H,30,31)/t18-,20-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459399 (US10759813, Example 18-41) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(=O)n([nH]1)-c1ccccc1)C(O)=O Show InChI InChI=1S/C27H24ClN3O5/c28-20-6-4-5-19(14-20)18-11-9-17(10-12-18)13-21(15-24(32)27(35)36)29-26(34)23-16-25(33)31(30-23)22-7-2-1-3-8-22/h1-12,14,16,21,24,30,32H,13,15H2,(H,29,34)(H,35,36)/t21-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459400 (US10759813, Example 18-42) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1nn(-c2cccc(Cl)c2)c(=O)[nH]1)C(O)=O Show InChI InChI=1S/C26H22Cl2N4O5/c27-18-4-1-3-17(12-18)16-9-7-15(8-10-16)11-20(14-22(33)25(35)36)29-24(34)23-30-26(37)32(31-23)21-6-2-5-19(28)13-21/h1-10,12-13,20,22,33H,11,14H2,(H,29,34)(H,35,36)(H,30,31,37)/t20-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459401 (US10759813, Example 18-43) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1nn(-c2ccccc2Cl)c(=O)[nH]1)C(O)=O Show InChI InChI=1S/C26H22Cl2N4O5/c27-18-5-3-4-17(13-18)16-10-8-15(9-11-16)12-19(14-22(33)25(35)36)29-24(34)23-30-26(37)32(31-23)21-7-2-1-6-20(21)28/h1-11,13,19,22,33H,12,14H2,(H,29,34)(H,35,36)(H,30,31,37)/t19-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459402 (US10759813, Example 18-44) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1nn(-c2ccc(F)cc2)c(=O)[nH]1)C(O)=O Show InChI InChI=1S/C26H22ClFN4O5/c27-18-3-1-2-17(13-18)16-6-4-15(5-7-16)12-20(14-22(33)25(35)36)29-24(34)23-30-26(37)32(31-23)21-10-8-19(28)9-11-21/h1-11,13,20,22,33H,12,14H2,(H,29,34)(H,35,36)(H,30,31,37)/t20-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459403 (US10759813, Example 18-45) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1nnc([nH]1)C(F)(F)F)C(O)=O Show InChI InChI=1S/C21H18ClF3N4O4/c22-14-3-1-2-13(9-14)12-6-4-11(5-7-12)8-15(10-16(30)19(32)33)26-18(31)17-27-20(29-28-17)21(23,24)25/h1-7,9,15-16,30H,8,10H2,(H,26,31)(H,32,33)(H,27,28,29)/t15-,16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459404 (US10759813, Example 18-46) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1n[nH]c(Cl)n1)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O4/c21-14-3-1-2-13(9-14)12-6-4-11(5-7-12)8-15(10-16(27)19(29)30)23-18(28)17-24-20(22)26-25-17/h1-7,9,15-16,27H,8,10H2,(H,23,28)(H,29,30)(H,24,25,26)/t15-,16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459405 (US10759813, Example 18-47) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1nn(-c2ccccc2)c(=O)[nH]1)C(O)=O Show InChI InChI=1S/C26H23ClN4O5/c27-19-6-4-5-18(14-19)17-11-9-16(10-12-17)13-20(15-22(32)25(34)35)28-24(33)23-29-26(36)31(30-23)21-7-2-1-3-8-21/h1-12,14,20,22,32H,13,15H2,(H,28,33)(H,34,35)(H,29,30,36)/t20-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459408 (US10759813, Example 18-50) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1ccc(O)nn1)C(O)=O Show InChI InChI=1S/C22H20ClN3O5/c23-16-3-1-2-15(11-16)14-6-4-13(5-7-14)10-17(12-19(27)22(30)31)24-21(29)18-8-9-20(28)26-25-18/h1-9,11,17,19,27H,10,12H2,(H,24,29)(H,26,28)(H,30,31)/t17-,19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459409 (US10759813, Example 19-1) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1Cl)NC(=O)c1cn(O)nn1)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O5/c21-13-5-6-16(22)15(8-13)12-3-1-11(2-4-12)7-14(9-18(27)20(29)30)23-19(28)17-10-26(31)25-24-17/h1-6,8,10,14,18,27,31H,7,9H2,(H,23,28)(H,29,30)/t14-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459410 (US10759813, Example 19-6) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cn(O)nn1)C(O)=O Show InChI InChI=1S/C20H18ClFN4O5/c21-13-5-6-16(22)15(8-13)12-3-1-11(2-4-12)7-14(9-18(27)20(29)30)23-19(28)17-10-26(31)25-24-17/h1-6,8,10,14,18,27,31H,7,9H2,(H,23,28)(H,29,30)/t14-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459411 (US10759813, Example 19-12) Show SMILES Cc1ccc(Cl)cc1-c1ccc(C[C@H](C[C@@H](O)C(O)=O)NC(=O)c2cn(O)nn2)cc1 Show InChI InChI=1S/C21H21ClN4O5/c1-12-2-7-15(22)9-17(12)14-5-3-13(4-6-14)8-16(10-19(27)21(29)30)23-20(28)18-11-26(31)25-24-18/h2-7,9,11,16,19,27,31H,8,10H2,1H3,(H,23,28)(H,29,30)/t16-,19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459412 (US10759813, Example 19-17) Show SMILES COc1ccccc1-c1ccc(C[C@H](C[C@@H](O)C(O)=O)NC(=O)c2cn(O)nn2)cc1 Show InChI InChI=1S/C21H22N4O6/c1-31-19-5-3-2-4-16(19)14-8-6-13(7-9-14)10-15(11-18(26)21(28)29)22-20(27)17-12-25(30)24-23-17/h2-9,12,15,18,26,30H,10-11H2,1H3,(H,22,27)(H,28,29)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459413 (US10759813, Example 19-18) Show SMILES CC(=O)OCOn1nncc1C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F Show InChI InChI=1S/C23H22ClFN4O7/c1-13(30)35-12-36-29-20(11-26-28-29)22(32)27-17(10-21(31)23(33)34)8-14-2-4-15(5-3-14)18-9-16(24)6-7-19(18)25/h2-7,9,11,17,21,31H,8,10,12H2,1H3,(H,27,32)(H,33,34)/t17-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459414 (US10759813, Example 19-19) Show SMILES COc1cc(on1)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F Show InChI InChI=1S/C22H20ClFN2O6/c1-31-20-11-19(32-26-20)21(28)25-15(10-18(27)22(29)30)8-12-2-4-13(5-3-12)16-9-14(23)6-7-17(16)24/h2-7,9,11,15,18,27H,8,10H2,1H3,(H,25,28)(H,29,30)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459415 (US10759813, Example 19-20) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1nn(-c2ccccc2)c(=O)[nH]1)C(O)=O Show InChI InChI=1S/C26H22ClFN4O5/c27-17-10-11-21(28)20(13-17)16-8-6-15(7-9-16)12-18(14-22(33)25(35)36)29-24(34)23-30-26(37)32(31-23)19-4-2-1-3-5-19/h1-11,13,18,22,33H,12,14H2,(H,29,34)(H,35,36)(H,30,31,37)/t18-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459416 (US10759813, Example 19-21) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1Cl)-c1ccccc1Cl)NC(=O)c1ccc2nnn(OCOC=O)c2c1)C(O)=O Show InChI InChI=1S/C26H22Cl2N4O7/c27-20-4-2-1-3-19(20)15-5-6-16(21(28)10-15)9-18(12-24(34)26(36)37)29-25(35)17-7-8-22-23(11-17)32(31-30-22)39-14-38-13-33/h1-8,10-11,13,18,24,34H,9,12,14H2,(H,29,35)(H,36,37)/t18-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459417 (US10759813, Example 20-1) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1Cl)-c1ccccc1)NC(=O)c1c[nH]nn1)C(O)=O Show InChI InChI=1S/C20H19ClN4O4/c21-16-9-13(12-4-2-1-3-5-12)6-7-14(16)8-15(10-18(26)20(28)29)23-19(27)17-11-22-25-24-17/h1-7,9,11,15,18,26H,8,10H2,(H,23,27)(H,28,29)(H,22,24,25)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459418 (US10759813, Example 20-2) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1Cl)-c1ccccc1)NC(=O)c1cnn[nH]1)C(O)=O Show InChI InChI=1S/C20H19ClN4O4/c21-16-9-13(12-4-2-1-3-5-12)6-7-14(16)8-15(10-18(26)20(28)29)23-19(27)17-11-22-25-24-17/h1-7,9,11,15,18,26H,8,10H2,(H,23,27)(H,28,29)(H,22,24,25)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459419 (US10759813, Example 20-3) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1Cl)-c1ccccc1)NC(=O)c1nn(-c2cccc(Cl)c2)c(=O)[nH]1)C(O)=O Show InChI InChI=1S/C26H22Cl2N4O5/c27-18-7-4-8-20(13-18)32-26(37)30-23(31-32)24(34)29-19(14-22(33)25(35)36)11-17-10-9-16(12-21(17)28)15-5-2-1-3-6-15/h1-10,12-13,19,22,33H,11,14H2,(H,29,34)(H,35,36)(H,30,31,37)/t19-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459420 (US10759813, Example 20-4) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1Cl)-c1ccccc1)NC(=O)c1nn(-c2ccccc2)c(=O)[nH]1)C(O)=O Show InChI InChI=1S/C26H23ClN4O5/c27-21-14-17(16-7-3-1-4-8-16)11-12-18(21)13-19(15-22(32)25(34)35)28-24(33)23-29-26(36)31(30-23)20-9-5-2-6-10-20/h1-12,14,19,22,32H,13,15H2,(H,28,33)(H,34,35)(H,29,30,36)/t19-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459421 (US10759813, Example 20-5) Show SMILES CN(C)C(=O)c1cc([nH]n1)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1Cl)-c1ccccc1 Show InChI InChI=1S/C24H25ClN4O5/c1-29(2)23(32)20-13-19(27-28-20)22(31)26-17(12-21(30)24(33)34)10-16-9-8-15(11-18(16)25)14-6-4-3-5-7-14/h3-9,11,13,17,21,30H,10,12H2,1-2H3,(H,26,31)(H,27,28)(H,33,34)/t17-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459422 (US10759813, Example 20-6) Show SMILES COCCN(C)C(=O)c1cc([nH]n1)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1Cl)-c1ccccc1 Show InChI InChI=1S/C26H29ClN4O6/c1-31(10-11-37-2)25(34)22-15-21(29-30-22)24(33)28-19(14-23(32)26(35)36)12-18-9-8-17(13-20(18)27)16-6-4-3-5-7-16/h3-9,13,15,19,23,32H,10-12,14H2,1-2H3,(H,28,33)(H,29,30)(H,35,36)/t19-,23-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459423 (US10759813, Example 20-7) Show SMILES CC(=O)c1cc([nH]n1)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1Cl)-c1ccccc1 Show InChI InChI=1S/C23H22ClN3O5/c1-13(28)19-12-20(27-26-19)22(30)25-17(11-21(29)23(31)32)9-16-8-7-15(10-18(16)24)14-5-3-2-4-6-14/h2-8,10,12,17,21,29H,9,11H2,1H3,(H,25,30)(H,26,27)(H,31,32)/t17-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459424 (US10759813, Example 20-8) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1Cl)-c1ccccc1)NC(=O)c1cc(n[nH]1)-c1cccnc1)C(O)=O Show InChI InChI=1S/C26H23ClN4O4/c27-21-12-17(16-5-2-1-3-6-16)8-9-18(21)11-20(13-24(32)26(34)35)29-25(33)23-14-22(30-31-23)19-7-4-10-28-15-19/h1-10,12,14-15,20,24,32H,11,13H2,(H,29,33)(H,30,31)(H,34,35)/t20-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459426 (US10759813, Example 21-1) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1Cl)-c1cccc(Cl)c1)NC(=O)c1cnn[nH]1)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O4/c21-14-3-1-2-11(6-14)12-4-5-13(16(22)8-12)7-15(9-18(27)20(29)30)24-19(28)17-10-23-26-25-17/h1-6,8,10,15,18,27H,7,9H2,(H,24,28)(H,29,30)(H,23,25,26)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459427 (US10759813, Example 21-2) Show SMILES COCc1cc([nH]n1)C(=O)N[C@@H](C[C@@H](O)C(O)=O)Cc1ccc(cc1Cl)-c1cccc(Cl)c1 Show InChI InChI=1S/C23H23Cl2N3O5/c1-33-12-18-10-20(28-27-18)22(30)26-17(11-21(29)23(31)32)8-15-6-5-14(9-19(15)25)13-3-2-4-16(24)7-13/h2-7,9-10,17,21,29H,8,11-12H2,1H3,(H,26,30)(H,27,28)(H,31,32)/t17-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459428 ((2R,4R)-5-(5′-Chloro-2′-fluorobiphenyl...) Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ccc2nnn(O)c2c1)C(O)=O |r| Show InChI InChI=1S/C24H20ClFN4O5/c25-16-6-7-19(26)18(11-16)14-3-1-13(2-4-14)9-17(12-22(31)24(33)34)27-23(32)15-5-8-20-21(10-15)30(35)29-28-20/h1-8,10-11,17,22,31,35H,9,12H2,(H,27,32)(H,33,34)/t17-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459429 (US10759813, Example 23-1) Show SMILES Cc1cccc(c1)-c1ccc(C[C@@H](C[C@H](O)C(O)=O)NC(=O)c2ccc3nnn(O)c3c2)cc1 Show InChI InChI=1S/C25H24N4O5/c1-15-3-2-4-18(11-15)17-7-5-16(6-8-17)12-20(14-23(30)25(32)33)26-24(31)19-9-10-21-22(13-19)29(34)28-27-21/h2-11,13,20,23,30,34H,12,14H2,1H3,(H,26,31)(H,32,33)/t20-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459430 (US10759813, Example 23-2) Show SMILES Cc1ccc(Cl)cc1-c1ccc(C[C@@H](C[C@H](O)C(O)=O)NC(=O)c2ccc3NNN(O)c3c2)cc1 Show InChI InChI=1S/C25H25ClN4O5/c1-14-2-8-18(26)12-20(14)16-5-3-15(4-6-16)10-19(13-23(31)25(33)34)27-24(32)17-7-9-21-22(11-17)30(35)29-28-21/h2-9,11-12,19,23,28-29,31,35H,10,13H2,1H3,(H,27,32)(H,33,34)/t19-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459431 (US10759813, Example 23-3) Show SMILES COc1ccccc1-c1ccc(C[C@@H](C[C@H](O)C(O)=O)NC(=O)c2ccc3nnn(O)c3c2)cc1 Show InChI InChI=1S/C25H24N4O6/c1-35-23-5-3-2-4-19(23)16-8-6-15(7-9-16)12-18(14-22(30)25(32)33)26-24(31)17-10-11-20-21(13-17)29(34)28-27-20/h2-11,13,18,22,30,34H,12,14H2,1H3,(H,26,31)(H,32,33)/t18-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459432 (US10759813, Example 23-4) Show SMILES O[C@@H](C[C@H](Cc1ccc(cc1)-c1cc(Cl)ccc1Cl)NC(=O)c1ccc2nnn(O)c2c1)C(O)=O Show InChI InChI=1S/C24H20Cl2N4O5/c25-16-6-7-19(26)18(11-16)14-3-1-13(2-4-14)9-17(12-22(31)24(33)34)27-23(32)15-5-8-20-21(10-15)30(35)29-28-20/h1-8,10-11,17,22,31,35H,9,12H2,(H,27,32)(H,33,34)/t17-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM459433 (US10759813, Example 23-8) Show SMILES O[C@@H](C[C@H](Cc1ccc(cc1)-c1cc(O)cc(Cl)c1)NC(=O)c1ccc2nnn(O)c2c1)C(O)=O Show InChI InChI=1S/C24H21ClN4O6/c25-17-8-16(9-19(30)11-17)14-3-1-13(2-4-14)7-18(12-22(31)24(33)34)26-23(32)15-5-6-20-21(10-15)29(35)28-27-20/h1-6,8-11,18,22,30-31,35H,7,12H2,(H,26,32)(H,33,34)/t18-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10759813 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NW0
					More data for this Ligand-Target Pair

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