Found 595 hits for UniProtKB: P08631 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50437405
(CHEMBL2408778)Show SMILES Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cnnn1CCCCCC(=O)NO Show InChI InChI=1S/C25H24ClN9O2/c26-18-10-8-16(9-11-18)23-22-24(27)28-15-29-25(22)35(31-23)19-6-4-5-17(13-19)20-14-30-33-34(20)12-3-1-2-7-21(36)32-37/h4-6,8-11,13-15,37H,1-3,7,12H2,(H,32,36)(H2,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 504 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of HCK (unknown origin) |
ACS Med Chem Lett 4: 779-783 (2013)
Article DOI: 10.1021/ml400175d BindingDB Entry DOI: 10.7270/Q2CZ38KR |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50119568
(CHEMBL3617738)Show SMILES O=C(CCCCCC(=O)N1CCC[C@@H]1c1ccco1)Nc1cccc(Nc2nccc(Nc3cc([nH]n3)C3CC3)n2)c1 |r| Show InChI InChI=1S/C31H36N8O3/c40-29(11-2-1-3-12-30(41)39-17-5-9-25(39)26-10-6-18-42-26)33-22-7-4-8-23(19-22)34-31-32-16-15-27(36-31)35-28-20-24(37-38-28)21-13-14-21/h4,6-8,10,15-16,18-21,25H,1-3,5,9,11-14,17H2,(H,33,40)(H3,32,34,35,36,37,38)/t25-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of Hck (unknown origin) |
ACS Med Chem Lett 6: 898-901 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00167 BindingDB Entry DOI: 10.7270/Q2833TTZ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50119566
(CHEMBL3617732)Show SMILES CCCC(=O)Nc1cccc(Nc2nccc(Nc3cc([nH]n3)C3CC3)n2)c1 Show InChI InChI=1S/C20H23N7O/c1-2-4-19(28)22-14-5-3-6-15(11-14)23-20-21-10-9-17(25-20)24-18-12-16(26-27-18)13-7-8-13/h3,5-6,9-13H,2,4,7-8H2,1H3,(H,22,28)(H3,21,23,24,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 980 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of Hck (unknown origin) |
ACS Med Chem Lett 6: 898-901 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00167 BindingDB Entry DOI: 10.7270/Q2833TTZ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50341519
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1 |r| Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals (Europe) Ltd.
Curated by ChEMBL
| Assay Description Inhibition of HCK |
J Med Chem 54: 2341-50 (2011)
Article DOI: 10.1021/jm101499u BindingDB Entry DOI: 10.7270/Q2KH0NPW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50119567
(CHEMBL3617740)Show SMILES C[C@@H](NC(=O)CCCCCC(=O)Nc1cccc(Nc2nccc(Nc3cc([nH]n3)C3CC3)n2)c1)c1ccco1 |r| Show InChI InChI=1S/C29H34N8O3/c1-19(24-9-6-16-40-24)31-27(38)10-3-2-4-11-28(39)32-21-7-5-8-22(17-21)33-29-30-15-14-25(35-29)34-26-18-23(36-37-26)20-12-13-20/h5-9,14-20H,2-4,10-13H2,1H3,(H,31,38)(H,32,39)(H3,30,33,34,35,36,37)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of Hck (unknown origin) |
ACS Med Chem Lett 6: 898-901 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00167 BindingDB Entry DOI: 10.7270/Q2833TTZ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50354476
(CHEMBL1836673)Show InChI InChI=1S/C20H18ClN5S/c1-27-20-24-18(23-16-9-5-8-15(21)12-16)17-13-22-26(19(17)25-20)11-10-14-6-3-2-4-7-14/h2-9,12-13H,10-11H2,1H3,(H,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena
Curated by ChEMBL
| Assay Description Inhibition human recombinant HcK using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATP |
Bioorg Med Chem Lett 21: 5928-33 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.079 BindingDB Entry DOI: 10.7270/Q29G5N6P |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50463479
(CHEMBL4249925)Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Inhibition of HCK (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50463483
(CHEMBL4245242)Show SMILES O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Inhibition of HCK (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50354480
(CHEMBL1836678)Show InChI InChI=1S/C21H21N5S/c1-15(16-9-5-3-6-10-16)14-26-20-18(13-22-26)19(24-21(25-20)27-2)23-17-11-7-4-8-12-17/h3-13,15H,14H2,1-2H3,(H,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena
Curated by ChEMBL
| Assay Description Inhibition human recombinant HcK using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATP |
Bioorg Med Chem Lett 21: 5928-33 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.079 BindingDB Entry DOI: 10.7270/Q29G5N6P |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50354481
(CHEMBL1836679)Show SMILES CSc1nc(Nc2cccc(Cl)c2)c2cnn(CC(C)c3ccccc3)c2n1 Show InChI InChI=1S/C21H20ClN5S/c1-14(15-7-4-3-5-8-15)13-27-20-18(12-23-27)19(25-21(26-20)28-2)24-17-10-6-9-16(22)11-17/h3-12,14H,13H2,1-2H3,(H,24,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena
Curated by ChEMBL
| Assay Description Inhibition human recombinant HcK using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATP |
Bioorg Med Chem Lett 21: 5928-33 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.079 BindingDB Entry DOI: 10.7270/Q29G5N6P |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50119571
(CHEMBL3617729)Show InChI InChI=1S/C11H13NO2/c1-2-11(13)12-7-3-5-9(12)10-6-4-8-14-10/h2,4,6,8-9H,1,3,5,7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| >1.25E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of Hck (unknown origin) |
ACS Med Chem Lett 6: 898-901 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00167 BindingDB Entry DOI: 10.7270/Q2833TTZ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50322535
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human HCK using KVEKIGEGTYGVVYK as substrate by radiometric hotspot kinase assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.8b00081 BindingDB Entry DOI: 10.7270/Q2WM1J37 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50268924
(CHEMBL4075002)Show SMILES CC(C)N1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:12.16,wD:9.9,(9.09,-24.29,;10.12,-23.15,;11.63,-23.47,;9.65,-21.68,;8.15,-21.36,;7.68,-19.91,;8.71,-18.78,;10.2,-19.09,;10.67,-20.55,;8.23,-17.32,;9.26,-16.18,;8.78,-14.71,;7.27,-14.4,;6.24,-15.55,;6.72,-17.01,;6.79,-12.95,;7.69,-11.68,;6.77,-10.43,;7.24,-8.96,;8.75,-8.65,;9.21,-7.18,;8.17,-6.04,;8.64,-4.57,;10.14,-4.24,;11.18,-5.38,;12.68,-5.04,;13.15,-3.57,;12.1,-2.44,;10.6,-2.77,;6.66,-6.37,;6.2,-7.84,;5.3,-10.92,;3.96,-10.16,;3.96,-8.62,;2.64,-10.92,;2.64,-12.47,;3.96,-13.24,;5.31,-12.47,)| Show InChI InChI=1S/C31H38N6O/c1-22(2)35-16-18-36(19-17-35)24-10-12-25(13-11-24)37-20-28(29-30(32)33-21-34-31(29)37)23-8-14-27(15-9-23)38-26-6-4-3-5-7-26/h3-9,14-15,20-22,24-25H,10-13,16-19H2,1-2H3,(H2,32,33,34)/t24-,25- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.257 | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies
Curated by ChEMBL
| Assay Description Inhibition of HCK (unknown origin) |
Bioorg Med Chem 25: 4259-4264 (2017)
Article DOI: 10.1016/j.bmc.2017.05.053 BindingDB Entry DOI: 10.7270/Q2SB4875 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50268924
(CHEMBL4075002)Show SMILES CC(C)N1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:12.16,wD:9.9,(9.09,-24.29,;10.12,-23.15,;11.63,-23.47,;9.65,-21.68,;8.15,-21.36,;7.68,-19.91,;8.71,-18.78,;10.2,-19.09,;10.67,-20.55,;8.23,-17.32,;9.26,-16.18,;8.78,-14.71,;7.27,-14.4,;6.24,-15.55,;6.72,-17.01,;6.79,-12.95,;7.69,-11.68,;6.77,-10.43,;7.24,-8.96,;8.75,-8.65,;9.21,-7.18,;8.17,-6.04,;8.64,-4.57,;10.14,-4.24,;11.18,-5.38,;12.68,-5.04,;13.15,-3.57,;12.1,-2.44,;10.6,-2.77,;6.66,-6.37,;6.2,-7.84,;5.3,-10.92,;3.96,-10.16,;3.96,-8.62,;2.64,-10.92,;2.64,-12.47,;3.96,-13.24,;5.31,-12.47,)| Show InChI InChI=1S/C31H38N6O/c1-22(2)35-16-18-36(19-17-35)24-10-12-25(13-11-24)37-20-28(29-30(32)33-21-34-31(29)37)23-8-14-27(15-9-23)38-26-6-4-3-5-7-26/h3-9,14-15,20-22,24-25H,10-13,16-19H2,1-2H3,(H2,32,33,34)/t24-,25- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies
Curated by ChEMBL
| Assay Description Inhibition of HCK (unknown origin) |
Bioorg Med Chem 25: 4259-4264 (2017)
Article DOI: 10.1016/j.bmc.2017.05.053 BindingDB Entry DOI: 10.7270/Q2SB4875 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM8793
(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:10.14,wD:7.7,(-.91,-10.51,;-1.37,-9.04,;-2.87,-8.71,;-3.34,-7.24,;-2.3,-6.11,;-.8,-6.44,;-.33,-7.91,;-2.72,-4.63,;-1.64,-3.52,;-2.06,-2.04,;-3.55,-1.66,;-4.63,-2.76,;-4.21,-4.25,;-4.03,-.2,;-3.12,1.05,;-4.03,2.3,;-3.55,3.76,;-4.69,4.8,;-4.36,6.3,;-2.89,6.77,;-2.56,8.27,;-1.1,8.74,;-.48,10.15,;1.05,10.33,;1.96,9.09,;1.35,7.68,;-.18,7.5,;-1.75,5.73,;-2.08,4.23,;-5.49,1.82,;-6.82,2.59,;-6.82,4.13,;-8.16,1.82,;-8.16,.28,;-6.82,-.49,;-5.49,.28,)| Show InChI InChI=1S/C29H34N6O/c1-33-15-17-34(18-16-33)22-9-11-23(12-10-22)35-19-26(27-28(30)31-20-32-29(27)35)21-7-13-25(14-8-21)36-24-5-3-2-4-6-24/h2-8,13-14,19-20,22-23H,9-12,15-18H2,1H3,(H2,30,31,32)/t22-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies
Curated by ChEMBL
| Assay Description Inhibition of recombinant human HCK SH3-SH2-KD (75 to 526 residues) after 20 mins by mobility shift assay |
Bioorg Med Chem Lett 27: 4994-4998 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.012 BindingDB Entry DOI: 10.7270/Q2X92DV1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM8793
(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:10.14,wD:7.7,(-.91,-10.51,;-1.37,-9.04,;-2.87,-8.71,;-3.34,-7.24,;-2.3,-6.11,;-.8,-6.44,;-.33,-7.91,;-2.72,-4.63,;-1.64,-3.52,;-2.06,-2.04,;-3.55,-1.66,;-4.63,-2.76,;-4.21,-4.25,;-4.03,-.2,;-3.12,1.05,;-4.03,2.3,;-3.55,3.76,;-4.69,4.8,;-4.36,6.3,;-2.89,6.77,;-2.56,8.27,;-1.1,8.74,;-.48,10.15,;1.05,10.33,;1.96,9.09,;1.35,7.68,;-.18,7.5,;-1.75,5.73,;-2.08,4.23,;-5.49,1.82,;-6.82,2.59,;-6.82,4.13,;-8.16,1.82,;-8.16,.28,;-6.82,-.49,;-5.49,.28,)| Show InChI InChI=1S/C29H34N6O/c1-33-15-17-34(18-16-33)22-9-11-23(12-10-22)35-19-26(27-28(30)31-20-32-29(27)35)21-7-13-25(14-8-21)36-24-5-3-2-4-6-24/h2-8,13-14,19-20,22-23H,9-12,15-18H2,1H3,(H2,30,31,32)/t22-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 0.427 | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies
Curated by ChEMBL
| Assay Description Inhibition of HCK (75 to 526 residues) (unknown origin) expressed in Sf9 insect cells after 120 mins |
Bioorg Med Chem 25: 4259-4264 (2017)
Article DOI: 10.1016/j.bmc.2017.05.053 BindingDB Entry DOI: 10.7270/Q2SB4875 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM8793
(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:10.14,wD:7.7,(-.91,-10.51,;-1.37,-9.04,;-2.87,-8.71,;-3.34,-7.24,;-2.3,-6.11,;-.8,-6.44,;-.33,-7.91,;-2.72,-4.63,;-1.64,-3.52,;-2.06,-2.04,;-3.55,-1.66,;-4.63,-2.76,;-4.21,-4.25,;-4.03,-.2,;-3.12,1.05,;-4.03,2.3,;-3.55,3.76,;-4.69,4.8,;-4.36,6.3,;-2.89,6.77,;-2.56,8.27,;-1.1,8.74,;-.48,10.15,;1.05,10.33,;1.96,9.09,;1.35,7.68,;-.18,7.5,;-1.75,5.73,;-2.08,4.23,;-5.49,1.82,;-6.82,2.59,;-6.82,4.13,;-8.16,1.82,;-8.16,.28,;-6.82,-.49,;-5.49,.28,)| Show InChI InChI=1S/C29H34N6O/c1-33-15-17-34(18-16-33)22-9-11-23(12-10-22)35-19-26(27-28(30)31-20-32-29(27)35)21-7-13-25(14-8-21)36-24-5-3-2-4-6-24/h2-8,13-14,19-20,22-23H,9-12,15-18H2,1H3,(H2,30,31,32)/t22-,23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies
Curated by ChEMBL
| Assay Description Inhibition of human HCK (81 to 526 residues) expressed in Sf9 insect cells after 120 mins |
Bioorg Med Chem 25: 4259-4264 (2017)
Article DOI: 10.1016/j.bmc.2017.05.053 BindingDB Entry DOI: 10.7270/Q2SB4875 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473766
(US10844077, Compound I-9)Show SMILES CCC(=O)N1CC[C@@H](C1)Nc1nccc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2C)n1 |r| Show InChI InChI=1S/C23H27N7O2S/c1-4-19(31)30-11-9-16(13-30)26-22-24-10-8-18(27-22)28-23-25-12-17(33-23)21(32)29-20-14(2)6-5-7-15(20)3/h5-8,10,12,16H,4,9,11,13H2,1-3H3,(H,29,32)(H2,24,25,26,27,28)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.495 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473751
(US10844077, Compound I-8)Show SMILES Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccnc(NCC3CCN(C3)C(=O)C=C)n2)s1 Show InChI InChI=1S/C24H27N7O2S/c1-4-20(32)31-11-9-17(14-31)12-26-23-25-10-8-19(28-23)29-24-27-13-18(34-24)22(33)30-21-15(2)6-5-7-16(21)3/h4-8,10,13,17H,1,9,11-12,14H2,2-3H3,(H,30,33)(H2,25,26,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.495 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473750
(US10844077, Compound I-7)Show SMILES Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccnc(NC3CCCCN(C3)C(=O)C=C)n2)s1 Show InChI InChI=1S/C25H29N7O2S/c1-4-21(33)32-13-6-5-10-18(15-32)28-24-26-12-11-20(29-24)30-25-27-14-19(35-25)23(34)31-22-16(2)8-7-9-17(22)3/h4,7-9,11-12,14,18H,1,5-6,10,13,15H2,2-3H3,(H,31,34)(H2,26,27,28,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.495 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473746
(US10844077, Compound I-3)Show SMILES Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccnc(N[C@H]3CCN(C3)C(=O)C=C)n2)s1 |r| Show InChI InChI=1S/C23H25N7O2S/c1-4-19(31)30-11-9-16(13-30)26-22-24-10-8-18(27-22)28-23-25-12-17(33-23)21(32)29-20-14(2)6-5-7-15(20)3/h4-8,10,12,16H,1,9,11,13H2,2-3H3,(H,29,32)(H2,24,25,26,27,28)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.495 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM93207
(Kinase inhibitor, 5)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(Nc3ccc(OCCN)cc3)ncc2c1 Show InChI InChI=1S/C31H26F3N5O2/c1-19-5-7-25(37-29(40)21-3-2-4-23(16-21)31(32,33)34)17-27(19)20-6-12-28-22(15-20)18-36-30(39-28)38-24-8-10-26(11-9-24)41-14-13-35/h2-12,15-18H,13-14,35H2,1H3,(H,37,40)(H,36,38,39) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Washington
| Assay Description Fluorescence assay used for determination of catch and release efficiency. |
ACS Chem Biol 8: 691-9 (2013)
Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM8794
(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:10.14,wD:7.7,(-.91,-10.51,;-1.37,-9.04,;-2.87,-8.71,;-3.34,-7.24,;-2.3,-6.11,;-.8,-6.44,;-.33,-7.91,;-2.72,-4.63,;-1.64,-3.52,;-2.06,-2.04,;-3.55,-1.66,;-4.63,-2.76,;-4.21,-4.25,;-4.03,-.2,;-3.12,1.05,;-4.03,2.3,;-3.55,3.76,;-4.69,4.8,;-4.36,6.3,;-2.89,6.77,;-2.56,8.27,;-1.1,8.74,;-.48,10.15,;1.05,10.33,;1.96,9.09,;1.35,7.68,;-.18,7.5,;-1.75,5.73,;-2.08,4.23,;-5.49,1.82,;-6.82,2.59,;-6.82,4.13,;-8.16,1.82,;-8.16,.28,;-6.82,-.49,;-5.49,.28,)| Show InChI InChI=1S/C28H33N7O/c1-33-15-17-34(18-16-33)21-9-11-22(12-10-21)35-28-25(27(29)30-19-31-28)26(32-35)20-7-13-24(14-8-20)36-23-5-3-2-4-6-23/h2-8,13-14,19,21-22H,9-12,15-18H2,1H3,(H2,29,30,31)/t21-,22- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114232 BindingDB Entry DOI: 10.7270/Q27W6H6X |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473701
(US10844077, Compound I-1)Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(CN3CCOCC3)nc(N[C@H]3CCN(C3)C(=O)C=C)n2)s1 |r| Show InChI InChI=1S/C27H31ClN8O3S/c1-3-23(37)36-8-7-18(16-36)30-26-31-19(15-35-9-11-39-12-10-35)13-22(32-26)33-27-29-14-21(40-27)25(38)34-24-17(2)5-4-6-20(24)28/h3-6,13-14,18H,1,7-12,15-16H2,2H3,(H,34,38)(H2,29,30,31,32,33)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473749
(US10844077, Compound I-4)Show SMILES Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccnc(N[C@@H]3CCN(C3)C(=O)C=C)n2)s1 |r| Show InChI InChI=1S/C23H25N7O2S/c1-4-19(31)30-11-9-16(13-30)26-22-24-10-8-18(27-22)28-23-25-12-17(33-23)21(32)29-20-14(2)6-5-7-15(20)3/h4-8,10,12,16H,1,9,11,13H2,2-3H3,(H,29,32)(H2,24,25,26,27,28)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473748
(US10844077, Compound I-2)Show SMILES Cc1cccc(C)c1NC(=O)c1cnc(Nc2cc(CN3CCOCC3)nc(N[C@H]3CCN(C3)C(=O)C=C)n2)s1 |r| Show InChI InChI=1S/C28H34N8O3S/c1-4-24(37)36-9-8-20(17-36)30-27-31-21(16-35-10-12-39-13-11-35)14-23(32-27)33-28-29-15-22(40-28)26(38)34-25-18(2)6-5-7-19(25)3/h4-7,14-15,20H,1,8-13,16-17H2,2-3H3,(H,34,38)(H2,29,30,31,32,33)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM97672
(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CC[C@@H](CC1)NC(=O)C=C |r,wU:23.26,26.33,(-3.76,2.88,;-3.76,1.34,;-5.09,.57,;-5.09,-.97,;-3.76,-1.74,;-2.43,-.97,;-.96,-1.45,;-.06,-.2,;-.96,1.05,;-.56,2.53,;.92,2.93,;1.32,4.42,;.23,5.51,;.63,7,;2.12,7.4,;3.21,6.31,;4.7,6.7,;5.09,8.19,;4.01,9.28,;2.52,8.88,;-1.25,5.11,;-1.65,3.62,;-2.43,.57,;-.56,-2.93,;-1.65,-4.02,;-1.25,-5.51,;.23,-5.91,;1.32,-4.82,;.92,-3.33,;.63,-7.4,;2.12,-7.79,;2.52,-9.28,;3.21,-6.7,;4.7,-7.1,)| Show InChI InChI=1S/C26H26N6O2/c1-2-22(33)30-18-10-12-19(13-11-18)32-26-23(25(27)28-16-29-26)24(31-32)17-8-14-21(15-9-17)34-20-6-4-3-5-7-20/h2-9,14-16,18-19H,1,10-13H2,(H,30,33)(H2,27,28,29)/t18-,19+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
PHARMACYCLICS LLC
US Patent
| Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in... |
US Patent US9181263 (2015)
BindingDB Entry DOI: 10.7270/Q2765D5Z |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM97672
(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CC[C@@H](CC1)NC(=O)C=C |r,wU:23.26,26.33,(-3.76,2.88,;-3.76,1.34,;-5.09,.57,;-5.09,-.97,;-3.76,-1.74,;-2.43,-.97,;-.96,-1.45,;-.06,-.2,;-.96,1.05,;-.56,2.53,;.92,2.93,;1.32,4.42,;.23,5.51,;.63,7,;2.12,7.4,;3.21,6.31,;4.7,6.7,;5.09,8.19,;4.01,9.28,;2.52,8.88,;-1.25,5.11,;-1.65,3.62,;-2.43,.57,;-.56,-2.93,;-1.65,-4.02,;-1.25,-5.51,;.23,-5.91,;1.32,-4.82,;.92,-3.33,;.63,-7.4,;2.12,-7.79,;2.52,-9.28,;3.21,-6.7,;4.7,-7.1,)| Show InChI InChI=1S/C26H26N6O2/c1-2-22(33)30-18-10-12-19(13-11-18)32-26-23(25(27)28-16-29-26)24(31-32)17-8-14-21(15-9-17)34-20-6-4-3-5-7-20/h2-9,14-16,18-19H,1,10-13H2,(H,30,33)(H2,27,28,29)/t18-,19+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacyclics LLC
US Patent
| Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition... |
US Patent US9278100 (2016)
BindingDB Entry DOI: 10.7270/Q20C4TMX |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473763
(US10844077, Compound II-1)Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2ccn(CC3CCN(C3)C(=O)C=C)n2)s1 Show InChI InChI=1S/C22H23ClN6O2S/c1-3-19(30)28-9-7-15(12-28)13-29-10-8-18(27-29)25-22-24-11-17(32-22)21(31)26-20-14(2)5-4-6-16(20)23/h3-6,8,10-11,15H,1,7,9,12-13H2,2H3,(H,26,31)(H,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.64 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50451482
(CHEMBL4208645)Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CC[C@@H](CC1)N[C@@H](CO)C(O)=O |r,wU:23.26,wD:26.33,30.35,(20.08,-15.89,;20.08,-17.43,;18.76,-18.2,;18.76,-19.75,;20.08,-20.51,;21.43,-19.74,;22.89,-20.2,;23.8,-18.95,;22.88,-17.71,;23.35,-16.24,;24.86,-15.92,;25.33,-14.46,;24.29,-13.32,;24.75,-11.85,;26.25,-11.52,;27.29,-12.66,;28.79,-12.33,;29.25,-10.86,;28.21,-9.72,;26.71,-10.05,;22.77,-13.66,;22.32,-15.12,;21.42,-18.2,;23.38,-21.67,;24.89,-21.97,;25.37,-23.43,;24.34,-24.58,;22.83,-24.27,;22.35,-22.81,;24.81,-26.04,;26.31,-26.36,;26.79,-27.81,;25.77,-28.95,;27.34,-25.21,;28.83,-25.53,;26.86,-23.76,)| Show InChI InChI=1S/C27H29N5O4/c28-25-24-22(17-6-12-21(13-7-17)36-20-4-2-1-3-5-20)14-32(26(24)30-16-29-25)19-10-8-18(9-11-19)31-23(15-33)27(34)35/h1-7,12-14,16,18-19,23,31,33H,8-11,15H2,(H,34,35)(H2,28,29,30)/t18-,19-,23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies
Curated by ChEMBL
| Assay Description Inhibition of recombinant human HCK SH3-SH2-KD (75 to 526 residues) after 20 mins by mobility shift assay |
Bioorg Med Chem Lett 27: 4994-4998 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.012 BindingDB Entry DOI: 10.7270/Q2X92DV1 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human HCK using KVEKIGEGTYGVVYK as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473764
(US10844077, Compound II-2)Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2ccn(CC3CCCN(C3)C(=O)C=C)n2)s1 Show InChI InChI=1S/C23H25ClN6O2S/c1-3-20(31)29-10-5-7-16(13-29)14-30-11-9-19(28-30)26-23-25-12-18(33-23)22(32)27-21-15(2)6-4-8-17(21)24/h3-4,6,8-9,11-12,16H,1,5,7,10,13-14H2,2H3,(H,27,32)(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.94 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142599
(US8933228, 1)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C31H29N7O3/c1-18-9-11-19(12-10-18)38-26(17-25(37-38)31(2,3)4)34-29(39)33-22-13-14-23(21-8-6-5-7-20(21)22)41-24-15-16-32-28-27(24)35-30(40)36-28/h5-17H,1-4H3,(H2,33,34,39)(H2,32,35,36,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <2 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142600
(US8933228, 2)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C30H27N7O3/c1-30(2,3)24-17-25(37(36-24)18-9-5-4-6-10-18)33-28(38)32-21-13-14-22(20-12-8-7-11-19(20)21)40-23-15-16-31-27-26(23)34-29(39)35-27/h4-17H,1-3H3,(H2,32,33,38)(H2,31,34,35,39) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <2 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142601
(US8933228, 3)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H31N7O3/c1-19-10-12-20(13-11-19)39-27(18-26(37-39)32(2,3)4)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)42-25-16-17-33-29-28(25)38(5)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142618
(US8933228, 9)Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C31H29N7O4/c1-31(2,3)25-17-26(38(37-25)18-9-11-19(41-4)12-10-18)34-29(39)33-22-13-14-23(21-8-6-5-7-20(21)22)42-24-15-16-32-28-27(24)35-30(40)36-28/h5-17H,1-4H3,(H2,33,34,39)(H2,32,35,36,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <2 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142607
(US8933228, 14)Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ncccc12)C(C)(C)C Show InChI InChI=1S/C30H28N8O4/c1-30(2,3)23-16-24(38(37-23)17-7-9-18(41-4)10-8-17)34-28(39)33-20-11-12-21(25-19(20)6-5-14-31-25)42-22-13-15-32-27-26(22)35-29(40)36-27/h5-16H,1-4H3,(H2,33,34,39)(H2,32,35,36,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <2 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM13268
(BMS-354825 2-Heteroarylamino-thiazole Analog 12m |...)Show SMILES Cc1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1 Show InChI InChI=1S/C17H16ClN5OS/c1-9-5-4-6-12(18)15(9)23-16(24)13-8-19-17(25-13)22-14-7-10(2)20-11(3)21-14/h4-8H,1-3H3,(H,23,24)(H,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description inhibitory activity against Hck kinase |
Bioorg Med Chem Lett 14: 6061-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.093 BindingDB Entry DOI: 10.7270/Q2FQ9W3D |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM473752
(US10844077, Compound I-10)Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2ccnc(N[C@H]3CCN(C3)C(=O)C=C)n2)s1 |r| Show InChI InChI=1S/C22H22ClN7O2S/c1-3-18(31)30-10-8-14(12-30)26-21-24-9-7-17(27-21)28-22-25-11-16(33-22)20(32)29-19-13(2)5-4-6-15(19)23/h3-7,9,11,14H,1,8,10,12H2,2H3,(H,29,32)(H2,24,25,26,27,28)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.42 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The inhibitory activities of exemplary compounds described herein against select protein kinases. |
US Patent US10844077 (2020)
BindingDB Entry DOI: 10.7270/Q2862KJ4 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM163700
(N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(triflu...)Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)c4cncc(c4)-c4cnn(C)c4)c3)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C32H34F3N7O2/c1-4-41-9-11-42(12-10-41)20-23-7-8-27(15-28(23)32(33,34)35)38-30(43)22-6-5-21(2)29(14-22)39-31(44)25-13-24(16-36-17-25)26-18-37-40(3)19-26/h5-8,13-19H,4,9-12,20H2,1-3H3,(H,38,43)(H,39,44) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.43 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc.
US Patent
| Assay Description The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening... |
US Patent US10597387 (2020)
BindingDB Entry DOI: 10.7270/Q2ZC85X9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50536679
(CHEMBL4568087)Show SMILES Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N |r| Show InChI InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of full-length human N-terminal GST-tagged HCK expressed in baculovirus expression system by Z'-LYTE assay |
Bioorg Med Chem Lett 26: 4362-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.003 BindingDB Entry DOI: 10.7270/Q2NP27X5 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142610
(US8933228, 26)Show SMILES CNS(=O)(=O)Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C33H32N8O5S/c1-33(2,3)27-17-28(41(40-27)21-11-9-20(10-12-21)19-47(44,45)34-4)38-32(43)37-24-13-14-25(23-8-6-5-7-22(23)24)46-26-15-16-35-31-30(26)36-18-29(42)39-31/h5-18,34H,19H2,1-4H3,(H,35,39,42)(H2,37,38,43) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142603
(US8933228, 5)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C31H27N7O3/c1-31(2,3)25-17-26(38(37-25)19-9-5-4-6-10-19)35-30(40)34-22-13-14-23(21-12-8-7-11-20(21)22)41-24-15-16-32-29-28(24)33-18-27(39)36-29/h4-18H,1-3H3,(H,32,36,39)(H2,34,35,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM378885
(US10266537, Compound 93)Show SMILES Cc1ccc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 |r,wU:26.27,wD:29.31,(-5.46,5.4,;-3.98,5.8,;-3.58,7.29,;-2.09,7.69,;-1,6.6,;.49,7,;1.57,5.91,;1.18,4.42,;3.06,6.31,;3.46,7.79,;4.95,8.19,;6.04,7.1,;7.53,7.5,;5.64,5.62,;4.15,5.22,;6.73,4.53,;8.22,4.93,;6.33,3.04,;7.82,3.44,;-1.4,5.11,;-2.89,4.71,;-3.29,3.22,;-3.68,1.74,;-4.08,.25,;-3.18,-1,;-4.08,-2.24,;-3.68,-3.73,;-2.2,-4.13,;-1.8,-5.62,;-2.89,-6.7,;-2.49,-8.19,;-4.38,-6.31,;-4.77,-4.82,;-5.55,-1.77,;-6.88,-2.54,;-8.22,-1.77,;-8.22,-.23,;-6.88,.54,;-6.88,2.08,;-5.55,-.23,)| Show InChI InChI=1S/C29H27F3N6O2/c1-16-4-7-20(36-28(40)19-5-3-17(2)23(14-19)29(30,31)32)13-18(16)6-12-24-25-26(33)34-15-35-27(25)38(37-24)21-8-10-22(39)11-9-21/h3-5,7,13-15,21-22,39H,8-11H2,1-2H3,(H,36,40)(H2,33,34,35)/t21-,22- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human HCK (230 to 497 residues) using GGMEDIYFEFMGGKKK as substrate incubated for 40 mins in presence of [gamma33P-ATP] by radiometric ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2M90DC6 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142604
(US8933228, 6)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H29N7O3/c1-19-9-11-20(12-10-19)39-27(17-26(38-39)32(2,3)4)36-31(41)35-23-13-14-24(22-8-6-5-7-21(22)23)42-25-15-16-33-30-29(25)34-18-28(40)37-30/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142605
(US8933228, 7)Show SMILES Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccccc4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C32H29N7O3/c1-19-30(40)37-29-28(34-19)25(16-17-33-29)42-24-15-14-23(21-12-8-9-13-22(21)24)35-31(41)36-27-18-26(32(2,3)4)38-39(27)20-10-6-5-7-11-20/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142619
(US8933228, 10)Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H31N7O4/c1-32(2,3)26-18-27(39(37-26)19-10-12-20(42-5)13-11-19)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)43-25-16-17-33-29-28(25)38(4)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142628
(US8933228, 20)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(CO)nc1 Show InChI InChI=1S/C31H28N8O4/c1-31(2,3)25-14-26(39(38-25)19-9-8-18(17-40)33-15-19)36-30(42)35-22-10-11-23(21-7-5-4-6-20(21)22)43-24-12-13-32-29-28(24)34-16-27(41)37-29/h4-16,40H,17H2,1-3H3,(H,32,37,41)(H2,35,36,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM142629
(US8933228, 21)Show SMILES Cc1ccc(s1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C30H27N7O3S/c1-17-9-12-26(41-17)37-24(15-23(36-37)30(2,3)4)34-29(39)33-20-10-11-21(19-8-6-5-7-18(19)20)40-22-13-14-31-28-27(22)32-16-25(38)35-28/h5-16H,1-4H3,(H,31,35,38)(H2,33,34,39) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd.
US Patent
| Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... |
US Patent US8933228 (2015)
BindingDB Entry DOI: 10.7270/Q2RV0MDW |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human HCK using KVEKIGEGTYGVVYK as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this Ligand-Target Pair | |