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Compile Data Set for Download or QSAR

Found 1328 hits of affinity data for UniProtKB/TrEMBL: P24666   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607111
PNG
(CHEMBL5218807)
Show SMILES Cc1c(Br)cc(NC(=O)NS(O)(=O)=O)cc1Br
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Article
PubMed
1.20n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50256796
PNG
(6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)c(O)cc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O5/c29-21-12-10-20(11-13-21)28-23(27(32)22-15-24(30)25(31)16-26(22)33-28)14-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-13,15-16,29-31H,14H2
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270n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by competitive inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50256796
PNG
(6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)c(O)cc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O5/c29-21-12-10-20(11-13-21)28-23(27(32)22-15-24(30)25(31)16-26(22)33-28)14-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-13,15-16,29-31H,14H2
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340n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by competitive inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM199180
PNG
(US9217012, 10)
Show SMILES CCc1ccc(cc1)C(=O)NCCCCC(NC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)COC1CC(C)CCC1C(C)C)C(N)=O
Show InChI InChI=1S/C46H62F2N5O9P/c1-5-31-15-19-34(20-16-31)43(56)50-24-10-9-13-37(42(49)55)52-45(58)39(27-33-17-21-35(22-18-33)46(47,48)63(59,60)61)53-44(57)38(26-32-11-7-6-8-12-32)51-41(54)28-62-40-25-30(4)14-23-36(40)29(2)3/h6-8,11-12,15-22,29-30,36-40H,5,9-10,13-14,23-28H2,1-4H3,(H2,49,55)(H,50,56)(H,51,54)(H,52,58)(H,53,57)(H2,59,60,61)
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US Patent
>1.00E+3>-34.2n/an/an/an/an/a7.025



Indiana University Research and Technology Corporation

US Patent


Assay Description
PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...


US Patent US9217012 (2015)


BindingDB Entry DOI: 10.7270/Q2FX788H
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50558461
PNG
(CHEMBL4760367)
Show SMILES OS(=O)(=O)C(C(=O)Nc1nc2ccc(cc2s1)[N+]([O-])=O)c1ccccc1
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1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00993
BindingDB Entry DOI: 10.7270/Q2DN48Q4
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50558482
PNG
(CHEMBL4742123)
Show SMILES OS(=O)(=O)C(C(=O)Nc1nc2ccccc2s1)c1ccccc1
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1.70E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of LMW-PTP isoform B (unknown origin) using para-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00993
BindingDB Entry DOI: 10.7270/Q2DN48Q4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50257418
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C28H20O6/c29-20-8-5-18(6-9-20)28-23(27(33)22-11-10-21(30)15-26(22)34-28)13-16-1-3-17(4-2-16)19-7-12-24(31)25(32)14-19/h1-12,14-15,29-32H,13H2
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2.23E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50257294
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O4/c29-22-12-10-21(11-13-22)28-25(27(31)24-15-14-23(30)17-26(24)32-28)16-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-15,17,29-30H,16H2
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2.50E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50257418
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C28H20O6/c29-20-8-5-18(6-9-20)28-23(27(33)22-11-10-21(30)15-26(22)34-28)13-16-1-3-17(4-2-16)19-7-12-24(31)25(32)14-19/h1-12,14-15,29-32H,13H2
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2.68E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50558482
PNG
(CHEMBL4742123)
Show SMILES OS(=O)(=O)C(C(=O)Nc1nc2ccccc2s1)c1ccccc1
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3.20E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00993
BindingDB Entry DOI: 10.7270/Q2DN48Q4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50250606
PNG
(CHEMBL4077342)
Show SMILES OP(O)(=O)C(F)(c1ccc(cc1)-c1cccc(Cc2cc(Cl)c(Cl)cc2Cl)c1F)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C24H21Cl3F2NO6PS/c25-20-14-22(27)21(26)13-17(20)12-16-2-1-3-19(23(16)28)15-4-6-18(7-5-15)24(29,37(31,32)33)38(34,35)30-8-10-36-11-9-30/h1-7,13-14H,8-12H2,(H2,31,32,33)
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6.20E+3n/an/an/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of LMW-PTP (unknown origin) using pNPP as substrate preincubated for 5 mins followed by substrate addition measured for 20 mins by spectro...


J Med Chem 60: 9299-9319 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01292
BindingDB Entry DOI: 10.7270/Q2NZ8B27
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50257294
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O4/c29-22-12-10-21(11-13-22)28-25(27(31)24-15-14-23(30)17-26(24)32-28)16-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-15,17,29-30H,16H2
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7.80E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50118216
PNG
((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Show SMILES Cc1ncc(COP(O)(O)=O)c(C=O)c1O
Show InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
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1.30E+4n/an/an/an/an/an/an/an/a



Saint John's University

Curated by ChEMBL


Assay Description
Competitive inhibition of LMW-PTP isoform A (unknown origin)


Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127342
BindingDB Entry DOI: 10.7270/Q2FJ2MBV
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50312261
PNG
((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
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1.48E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of human HCPTPA


Bioorg Med Chem Lett 19: 6851-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.090
BindingDB Entry DOI: 10.7270/Q21G0MDK
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607111
PNG
(CHEMBL5218807)
Show SMILES Cc1c(Br)cc(NC(=O)NS(O)(=O)=O)cc1Br
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n/an/a 4n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576941
PNG
(CHEMBL4875137)
Show SMILES Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cncc3Cl)c2n1
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607137
PNG
(CHEMBL5219822)
Show SMILES N.OS(=O)(=O)NC(=O)Nc1ccc(N2CCOCC2)c(Br)c1
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n/an/a 8n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576927
PNG
(CHEMBL4856707)
Show SMILES Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1
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n/an/a 20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607138
PNG
(CHEMBL5218783)
Show SMILES N.OS(=O)(=O)NC(=O)Nc1nccs1
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n/an/a 49n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607136
PNG
(CHEMBL5220687)
Show SMILES N.OS(=O)(=O)NC(=O)Nc1nc2ccccc2s1
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n/an/a 56n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576940
PNG
(CHEMBL4857535)
Show SMILES Nc1ncn(Cc2c(Cl)cncc2Cl)c2ncnc12
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n/an/a 83n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576928
PNG
(CHEMBL4855952)
Show SMILES Cc1cccc(c1)-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1
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n/an/a 87n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576921
PNG
(CHEMBL4874911)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccccc1
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n/an/a 104n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576933
PNG
(CHEMBL4848127)
Show SMILES COc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1
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n/an/a 106n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576932
PNG
(CHEMBL4873827)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccc(F)cc1
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n/an/a 117n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576929
PNG
(CHEMBL4859307)
Show SMILES Cc1ccc(cc1)-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1
PDB

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TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607139
PNG
(CHEMBL5220615)
Show SMILES N.OS(=O)(=O)NC(=O)Nc1ccccc1
PDB

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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576930
PNG
(CHEMBL4858034)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccccc1F
PDB

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TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576924
PNG
(CHEMBL4861843)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccccc1Cl
PDB

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TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607115
PNG
(CHEMBL5220051)
Show SMILES OS(=O)(=O)CC(=O)Nc1nc2ccc(cc2s1)[N+]([O-])=O
PDB

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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50341993
PNG
(4-((3-((3-(4-carboxybenzyl)-4-oxo-2-(phenylimino)t...)
Show SMILES OC(=O)c1ccc(COc2cccc(\C=C3/S\C(=N/c4ccccc4)N(Cc4ccc(cc4)C(O)=O)C3=O)c2)cc1
Show InChI InChI=1S/C32H24N2O6S/c35-29-28(18-23-5-4-8-27(17-23)40-20-22-11-15-25(16-12-22)31(38)39)41-32(33-26-6-2-1-3-7-26)34(29)19-21-9-13-24(14-10-21)30(36)37/h1-18H,19-20H2,(H,36,37)(H,38,39)/b28-18-,33-32-
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University of Messina

Curated by ChEMBL


Assay Description
Inhibition of human LMW-PTPase isoform 2


J Med Chem 55: 2-22 (2012)


Article DOI: 10.1021/jm200607g
BindingDB Entry DOI: 10.7270/Q2057H1N
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576919
PNG
(CHEMBL4847980)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2ncnc12
PDB

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TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576931
PNG
(CHEMBL4870698)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1cccc(F)c1
PDB

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TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576934
PNG
(CHEMBL4868378)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccccc1C#N
PDB

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TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576926
PNG
(CHEMBL4857590)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccc(Cl)cc1
PDB

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Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607120
PNG
(CHEMBL5218478)
Show SMILES CS(=O)(=O)c1ccc2nc(NC(=O)CS(O)(=O)=O)sc2c1
PDB

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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607121
PNG
(CHEMBL5219403)
Show SMILES OS(=O)(=O)CC(=O)Nc1nc2ccc(cc2s1)C(=O)N1CCCC1
PDB

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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576920
PNG
(CHEMBL4852414)
Show SMILES Cc1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1
PDB

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TBA

Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50436358
PNG
(CHEMBL2396718)
Show SMILES CCCNC(=O)COc1ccc(cc1)-c1oc2cc(O)c(cc2c1C#Cc1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant LMWPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis


J Med Chem 56: 4990-5008 (2013)


Article DOI: 10.1021/jm400248c
BindingDB Entry DOI: 10.7270/Q2N017XW
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50576925
PNG
(CHEMBL4846731)
Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1cccc(Cl)c1
PDB

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Assay Description
Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02126
BindingDB Entry DOI: 10.7270/Q21G0R2R
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607117
PNG
(CHEMBL5218609)
Show SMILES Cc1cc([N+]([O-])=O)c2nc(NC(=O)CS(O)(=O)=O)sc2c1
PDB

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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM50607118
PNG
(CHEMBL5219065)
Show SMILES OS(=O)(=O)CC(=O)Nc1nc2cc(ccc2s1)[N+]([O-])=O
PDB

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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01143
BindingDB Entry DOI: 10.7270/Q2BK1HGF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM533100
PNG
(US10626094, Example I30 | US11220486, Compound I30...)
Show SMILES CCN1CCC(Cc2cccc(Nc3cc(nc4ccccc34)-c3ccc(OC)cc3)c2)CC1
PDB

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TBA

Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM533101
PNG
(US10626094, Example I31 | US11220486, Compound I31...)
Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(CC3CCN(C)CC3)c2)c2ccccc2n1
PDB

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Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM532983
PNG
((3-piperidylpropyl){2-[2- (trifluoromethoxy)phenyl...)
Show SMILES FC(F)(F)Oc1ccccc1-c1cc(NCCCC2CCCNC2)c2ccccc2n1
PDB

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Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM533021
PNG
(3-[2-(4-Methoxy-phenyl)-quinolin-4-ylamino]- benzo...)
Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(c2)C#N)c2ccccc2n1
PDB

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Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM533030
PNG
(4-{[2-(4-methoxyphenyl)-4- quinolyl]amino}benzenec...)
Show SMILES COc1ccc(cc1)-c1cc(Nc2ccc(cc2)C#N)c2ccccc2n1
PDB

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Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM533031
PNG
((6-methoxy(3-pyridyl))[2-(4-methoxyphenyl)(4- quin...)
Show SMILES COc1ccc(cc1)-c1cc(Nc2ccc(OC)nc2)c2ccccc2n1
PDB

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Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM533033
PNG
(US10626094, Example G50 | US11220486, Compound G50...)
Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(CN3CCCC3)c2)c2ccccc2n1
PDB

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Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Homo sapiens (Human))
BDBM533033
PNG
(US10626094, Example G50 | US11220486, Compound G50...)
Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(CN3CCCC3)c2)c2ccccc2n1
PDB

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Assay Description
A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2280BSF
More data for this
Ligand-Target Pair
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