Found 1328 hits of affinity data for UniProtKB/TrEMBL: P24666 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607111
(CHEMBL5218807) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50256796
(6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...)Show SMILES Oc1ccc(cc1)-c1oc2cc(O)c(O)cc2c(=O)c1Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C28H20O5/c29-21-12-10-20(11-13-21)28-23(27(32)22-15-24(30)25(31)16-26(22)33-28)14-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-13,15-16,29-31H,14H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E.
Curated by ChEMBL
| Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by competitive inhibition assay |
Bioorg Med Chem 17: 2658-72 (2009)
Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50256796
(6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...)Show SMILES Oc1ccc(cc1)-c1oc2cc(O)c(O)cc2c(=O)c1Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C28H20O5/c29-21-12-10-20(11-13-21)28-23(27(32)22-15-24(30)25(31)16-26(22)33-28)14-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-13,15-16,29-31H,14H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E.
Curated by ChEMBL
| Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by competitive inhibition assay |
Bioorg Med Chem 17: 2658-72 (2009)
Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM199180
(US9217012, 10)Show SMILES CCc1ccc(cc1)C(=O)NCCCCC(NC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)COC1CC(C)CCC1C(C)C)C(N)=O Show InChI InChI=1S/C46H62F2N5O9P/c1-5-31-15-19-34(20-16-31)43(56)50-24-10-9-13-37(42(49)55)52-45(58)39(27-33-17-21-35(22-18-33)46(47,48)63(59,60)61)53-44(57)38(26-32-11-7-6-8-12-32)51-41(54)28-62-40-25-30(4)14-23-36(40)29(2)3/h6-8,11-12,15-22,29-30,36-40H,5,9-10,13-14,23-28H2,1-4H3,(H2,49,55)(H,50,56)(H,51,54)(H,52,58)(H,53,57)(H2,59,60,61) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| >1.00E+3 | >-34.2 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Indiana University Research and Technology Corporation
US Patent
| Assay Description PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ... |
US Patent US9217012 (2015)
BindingDB Entry DOI: 10.7270/Q2FX788H |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50558461
(CHEMBL4760367)Show SMILES OS(=O)(=O)C(C(=O)Nc1nc2ccc(cc2s1)[N+]([O-])=O)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4 |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50558482
(CHEMBL4742123) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Competitive inhibition of LMW-PTP isoform B (unknown origin) using para-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50257418
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...)Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C28H20O6/c29-20-8-5-18(6-9-20)28-23(27(33)22-11-10-21(30)15-26(22)34-28)13-16-1-3-17(4-2-16)19-7-12-24(31)25(32)14-19/h1-12,14-15,29-32H,13H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E.
Curated by ChEMBL
| Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay |
Bioorg Med Chem 17: 2658-72 (2009)
Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50257294
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...)Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C28H20O4/c29-22-12-10-21(11-13-22)28-25(27(31)24-15-14-23(30)17-26(24)32-28)16-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-15,17,29-30H,16H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E.
Curated by ChEMBL
| Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay |
Bioorg Med Chem 17: 2658-72 (2009)
Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50257418
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...)Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C28H20O6/c29-20-8-5-18(6-9-20)28-23(27(33)22-11-10-21(30)15-26(22)34-28)13-16-1-3-17(4-2-16)19-7-12-24(31)25(32)14-19/h1-12,14-15,29-32H,13H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E.
Curated by ChEMBL
| Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay |
Bioorg Med Chem 17: 2658-72 (2009)
Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50558482
(CHEMBL4742123) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50250606
(CHEMBL4077342)Show SMILES OP(O)(=O)C(F)(c1ccc(cc1)-c1cccc(Cc2cc(Cl)c(Cl)cc2Cl)c1F)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C24H21Cl3F2NO6PS/c25-20-14-22(27)21(26)13-17(20)12-16-2-1-3-19(23(16)28)15-4-6-18(7-5-15)24(29,37(31,32)33)38(34,35)30-8-10-36-11-9-30/h1-7,13-14H,8-12H2,(H2,31,32,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of LMW-PTP (unknown origin) using pNPP as substrate preincubated for 5 mins followed by substrate addition measured for 20 mins by spectro... |
J Med Chem 60: 9299-9319 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01292 BindingDB Entry DOI: 10.7270/Q2NZ8B27 |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50257294
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...)Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C28H20O4/c29-22-12-10-21(11-13-22)28-25(27(31)24-15-14-23(30)17-26(24)32-28)16-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-15,17,29-30H,16H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E.
Curated by ChEMBL
| Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay |
Bioorg Med Chem 17: 2658-72 (2009)
Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50118216
((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)Show InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Saint John's University
Curated by ChEMBL
| Assay Description Competitive inhibition of LMW-PTP isoform A (unknown origin) |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2020.127342 BindingDB Entry DOI: 10.7270/Q2FJ2MBV |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50312261
((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human HCPTPA |
Bioorg Med Chem Lett 19: 6851-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.090 BindingDB Entry DOI: 10.7270/Q21G0MDK |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607111
(CHEMBL5218807) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576941
(CHEMBL4875137)Show SMILES Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cncc3Cl)c2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607137
(CHEMBL5219822) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576927
(CHEMBL4856707)Show SMILES Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607138
(CHEMBL5218783) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607136
(CHEMBL5220687) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576940
(CHEMBL4857535) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576928
(CHEMBL4855952)Show SMILES Cc1cccc(c1)-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576921
(CHEMBL4874911) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576933
(CHEMBL4848127)Show SMILES COc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576932
(CHEMBL4873827)Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccc(F)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576929
(CHEMBL4859307)Show SMILES Cc1ccc(cc1)-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607139
(CHEMBL5220615) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 121 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576930
(CHEMBL4858034)Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccccc1F | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576924
(CHEMBL4861843)Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccccc1Cl | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 171 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607115
(CHEMBL5220051)Show SMILES OS(=O)(=O)CC(=O)Nc1nc2ccc(cc2s1)[N+]([O-])=O | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50341993
(4-((3-((3-(4-carboxybenzyl)-4-oxo-2-(phenylimino)t...)Show SMILES OC(=O)c1ccc(COc2cccc(\C=C3/S\C(=N/c4ccccc4)N(Cc4ccc(cc4)C(O)=O)C3=O)c2)cc1 Show InChI InChI=1S/C32H24N2O6S/c35-29-28(18-23-5-4-8-27(17-23)40-20-22-11-15-25(16-12-22)31(38)39)41-32(33-26-6-2-1-3-7-26)34(29)19-21-9-13-24(14-10-21)30(36)37/h1-18H,19-20H2,(H,36,37)(H,38,39)/b28-18-,33-32- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Messina
Curated by ChEMBL
| Assay Description Inhibition of human LMW-PTPase isoform 2 |
J Med Chem 55: 2-22 (2012)
Article DOI: 10.1021/jm200607g BindingDB Entry DOI: 10.7270/Q2057H1N |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576919
(CHEMBL4847980) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 239 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576931
(CHEMBL4870698)Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1cccc(F)c1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 239 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576934
(CHEMBL4868378)Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccccc1C#N | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576926
(CHEMBL4857590)Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1ccc(Cl)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 288 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607120
(CHEMBL5218478) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607121
(CHEMBL5219403)Show SMILES OS(=O)(=O)CC(=O)Nc1nc2ccc(cc2s1)C(=O)N1CCCC1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576920
(CHEMBL4852414) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 306 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50436358
(CHEMBL2396718)Show SMILES CCCNC(=O)COc1ccc(cc1)-c1oc2cc(O)c(cc2c1C#Cc1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of recombinant LMWPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis |
J Med Chem 56: 4990-5008 (2013)
Article DOI: 10.1021/jm400248c BindingDB Entry DOI: 10.7270/Q2N017XW |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50576925
(CHEMBL4846731)Show SMILES Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1cccc(Cl)c1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human LMPTP-A using OMFP or pNPP as substrate by fluorescence assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02126 BindingDB Entry DOI: 10.7270/Q21G0R2R |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607117
(CHEMBL5218609)Show SMILES Cc1cc([N+]([O-])=O)c2nc(NC(=O)CS(O)(=O)=O)sc2c1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM50607118
(CHEMBL5219065)Show SMILES OS(=O)(=O)CC(=O)Nc1nc2cc(ccc2s1)[N+]([O-])=O | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM533100
(US10626094, Example I30 | US11220486, Compound I30...)Show SMILES CCN1CCC(Cc2cccc(Nc3cc(nc4ccccc34)-c3ccc(OC)cc3)c2)CC1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM533101
(US10626094, Example I31 | US11220486, Compound I31...)Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(CC3CCN(C)CC3)c2)c2ccccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM532983
((3-piperidylpropyl){2-[2- (trifluoromethoxy)phenyl...)Show SMILES FC(F)(F)Oc1ccccc1-c1cc(NCCCC2CCCNC2)c2ccccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM533021
(3-[2-(4-Methoxy-phenyl)-quinolin-4-ylamino]- benzo...)Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(c2)C#N)c2ccccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM533030
(4-{[2-(4-methoxyphenyl)-4- quinolyl]amino}benzenec...)Show SMILES COc1ccc(cc1)-c1cc(Nc2ccc(cc2)C#N)c2ccccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM533031
((6-methoxy(3-pyridyl))[2-(4-methoxyphenyl)(4- quin...) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM533033
(US10626094, Example G50 | US11220486, Compound G50...)Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(CN3CCCC3)c2)c2ccccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human)) | BDBM533033
(US10626094, Example G50 | US11220486, Compound G50...)Show SMILES COc1ccc(cc1)-c1cc(Nc2cccc(CN3CCCC3)c2)c2ccccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A listing of materials is provided: Item, source, catalog no. LMPTP-A Enzyme Stock Solution (4.22 mg/ml or 206.8 μM), SBMRI Protei... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BSF |
More data for this Ligand-Target Pair | |