Found 86 hits for UniProtKB: Q02294 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50022784
((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 27: 699-711 (2002)
Article DOI: 10.1016/S0893-133X(02)00346-9 BindingDB Entry DOI: 10.7270/Q2GQ6W98 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM82071
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 25: 871-80 (2001)
Article DOI: 10.1016/S0893-133X(01)00298-6 BindingDB Entry DOI: 10.7270/Q25M648W |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM84745
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 25: 871-80 (2001)
Article DOI: 10.1016/S0893-133X(01)00298-6 BindingDB Entry DOI: 10.7270/Q25M648W |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50049750
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
Neuropharmacology 35: 725-34 (1996)
Article DOI: 10.1016/0028-3908(96)84644-2 BindingDB Entry DOI: 10.7270/Q237777N |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 270: 310-8 (1994)
BindingDB Entry DOI: 10.7270/Q2HH6HKJ |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50133817
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pudue Pharma Discovery Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 377-86 (2003)
Article DOI: 10.1124/jpet.102.045674 BindingDB Entry DOI: 10.7270/Q2TX3CX5 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50386813
(CHEMBL2047726)Show SMILES FC(F)(F)c1cccc(CN2C[C@@H]3CC[C@H](NC(=O)C(C4CCCCC4)C4CCCCC4)[C@@H]3C2)c1 |r| Show InChI InChI=1S/C29H41F3N2O/c30-29(31,32)24-13-7-8-20(16-24)17-34-18-23-14-15-26(25(23)19-34)33-28(35)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h7-8,13,16,21-23,25-27H,1-6,9-12,14-15,17-19H2,(H,33,35)/t23-,25+,26-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat Cav2.2 expressed in HEK293 cells under inactivating depolarizing conditions at holding potential of -115mV and stepped to 0 mV once... |
Bioorg Med Chem 20: 4128-39 (2012)
Article DOI: 10.1016/j.bmc.2012.04.057 BindingDB Entry DOI: 10.7270/Q2TQ62JK |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50386813
(CHEMBL2047726)Show SMILES FC(F)(F)c1cccc(CN2C[C@@H]3CC[C@H](NC(=O)C(C4CCCCC4)C4CCCCC4)[C@@H]3C2)c1 |r| Show InChI InChI=1S/C29H41F3N2O/c30-29(31,32)24-13-7-8-20(16-24)17-34-18-23-14-15-26(25(23)19-34)33-28(35)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h7-8,13,16,21-23,25-27H,1-6,9-12,14-15,17-19H2,(H,33,35)/t23-,25+,26-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat Cav2.2 expressed in HEK293 cells under inactivating depolarizing conditions at holding potential of -115mV and stepped to 0 mV once... |
Bioorg Med Chem 20: 4128-39 (2012)
Article DOI: 10.1016/j.bmc.2012.04.057 BindingDB Entry DOI: 10.7270/Q2TQ62JK |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481859
(CHEMBL1088309)Show SMILES O=C(CCCCC(c1ccccc1)c1ccccc1)N1CCN(C\C=C\c2ccccc2)CC1 Show InChI InChI=1S/C31H36N2O/c34-31(33-25-23-32(24-26-33)22-12-15-27-13-4-1-5-14-27)21-11-10-20-30(28-16-6-2-7-17-28)29-18-8-3-9-19-29/h1-9,12-19,30H,10-11,20-26H2/b15-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481859
(CHEMBL1088309)Show SMILES O=C(CCCCC(c1ccccc1)c1ccccc1)N1CCN(C\C=C\c2ccccc2)CC1 Show InChI InChI=1S/C31H36N2O/c34-31(33-25-23-32(24-26-33)22-12-15-27-13-4-1-5-14-27)21-11-10-20-30(28-16-6-2-7-17-28)29-18-8-3-9-19-29/h1-9,12-19,30H,10-11,20-26H2/b15-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50017702
(1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...)Show SMILES Fc1ccc(cc1)C(N1CCN(C\C=C\c2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50095765
(1-(2,3,4-trimethoxybenzyl)-4-(bis(4-fluorophenyl)m...)Show SMILES COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC Show InChI InChI=1S/C27H30F2N2O3/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20/h4-13,25H,14-18H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481860
(CHEMBL1087660)Show SMILES Fc1ccc(cc1)C(CCCCC(=O)N1CCN(C\C=C\c2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C31H34F2N2O/c32-28-16-12-26(13-17-28)30(27-14-18-29(33)19-15-27)10-4-5-11-31(36)35-23-21-34(22-24-35)20-6-9-25-7-2-1-3-8-25/h1-3,6-9,12-19,30H,4-5,10-11,20-24H2/b9-6+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481862
(CHEMBL1087275)Show SMILES COc1ccc(\C=C\C(=O)N2CCN(CC2)C(=O)CCCCC(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C32H36N2O3/c1-37-29-19-16-26(17-20-29)18-21-32(36)34-24-22-33(23-25-34)31(35)15-9-8-14-30(27-10-4-2-5-11-27)28-12-6-3-7-13-28/h2-7,10-13,16-21,30H,8-9,14-15,22-25H2,1H3/b21-18+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481858
(CHEMBL1086621)Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCN(CCCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 Show InChI InChI=1S/C32H38F2N2O4/c1-38-29-21-25(22-30(39-2)31(29)40-3)32(37)36-19-17-35(18-20-36)16-6-4-5-7-28(23-8-12-26(33)13-9-23)24-10-14-27(34)15-11-24/h8-15,21-22,28H,4-7,16-20H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50461289
(MK-6721 | NMED-160 | NP-118809 | Z-160 | Z160)Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481868
(CHEMBL1088610)Show SMILES O=C(CCCCC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(=O)\C=C\c1cccc2OCOc12 Show InChI InChI=1S/C32H34N2O4/c35-30(17-8-7-15-28(25-10-3-1-4-11-25)26-12-5-2-6-13-26)33-20-22-34(23-21-33)31(36)19-18-27-14-9-16-29-32(27)38-24-37-29/h1-6,9-14,16,18-19,28H,7-8,15,17,20-24H2/b19-18+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481864
(CHEMBL1087237)Show SMILES Nc1ccc(\C=C\C(=O)N2CCN(CC2)C(=O)CCCCC(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C31H35N3O2/c32-28-18-15-25(16-19-28)17-20-31(36)34-23-21-33(22-24-34)30(35)14-8-7-13-29(26-9-3-1-4-10-26)27-11-5-2-6-12-27/h1-6,9-12,15-20,29H,7-8,13-14,21-24,32H2/b20-17+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481466
(CHEMBL599217)Show SMILES O=C(NC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C31H31N3O/c35-31(32-29(25-13-5-1-6-14-25)26-15-7-2-8-16-26)34-23-21-33(22-24-34)30(27-17-9-3-10-18-27)28-19-11-4-12-20-28/h1-20,29-30H,21-24H2,(H,32,35) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481861
(CHEMBL1087779)Show SMILES COc1ccc(\C=C\CN2CCN(CC2)C(=O)CCCCC(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C32H38N2O2/c1-36-30-20-18-27(19-21-30)11-10-22-33-23-25-34(26-24-33)32(35)17-9-8-16-31(28-12-4-2-5-13-28)29-14-6-3-7-15-29/h2-7,10-15,18-21,31H,8-9,16-17,22-26H2,1H3/b11-10+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481869
(CHEMBL1088308)Show SMILES COc1cc(CN2CCN(CC2)C(=O)CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)cc(OC)c1OC Show InChI InChI=1S/C32H38F2N2O4/c1-38-29-20-23(21-30(39-2)32(29)40-3)22-35-16-18-36(19-17-35)31(37)7-5-4-6-28(24-8-12-26(33)13-9-24)25-10-14-27(34)15-11-25/h8-15,20-21,28H,4-7,16-19,22H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481863
(CHEMBL1088464)Show SMILES O=C(CCCCC(c1ccccc1)c1ccccc1)N1CCN(C\C=C\c2cccc3OCOc23)CC1 Show InChI InChI=1S/C32H36N2O3/c35-31(19-8-7-17-29(26-11-3-1-4-12-26)27-13-5-2-6-14-27)34-23-21-33(22-24-34)20-10-16-28-15-9-18-30-32(28)37-25-36-30/h1-6,9-16,18,29H,7-8,17,19-25H2/b16-10+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481449
(CHEMBL599408)Show SMILES O=C(CN1CCN(CC1)C(c1ccccc1)c1ccccc1)N(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C31H31N3O/c35-30(34(28-17-9-3-10-18-28)29-19-11-4-12-20-29)25-32-21-23-33(24-22-32)31(26-13-5-1-6-14-26)27-15-7-2-8-16-27/h1-20,31H,21-25H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50438747
(CHEMBL2414787)Show SMILES CC(C)N[C@@H](CC(C)(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)S(=O)(=O)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C24H36F3N3O3S/c1-15(2)28-21(12-23(3,4)5)22(31)29-20-11-6-16-13-30(14-19(16)20)34(32,33)18-9-7-17(8-10-18)24(25,26)27/h7-10,15-16,19-21,28H,6,11-14H2,1-5H3,(H,29,31)/t16-,19+,20+,21+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com
Curated by ChEMBL
| Assay Description Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under hyperpolarized condition by whole cell patch-clamp manual electrophysiology a... |
Bioorg Med Chem Lett 23: 4857-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.074 BindingDB Entry DOI: 10.7270/Q2280915 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481867
(CHEMBL1088174)Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCN(CC1)C(=O)CCCCC(c1ccc(F)cc1)c1ccc(F)cc1 Show InChI InChI=1S/C32H36F2N2O5/c1-39-28-20-24(21-29(40-2)31(28)41-3)32(38)36-18-16-35(17-19-36)30(37)7-5-4-6-27(22-8-12-25(33)13-9-22)23-10-14-26(34)15-11-23/h8-15,20-21,27H,4-7,16-19H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434732
(CHEMBL2385364)Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO)CN1 |r| Show InChI InChI=1S/C22H30N2O/c1-18-17-24(21(16-23-18)14-8-9-15-25)22(19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-7,10-13,18,21-23,25H,8-9,14-17H2,1H3/t18-,21-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50438746
(CHEMBL2414771)Show SMILES CN[C@@H](CC(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H30F3N3O/c1-13(2)10-19(25-3)20(28)26-18-9-4-14-11-27(12-17(14)18)16-7-5-15(6-8-16)21(22,23)24/h5-8,13-14,17-19,25H,4,9-12H2,1-3H3,(H,26,28)/t14-,17+,18+,19+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com
Curated by ChEMBL
| Assay Description Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under depolarized condition by whole cell patch-clamp manual electrophysiology assa... |
Bioorg Med Chem Lett 23: 4857-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.074 BindingDB Entry DOI: 10.7270/Q2280915 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-3/N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50117922
((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)Show SMILES COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C |r| Show InChI InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Idorsia Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat Cav2.2-alpha1beta/beta3 expressed in HEK293 cells assessed as decrease in calcium mobilization response to KCl after 1 hr by Fluo-4... |
J Med Chem 60: 9769-9789 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01236 BindingDB Entry DOI: 10.7270/Q24M9745 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434737
(CHEMBL2385359)Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1 |r| Show InChI InChI=1S/C28H44N2OSi/c1-23-22-30(27(24-15-9-7-10-16-24)25-17-11-8-12-18-25)26(21-29-23)19-13-14-20-31-32(5,6)28(2,3)4/h7-12,15-18,23,26-27,29H,13-14,19-22H2,1-6H3/t23-,26-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434738
(CHEMBL2385358)Show SMILES CCCCC[C@@H]1CN[C@H](C)CN1C(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C23H32N2/c1-3-4-7-16-22-17-24-19(2)18-25(22)23(20-12-8-5-9-13-20)21-14-10-6-11-15-21/h5-6,8-15,19,22-24H,3-4,7,16-18H2,1-2H3/t19-,22-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434735
(CHEMBL2385361)Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCO[Si](C)(C)C(C)(C)C)CN1S(=O)(=O)c1ccc(C)cc1 |r| Show InChI InChI=1S/C34H48N2O3SSi/c1-27-20-22-32(23-21-27)40(37,38)36-26-31(19-14-24-39-41(6,7)34(3,4)5)35(25-28(36)2)33(29-15-10-8-11-16-29)30-17-12-9-13-18-30/h8-13,15-18,20-23,28,31,33H,14,19,24-26H2,1-7H3/t28-,31-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434742
(CHEMBL2385371)Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](Cc2ccccc2)CN1 |r| Show InChI InChI=1S/C25H28N2/c1-20-19-27(24(18-26-20)17-21-11-5-2-6-12-21)25(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,20,24-26H,17-19H2,1H3/t20-,24-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50438746
(CHEMBL2414771)Show SMILES CN[C@@H](CC(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H30F3N3O/c1-13(2)10-19(25-3)20(28)26-18-9-4-14-11-27(12-17(14)18)16-7-5-15(6-8-16)21(22,23)24/h5-8,13-14,17-19,25H,4,9-12H2,1-3H3,(H,26,28)/t14-,17+,18+,19+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com
Curated by ChEMBL
| Assay Description Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under hyperpolarized condition by whole cell patch-clamp manual electrophysiology a... |
Bioorg Med Chem Lett 23: 4857-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.074 BindingDB Entry DOI: 10.7270/Q2280915 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434734
(CHEMBL2385362)Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1S(=O)(=O)c1ccc(C)cc1 |r| Show InChI InChI=1S/C35H50N2O3SSi/c1-28-21-23-33(24-22-28)41(38,39)37-27-32(20-14-15-25-40-42(6,7)35(3,4)5)36(26-29(37)2)34(30-16-10-8-11-17-30)31-18-12-9-13-19-31/h8-13,16-19,21-24,29,32,34H,14-15,20,25-27H2,1-7H3/t29-,32-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434741
(CHEMBL2385372)Show SMILES C[C@@H]1CN(Cc2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1 |r| Show InChI InChI=1S/C22H40N2OSi/c1-19-17-24(18-20-12-8-7-9-13-20)21(16-23-19)14-10-11-15-25-26(5,6)22(2,3)4/h7-9,12-13,19,21,23H,10-11,14-18H2,1-6H3/t19-,21-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481853
(CHEMBL1081018)Show SMILES C(CN1CCN(CC1)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H34N2/c1-5-13-27(14-6-1)31(28-15-7-2-8-16-28)21-22-33-23-25-34(26-24-33)32(29-17-9-3-10-18-29)30-19-11-4-12-20-30/h1-20,31-32H,21-26H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481854
(CHEMBL1081016)Show SMILES C(CC(c1ccccc1)c1ccccc1)CN1CCN(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C33H36N2/c1-5-14-28(15-6-1)32(29-16-7-2-8-17-29)22-13-23-34-24-26-35(27-25-34)33(30-18-9-3-10-19-30)31-20-11-4-12-21-31/h1-12,14-21,32-33H,13,22-27H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481453
(CHEMBL597148)Show SMILES O=C(CN(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C31H31N3O/c35-30(25-34(28-17-9-3-10-18-28)29-19-11-4-12-20-29)32-21-23-33(24-22-32)31(26-13-5-1-6-14-26)27-15-7-2-8-16-27/h1-20,31H,21-25H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434747
(CHEMBL2385366)Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)[C@H](Cc2ccccc2)CN1 |r| Show InChI InChI=1S/C19H23FN2/c1-15-13-22(14-17-7-9-18(20)10-8-17)19(12-21-15)11-16-5-3-2-4-6-16/h2-10,15,19,21H,11-14H2,1H3/t15-,19-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434731
(CHEMBL2385365)Show InChI InChI=1S/C16H26N2O/c1-14-12-18(13-15-7-3-2-4-8-15)16(11-17-14)9-5-6-10-19/h2-4,7-8,14,16-17,19H,5-6,9-13H2,1H3/t14-,16-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434740
(CHEMBL2385356)Show InChI InChI=1S/C17H28N2/c1-3-4-6-11-17-12-18-15(2)13-19(17)14-16-9-7-5-8-10-16/h5,7-10,15,17-18H,3-4,6,11-14H2,1-2H3/t15-,17-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434736
(CHEMBL2385360)Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCO[Si](C)(C)C(C)(C)C)CN1 |r| Show InChI InChI=1S/C27H42N2OSi/c1-22-21-29(25(20-28-22)18-13-19-30-31(5,6)27(2,3)4)26(23-14-9-7-10-15-23)24-16-11-8-12-17-24/h7-12,14-17,22,25-26,28H,13,18-21H2,1-6H3/t22-,25-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434739
(CHEMBL2385357)Show InChI InChI=1S/C21H36N2/c1-3-4-5-6-7-8-12-15-21-16-22-19(2)17-23(21)18-20-13-10-9-11-14-20/h9-11,13-14,19,21-22H,3-8,12,15-18H2,1-2H3/t19-,21-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434744
(CHEMBL2385369)Show SMILES C[C@@H]1CN(Cc2ccccc2)[C@H](Cc2ccccc2)CN1 |r| Show InChI InChI=1S/C19H24N2/c1-16-14-21(15-18-10-6-3-7-11-18)19(13-20-16)12-17-8-4-2-5-9-17/h2-11,16,19-20H,12-15H2,1H3/t16-,19-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434745
(CHEMBL2385368)Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)[C@H](Cc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C33H33FN2O/c1-25-22-35(23-27-17-19-30(34)20-18-27)31(21-26-11-5-2-6-12-26)24-36(25)33(37)32(28-13-7-3-8-14-28)29-15-9-4-10-16-29/h2-20,25,31-32H,21-24H2,1H3/t25-,31-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434746
(CHEMBL2385367)Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)[C@H](Cc2ccccc2)CN1S(=O)(=O)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H26F4N2O2S/c1-19-16-31(17-21-7-11-23(27)12-8-21)24(15-20-5-3-2-4-6-20)18-32(19)35(33,34)25-13-9-22(10-14-25)26(28,29)30/h2-14,19,24H,15-18H2,1H3/t19-,24-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434743
(CHEMBL2385370)Show SMILES C[C@@H]1CN(Cc2ccccc2)[C@H](Cc2ccccc2)CN1S(=O)(=O)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H27F3N2O2S/c1-20-17-30(18-22-10-6-3-7-11-22)24(16-21-8-4-2-5-9-21)19-31(20)34(32,33)25-14-12-23(13-15-25)26(27,28)29/h2-15,20,24H,16-19H2,1H3/t20-,24-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50434733
(CHEMBL2385363)Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1S(=O)(=O)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C35H47F3N2O3SSi/c1-27-25-39(33(28-15-9-7-10-16-28)29-17-11-8-12-18-29)31(19-13-14-24-43-45(5,6)34(2,3)4)26-40(27)44(41,42)32-22-20-30(21-23-32)35(36,37)38/h7-12,15-18,20-23,27,31,33H,13-14,19,24-26H2,1-6H3/t27-,31-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 3257-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.114 BindingDB Entry DOI: 10.7270/Q21N82H2 |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat)) | BDBM50438747
(CHEMBL2414787)Show SMILES CC(C)N[C@@H](CC(C)(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)S(=O)(=O)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C24H36F3N3O3S/c1-15(2)28-21(12-23(3,4)5)22(31)29-20-11-6-16-13-30(14-19(16)20)34(32,33)18-9-7-17(8-10-18)24(25,26)27/h7-10,15-16,19-21,28H,6,11-14H2,1-5H3,(H,29,31)/t16-,19+,20+,21+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com
Curated by ChEMBL
| Assay Description Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under depolarized condition by whole cell patch-clamp manual electrophysiology assa... |
Bioorg Med Chem Lett 23: 4857-61 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.074 BindingDB Entry DOI: 10.7270/Q2280915 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-1/N-type calcium channel subunit alpha-1B/calcium channel subunit alpha-2/delta-1
(Rattus norvegicus-Rattus norvegicus (Rat)) | BDBM50481865
(CHEMBL1081175)Show SMILES C(CCN1CCN(CC1)C(c1ccccc1)c1ccccc1)CC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C34H38N2/c1-5-15-29(16-6-1)33(30-17-7-2-8-18-30)23-13-14-24-35-25-27-36(28-26-35)34(31-19-9-3-10-20-31)32-21-11-4-12-22-32/h1-12,15-22,33-34H,13-14,23-28H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Calgary
Curated by ChEMBL
| Assay Description Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce... |
Bioorg Med Chem Lett 19: 6467-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.008 BindingDB Entry DOI: 10.7270/Q2PV6P57 |
More data for this Ligand-Target Pair | |