Found 267 hits of affinity data for UniProtKB/TrEMBL: Q16850 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM31768
(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)Show SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| Show InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1 | PDB
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Discovery Research
Curated by ChEMBL
| Assay Description
Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes |
J Med Chem 36: 2235-7 (1993)
BindingDB Entry DOI: 10.7270/Q2ZW1K0P |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50044425
(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)Show SMILES Nc1ccc(SC[C@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 Show InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Discovery Research
Curated by ChEMBL
| Assay Description
Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes |
J Med Chem 36: 2235-7 (1993)
BindingDB Entry DOI: 10.7270/Q2ZW1K0P |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50044425
(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)Show SMILES Nc1ccc(SC[C@H]2CO[C@@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 Show InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| PubMed
| 40.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Discovery Research
Curated by ChEMBL
| Assay Description
Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes |
J Med Chem 36: 2235-7 (1993)
BindingDB Entry DOI: 10.7270/Q2ZW1K0P |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM31768
(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)Show SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| Show InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1 | PDB
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| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Discovery Research
Curated by ChEMBL
| Assay Description
Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes |
J Med Chem 36: 2235-7 (1993)
BindingDB Entry DOI: 10.7270/Q2ZW1K0P |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50215880
(CHEMBL52311 | Ro-092364)Show SMILES CC1(C)CC[C@@H](COc2ccc(OC(F)(F)F)cc2)[C@H](Cn2cncn2)C1OCCO Show InChI InChI=1S/C21H28F3N3O4/c1-20(2)8-7-15(12-30-16-3-5-17(6-4-16)31-21(22,23)24)18(19(20)29-10-9-28)11-27-14-25-13-26-27/h3-6,13-15,18-19,28H,7-12H2,1-2H3/t15-,18-,19?/m0/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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| n/a | n/a | 22.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 |
Bioorg Med Chem Lett 8: 1819-24 (1998)
BindingDB Entry DOI: 10.7270/Q2H997D2 |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50215878
(CHEMBL54768 | Ro-092056)Show SMILES CCc1ccc(CC[C@@H]2CCC(C)(C)[C@H](OC)[C@H]2Cn2cncn2)cc1 Show InChI InChI=1S/C22H33N3O/c1-5-17-6-8-18(9-7-17)10-11-19-12-13-22(2,3)21(26-4)20(19)14-25-16-23-15-24-25/h6-9,15-16,19-21H,5,10-14H2,1-4H3/t19-,20+,21-/m1/s1 | PDB
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| CHEMBL
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PC sid
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| n/a | n/a | 28.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 |
Bioorg Med Chem Lett 8: 1819-24 (1998)
BindingDB Entry DOI: 10.7270/Q2H997D2 |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50215878
(CHEMBL54768 | Ro-092056)Show SMILES CCc1ccc(CC[C@@H]2CCC(C)(C)[C@H](OC)[C@H]2Cn2cncn2)cc1 Show InChI InChI=1S/C22H33N3O/c1-5-17-6-8-18(9-7-17)10-11-19-12-13-22(2,3)21(26-4)20(19)14-25-16-23-15-24-25/h6-9,15-16,19-21H,5,10-14H2,1-4H3/t19-,20+,21-/m1/s1 | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
| n/a | n/a | 28.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of Lanosterol 14-alpha demethylase (Candida albicans CY1005) |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80190-6
BindingDB Entry DOI: 10.7270/Q2RF5XRV |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM31773
(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)Show InChI InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2 | PDB
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| PDB
Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
ACT LLC
Curated by ChEMBL
| Assay Description
Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay |
Drug Metab Dispos 35: 493-500 (2007)
Article DOI: 10.1124/dmd.106.013888
BindingDB Entry DOI: 10.7270/Q2DF6S2H |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50215879
(CHEMBL415943 | Ro-092435)Show SMILES CO\N=C1/[C@@H](Cn2cncn2)[C@H](COc2ccc(OC(F)(F)F)cc2)CCC1(C)C Show InChI InChI=1S/C20H25F3N4O3/c1-19(2)9-8-14(17(18(19)26-28-3)10-27-13-24-12-25-27)11-29-15-4-6-16(7-5-15)30-20(21,22)23/h4-7,12-14,17H,8-11H2,1-3H3/b26-18+/t14-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 56.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 |
Bioorg Med Chem Lett 8: 1819-24 (1998)
BindingDB Entry DOI: 10.7270/Q2H997D2 |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50215883
(CHEMBL53214 | Ro-092182)Show SMILES CCc1ccc(CC[C@@H]2CCC(C)(C)\C(=N\O)[C@H]2Cn2cncn2)cc1 Show InChI InChI=1S/C21H30N4O/c1-4-16-5-7-17(8-6-16)9-10-18-11-12-21(2,3)20(24-26)19(18)13-25-15-22-14-23-25/h5-8,14-15,18-19,26H,4,9-13H2,1-3H3/b24-20+/t18-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 73.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 |
Bioorg Med Chem Lett 8: 1819-24 (1998)
BindingDB Entry DOI: 10.7270/Q2H997D2 |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50215876
(CHEMBL53213 | Ro-092173)Show SMILES CCc1ccc(CC[C@@H]2CCC(C)(C)C(OCCO)[C@H]2Cn2cncn2)cc1 Show InChI InChI=1S/C23H35N3O2/c1-4-18-5-7-19(8-6-18)9-10-20-11-12-23(2,3)22(28-14-13-27)21(20)15-26-17-24-16-25-26/h5-8,16-17,20-22,27H,4,9-15H2,1-3H3/t20-,21+,22?/m1/s1 | PDB
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
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Similars
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| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 |
Bioorg Med Chem Lett 8: 1819-24 (1998)
BindingDB Entry DOI: 10.7270/Q2H997D2 |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50011478
(ITRAZOLE)Show SMILES CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OCC3COC(Cn4cncn4)(O3)c3ccc(Cl)cc3Cl)cc2)c1=O Show InChI InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3 | PDB
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PC sid
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| Article
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of Lanosterol 14-alpha demethylase (Candida albicans CY1005) |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80190-6
BindingDB Entry DOI: 10.7270/Q2RF5XRV |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50215882
(CHEMBL298394 | Ro-092183)Show SMILES CCc1ccc(CC[C@@H]2CCC(C)(C)\C(=N\OC)[C@H]2Cn2cncn2)cc1 Show InChI InChI=1S/C22H32N4O/c1-5-17-6-8-18(9-7-17)10-11-19-12-13-22(2,3)21(25-27-4)20(19)14-26-16-23-15-24-26/h6-9,15-16,19-20H,5,10-14H2,1-4H3/b25-21+/t19-,20+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 86.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of cytochrome P450 lanosterol C14 demethylase in Candida albicans CY1005 |
Bioorg Med Chem Lett 8: 1819-24 (1998)
BindingDB Entry DOI: 10.7270/Q2H997D2 |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM50469749
(CHEMBL349069 | Ro-092127)Show SMILES CCc1ccc(CC[C@@H]2CCC(C)(C)[C@H](OC)[C@H]2Cn2ccnc2)cc1 Show InChI InChI=1S/C23H34N2O/c1-5-18-6-8-19(9-7-18)10-11-20-12-13-23(2,3)22(26-4)21(20)16-25-15-14-24-17-25/h6-9,14-15,17,20-22H,5,10-13,16H2,1-4H3/t20-,21+,22-/m1/s1 | PDB
UniProtKB/SwissProt
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 90.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of Lanosterol 14-alpha demethylase (Candida albicans CY1005) |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80190-6
BindingDB Entry DOI: 10.7270/Q2RF5XRV |
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628756
(Preparation of 2-(3,4-Dichlorophenyl)-N-[(2R)-2-Hy...)Show SMILES CCCN(C[C@H](O)c1cccnc1)C(=O)Cc1ccc(Cl)c(Cl)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628757
(US20230339890, Compound 31) | PDB
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628761
(US20230339890, Compound 105)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(c(F)c1)C(F)(F)F | PDB
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628763
(Preparation of N-[(2S)-2-Hydroxy-2-(3-Pyridyl)Ethy...)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc2ccccc2c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628770
(US20230339890, Compound 130)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1cnc(nc1)C(C)(C)C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628771
(US20230339890, Compound 8)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(Cl)c(Cl)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628775
(US20230339890, Compound 107)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)N1Cc2cc(Cl)c(Cl)cc2C1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628776
(US20230339890, Compound 131)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)C1Cc2cc(Cl)c(Br)cc2C1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628788
(US20230339890, Compound 109)Show SMILES CCCN(CC(O)c1cnccc1OC)C(=O)Cc1ccc(Cl)c(Cl)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628792
(US20230339890, Compound 11)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)C1Cc2cc(Cl)c(Cl)cc2C1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628797
(US20230339890, Compound 134)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)C1Cc2cc(Cl)c(cc2C1)C#N | PDB
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628803
(US20230339890, Compound 135)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)N1Cc2cc(Cl)c(Br)cc2C1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628780
(US20230339890, Compound 84 | US20230339890, Compou...)Show SMILES Cc1ccncc1C(O)CN(CC1COC1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628809
(US20230339890, Compound 136)Show SMILES CCCN(CC(O)c1cnccc1N)C(=O)C(C)c1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628812
(US20230339890, Compound 64)Show SMILES O[C@H](CN(Cc1ccccc1)C(=O)Cc1ccc(nc1)C(F)(F)F)c1cccnc1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628815
(US20230339890, Compound 137)Show SMILES CC(C)(C)OC(=O)N(CCc1ccc2ccccc2c1)CC(O)c1cccnc1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628820
(US20230339890, Compound 90 | US20230339890, Compou...)Show SMILES CC(C)c1ccncc1C(O)CN(CC1COC1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628823
(Preparation of 2-(3-Chloro-4-Methyl-Phenyl)-N-[(2S...)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(C)c(Cl)c1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628820
(US20230339890, Compound 90 | US20230339890, Compou...)Show SMILES CC(C)c1ccncc1C(O)CN(CC1COC1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628830
(US20230339890, Compound 139)Show SMILES CC(C)(C)OC(=O)NCCCCCN(CC(O)c1cccnc1)C(=O)Cc1ccc(Cl)c(Cl)c1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628831
(Preparation of N-[(2S)-2-Hydroxy-2-(3-Pyridyl)Ethy...)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628762
(US20230339890, Compound 129 | US20230339890, Compo...)Show SMILES CCCN(CC(O)c1cnccn1)C(=O)C1Cc2cc(Cl)c(Cl)cc2C1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628834
(US20230339890, Compound 67)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc2cc(Cl)sc2c1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628820
(US20230339890, Compound 90 | US20230339890, Compou...)Show SMILES CC(C)c1ccncc1C(O)CN(CC1COC1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628837
(US20230339890, Compound 140)Show SMILES CC(C)(C)OC(=O)NCCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628838
(US20230339890, Compound 18)Show SMILES CC(C)N(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(Cl)c(Cl)c1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628843
(US20230339890, Compound 141)Show SMILES CC(C)(C)OC(=O)NCCCCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628766
(US20230339890, Compound 32 | US20230339890, Compou...)Show SMILES CCCN(CC(O)c1cccnn1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628849
(US20230339890, Compound 142)Show SMILES CC(C)(C)OC(=O)NCCCCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(C#N)c(Cl)c1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628851
(Preparation of N-[(2S)-2-Hydroxy-2-(3-Pyridyl)Ethy...)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cn1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628852
(US20230339890, Compound 70)Show SMILES CCC(=O)N(C[C@@H](O)c1cccnc1)C1CCc2cc(Cl)c(Cl)cc2C1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628854
(US20230339890, Compound 119)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(C#N)c(F)c1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628855
(US20230339890, Compound 143)Show SMILES CC(C)(C)OC(=O)NCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(nc1)C(F)(F)F | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628856
(Preparation of 2-[3-Chloro-4-(Trifluoromethoxy)Phe...)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)c(Cl)c1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628858
(US20230339890, Compound 71)Show SMILES O[C@H](CN(C1CCC1)C(=O)Cc1ccc(Cl)c(Cl)c1)c1cccnc1 | PDB
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM628860
(US20230339890, Compound 120)Show SMILES CCCN(C[C@@H](O)c1cccnc1)C(=O)C1Cc2ccc(Cl)c(Cl)c2C1 | PDB
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