Compile Data Set for Download or QSAR

Found 17 hits of affinity data for UniProtKB/TrEMBL: Q62976   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412339 (CHEMBL496460) Show SMILES COc1ccc(Br)cc1C1Sc2ccc(cc2NC1=O)C(F)(F)F Show InChI InChI=1S/C16H11BrF3NO2S/c1-23-12-4-3-9(17)7-10(12)14-15(22)21-11-6-8(16(18,19)20)2-5-13(11)24-14/h2-7,14H,1H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39.8	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Pisa Curated by ChEMBL					Assay Description Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...				J Med Chem 51: 5085-92 (2008) Article DOI: 10.1021/jm701605f BindingDB Entry DOI: 10.7270/Q2R49S16
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412337 (CHEMBL498516) Show SMILES COc1ccc(Br)cc1C1Sc2ccc(cc2N(C)C1=O)C(F)(F)F Show InChI InChI=1S/C17H13BrF3NO2S/c1-22-12-7-9(17(19,20)21)3-6-14(12)25-15(16(22)23)11-8-10(18)4-5-13(11)24-2/h3-8,15H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	617	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Pisa Curated by ChEMBL					Assay Description Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...				J Med Chem 51: 5085-92 (2008) Article DOI: 10.1021/jm701605f BindingDB Entry DOI: 10.7270/Q2R49S16
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50347497 (CHEMBL384903) Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F |(19.17,-33.76,;20.68,-34.08,;21.16,-35.54,;22.67,-35.85,;23.69,-34.69,;23.2,-33.23,;21.7,-32.94,;21.22,-31.47,;19.75,-31.01,;18.41,-31.79,;17.08,-31.01,;17.08,-29.47,;18.41,-28.7,;19.74,-29.46,;21.21,-28.98,;22.12,-30.22,;23.66,-30.22,;15.74,-28.7,;14.4,-27.93,;16.51,-27.37,;14.98,-30.04,;25.2,-35,;26.69,-35.39,;25.55,-33.5,;24.86,-36.5,)| Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta				Eur J Med Chem 43: 792-9 (2008) Article DOI: 10.1016/j.ejmech.2007.06.005 BindingDB Entry DOI: 10.7270/Q2JM2BVW
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50347497 (CHEMBL384903) Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F |(19.17,-33.76,;20.68,-34.08,;21.16,-35.54,;22.67,-35.85,;23.69,-34.69,;23.2,-33.23,;21.7,-32.94,;21.22,-31.47,;19.75,-31.01,;18.41,-31.79,;17.08,-31.01,;17.08,-29.47,;18.41,-28.7,;19.74,-29.46,;21.21,-28.98,;22.12,-30.22,;23.66,-30.22,;15.74,-28.7,;14.4,-27.93,;16.51,-27.37,;14.98,-30.04,;25.2,-35,;26.69,-35.39,;25.55,-33.5,;24.86,-36.5,)| Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Pisa Curated by ChEMBL					Assay Description Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...				J Med Chem 51: 5085-92 (2008) Article DOI: 10.1021/jm701605f BindingDB Entry DOI: 10.7270/Q2R49S16
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50347497 (CHEMBL384903) Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F |(19.17,-33.76,;20.68,-34.08,;21.16,-35.54,;22.67,-35.85,;23.69,-34.69,;23.2,-33.23,;21.7,-32.94,;21.22,-31.47,;19.75,-31.01,;18.41,-31.79,;17.08,-31.01,;17.08,-29.47,;18.41,-28.7,;19.74,-29.46,;21.21,-28.98,;22.12,-30.22,;23.66,-30.22,;15.74,-28.7,;14.4,-27.93,;16.51,-27.37,;14.98,-30.04,;25.2,-35,;26.69,-35.39,;25.55,-33.5,;24.86,-36.5,)| Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction				Eur J Med Chem 43: 2618-26 (2008) Article DOI: 10.1016/j.ejmech.2008.02.032 BindingDB Entry DOI: 10.7270/Q2WM1FMQ
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412335 (CHEMBL498702) Show SMILES COc1ccc(Br)cc1[C@@H](O)[C@H]1Sc2ccc(cc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H13BrF3NO3S/c1-25-12-4-3-9(18)7-10(12)14(23)15-16(24)22-11-6-8(17(19,20)21)2-5-13(11)26-15/h2-7,14-15,23H,1H3,(H,22,24)/t14-,15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Pisa Curated by ChEMBL					Assay Description Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...				J Med Chem 51: 5085-92 (2008) Article DOI: 10.1021/jm701605f BindingDB Entry DOI: 10.7270/Q2R49S16
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412334 (CHEMBL525555) Show SMILES COc1ccc(Br)cc1C1Sc2ccccc2NC1=O Show InChI InChI=1S/C15H12BrNO2S/c1-19-12-7-6-9(16)8-10(12)14-15(18)17-11-4-2-3-5-13(11)20-14/h2-8,14H,1H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Pisa Curated by ChEMBL					Assay Description Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...				J Med Chem 51: 5085-92 (2008) Article DOI: 10.1021/jm701605f BindingDB Entry DOI: 10.7270/Q2R49S16
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50413656 (CHEMBL511502) Show SMILES Cc1c(nnn1Cc1ccccc1O)C(=O)Nc1ccccc1 Show InChI InChI=1S/C17H16N4O2/c1-12-16(17(23)18-14-8-3-2-4-9-14)19-20-21(12)11-13-7-5-6-10-15(13)22/h2-10,22H,11H2,1H3,(H,18,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction				Eur J Med Chem 43: 2618-26 (2008) Article DOI: 10.1016/j.ejmech.2008.02.032 BindingDB Entry DOI: 10.7270/Q2WM1FMQ
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412110 (CHEMBL454860) Show SMILES COc1ccc(cc1NC(=O)Cc1ccccc1O)[N+]([O-])=O Show InChI InChI=1S/C15H14N2O5/c1-22-14-7-6-11(17(20)21)9-12(14)16-15(19)8-10-4-2-3-5-13(10)18/h2-7,9,18H,8H2,1H3,(H,16,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta				Eur J Med Chem 43: 792-9 (2008) Article DOI: 10.1016/j.ejmech.2007.06.005 BindingDB Entry DOI: 10.7270/Q2JM2BVW
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412109 (CHEMBL455120) Show SMILES Cc1cc(ccc1NC(=O)Cc1ccccc1O)[N+]([O-])=O Show InChI InChI=1S/C15H14N2O4/c1-10-8-12(17(20)21)6-7-13(10)16-15(19)9-11-4-2-3-5-14(11)18/h2-8,18H,9H2,1H3,(H,16,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta				Eur J Med Chem 43: 792-9 (2008) Article DOI: 10.1016/j.ejmech.2007.06.005 BindingDB Entry DOI: 10.7270/Q2JM2BVW
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50413657 (CHEMBL511864) Show SMILES Cc1c(nnn1Cc1ccccc1O)C(=O)Nc1ccccc1O Show InChI InChI=1S/C17H16N4O3/c1-11-16(17(24)18-13-7-3-5-9-15(13)23)19-20-21(11)10-12-6-2-4-8-14(12)22/h2-9,22-23H,10H2,1H3,(H,18,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction				Eur J Med Chem 43: 2618-26 (2008) Article DOI: 10.1016/j.ejmech.2008.02.032 BindingDB Entry DOI: 10.7270/Q2WM1FMQ
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50413658 (CHEMBL517023) Show SMILES Cc1c(nnn1Cc1ccccc1O)C(=O)NCc1ccccc1O Show InChI InChI=1S/C18H18N4O3/c1-12-17(18(25)19-10-13-6-2-4-8-15(13)23)20-21-22(12)11-14-7-3-5-9-16(14)24/h2-9,23-24H,10-11H2,1H3,(H,19,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction				Eur J Med Chem 43: 2618-26 (2008) Article DOI: 10.1016/j.ejmech.2008.02.032 BindingDB Entry DOI: 10.7270/Q2WM1FMQ
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412336 (CHEMBL526824) Show SMILES COc1ccccc1C1CNc2cc(ccc2S1)C(F)(F)F Show InChI InChI=1S/C16H14F3NOS/c1-21-13-5-3-2-4-11(13)15-9-20-12-8-10(16(17,18)19)6-7-14(12)22-15/h2-8,15,20H,9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Pisa Curated by ChEMBL					Assay Description Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...				J Med Chem 51: 5085-92 (2008) Article DOI: 10.1021/jm701605f BindingDB Entry DOI: 10.7270/Q2R49S16
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412108 (CHEMBL455121) Show SMILES Oc1ccccc1CC(=O)Nc1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C14H12N2O4/c17-13-4-2-1-3-10(13)9-14(18)15-11-5-7-12(8-6-11)16(19)20/h1-8,17H,9H2,(H,15,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta				Eur J Med Chem 43: 792-9 (2008) Article DOI: 10.1016/j.ejmech.2007.06.005 BindingDB Entry DOI: 10.7270/Q2JM2BVW
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412111 (CHEMBL452258) Show SMILES COc1ccccc1CC(=O)Nc1cc(C)ccc1O Show InChI InChI=1S/C16H17NO3/c1-11-7-8-14(18)13(9-11)17-16(19)10-12-5-3-4-6-15(12)20-2/h3-9,18H,10H2,1-2H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta				Eur J Med Chem 43: 792-9 (2008) Article DOI: 10.1016/j.ejmech.2007.06.005 BindingDB Entry DOI: 10.7270/Q2JM2BVW
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412107 (CHEMBL452008) Show SMILES Fc1ccccc1NC(=O)Cc1ccccc1C(F)(F)F Show InChI InChI=1S/C15H11F4NO/c16-12-7-3-4-8-13(12)20-14(21)9-10-5-1-2-6-11(10)15(17,18)19/h1-8H,9H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta				Eur J Med Chem 43: 792-9 (2008) Article DOI: 10.1016/j.ejmech.2007.06.005 BindingDB Entry DOI: 10.7270/Q2JM2BVW
					More data for this Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1 (Rattus norvegicus)	BDBM50412338 (CHEMBL525920) Show SMILES COc1c(Br)cc(Br)cc1C1Sc2ccc(cc2NC1=O)C(F)(F)F Show InChI InChI=1S/C16H10Br2F3NO2S/c1-24-13-9(5-8(17)6-10(13)18)14-15(23)22-11-4-7(16(19,20)21)2-3-12(11)25-14/h2-6,14H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Pisa Curated by ChEMBL					Assay Description Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...				J Med Chem 51: 5085-92 (2008) Article DOI: 10.1021/jm701605f BindingDB Entry DOI: 10.7270/Q2R49S16
					More data for this Ligand-Target Pair