Compile Data Set for Download or QSAR

Found 85 hits of affinity data for UniProtKB/TrEMBL: Q92876   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kallikrein-6 (Homo sapiens (Human))	BDBM588055 (US11541023, Compound 3) Show SMILES NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574434 (CHEMBL4861066) Show SMILES Cl.NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Non-competitive inhibition of KLK6 (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588057 (US11541023, Compound 5) Show SMILES COc1ccc2c(O)c(ccc2c1)C(=O)Nc1ccc(CN)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574435 (CHEMBL4862261) Show SMILES Cl.COc1ccc2c(O)c(ccc2c1)C(=O)Nc1ccc(CN)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of KLK6 (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574432 (CHEMBL4863108) Show SMILES Cl.CC(C)c1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of KLK6 (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459512 (CHEMBL4211240) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccc(Cl)cc1)C(N)=O |r| Show InChI InChI=1S/C19H29ClN6O3/c1-11(2)10-15(16(21)27)26-18(29)14(4-3-9-24-19(22)23)25-17(28)12-5-7-13(20)8-6-12/h5-8,11,14-15H,3-4,9-10H2,1-2H3,(H2,21,27)(H,25,28)(H,26,29)(H4,22,23,24)/t14-,15-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of human KLK6 expressed in baculovirus/insect cell line system using Abz-KLRSSKQ-EDDnp substrate				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588058 (US11541023, Compound 6) Show SMILES CC(C)c1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588056 (US11541023, Compound 4) Show SMILES Cc1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	1.92E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574431 (CHEMBL4847066) Show SMILES Cl.Cc1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of KLK6 (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588054 (US11541023, Compound 2) Show SMILES NCc1ccc(NC(=O)c2ccc3ccccc3c2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	2.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574433 (CHEMBL4852575) Show SMILES Cl.NCc1ccc(NC(=O)c2ccc3ccccc3c2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of KLK6 (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574430 (CHEMBL4853943) Show SMILES Cl.CC(C)(C)c1ccc(O)c(c1)C(=O)Nc1ccc(CN)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of KLK6 (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588053 (US11541023, Compound 1) Show SMILES CC(C)(C)c1ccc(O)c(c1)C(=O)Nc1ccc(CN)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	4.44E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50256261 (CHEMBL4059991) Show SMILES CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSCc3cc(CSC[C@@H](NC1=O)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(O)=O)cc(CSC[C@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N2)c3 |r| Show InChI InChI=1S/C117H160N32O28S3/c1-59(2)37-78-100(161)141-86(105(166)129-60(3)111(172)146(9)52-95(156)145(8)51-94(155)144(7)50-93(154)132-76(27-16-32-124-116(120)121)98(159)133-77(115(176)177)28-17-33-125-117(122)123)57-179-54-65-38-64-39-66(40-65)55-180-58-87(114(175)149-36-20-31-90(149)109(170)137-79(41-67-47-126-73-24-13-10-21-70(67)73)101(162)135-83(46-96(157)158)99(160)130-61(4)112(173)147-34-18-29-88(147)107(168)136-78)142-103(164)80(42-68-48-127-74-25-14-11-22-71(68)74)138-108(169)89-30-19-35-148(89)113(174)84(45-92(119)153)140-102(163)81(43-69-49-128-75-26-15-12-23-72(69)75)139-110(171)97(62(5)150)143-104(165)82(44-91(118)152)134-106(167)85(56-178-53-64)131-63(6)151/h10-15,21-26,38-40,47-49,59-62,76-90,97,126-128,150H,16-20,27-37,41-46,50-58H2,1-9H3,(H2,118,152)(H2,119,153)(H,129,166)(H,130,160)(H,131,151)(H,132,154)(H,133,159)(H,134,167)(H,135,162)(H,136,168)(H,137,170)(H,138,169)(H,139,171)(H,140,163)(H,141,161)(H,142,164)(H,143,165)(H,157,158)(H,176,177)(H4,120,121,124)(H4,122,123,125)/t60-,61-,62+,76+,77+,78-,79-,80-,81-,82-,83-,84-,85-,86+,87-,88-,89-,90-,97-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bicycle Therapeutics Limited, Building 900, Babraham Research Campus , Cambridge CB22 3AT , U.K. Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged KLK6 isoform 1 (1 to 244 residues) expressed in HEK293 cells using fluorogenic Boc-QARAMC pepti...				J Med Chem 61: 2823-2836 (2018) Article DOI: 10.1021/acs.jmedchem.7b01625 BindingDB Entry DOI: 10.7270/Q2862JW6
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50256260 (CHEMBL4094403) Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC[C@H](C)NC(=O)[C@H]2CSCc3cc(CSC[C@H](NC1=O)C(O)=O)cc(CSC[C@H](NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N2)c3 |r| Show InChI InChI=1S/C76H105N19O19S3/c1-40(2)22-53-67(105)94-60(75(113)114)38-117-35-47-24-45-23-46(25-47)34-116-37-59(71(109)84-41(3)30-82-52(28-48-31-80-39-83-48)66(104)87-51(17-18-62(77)99)65(103)89-55(29-63(100)101)69(107)88-53)93-64(102)50(12-8-9-20-81-76(78)79)86-68(106)54(26-44-13-15-49(98)16-14-44)90-73(111)61-19-21-95(61)74(112)56(27-43-10-6-5-7-11-43)91-70(108)57(32-96)92-72(110)58(36-115-33-45)85-42(4)97/h5-7,10-11,13-16,23-25,31,39-41,50-61,82,96,98H,8-9,12,17-22,26-30,32-38H2,1-4H3,(H2,77,99)(H,80,83)(H,84,109)(H,85,97)(H,86,106)(H,87,104)(H,88,107)(H,89,103)(H,90,111)(H,91,108)(H,92,110)(H,93,102)(H,94,105)(H,100,101)(H,113,114)(H4,78,79,81)/t41-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59+,60-,61?/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bicycle Therapeutics Limited, Building 900, Babraham Research Campus , Cambridge CB22 3AT , U.K. Curated by ChEMBL					Assay Description Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma				J Med Chem 61: 2823-2836 (2018) Article DOI: 10.1021/acs.jmedchem.7b01625 BindingDB Entry DOI: 10.7270/Q2862JW6
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50256262 (CHEMBL4070056) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H]2CSCc3cc(CSC[C@H](NC1=O)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(O)=O)cc(CSC[C@H](NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N2)c3)C(C)C |r| Show InChI InChI=1S/C114H161N29O28S3/c1-10-62(4)94-107(166)136-85(101(160)124-63(5)108(167)141(9)53-91(151)140(8)52-90(150)139(7)51-89(149)126-75(22-16-39-122-113(117)118)95(154)128-77(111(170)171)23-17-40-123-114(119)120)59-173-56-70-43-69-44-71(45-70)57-174-60-86(103(162)137-93(61(2)3)106(165)131-79(47-67-27-33-73(147)34-28-67)98(157)132-82(49-68-29-35-74(148)36-30-68)109(168)142-41-18-24-87(142)104(163)130-80(50-92(152)153)99(158)138-94)135-96(155)76(21-14-15-38-121-112(115)116)127-97(156)78(46-66-25-31-72(146)32-26-66)129-105(164)88-37-42-143(88)110(169)81(48-65-19-12-11-13-20-65)133-100(159)83(54-144)134-102(161)84(58-172-55-69)125-64(6)145/h11-13,19-20,25-36,43-45,61-63,75-88,93-94,144,146-148H,10,14-18,21-24,37-42,46-60H2,1-9H3,(H,124,160)(H,125,145)(H,126,149)(H,127,156)(H,128,154)(H,129,164)(H,130,163)(H,131,165)(H,132,157)(H,133,159)(H,134,161)(H,135,155)(H,136,166)(H,137,162)(H,138,158)(H,152,153)(H,170,171)(H4,115,116,121)(H4,117,118,122)(H4,119,120,123)/t62-,63-,75+,76-,77+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88?,93-,94-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bicycle Therapeutics Limited, Building 900, Babraham Research Campus , Cambridge CB22 3AT , U.K. Curated by ChEMBL					Assay Description Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma				J Med Chem 61: 2823-2836 (2018) Article DOI: 10.1021/acs.jmedchem.7b01625 BindingDB Entry DOI: 10.7270/Q2862JW6
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459537 (CHEMBL4217078) Show SMILES Cc1nn(c(C)c1NC(=O)C(OC(=O)Cc1c(C)[nH]c2ccccc12)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C25H23F3N4O3/c1-14-19(18-11-7-8-12-20(18)29-14)13-21(33)35-23(25(26,27)28)24(34)30-22-15(2)31-32(16(22)3)17-9-5-4-6-10-17/h4-12,23,29H,13H2,1-3H3,(H,30,34)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459539 (CHEMBL4206734) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cc(ccc12)C(N)=N)-c1ccccc1 Show InChI InChI=1S/C25H26N6O3/c1-14-20(19-10-9-17(25(26)27)11-21(19)28-14)12-23(33)34-13-22(32)29-24-15(2)30-31(16(24)3)18-7-5-4-6-8-18/h4-11,28H,12-13H2,1-3H3,(H3,26,27)(H,29,32)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of KLK6 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured a...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459525 (CHEMBL4212718) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccc(cc12)C(N)=N)-c1ccccc1 Show InChI InChI=1S/C25H26N6O3/c1-14-19(20-11-17(25(26)27)9-10-21(20)28-14)12-23(33)34-13-22(32)29-24-15(2)30-31(16(24)3)18-7-5-4-6-8-18/h4-11,28H,12-13H2,1-3H3,(H3,26,27)(H,29,32)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459515 (CHEMBL4216138) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cnccc12)-c1ccccc1 Show InChI InChI=1S/C23H23N5O3/c1-14-19(18-9-10-24-12-20(18)25-14)11-22(30)31-13-21(29)26-23-15(2)27-28(16(23)3)17-7-5-4-6-8-17/h4-10,12,25H,11,13H2,1-3H3,(H,26,29)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459538 (CHEMBL4218203) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H24N4O3/c1-15-20(19-11-7-8-12-21(19)25-15)13-23(30)31-14-22(29)26-24-16(2)27-28(17(24)3)18-9-5-4-6-10-18/h4-12,25H,13-14H2,1-3H3,(H,26,29)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459545 (CHEMBL4210314) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cc(ccc12)C#C)-c1ccccc1 Show InChI InChI=1S/C26H24N4O3/c1-5-19-11-12-21-22(16(2)27-23(21)13-19)14-25(32)33-15-24(31)28-26-17(3)29-30(18(26)4)20-9-7-6-8-10-20/h1,6-13,27H,14-15H2,2-4H3,(H,28,31)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459527 (CHEMBL4203947) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c([nH]c2ccccc12)C#C)-c1ccccc1 Show InChI InChI=1S/C25H22N4O3/c1-4-21-20(19-12-8-9-13-22(19)26-21)14-24(31)32-15-23(30)27-25-16(2)28-29(17(25)3)18-10-6-5-7-11-18/h1,5-13,26H,14-15H2,2-3H3,(H,27,30)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459508 (CHEMBL4211164) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ncccc12)-c1ccccc1 Show InChI InChI=1S/C23H23N5O3/c1-14-19(18-10-7-11-24-23(18)25-14)12-21(30)31-13-20(29)26-22-15(2)27-28(16(22)3)17-8-5-4-6-9-17/h4-11H,12-13H2,1-3H3,(H,24,25)(H,26,29)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459535 (CHEMBL4214705) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccc(cc12)C#C)-c1ccccc1 Show InChI InChI=1S/C26H24N4O3/c1-5-19-11-12-23-22(13-19)21(16(2)27-23)14-25(32)33-15-24(31)28-26-17(3)29-30(18(26)4)20-9-7-6-8-10-20/h1,6-13,27H,14-15H2,2-4H3,(H,28,31)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459531 (CHEMBL4207925) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccc(Cl)cc12)-c1ccccc1 Show InChI InChI=1S/C24H23ClN4O3/c1-14-19(20-11-17(25)9-10-21(20)26-14)12-23(31)32-13-22(30)27-24-15(2)28-29(16(24)3)18-7-5-4-6-8-18/h4-11,26H,12-13H2,1-3H3,(H,27,30)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459522 (CHEMBL4218314) Show SMILES Cc1[nH]c2ccccc2c1CC(=O)NCC(=O)Nc1cnn(c1C)-c1ccccc1 Show InChI InChI=1S/C23H23N5O2/c1-15-19(18-10-6-7-11-20(18)26-15)12-22(29)24-14-23(30)27-21-13-25-28(16(21)2)17-8-4-3-5-9-17/h3-11,13,26H,12,14H2,1-2H3,(H,24,29)(H,27,30)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459538 (CHEMBL4218203) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H24N4O3/c1-15-20(19-11-7-8-12-21(19)25-15)13-23(30)31-14-22(29)26-24-16(2)27-28(17(24)3)18-9-5-4-6-10-18/h4-12,25H,13-14H2,1-3H3,(H,26,29)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of KLK6 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured a...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459516 (CHEMBL4211677) Show SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccncc12)-c1ccccc1 Show InChI InChI=1S/C23H23N5O3/c1-14-18(19-12-24-10-9-20(19)25-14)11-22(30)31-13-21(29)26-23-15(2)27-28(16(23)3)17-7-5-4-6-8-17/h4-10,12,25H,11,13H2,1-3H3,(H,26,29)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459511 (CHEMBL4212332) Show SMILES Cc1cc2ccccc2n1CC(=O)OCC(=O)Nc1c(C)nn(c1C)-c1ccccc1 Show InChI InChI=1S/C24H24N4O3/c1-16-13-19-9-7-8-12-21(19)27(16)14-23(30)31-15-22(29)25-24-17(2)26-28(18(24)3)20-10-5-4-6-11-20/h4-13H,14-15H2,1-3H3,(H,25,29)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459529 (CHEMBL4208878) Show SMILES NCc1ccc(NC(=O)c2c([O-])ccc[n+]2Cc2nccn2Cc2ccccc2)cc1 Show InChI InChI=1S/C24H23N5O2/c25-15-18-8-10-20(11-9-18)27-24(31)23-21(30)7-4-13-29(23)17-22-26-12-14-28(22)16-19-5-2-1-3-6-19/h1-14H,15-17,25H2,(H-,27,30,31)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588055 (US11541023, Compound 3) Show SMILES NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459541 (CHEMBL4204137) Show SMILES Cc1[nH]c2cccnc2c1CC(=O)NCC(=O)Nc1onc(c1C)-c1ccccc1 Show InChI InChI=1S/C22H21N5O3/c1-13-20(15-7-4-3-5-8-15)27-30-22(13)26-19(29)12-24-18(28)11-16-14(2)25-17-9-6-10-23-21(16)17/h3-10,25H,11-12H2,1-2H3,(H,24,28)(H,26,29)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459526 (CHEMBL4218619) Show SMILES Cc1nn(c(C)c1NC(=O)CNC(=O)Cc1c(C)[nH]c2cc(ccc12)C(N)=N)-c1ccccc1 Show InChI InChI=1S/C25H27N7O2/c1-14-20(19-10-9-17(25(26)27)11-21(19)29-14)12-22(33)28-13-23(34)30-24-15(2)31-32(16(24)3)18-7-5-4-6-8-18/h4-11,29H,12-13H2,1-3H3,(H3,26,27)(H,28,33)(H,30,34)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588055 (US11541023, Compound 3) Show SMILES NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (PAR2) and 1 μl o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459524 (CHEMBL4215806) Show SMILES Cc1nn(C)c(C)c1NC(=O)CNC(=O)Cc1c(C)[nH]c2cccnc12 Show InChI InChI=1S/C18H22N6O2/c1-10-13(18-14(21-10)6-5-7-19-18)8-15(25)20-9-16(26)22-17-11(2)23-24(4)12(17)3/h5-7,21H,8-9H2,1-4H3,(H,20,25)(H,22,26)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50386418 (CHEMBL2047313) Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N(Cc1ccccc1)[C@H]1CCN(Cc2ccc(s2)C(N)=N)C1=O |r| Show InChI InChI=1S/C28H28N4O4S2/c1-36-22-9-7-20-8-11-24(16-21(20)15-22)38(34,35)32(17-19-5-3-2-4-6-19)25-13-14-31(28(25)33)18-23-10-12-26(37-23)27(29)30/h2-12,15-16,25H,13-14,17-18H2,1H3,(H3,29,30)/t25-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of N-terminus His6-tagged human kallikrein 6 expressed in baculovirus infected insect sf9 cells using Boc-Phe-Ser-Arg-AMC as substrate by ...				ACS Med Chem Lett 3: 159-164 (2012) Article DOI: 10.1021/ml200291e BindingDB Entry DOI: 10.7270/Q2FN177M
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588054 (US11541023, Compound 2) Show SMILES NCc1ccc(NC(=O)c2ccc3ccccc3c2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588058 (US11541023, Compound 6) Show SMILES CC(C)c1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574434 (CHEMBL4861066) Show SMILES Cl.NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KLK6 (unknown origin) assessed as release of AMC fluorescent product using Boc-QAR-AMC as substrate incubated for 30 mins by microplate...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459520 (CHEMBL4203193) Show SMILES CC(C(=O)OC(C(=O)Nc1c(C)nn(c1C)-c1ccccc1)C(F)(F)F)c1c(C)[nH]c2ccccc12 Show InChI InChI=1S/C26H25F3N4O3/c1-14(21-15(2)30-20-13-9-8-12-19(20)21)25(35)36-23(26(27,28)29)24(34)31-22-16(3)32-33(17(22)4)18-10-6-5-7-11-18/h5-14,23,30H,1-4H3,(H,31,34)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574431 (CHEMBL4847066) Show SMILES Cl.Cc1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KLK6 (unknown origin) assessed as release of AMC fluorescent product using Boc-QAR-AMC as substrate incubated for 30 mins by microplate...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588055 (US11541023, Compound 3) Show SMILES NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (MBP3) and 1 μl o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588054 (US11541023, Compound 2) Show SMILES NCc1ccc(NC(=O)c2ccc3ccccc3c2O)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (PAR2) and 1 μl o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459543 (CHEMBL4203033) Show SMILES CN(C(=O)CNC(=O)Cc1c(C)[nH]c2cccnc12)c1c(C)nn(c1C)-c1ccccc1 Show InChI InChI=1S/C24H26N6O2/c1-15-19(23-20(27-15)11-8-12-25-23)13-21(31)26-14-22(32)29(4)24-16(2)28-30(17(24)3)18-9-6-5-7-10-18/h5-12,27H,13-14H2,1-4H3,(H,26,31)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50386416 (CHEMBL2047314) Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N(Cc1ccsc1)[C@H]1CCN(Cc2csc(c2)C(N)=N)C1=O |r| Show InChI InChI=1S/C26H26N4O4S3/c1-34-21-4-2-19-3-5-22(12-20(19)11-21)37(32,33)30(14-17-7-9-35-15-17)23-6-8-29(26(23)31)13-18-10-24(25(27)28)36-16-18/h2-5,7,9-12,15-16,23H,6,8,13-14H2,1H3,(H3,27,28)/t23-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of N-terminus His6-tagged human kallikrein 6 expressed in baculovirus infected insect sf9 cells using Boc-Phe-Ser-Arg-AMC as substrate by ...				ACS Med Chem Lett 3: 159-164 (2012) Article DOI: 10.1021/ml200291e BindingDB Entry DOI: 10.7270/Q2FN177M
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50574432 (CHEMBL4863108) Show SMILES Cl.CC(C)c1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KLK6 (unknown origin) assessed as release of AMC fluorescent product using Boc-QAR-AMC as substrate incubated for 30 mins by microplate...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02175 BindingDB Entry DOI: 10.7270/Q2Z89H6C
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588057 (US11541023, Compound 5) Show SMILES COc1ccc2c(O)c(ccc2c1)C(=O)Nc1ccc(CN)cc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (Boc-QAR-AMC) and 1 &#...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM50459507 (CHEMBL4215383) Show SMILES Cc1[nH]c2ccccc2c1CC(=O)OCC(=O)Nc1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C23H25N3O4/c1-16-20(19-4-2-3-5-21(19)24-16)14-23(28)30-15-22(27)25-17-6-8-18(9-7-17)26-10-12-29-13-11-26/h2-9,24H,10-15H2,1H3,(H,25,27)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
German Cancer Research Center (DKFZ) Curated by ChEMBL					Assay Description Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...				J Med Chem 61: 8859-8874 (2018) Article DOI: 10.1021/acs.jmedchem.8b01106 BindingDB Entry DOI: 10.7270/Q279479B
					More data for this Ligand-Target Pair
Kallikrein-6 (Homo sapiens (Human))	BDBM588056 (US11541023, Compound 4) Show SMILES Cc1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	5.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In a typical test, 100 μl of reaction medium contains the buffer, 1 μl of recombinant enzyme, 1 μl of substrate (PAR2) and 1 μl o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K35ZH4
					More data for this Ligand-Target Pair

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