The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
18242984 |
6 |
Constraining the amide bond in N-sulfonylated dipeptide VLA-4 antagonists. |
Merck Research Laboratories |
20705461 |
38 |
Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists. |
New Drug Discovery Research |
20022493 |
35 |
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists. |
Merck Research Laboratories |
19441819 |
17 |
Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4. |
Merck Research Laboratories |
19124247 |
9 |
A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid. |
Daiichi Sankyo |
19072684 |
11 |
Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin. |
University of California Davis |
18952443 |
26 |
Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist. |
Daiichi Sankyo |
18539454 |
47 |
Imidazopyridines as VLA-4 integrin antagonists. |
Ucb Pharma |
18160288 |
31 |
Synthetic study of VLA-4/VCAM-1 inhibitors: synthesis and structure-activity relationship of piperazinylphenylalanine derivatives. |
Kyowa Hakko Kogyo |
10866374 |
11 |
The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic. |
Roche Research Center |
10866373 |
8 |
Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists. |
Roche Research Center |
10866372 |
7 |
Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists. |
Roche Research Center |
23899692 |
10 |
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. |
Massachusetts General Hospital and Harvard Medical School |