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PMID | Data | Article Title | Citation | Organization | Data Download |
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1997328 | 39 | Structural requirements for the binding of the pituitary adenylate-cyclase-activating peptide to receptors and adenylate-cyclase activation in pancreatic and neuronal membranes. | Eur J Biochem 195: 535-41 (1991) | Université Libre de Bruxelles | 2D 3D TSV |
1995903 | 49 | Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. | J Med Chem 34: 798-806 (1991) | Purdue University | 2D 3D TSV |
1995900 | 4 | Romazarit: a potential disease-modifying antirheumatic drug. | J Med Chem 34: 772-7 (1991) | Roche Products Limited | 2D 3D TSV |
1995895 | 6 | Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake. | J Med Chem 34: 702-5 (1991) | University of Maryland | 2D 3D TSV |
1995893 | 81 | Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships. | J Med Chem 34: 687-92 (1991) | Ferrosan A/S | 2D 3D TSV |
1995891 | 9 | Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships. | J Med Chem 34: 663-9 (1991) | Institut de Chimie des Substances Naturelles | 2D 3D TSV |
1995889 | 14 | 4',5'-unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase. | J Med Chem 34: 647-56 (1991) | Merrell Dow Research Institute | 2D 3D TSV |
1995887 | 14 | Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys. | J Med Chem 34: 633-42 (1991) | Upjohn Company | 2D 3D TSV |
1995886 | 15 | Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase. | J Med Chem 34: 624-8 (1991) | Pfizer Inc | 2D 3D TSV |
1995885 | 15 | Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds. | J Med Chem 34: 616-24 (1991) | Dainippon Pharmaceutical Company, Ltd. | 2D 3D TSV |
1995884 | 4 | Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid. | J Med Chem 34: 611-6 (1991) | Duquesne University | 2D 3D TSV |
1995880 | 8 | Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain. | J Med Chem 34: 574-9 (1991) | Harvard Medical School | 2D 3D TSV |
1995876 | 9 | 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 14. 2,3-Dihydro-1-(2,4-diamino-5-pyrimidyl)-1H-indenes as conformationally restricted analogues of trimethoprim. | J Med Chem 34: 550-5 (1991) | Wellcome Research Laboratories | 2D 3D TSV |
1995872 | 5 | Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors. | J Med Chem 34: 511-7 (1991) | University of Calgary | 2D 3D TSV |
1995871 | 25 | A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin. | J Med Chem 34: 497-510 (1991) | Uppsala University | 2D 3D TSV |
1995868 | 4 | The renewed potential for folate antagonists in contemporary cancer chemotherapy. | J Med Chem 34: 479-85 (1991) | Parke-Davis Pharmaceutical Research Division | 2D 3D TSV |
1994002 | 59 | Antagonist binding profiles of five cloned human muscarinic receptor subtypes. | J Pharmacol Exp Ther 256: 727-33 (1991) | National Institute of Neurological Disorders and Stroke | 2D 3D TSV |
1992155 | 30 | Design of potent protein kinase inhibitors using the bisubstrate approach. | J Med Chem 34: 73-8 (1991) | URA CNRS 1309 | 2D 3D TSV |
1992151 | 10 | Design of a well-absorbed renin inhibitor. | J Med Chem 34: 469-71 (1991) | Abbott Laboratories | 2D 3D TSV |
1992150 | 60 | 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. | J Med Chem 34: 466-9 (1991) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1992149 | 15 | Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase. | J Med Chem 34: 463-6 (1991) | Warner-Lambert Company | 2D 3D TSV |
1992147 | 10 | trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline. | J Med Chem 34: 455-7 (1991) | Abbott Laboratories | 2D 3D TSV |
1992145 | 5 | Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats. | J Med Chem 34: 439-47 (1991) | Research and Development Laboratories | 2D 3D TSV |
1992139 | 89 | Disubstituted tetrahydrofurans and dioxolanes and PAF antagonists. | J Med Chem 34: 373-86 (1991) | J. Uriach & Cía. S.A. | 2D 3D TSV |
1992138 | 9 | Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors. | J Med Chem 34: 367-73 (1991) | Warner-Lambert Company | 2D 3D TSV |
1992137 | 23 | Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus. | J Med Chem 34: 357-66 (1991) | Warner-Lambert Company | 2D 3D TSV |
1992129 | 27 | Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones. | J Med Chem 34: 291-8 (1991) | Pfizer Inc | 2D 3D TSV |
1992127 | 6 | 2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines. | J Med Chem 34: 276-81 (1991) | Purdue University | 2D 3D TSV |
1992126 | 54 | Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. | J Med Chem 34: 267-76 (1991) | Takeda Chemical Industries, Ltd | 2D 3D TSV |
1992122 | 6 | Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate. | J Med Chem 34: 227-34 (1991) | Institute | 2D 3D TSV |
1992121 | 13 | Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase. | J Med Chem 34: 222-7 (1991) | University of South Alabama | 2D 3D TSV |
1992118 | 5 | Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity. | J Med Chem 34: 203-8 (1991) | Institute | 2D 3D TSV |
1992113 | 12 | 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 3.1 Synthesis and biological properties of aminodeoxystatine and difluorostatone derivatives. | J Med Chem 34: 151-7 (1991) | ICI Pharmaceuticals Group | 2D 3D TSV |
1992112 | 53 | Novel 5-HT3 antagonists. Indole oxadiazoles. | J Med Chem 34: 140-51 (1991) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1988661 | 44 | In vitro pharmacological profile of a novel structural class of oxytocin antagonists. | J Pharmacol Exp Ther 256: 304-8 (1991) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
1987453 | 10 | [3H]cytisine binding to nicotinic cholinergic receptors in brain. | Mol Pharmacol 39: 9-12 (1991) | Georgetown University | 2D 3D TSV |
1982626 | 30 | Neurochemical profile of eltoprazine. | Drug Metabol Drug Interact 8: 85-114 (1990) | Duphar B.V. | 2D 3D TSV |
1977911 | 1 | Potent anticonflict activity and lessening of memory impairment with a series of novel [1]benzothieno[2,3-c]pyridines and 1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridines. | J Med Chem 33: 3110-6 (1990) | Asahi Chemical Industry Company, Ltd. | 2D 3D TSV |
1977909 | 36 | Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of [beta-(Aroylamino)ethyl]piperazines and -piperidines and [2-[(Arylamino)carbonyl]ethyl]piperazines, -pyrazinopyridoindoles, and -pyrazinoisoquinolines. A new class of potent H1 antagonists. | J Med Chem 33: 2970-6 (1990) | Central Drug Research Institute | 2D 3D TSV |
1977908 | 10 | (R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex. | J Med Chem 33: 2961-3 (1990) | Merrell Dow Research Institute | 2D 3D TSV |
1977907 | 33 | (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. | J Med Chem 33: 2948-50 (1990) | Abbott Laboratories | 2D 3D TSV |
1976813 | 83 | 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity. | J Med Chem 33: 2899-905 (1990) | Wyeth-Ayerst Research | 2D 3D TSV |
1976812 | 62 | Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity. | J Med Chem 33: 2883-91 (1990) | Berlex Laboratories | 2D 3D TSV |
1975644 | 47 | Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. | Nature 347: 146-51 (1990) | U. 109 | 2D 3D TSV |
1975275 | 113 | Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor. | J Med Chem 33: 2421-9 (1990) | University of Oregon | 2D 3D TSV |
1975274 | 16 | Synthesis and dopamine receptor affinities of 2-(4-fluoro-3- hydroxyphenyl)ethylamine and N-substituted derivatives. | J Med Chem 33: 2408-12 (1990) | University of Camerino | 2D 3D TSV |
1973734 | 16 | Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study. | J Med Chem 33: 2305-9 (1990) | Astra Research Centre AB | 2D 3D TSV |
1973733 | 17 | Conformational analysis and structure-activity relationships of selective dopamine D-1 receptor agonists and antagonists of the benzazepine series. | J Med Chem 33: 2197-204 (1990) | Royal Danish School of Pharmacy | 2D 3D TSV |
1972964 | 40 | Design and synthesis of highly potent and selective cyclic dynorphin A analogues. | J Med Chem 33: 1874-9 (1990) | University of Arizona | 2D 3D TSV |
1971309 | 31 | Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. | J Med Chem 33: 1800-5 (1990) | Northeastern University | 2D 3D TSV |
1971308 | 22 | trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. | J Med Chem 33: 1756-64 (1990) | Purdue University | 2D 3D TSV |
1969484 | 38 | Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds. | J Med Chem 33: 1155-63 (1990) | Astra Research Centre AB | 2D 3D TSV |
1969483 | 11 | Dehydrogenase binding by tiazofurin anabolites. | J Med Chem 33: 1123-7 (1990) | University of Rochester Medical Center | 2D 3D TSV |
1968985 | 56 | Characteristics of 125I-iodocyanopindolol binding to beta-adrenergic and serotonin-1B receptors of rat brain: selectivity of beta-adrenergic agents. | Jpn J Pharmacol 52: 195-200 (1990) | Niigata College of Pharmacy | 2D 3D TSV |
1968512 | 18 | Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model. | J Med Chem 33: 1015-22 (1990) | University of Lund | 2D 3D TSV |
1967654 | 12 | Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid. | J Med Chem 33: 833-8 (1990) | Syntex Research | 2D 3D TSV |
1967653 | 2 | Analogues of carbamyl aspartate as inhibitors of dihydroorotase: preparation of boronic acid transition-state analogues and a zinc chelator carbamylhomocysteine. | J Med Chem 33: 819-23 (1990) | Mayo Clinic | 2D 3D TSV |
1967652 | 27 | Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. | J Med Chem 33: 809-14 (1990) | Vanderbilt University | 2D 3D TSV |
1967651 | 2 | Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA). | J Med Chem 33: 703-10 (1990) | Purdue University | 2D 3D TSV |
1967318 | 8 | Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. | J Med Chem 33: 445-50 (1990) | Warner-Lambert Company | 2D 3D TSV |
1967317 | 11 | Histamine H3 ligands: just pharmacological tools or potential therapeutic agents? | J Med Chem 33: 4-11 (1990) | Vrije Universiteit | 2D 3D TSV |
1967314 | 35 | 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties. | J Med Chem 33: 311-7 (1990) | Warner-Lambert Company | 2D 3D TSV |
1967313 | 21 | Synthesis and beta-adrenergic antagonist activity of stereoisomeric practolol and propranolol derivatives. | J Med Chem 33: 216-23 (1990) | University of California | 2D 3D TSV |
1967312 | 91 | Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues. | J Med Chem 33: 206-12 (1990) | Eisai Co., Ltd | 2D 3D TSV |
1963602 | 44 | NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity. | Eur J Pharmacol 189: 381-91 (1990) | Royal Danish School of Pharmacy | 2D 3D TSV |
1956054 | 27 | Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere. | J Med Chem 34: 3340-2 (1991) | Roche Products Ltd | 2D 3D TSV |
1956050 | 18 | Gossypol and derivatives: a new class of aldose reductase inhibitors. | J Med Chem 34: 3301-5 (1991) | University of New Mexico School of Medicine | 2D 3D TSV |
1956045 | 88 | Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites. | J Med Chem 34: 3267-80 (1991) | E. Merck Darmstadt | 2D 3D TSV |
1956044 | 115 | Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. | J Med Chem 34: 3248-60 (1991) | Warner-Lambert Company | 2D 3D TSV |
1956042 | 39 | Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands. | J Med Chem 34: 3235-41 (1991) | Research Biochemicals Inc. | 2D 3D TSV |
1956041 | 28 | Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors. | J Med Chem 34: 3229-34 (1991) | Alcon Laboratories Inc | 2D 3D TSV |
1956039 | 34 | (Aminoalkyl)carbamates of forskolin: intermediates for the synthesis of functionalized derivatives of forskolin with different specificities for adenylyl cyclase and the glucose transporter. | J Med Chem 34: 3204-12 (1991) | Food and Drug Administration | 2D 3D TSV |
1956038 | 21 | Synthesis and ocular antihypertensive activity of new imidazolidine derivatives containing a beta-blocking side chain. | J Med Chem 34: 3197-204 (1991) | Institut de Pharmacologie (UA 589 CNRS) | 2D 3D TSV |
1956033 | 121 | Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues. | J Med Chem 34: 3164-71 (1991) | Research Triangle Institute | 2D 3D TSV |
1955879 | 2 | Bisbenzylisoquinoline Alkaloids | J Nat Prod 54: 645-749 (1991) | TBA | 2D 3D TSV |
1930610 | 41 | Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors. | Neuropsychopharmacology 5: 43-7 (1991) | Eli Lilly and Company | 2D 3D TSV |
1920365 | 8 | [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain. | J Med Chem 34: 3144-6 (1991) | Research Biochemicals Inc. | 2D 3D TSV |
1920361 | 52 | Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro. | J Med Chem 34: 3114-25 (1991) | SmithKline Beecham Pharmaceuticals Research and Development | 2D 3D TSV |
1920360 | 13 | Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives. | J Med Chem 34: 3105-14 (1991) | Ciba-Geigy Limited | 2D 3D TSV |
1920359 | 40 | Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides. | J Med Chem 34: 3098-105 (1991) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
1920350 | 22 | Muscarinic receptor binding profile of para-substituted caramiphen analogues. | J Med Chem 34: 2984-9 (1991) | Virginia Commonwealth University | 2D 3D TSV |
1910091 | 7 | Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone omega-chains. | J Med Chem 34: 2882-91 (1991) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1910089 | 30 | Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679. | J Med Chem 34: 2852-7 (1991) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1909177 | 6 | Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase. | Biochemistry 30: 8480-7 (1991) | Arizona State University | 2D 3D TSV |
1908523 | 7 | Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine. | J Med Chem 34: 2600-6 (1991) | Institute | 2D 3D TSV |
1908522 | 5 | Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives. | J Med Chem 34: 2504-20 (1991) | Wyeth-Ayerst Research | 2D 3D TSV |
1908521 | 106 | Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. | J Med Chem 34: 2477-83 (1991) | Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer | 2D 3D TSV |
1906108 | 27 | Relative structure-inhibition analyses of the N-benzoyl and N-(phenylsulfonyl) amino acid aldose reductase inhibitors. | J Med Chem 34: 2120-6 (1991) | Auburn University | 2D 3D TSV |
1903450 | 34 | 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. | J Med Chem 34: 1560-70 (1991) | Sterling Research Group | 2D 3D TSV |
1901912 | 1 | Quinazolineacetic acids and related analogues as aldose reductase inhibitors. | J Med Chem 34: 1492-503 (1991) | Wyeth-Ayerst Research | 2D 3D TSV |
1901910 | 87 | New inhibitors of human renin that contain novel replacements at the P2 site. | J Med Chem 34: 1258-71 (1991) | Warner-Lambert Company | 2D 3D TSV |
1900533 | 30 | Antinociceptive (aminoalkyl)indoles. | J Med Chem 34: 1099-110 (1991) | Sterling Research Group | 2D 3D TSV |
1900532 | 44 | A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. | J Med Chem 34: 1011-8 (1991) | Pfizer Inc | 2D 3D TSV |
1899453 | 74 | On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. | J Med Chem 34: 46-54 (1991) | Pomona College | 2D 3D TSV |
1899452 | 90 | Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. | J Med Chem 34: 108-22 (1991) | Pfizer Inc | 2D 3D TSV |
1895310 | 9 | A selective, reversible, competitive inhibitor of monoamine oxidase A containing no nitrogen, with negligible potentiation of tyramine-induced blood pressure rise. | J Med Chem 34: 2931-3 (1991) | Burroughs Wellcome Co. | 2D 3D TSV |
1895309 | 27 | Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors. | J Med Chem 34: 2928-31 (1991) | Nova Pharmaceutical Corporation | 2D 3D TSV |
1895308 | 9 | Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. | J Med Chem 34: 2919-22 (1991) | Exploratory Chemistry Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1895306 | 13 | Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogues of 1-methylisoguanosine. | J Med Chem 34: 2892-8 (1991) | Griffith University | 2D 3D TSV |
1895305 | 75 | N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. | J Med Chem 34: 2877-82 (1991) | University of South Florida | 2D 3D TSV |
1895300 | 15 | Modification of the enkephalin"message" with an artificial polycationic C-terminus. | J Med Chem 34: 2816-21 (1991) | Case Western Reserve University | 2D 3D TSV |
1895299 | 59 | Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety. | J Med Chem 34: 2804-15 (1991) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1895294 | 14 | Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid. | J Med Chem 34: 2746-54 (1991) | University of South Alabama | 2D 3D TSV |
1895293 | 44 | Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor. | J Med Chem 34: 2726-35 (1991) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1895292 | 16 | Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters. | J Med Chem 34: 2719-25 (1991) | Research Triangle Institute | 2D 3D TSV |
1895289 | 8 | Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors. | J Med Chem 34: 2692-701 (1991) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1895288 | 23 | New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives. | J Med Chem 34: 2685-91 (1991) | Universität des Saarlandes | 2D 3D TSV |
1875353 | 14 | Acyclic analogues of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport. | J Med Chem 34: 2638-43 (1991) | University of Minnesota | 2D 3D TSV |
1875352 | 12 | Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl)piperidines and the 1-(1-phenyl-4-methylcyclohexyl)piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl)piperidine. | J Med Chem 34: 2615-23 (1991) | Istituto Superiore di Sanità | 2D 3D TSV |
1875350 | 20 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. | J Med Chem 34: 2579-88 (1991) | Purdue University | 2D 3D TSV |
1875349 | 94 | Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines. | J Med Chem 34: 2570-9 (1991) | Ciba-Geigy Corporation | 2D 3D TSV |
1875348 | 65 | Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives. | J Med Chem 34: 2525-47 (1991) | E. I. du Pont de Nemours & Company, Inc. | 2D 3D TSV |
1875347 | 23 | Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors. | J Med Chem 34: 2496-504 (1991) | Tohoku College of Pharmacy | 2D 3D TSV |
1875346 | 17 | 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives. | J Med Chem 34: 2489-95 (1991) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
1875344 | 9 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogues of lovastatin. | J Med Chem 34: 2474-7 (1991) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
1875343 | 7 | Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 alpha-esters containing a functional group. | J Med Chem 34: 2468-73 (1991) | Mitsubishi Kasei Corporation | 2D 3D TSV |
1875338 | 7 | Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties. | J Med Chem 34: 2410-4 (1991) | Searle R & D and MCR | 2D 3D TSV |
1875337 | 10 | Synthesis and biological activity of angiotensin II analogues containing a Val-His replacement, Val psi[CH(CONH2)NH]His. | J Med Chem 34: 2402-10 (1991) | Berlex Laboratories | 2D 3D TSV |
1875334 | 16 | Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity. | J Med Chem 34: 2344-56 (1991) | Upjohn Company | 2D 3D TSV |
1875333 | 132 | Cholinergic activity of acetylenic imidazoles and related compounds. | J Med Chem 34: 2314-27 (1991) | Upjohn Company | 2D 3D TSV |
1875332 | 33 | HIV protease: a novel chemotherapeutic target for AIDS. | J Med Chem 34: 2305-14 (1991) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1874734 | 53 | The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. | J Biol Chem 266: 15771-81 (1991) | Laboratoires Glaxo | 2D 3D TSV |
1868065 | 5 | Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetase. | Biochemistry 30: 7901-7 (1991) | Texas A&M University | 2D 3D TSV |
1857334 | 1 | Cloning and expression of an A1 adenosine receptor from rat brain. | Mol Pharmacol 40: 1-7 (1991) | National Institute of Mental Health | 2D 3D TSV |
1851847 | 22 | Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists. | J Med Chem 34: 1751-3 (1991) | Rochester | 2D 3D TSV |
1851846 | 23 | Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole. | J Med Chem 34: 1715-20 (1991) | University of Minnesota | 2D 3D TSV |
1851845 | 17 | Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity. | J Med Chem 34: 1704-7 (1991) | Rhone-Poulenc Rorer Central Research | 2D 3D TSV |
1851843 | 96 | Synthesis and structure-activity relationships of deltorphin analogues. | J Med Chem 34: 1656-61 (1991) | University of Ferrara | 2D 3D TSV |
1849997 | 42 | Function of negative charge in the"address domain" of deltorphins. | J Med Chem 34: 1350-5 (1991) | National Institute of Environmental Health Sciences | 2D 3D TSV |
1849996 | 7 | Synthesis and biochemical evaluation of baclofen analogues locked in the baclofen solid-state conformation. | J Med Chem 34: 1307-13 (1991) | Centre de Neurochimie du CNRS | 2D 3D TSV |
1849995 | 12 | Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine. | J Med Chem 34: 1292-6 (1991) | University of Minnesota | 2D 3D TSV |
1849993 | 13 | Peptide leukotrienes: current status of research. | J Med Chem 34: 1235-42 (1991) | ICI Pharmaceuticals Group | 2D 3D TSV |
1848629 | 42 | gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands. | J Pharmacol Exp Ther 256: 1154-60 (1991) | Georgetown University | 2D 3D TSV |
1848295 | 33 | Identification and exploitation of the sigma-opiate pharmacophore. | J Med Chem 34: 1094-8 (1991) | Virginia Commonwealth University | 2D 3D TSV |
1848293 | 24 | Studies on (H(+)-K+)-ATPase inhibitors of gastric acid secretion. Prodrugs of 2-[(2-pyridinylmethyl)sulfinyl]benzimidazole proton-pump inhibitors. | J Med Chem 34: 1049-62 (1991) | Upjohn Company | 2D 3D TSV |
1848292 | 116 | Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | J Med Chem 34: 1028-36 (1991) | ICI Pharmaceuticals Group | 2D 3D TSV |
1847432 | 13 | New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics. | J Med Chem 34: 827-41 (1991) | Anaquest, Inc. | 2D 3D TSV |
1847426 | 56 | Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors. | J Med Chem 34: 518-25 (1991) | Warner-Lambert Company | 2D 3D TSV |
1846921 | 56 | (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics. | J Med Chem 34: 397-403 (1991) | Zambeletti Research Laboratories | 2D 3D TSV |
1846919 | 26 | Highly selective kappa opioid analgesics. 4. Synthesis of some conformationally restricted naphthalene derivatives with high receptor affinity and selectivity. | J Med Chem 34: 190-4 (1991) | Parke-Davis Research Unit | 2D 3D TSV |
1846918 | 12 | 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists. | J Med Chem 34: 181-9 (1991) | ICI Pharmaceuticals Group | 2D 3D TSV |
1840645 | 85 | Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. | Nature 350: 610-4 (1991) | University of Toronto | 2D 3D TSV |
1836757 | 5 | Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor. | EMBO J 10: 4017-23 (1991) | University of Heidelberg | 2D 3D TSV |
1833546 | 47 | Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. | J Med Chem 34: 2946-53 (1991) | Abbott Laboratories | 2D 3D TSV |
1831904 | 27 | Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. | Proc Natl Acad Sci U S A 88: 7491-5 (1991) | Duke University | 2D 3D TSV |
1829485 | 15 | Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids. | J Med Chem 34: 1790-7 (1991) | Ciba-Geigy Corporation | 2D 3D TSV |
1828505 | 19 | Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain. | J Pharmacol Exp Ther 257: 1253-63 (1991) | University of Pennsylvania | 2D 3D TSV |
1827843 | 27 | Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors. | J Med Chem 34: 1612-24 (1991) | University of California | 2D 3D TSV |
1826762 | 58 | Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. | Nature 350: 614-9 (1991) | University of Toronto | 2D 3D TSV |
1826745 | 4 | Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors. | J Med Chem 34: 1511-4 (1991) | Eli Lilly and Company | 2D 3D TSV |
1825337 | 22 | Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. | J Med Chem 34: 725-36 (1991) | Ciba-Geigy Corporation | 2D 3D TSV |
1825116 | 36 | Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding. | J Med Chem 34: 86-9 (1991) | Pfizer Inc | 2D 3D TSV |
1825115 | 16 | Antidopaminergic effects of the stereoisomers of N-[(1-alkyl-2- pyrrolidinyl)methyl]-5-sulfamoylbenzamides and -2,3-dihydrobenzofuran-7-carboxamides. | J Med Chem 34: 261-7 (1991) | Yoshitomi Pharmaceutical Industries Ltd | 2D 3D TSV |
1812212 | 5 | Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. | J Nat Prod 54: 1595-600 | Sanofi Recherche | 2D 3D TSV |
1800642 | 2 | Methylpendolmycin, an indolactam from a Nocardiopsis sp. | J Nat Prod 54: 1440-3 | Sterling Research Group | 2D 3D TSV |
1766006 | 8 | Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. | J Med Chem 34: 3399-402 (1992) | Mayo Clinic | 2D 3D TSV |
1766005 | 5 | Examination of HIV-1 protease secondary structure specificity using conformationally constrained inhibitors. | J Med Chem 34: 3395-9 (1992) | University of Illinois | 2D 3D TSV |
1766003 | 18 | Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. | J Med Chem 34: 3388-90 (1992) | University of South Florida | 2D 3D TSV |
1766000 | 90 | Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors. | J Med Chem 34: 3350-9 (1992) | Abbott Laboratories | 2D 3D TSV |
1738153 | 45 | A novel class of enkephalinase inhibitors containing a C-terminal sulfo group. | J Med Chem 35: 602-8 (1992) | Dainippon Pharmaceutical Co., Ltd | 2D 3D TSV |
1738152 | 21 | Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. | J Med Chem 35: 590-601 (1992) | University of Illinois | 2D 3D TSV |
1738151 | 69 | QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. | J Med Chem 35: 584-9 (1992) | University of Illinois | 2D 3D TSV |
1738148 | 16 | Renin inhibitory pentols showing improved enteral bioavailability. | J Med Chem 35: 559-67 (1992) | Hoechst AG | 2D 3D TSV |
1738141 | 64 | Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain. | J Med Chem 35: 457-65 (1992) | Pfizer Inc | 2D 3D TSV |
1738140 | 26 | alpha-Keto amide inhibitors of aminopeptidases. | J Med Chem 35: 451-6 (1992) | University of Wisconsin-Madison | 2D 3D TSV |
1738138 | 62 | Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. | J Med Chem 35: 407-22 (1992) | NIDDK | 2D 3D TSV |
1738111 | 26 | Characterization of 5-hydroxytryptamine1B receptors in rat spinal cord via [125I]iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release. | J Pharmacol Exp Ther 260: 614-26 (1992) | University of Texas | 2D 3D TSV |
1732557 | 20 | Improvements in the minimum binding sequence of C5a: examination of His-67. | J Med Chem 35: 402-6 (1992) | Abbott Laboratories | 2D 3D TSV |
1732551 | 6 | Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin. | J Med Chem 35: 332-7 (1992) | Southern Research Institute | 2D 3D TSV |
1732550 | 12 | New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents. | J Med Chem 35: 324-31 (1992) | Toyo Jozo Company, Ltd. | 2D 3D TSV |
1732549 | 4 | Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. | J Med Chem 35: 320-4 (1992) | SRI International | 2D 3D TSV |
1732545 | 27 | Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. | J Med Chem 35: 285-94 (1992) | University of Uppsala | 2D 3D TSV |
1732541 | 60 | Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects. | J Med Chem 35: 241-52 (1992) | Hokkaido University | 2D 3D TSV |
1732540 | 10 | Structure-function studies in a series of carboxyl-terminal octapeptide analogues of anaphylatoxin C5a. | J Med Chem 35: 220-3 (1992) | Abbott Laboratories | 2D 3D TSV |
1732537 | 3 | Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane. | J Med Chem 35: 203-11 (1992) | Purdue University | 2D 3D TSV |
1732534 | 8 | Total synthesis of uracil analogues of sinefungin. | J Med Chem 35: 63-7 (1992) | CNRS | 2D 3D TSV |
1732532 | 139 | Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives. | J Med Chem 35: 28-38 (1992) | Rotta Research Laboratorium | 2D 3D TSV |
1732531 | 88 | Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors. | J Med Chem 35: 2-14 (1992) | Warner-Lambert Company | 2D 3D TSV |
1732526 | 101 | Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. | J Med Chem 35: 177-84 (1992) | Roche Products Limited | 2D 3D TSV |
1732525 | 11 | Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones. | J Med Chem 35: 172-6 (1992) | R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
1732523 | 46 | Preparation and biological activities of potential vasopressin photoaffinity labels. | J Med Chem 35: 151-7 (1992) | University of Sherbrooke | 2D 3D TSV |
1732522 | 42 | Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor. | J Med Chem 35: 15-27 (1992) | Sandoz Pharma Ltd | 2D 3D TSV |
1732521 | 12 | N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor. | J Med Chem 35: 141-4 (1992) | Research Triangle Institute | 2D 3D TSV |
1732520 | 21 | 2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor. | J Med Chem 35: 135-40 (1992) | Research Triangle Institute | 2D 3D TSV |
1732519 | 15 | Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. | J Med Chem 35: 124-35 (1992) | Sterling Research Group | 2D 3D TSV |
1732516 | 6 | Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans delta 24-sterol methyltransferase. | J Med Chem 35: 100-6 (1992) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1731937 | 20 | Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli. | Biochemistry 31: 799-805 (1992) | University of Akron | 2D 3D TSV |
1720175 | 8 | Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes. | J Med Chem 34: 3305-9 (1991) | Veterans Affairs Medical Center | 2D 3D TSV |
1716683 | 16 | 2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors. | J Med Chem 34: 2922-5 (1991) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1716682 | 64 | Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-a receptor agonists. | J Med Chem 34: 2837-42 (1991) | Abbott Laboratories | 2D 3D TSV |
1714957 | 12 | Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity. | J Med Chem 34: 2430-8 (1991) | Hebrew University of Jerusalem | 2D 3D TSV |
1714956 | 17 | Novel gonadotropin-releasing hormone antagonists: peptides incorporating modified N omega-cyanoguanidino moieties. | J Med Chem 34: 2395-402 (1991) | Salk Institute | 2D 3D TSV |
1712396 | 5 | Potent inhibitory effect of a series of modified cyclodextrin sulfates (mCDS) on the replication of HIV-1 in vitro. | J Med Chem 34: 2301-4 (1991) | Tanabe Seiyaku Co., Ltd | 2D 3D TSV |
1712395 | 43 | Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones. | J Med Chem 34: 2231-41 (1991) | Boehringer Ingelheim Pharmaceuticals Inc | 2D 3D TSV |
1710653 | 155 | Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. | J Nat Prod 54: 143-54 | University of Illinois | 2D 3D TSV |
1706716 | 29 | Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. | J Biol Chem 266: 6365-9 (1991) | Duke University | 2D 3D TSV |
1706470 | 9 | Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. | Mol Pharmacol 39: 346-51 (1991) | Abbott Laboratories | 2D 3D TSV |
1705574 | 2 | Differential Inhibition of Reverse Transcriptase and Various DNA Polymerases by Digallic Acid and Its Derivatives | J Nat Prod 53: 1234-1240 (1990) | TBA | 2D 3D TSV |
1704434 | 16 | Pharmacologic comparison of selected agonists for the M1 muscarinic receptor in transfected murine fibroblast cells (B82). | J Pharmacol Exp Ther 256: 689-94 (1991) | University of Arizona | 2D 3D TSV |
1701834 | 20 | Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists. | J Med Chem 33: 3199-204 (1991) | University of Paris | 2D 3D TSV |
1700123 | 26 | Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. | J Med Chem 33: 2950-2 (1990) | Abbott Laboratories | 2D 3D TSV |
1697345 | 3 | 5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity. | J Med Chem 33: 2481-7 (1990) | Institute for Medical Research | 2D 3D TSV |
1695682 | 41 | Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists. | J Med Chem 33: 2101-8 (1990) | Istituto De Angeli | 2D 3D TSV |
1694546 | 64 | Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors. | J Med Chem 33: 1906-10 (1990) | Vanderbilt University | 2D 3D TSV |
1694545 | 28 | Potent and highly selective neurokinin antagonists. | J Med Chem 33: 1848-51 (1990) | Glaxo Group Research Ltd. | 2D 3D TSV |
1684995 | 27 | (+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship. | J Med Chem 34: 3366-71 (1992) | Northeastern University | 2D 3D TSV |
1683407 | 32 | Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone. | J Med Chem 34: 3316-28 (1991) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1681106 | 27 | Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds. | J Med Chem 34: 3085-90 (1991) | Pfizer Inc | 2D 3D TSV |
1680195 | 23 | Dopamine autoreceptor agonists as potential antipsychotics. 3.6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine. | J Med Chem 34: 2736-46 (1991) | Warner-Lambert Company | 2D 3D TSV |
1676759 | 12 | Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone. | J Med Chem 34: 2242-7 (1991) | University of Santiago de Compostela | 2D 3D TSV |
1676758 | 12 | Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists. | J Med Chem 34: 2023-30 (1991) | H. Lundbeck A/S | 2D 3D TSV |
1676428 | 47 | Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. | J Med Chem 34: 1896-907 (1991) | Hebrew University of Jerusalem | 2D 3D TSV |
1676427 | 21 | 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents. | J Med Chem 34: 1860-6 (1991) | Pfizer Inc | 2D 3D TSV |
1676426 | 1 | Structure/activity and molecular modeling studies of the lophotoxin family of irreversible nicotinic receptor antagonists. | J Med Chem 34: 1798-804 (1991) | University of California San Diego | 2D 3D TSV |
1676425 | 9 | Substituent effect on the stereochemistry of H2-receptor antagonists of the phenylformamidine series. A conformation-dependent mode of interaction with the H2 receptor. | J Med Chem 34: 1772-6 (1991) | Research Laboratories of Istituto De Angeli | 2D 3D TSV |
1674541 | 24 | Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity. | J Med Chem 34: 1707-14 (1991) | Harvard Medical School | 2D 3D TSV |
1673158 | 9 | Optical isomers of rocastine and close analogues: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical antihistamines. | J Med Chem 34: 1314-28 (1991) | A.H. Robins Company | 2D 3D TSV |
1672158 | 40 | Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners. | J Med Chem 34: 948-55 (1991) | Astra Research Centre AB | 2D 3D TSV |
1672156 | 81 | Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents. | J Med Chem 34: 1068-72 (1991) | Hoechst-Roussel Pharmaceuticals Inc | 2D 3D TSV |
1672155 | 14 | Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol. | J Med Chem 34: 1063-8 (1991) | National Institute of Diabetes | 2D 3D TSV |
1671705 | 126 | Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors. | J Med Chem 34: 705-17 (1991) | Syntex Research | 2D 3D TSV |
1671420 | 49 | Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. | J Med Chem 34: 457-61 (1991) | Schering-Plough Corporation | 2D 3D TSV |
1671419 | 48 | Rationally designed"dipeptoid" analogues of CCK. alpha-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties. | J Med Chem 34: 404-14 (1991) | Parke-Davis Research Unit | 2D 3D TSV |
1671416 | 15 | Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. | J Med Chem 34: 248-56 (1991) | Warner-Lambert Company | 2D 3D TSV |
1671415 | 24 | R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue. | J Med Chem 34: 24-8 (1991) | Northeastern University | 2D 3D TSV |
1671414 | 10 | Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds. | J Med Chem 34: 194-7 (1991) | Istituto Superiore di Sanità | 2D 3D TSV |
1662725 | 48 | Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands. | J Med Chem 34: 3360-5 (1992) | Virginia Commonwealth University | 2D 3D TSV |
1662620 | 12 | Characterization of a guanosine-nucleotide-binding-protein-coupled receptor for pituitary adenylate-cyclase-activating polypeptide on plasma membranes from rat brain. | Eur J Biochem 202: 951-8 (1991) | Georg-August-University | 2D 3D TSV |
1661335 | 95 | Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins. | J Recept Res 11: 891-907 (1991) | Center for Bio-Pharmaceutical Sciences | 2D 3D TSV |
1659638 | 8 | Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol. | J Med Chem 34: 3310-6 (1991) | Virginia Commonwealth University | 2D 3D TSV |
1659636 | 51 | Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists. | J Med Chem 34: 3149-58 (1991) | ICI Pharmaceuticals Group | 2D 3D TSV |
1656045 | 26 | Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. | J Med Chem 34: 3125-32 (1991) | Clinical Research Institute of Montreal | 2D 3D TSV |
1656044 | 18 | Synthesis and receptor binding of enantiomeric N-substituted cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamines as high-affinity sigma receptor ligands. | J Med Chem 34: 3058-65 (1991) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
1656043 | 4 | New 5H-pyridazino[4,5-b]indole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics. | J Med Chem 34: 3023-9 (1991) | Universidad de Navarra | 2D 3D TSV |
1656041 | 75 | Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. | J Med Chem 34: 2962-83 (1991) | Hoechst AG | 2D 3D TSV |
1656026 | 160 | Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line. | J Pharmacol Exp Ther 259: 323-9 (1991) | University of Nebraska | 2D 3D TSV |
1654492 | 20 | Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon. | Life Sci 49: 1155-61 (1991) | Technion-Israel Institute of Technology | 2D 3D TSV |
1654430 | 51 | 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. | J Med Chem 34: 2906-16 (1991) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1654429 | 2 | Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides. | J Med Chem 34: 2787-97 (1991) | University of Minnesota | 2D 3D TSV |
1652050 | 19 | Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. | Mol Pharmacol 40: 143-8 (1991) | Seattle Veterans Affairs Medical Center | 2D 3D TSV |
1652026 | 43 | Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity. | J Med Chem 34: 2633-8 (1991) | Virginia Commonwealth University | 2D 3D TSV |
1652025 | 45 | (1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics. | J Med Chem 34: 2624-33 (1991) | Zambeletti Research Laboratories | 2D 3D TSV |
1652024 | 4 | Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride. | J Med Chem 34: 2607-15 (1991) | Yale University | 2D 3D TSV |
1652023 | 179 | Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. | J Med Chem 34: 2561-9 (1991) | Abbott Laboratories | 2D 3D TSV |
1652022 | 18 | 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. | J Med Chem 34: 2557-60 (1991) | Laboratoire de Pharmacie Chimique, Facult� de Pharmacie, Lille, France. | 2D 3D TSV |
1652019 | 12 | Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. | J Med Chem 34: 2438-44 (1991) | University of Washington | 2D 3D TSV |
1652014 | 44 | Sulfonylbenzoyl-nitrostyrenes: potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase. | J Med Chem 34: 2328-37 (1991) | Ciba-Geigy Ltd | 2D 3D TSV |
1650832 | 7 | Competition of leukotrienes and ICI-198,615 for [3H]LTD4 binding sites in guinea pig lung membranes suggests the involvement of two LTD4 receptor subtypes. | J Pharmacol Exp Ther 258: 531-6 (1991) | Pfizer Inc | 2D 3D TSV |
1648621 | 55 | (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity. | J Med Chem 34: 2176-86 (1991) | ICI Pharmaceuticals Group | 2D 3D TSV |
1648141 | 21 | Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide. | J Med Chem 34: 1891-6 (1991) | University of Notre Dame | 2D 3D TSV |
1648140 | 14 | Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines. | J Med Chem 34: 1867-70 (1991) | Institutions | 2D 3D TSV |
1648139 | 34 | Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors. | J Med Chem 34: 1855-9 (1991) | Virginia Commonwealth University | 2D 3D TSV |
1648138 | 33 | Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. | J Med Chem 34: 1850-4 (1991) | Universitá di Catania | 2D 3D TSV |
1648137 | 30 | Topographically designed analogues of [D-Pen,D-Pen5]enkephalin. | J Med Chem 34: 1823-30 (1991) | University of Arizona | 2D 3D TSV |
1648136 | 12 | An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists. | J Med Chem 34: 1757-62 (1991) | University of Minnesota | 2D 3D TSV |
1646322 | 13 | Pharmacological profiles for rat cortical M1 and M2 muscarinic receptors using selective antagonists: comparison with N1E-115 muscarinic receptors. | J Pharmacol Exp Ther 257: 1121-9 (1991) | Mayo Clinic | 2D 3D TSV |
1635066 | 17 | Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity. | J Med Chem 35: 2697-703 (1992) | Istituto Chimico Internazionale Dr. G. Rende | 2D 3D TSV |
1635064 | 8 | Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity. | J Med Chem 35: 2658-67 (1992) | Eli Lilly and Company | 2D 3D TSV |
1635061 | 4 | N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid. | J Med Chem 35: 2626-30 (1992) | Harvard Medical School | 2D 3D TSV |
1635058 | 50 | Rationally designed"dipeptoid" analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988. | J Med Chem 35: 2573-81 (1992) | Parke-Davis Neuroscience Research Centre | 2D 3D TSV |
1635057 | 48 | Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. | J Med Chem 35: 2562-72 (1992) | Parke-Davis Pharmaceutical Research Division of Warner-Lambert Co. | 2D 3D TSV |
1635055 | 7 | Synthesis and X-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands. | J Med Chem 35: 2534-42 (1992) | Eli Lilly and Company | 2D 3D TSV |
1635054 | 17 | A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. | J Med Chem 35: 2525-33 (1992) | Merck Research Laboratories | 2D 3D TSV |
1635053 | 47 | 5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors. | J Med Chem 35: 2501-24 (1992) | Wyeth-Ayerst Research | 2D 3D TSV |
1620241 | 6 | SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. | Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992) | Sandoz Pharma Ltd | 2D 3D TSV |
1619622 | 51 | Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter. | J Med Chem 35: 2497-500 (1992) | Research Triangle Institute | 2D 3D TSV |
1619616 | 94 | Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands. | J Med Chem 35: 2392-406 (1992) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1619615 | 71 | 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. | J Med Chem 35: 2363-8 (1992) | Universit£ di Camerino | 2D 3D TSV |
1613758 | 95 | (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. | J Med Chem 35: 2342-5 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1613755 | 12 | Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. | J Med Chem 35: 2321-7 (1992) | Institute of Cancer Research | 2D 3D TSV |
1613754 | 2 | Structural studies on bio-active compounds. 20. Molecular modeling and crystallographic studies on methylbenzoprim, a potent inhibitor of dihydrofolate reductase. | J Med Chem 35: 2315-20 (1992) | Aston University | 2D 3D TSV |
1613751 | 68 | Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines . | J Med Chem 35: 2274-83 (1992) | Novo Nordisk CNS Division | 2D 3D TSV |
1613750 | 46 | Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects. | J Med Chem 35: 2253-60 (1992) | Yamasa Shoyu Co., Ltd | 2D 3D TSV |
1613748 | 8 | Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. | J Med Chem 35: 2231-8 (1992) | Freie Universit£t Berlin | 2D 3D TSV |
1613747 | 10 | Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones. | J Med Chem 35: 2210-4 (1992) | Universität des Saarlandes | 2D 3D TSV |
1613746 | 48 | Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol. | J Med Chem 35: 2184-91 (1992) | Research Triangle Institute | 2D 3D TSV |
1613745 | 1 | Synthesis of carbon-11 labeled iodinated cocaine derivatives and their distribution in baboon brain measured using positron emission tomography. | J Med Chem 35: 2178-83 (1992) | Brookhaven National Laboratory | 2D 3D TSV |
1613744 | 69 | Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors. | J Med Chem 35: 2169-77 (1992) | Pfizer Inc | 2D 3D TSV |
1613743 | 29 | Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives. | J Med Chem 35: 2155-62 (1992) | Pfizer Inc | 2D 3D TSV |
1610807 | 6 | Interaction of flexible analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of N-methyl-4-phenylpyridinium with highly purified monoamine oxidase A and B. | Biochemistry 31: 5611-5 (1992) | University of California San Francisco | 2D 3D TSV |
1597860 | 24 | Renin inhibitors containing C-termini derived from mercaptoheterocycles. | J Med Chem 35: 2103-12 (1992) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
1597859 | 14 | Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones. | J Med Chem 35: 2095-103 (1992) | Warner-Lambert Company | 2D 3D TSV |
1597858 | 56 | Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors. | J Med Chem 35: 2085-94 (1992) | Tanabe Seiyaku Co., Ltd | 2D 3D TSV |
1597856 | 20 | Ester and amide derivatives of E64c as inhibitors of platelet calpains. | J Med Chem 35: 2048-54 (1992) | State University of New York Health Science Center | 2D 3D TSV |
1597855 | 194 | Cyclic RGD peptide analogues as antiplatelet antithrombotics. | J Med Chem 35: 2040-8 (1992) | Genentech | 2D 3D TSV |
1597853 | 2 | A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. | J Med Chem 35: 1978-86 (1992) | National Cancer Institute-Frederick | 2D 3D TSV |
1593278 | 1 | Metabolism of the Catharanthus Alkaloids: from Streptomyces griseus to Monoamine Oxidase B | J Nat Prod 55: 269-284 (1992) | TBA | 2D 3D TSV |
1588567 | 18 | Synthesis and pharmacological investigation of the enantiomers of muscarone and allomuscarone. | J Med Chem 35: 1915-20 (1992) | Istituto Chimico-Farmaceutico dell'Università | 2D 3D TSV |
1588560 | 19 | Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter. | J Med Chem 35: 1813-7 (1992) | Research Triangle Institute | 2D 3D TSV |
1588558 | 9 | 4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase. | J Med Chem 35: 1782-91 (1992) | University of Kansas | 2D 3D TSV |
1588555 | 83 | C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties. | J Med Chem 35: 1735-46 (1992) | Abbott Laboratories | 2D 3D TSV |
1588554 | 66 | Nonpeptide renin inhibitors employing a novel 3-aza(or oxa)-2,4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement. | J Med Chem 35: 1722-34 (1992) | Abbott Laboratories | 2D 3D TSV |
1588553 | 32 | 1,2,3-trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors. | J Med Chem 35: 1710-21 (1992) | University of Texas | 2D 3D TSV |
1588552 | 30 | HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity. | J Med Chem 35: 1702-9 (1992) | Merck Research Laboratories | 2D 3D TSV |
1588551 | 21 | Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design. | J Med Chem 35: 1685-701 (1992) | Merck Research Laboratories | 2D 3D TSV |
1588550 | 10 | Definition and display of steric, hydrophobic, and hydrogen-bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design. | J Med Chem 35: 1671-84 (1992) | Ciba-Geigy Corporation | 2D 3D TSV |
1588549 | 9 | Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles. | J Med Chem 35: 1663-70 (1992) | Sterling Winthrop Pharmaceuticals Research Division | 2D 3D TSV |
1586393 | 43 | Localization and function of the D3 dopamine receptor. | Arzneimittelforschung 42: 224-30 (1992) | U. 109 | 2D 3D TSV |
1578493 | 103 | Analogues of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor. | J Med Chem 35: 1650-62 (1992) | American Cyanamid Company | 2D 3D TSV |
1578488 | 74 | Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. | J Med Chem 35: 1609-17 (1992) | Warner-Lambert Company | 2D 3D TSV |
1578487 | 12 | Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-o | J Med Chem 35: 1605-9 (1992) | Warner-Lambert Company | 2D 3D TSV |
1578486 | 53 | Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. | J Med Chem 35: 1597-605 (1992) | Georgia Institute of Technology | 2D 3D TSV |
1578485 | 19 | Synthesis and evaluation of a new series of mechanism-based aromatase inhibitors. | J Med Chem 35: 1588-97 (1992) | Centre de Recherches Roussel-Uclaf | 2D 3D TSV |
1578484 | 26 | Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. | J Med Chem 35: 1578-88 (1992) | Harvard Medical School | 2D 3D TSV |
1578483 | 36 | Rationally designed"dipeptoid" analogues of CCK. A Free-Wilson/Fujita-Ban analysis of some alpha-methyltryptophan derivatives as CCK-B antagonists. | J Med Chem 35: 1572-7 (1992) | Parke-Davis Neuroscience Research Centre | 2D 3D TSV |
1578481 | 5 | Structure-activity studies of a novel bicyclic oxytocin antagonist. | J Med Chem 35: 1558-63 (1992) | University of Arizona | 2D 3D TSV |
1578480 | 26 | Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors. | J Med Chem 35: 1550-7 (1992) | Abbott Laboratories | 2D 3D TSV |
1578479 | 24 | Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology. | J Med Chem 35: 1541-50 (1992) | Uppsala University | 2D 3D TSV |
1578478 | 30 | Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl)ureas. | J Med Chem 35: 1515-20 (1992) | Wyeth Research | 2D 3D TSV |
1573641 | 60 | SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. | J Med Chem 35: 1486-9 (1992) | Searle Research and Development | 2D 3D TSV |
1573640 | 54 | Amide bond replacements incorporated into CCK-B selective"dipeptoids". | J Med Chem 35: 1472-84 (1992) | Parke-Davis Neuroscience Research Center | 2D 3D TSV |
1573639 | 17 | Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues. | J Med Chem 35: 1451-7 (1992) | Warner-Lambert Company | 2D 3D TSV |
1573636 | 28 | Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues. | J Med Chem 35: 1429-34 (1992) | Pfizer Inc | 2D 3D TSV |
1573634 | 5 | Inhibition of pig kidney L-aromatic amino acid decarboxylase by 2,3-methano-m-tyrosines. | J Med Chem 35: 1410-7 (1992) | University of Georgia | 2D 3D TSV |
1573633 | 15 | Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. | J Med Chem 35: 1399-410 (1992) | Wellcome Research Laboratories | 2D 3D TSV |
1573631 | 16 | 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. | J Med Chem 35: 1339-44 (1992) | Ciba-Geigy AG | 2D 3D TSV |
1567835 | 4 | Steady-state kinetic mechanism of Ras farnesyl:protein transferase. | Biochemistry 31: 3800-7 (1992) | Merck Research Laboratories | 2D 3D TSV |
1565658 | 57 | Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. | Proc Natl Acad Sci U S A 89: 3630-4 (1992) | Synaptic Pharmaceutical Corporation | 2D 3D TSV |
1560443 | 32 | Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides. | J Med Chem 35: 1318-20 (1992) | Syntex Research | 2D 3D TSV |
1560441 | 35 | Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues). | J Med Chem 35: 1290-5 (1992) | Institute of Research | 2D 3D TSV |
1560440 | 42 | Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. | J Med Chem 35: 1280-90 (1992) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1554381 | 19 | Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase. | Biochem Pharmacol 43: 1089-93 (1992) | National Institutes of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
1552513 | 36 | Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity. | J Med Chem 35: 994-1001 (1992) | Roche Products Limited | 2D 3D TSV |
1552510 | 178 | Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter. | J Med Chem 35: 969-81 (1992) | Research Triangle Institute | 2D 3D TSV |
1552504 | 8 | Selective irreversible inhibitors of aldose reductase. | J Med Chem 35: 1117-20 (1992) | Ohio State University | 2D 3D TSV |
1552502 | 74 | Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine. | J Med Chem 35: 1102-8 (1992) | University of South Carolina | 2D 3D TSV |
1552500 | 28 | Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions. | J Med Chem 35: 1058-67 (1992) | National Cancer Institute-Bethesda | 2D 3D TSV |
1552499 | 23 | Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718. | J Med Chem 35: 1042-9 (1992) | Center for Bio-Pharmaceutical Sciences | 2D 3D TSV |
1552498 | 55 | Renin inhibitors containing alpha-heteroatom amino acids as P2 residues. | J Med Chem 35: 1032-42 (1992) | Warner-Lambert Company | 2D 3D TSV |
1552497 | 38 | Novel 5-HT3 antagonists: indol-3-ylspiro(azabicycloalkane-3,5'(4'H)-oxazoles). | J Med Chem 35: 1019-31 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1548683 | 7 | Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone. | J Med Chem 35: 931-8 (1992) | Eli Lilly and Company | 2D 3D TSV |
1548682 | 126 | 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. | J Med Chem 35: 924-30 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1548680 | 12 | Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. | J Med Chem 35: 911-6 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1548679 | 20 | Development of high-affinity 5-HT3 receptor antagonists. 2. Two novel tricyclic benzamides. | J Med Chem 35: 903-11 (1992) | Rh£ne-Poulenc Rorer Central Research | 2D 3D TSV |
1548678 | 5 | 5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a new class of monoamine oxidase-B inactivators. | J Med Chem 35: 885-9 (1992) | Northwestern University | 2D 3D TSV |
1548677 | 23 | New nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties, and structure-activity relationships of 2-alkyl benzimidazole derivatives. | J Med Chem 35: 877-85 (1992) | ICI Pharmaceuticals Group | 2D 3D TSV |
1548676 | 28 | Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. | J Med Chem 35: 847-58 (1992) | Agouron Pharmaceuticals Inc | 2D 3D TSV |
1548675 | 10 | Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors. | J Med Chem 35: 833-46 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1548674 | 13 | New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin. | J Med Chem 35: 823-32 (1992) | Wyeth-Ayerst Research | 2D 3D TSV |
1542100 | 67 | Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity. | J Med Chem 35: 734-40 (1992) | Virginia Commonwealth University | 2D 3D TSV |
1542094 | 20 | 4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists. | J Med Chem 35: 676-83 (1992) | J. Uriach & Cía. S.A. | 2D 3D TSV |
1542092 | 38 | Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones. | J Med Chem 35: 641-62 (1992) | Boehringer Ingelheim Pharmaceuticals Inc | 2D 3D TSV |
1542091 | 38 | A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor. | J Med Chem 35: 629-35 (1992) | Center for Bio-Pharmaceutical Sciences | 2D 3D TSV |
1535661 | 24 | Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site. | J Med Chem 35: 2369-74 (1992) | Polish Academy of Sciences | 2D 3D TSV |
1535660 | 14 | Conformational analysis of dopamine D-2 receptor antagonists of the benzamide series in relation to a recently proposed D-2 receptor-interaction model. | J Med Chem 35: 2355-63 (1992) | University of Lund | 2D 3D TSV |
1535377 | 5 | Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives. | J Med Chem 35: 2202-9 (1992) | Takeda Chemical Industries, Ltd | 2D 3D TSV |
1534585 | 8 | Benzofuran bioisosteres of hallucinogenic tryptamines. | J Med Chem 35: 2061-4 (1992) | Purdue University | 2D 3D TSV |
1534584 | 59 | 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor. | J Med Chem 35: 1954-68 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1534126 | 35 | Affinity of human growth hormone-releasing factor (1-29)NH2 analogues for GRF binding sites in rat adenopituitary. | J Med Chem 35: 1864-9 (1992) | Notre-Dame Hospital Research | 2D 3D TSV |
1534125 | 1 | 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site. | J Med Chem 35: 1791-9 (1992) | Marion Merrell Dow Research Institute | 2D 3D TSV |
1533424 | 20 | Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. | J Med Chem 35: 1466-71 (1992) | Research Biochemicals Inc. | 2D 3D TSV |
1531365 | 7 | A study on the contribution of the 1-phenyl substituent to the molecular electrostatic potentials of some benzazepines in relation to selective dopamine D-1 receptor activity. | J Med Chem 35: 502-7 (1992) | University of Lund | 2D 3D TSV |
1531364 | 42 | Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. | J Med Chem 35: 423-30 (1992) | University of Pennsylvania | 2D 3D TSV |
1531075 | 13 | (+/-)-3-allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship. | J Med Chem 35: 67-72 (1992) | Northeastern University | 2D 3D TSV |
1527792 | 55 | Specific inhibition of HIV-1 protease by boronated porphyrins. | J Med Chem 35: 3426-8 (1992) | University of California | 2D 3D TSV |
1527791 | 8 | Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | J Med Chem 35: 3388-93 (1992) | British Bio-technology Limited | 2D 3D TSV |
1527788 | 4 | 3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine. | J Med Chem 35: 3369-72 (1992) | Purdue University | 2D 3D TSV |
1527787 | 11 | Synthesis and biological activity of ketomethylene pseudopeptide analogues as thrombin inhibitors. | J Med Chem 35: 3364-9 (1992) | Thrombosis Research Institute | 2D 3D TSV |
1527785 | 6 | Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines. | J Med Chem 35: 3353-8 (1992) | URA CNRS 1111 | 2D 3D TSV |
1527782 | 8 | Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors. | J Med Chem 35: 3331-41 (1992) | National Research Council of Canada | 2D 3D TSV |
1517742 | 9 | Inhibition of Angiotensin-I-Converting Enzyme by Tetrahydroxyxanthones Isolated from Tripterospermum lanceolatum | J Nat Prod 55: 691-695 (1992) | TBA | 2D 3D TSV |
1513320 | 26 | Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor. | Mol Pharmacol 42: 180-5 (1992) | Synaptic Pharmaceutical Corporation | 2D 3D TSV |
1507212 | 42 | Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. | J Med Chem 35: 3270-9 (1992) | University of Uppsala | 2D 3D TSV |
1507211 | 28 | Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors. | J Med Chem 35: 3263-9 (1992) | Marion Merrell Dow Research Institute | 2D 3D TSV |
1507209 | 7 | Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles. | J Med Chem 35: 3239-46 (1992) | Vrije Universiteit | 2D 3D TSV |
1507204 | 18 | Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity. | J Med Chem 35: 3148-55 (1992) | DuPont Pharmaceuticals Company | 2D 3D TSV |
1507203 | 96 | Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine. | J Med Chem 35: 3141-7 (1992) | University of South Carolina | 2D 3D TSV |
1507200 | 40 | 1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives. | J Med Chem 35: 3115-29 (1992) | Pfizer Inc | 2D 3D TSV |
1507199 | 8 | Synthesis and pharmacological evaluation of enantiomerically pure 4-deoxy-4-fluoromuscarines. | J Med Chem 35: 3102-10 (1992) | C.N.R.-Centro Studio Sostanze Organiche Naturali | 2D 3D TSV |
1507198 | 11 | Mapping the binding site of tissue kallikrein: preparation and testing of all possible substrate analog inhibitors homologous with the sequence of kininogen between Ser386 and Gln392. | J Med Chem 35: 3094-102 (1992) | University Hospital | 2D 3D TSV |
1501235 | 11 | Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase. | J Med Chem 35: 3080-1 (1992) | Glaxo Group Research Limited | 2D 3D TSV |
1501234 | 111 | Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. | J Med Chem 35: 3066-75 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1501233 | 7 | 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase. | J Med Chem 35: 3050-8 (1992) | Istituto di Chimica Farmaceutica Applicata | 2D 3D TSV |
1501231 | 1 | PgH2 analogs as potential antiplatelet derivatives. | J Med Chem 35: 3033-9 (1992) | University of Illinois | 2D 3D TSV |
1501230 | 8 | Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors. | J Med Chem 35: 3027-33 (1992) | Merck Research Laboratories | 2D 3D TSV |
1501226 | 2 | Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate). | J Med Chem 35: 3002-6 (1992) | Southern Research Institute | 2D 3D TSV |
1501221 | 18 | Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex. | J Med Chem 35: 2939-51 (1992) | Fisons plc | 2D 3D TSV |
1501220 | 52 | Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo. | J Med Chem 35: 2919-28 (1992) | Abbott Laboratories | 2D 3D TSV |
1501121 | 12 | Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. | J Pharmacol Exp Ther 262: 759-68 (1992) | Sanofi Recherche | 2D 3D TSV |
1495020 | 14 | Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis. | J Med Chem 35: 2912-5 (1992) | Pennsylvania State University | 2D 3D TSV |
1495019 | 57 | Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. | J Med Chem 35: 2881-90 (1992) | Hokkaido University | 2D 3D TSV |
1495016 | 3 | 2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents. | J Med Chem 35: 2855-63 (1992) | R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
1495014 | 36 | Stereoisomers of ketoconazole: preparation and biological activity. | J Med Chem 35: 2818-25 (1992) | Syntex Research | 2D 3D TSV |
1495013 | 24 | N-methylated analogs of Ac[Nle28,31]CCK(26-33): synthesis, activity, and receptor selectivity. | J Med Chem 35: 2806-11 (1992) | Hadassah-University Hospital | 2D 3D TSV |
1495010 | 19 | Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids. | J Med Chem 35: 2772-81 (1992) | Merck Research Laboratories | 2D 3D TSV |
1495009 | 32 | Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents. | J Med Chem 35: 2761-8 (1992) | ICI Pharmaceuticals Group | 2D 3D TSV |
1479591 | 8 | Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor. | J Med Chem 35: 4914-7 (1993) | Searle Research & Development | 2D 3D TSV |
1479590 | 73 | Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. | J Med Chem 35: 4903-10 (1993) | Virginia Commonwealth University | 2D 3D TSV |
1479589 | 36 | 5-HT3 receptor antagonists. 1. New quinoline derivatives. | J Med Chem 35: 4893-902 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1479587 | 4 | ATP-citrate lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-beta-lactam containing analogues of citric acid as potential tight-binding inhibitors. | J Med Chem 35: 4875-84 (1992) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1479586 | 8 | New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones. | J Med Chem 35: 4866-74 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1479581 | 11 | Inhibition of human leukocyte elastase by N-substituted peptides containing alpha,alpha-difluorostatone residues at P1. | J Med Chem 35: 4795-808 (1993) | Boehringer Ingelheim Pharmaceuticals Inc | 2D 3D TSV |
1479580 | 10 | Synthesis and physicochemical properties of sulfamate derivatives as topical antiglaucoma agents. | J Med Chem 35: 4790-4 (1992) | A.H. Robins Company | 2D 3D TSV |
1479375 | 215 | Protein-Tyrosine Kinase Inhibition: Mechanism-Based Discovery of Antitumor Agents | J Nat Prod 55: 1529-1560 (1992) | TBA | 2D 3D TSV |
1469704 | 5 | Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. | J Med Chem 35: 4764-6 (1993) | Mayo Foundation | 2D 3D TSV |
1469703 | 14 | Dihydropyrimidine angiotensin II receptor antagonists. | J Med Chem 35: 4751-63 (1993) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1469699 | 12 | Synthesis, configuration, and activity of isomeric 2-phenyl-2-(N-piperidinyl)bicyclo[3.1.0]hexanes at phencyclidine and sigma binding sites. | J Med Chem 35: 4704-12 (1993) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
1469697 | 37 | Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites. | J Med Chem 35: 4683-9 (1993) | National Institute on Drug Abuse | 2D 3D TSV |
1469694 | 22 | Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. | J Med Chem 35: 4640-2 (1993) | Merck Research Laboratories | 2D 3D TSV |
1469689 | 9 | Dihydroxynitrobenzaldehydes and hydroxymethoxynitrobenzaldehydes: synthesis and biological activity as catechol-O-methyltransferase inhibitors. | J Med Chem 35: 4584-8 (1993) | Instituto de Química Orgánica General (CSIC) | 2D 3D TSV |
1469688 | 31 | 2-(N'-aralkylidenehydrazino)adenosines: potent and selective coronary vasodilators. | J Med Chem 35: 4562-6 (1993) | University of South Florida | 2D 3D TSV |
1469687 | 42 | 2-(N'-alkylidenehydrazino)adenosines: potent and selective coronary vasodilators. | J Med Chem 35: 4557-61 (1993) | University of South Florida | 2D 3D TSV |
1469686 | 53 | Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives. | J Med Chem 35: 4542-8 (1993) | Eisai Co., Ltd | 2D 3D TSV |
1464308 | 17 | The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. | EMBO J 11: 4779-86 (1992) | CNRS | 2D 3D TSV |
1447752 | 28 | Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. | J Med Chem 35: 4503-5 (1992) | Pfizer Inc | 2D 3D TSV |
1447744 | 2 | A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. | J Med Chem 35: 4450-4 (1992) | Princeton University | 2D 3D TSV |
1447743 | 3 | Synthesis and biological activity of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds. | J Med Chem 35: 4442-9 (1992) | Warner-Lambert Company | 2D 3D TSV |
1447739 | 43 | Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. | J Med Chem 35: 4384-92 (1992) | Rhone-Poulenc Rorer | 2D 3D TSV |
1447738 | 26 | Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs. | J Med Chem 35: 4373-83 (1992) | Ciba-Geigy Corporation | 2D 3D TSV |
1447737 | 7 | Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids. | J Med Chem 35: 4366-72 (1992) | Ciba-Geigy Corporation | 2D 3D TSV |
1447736 | 17 | Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octaonic acid and related compounds. | J Med Chem 35: 4362-5 (1992) | Ciba-Geigy Corporation | 2D 3D TSV |
1447735 | 17 | Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes. | J Med Chem 35: 4334-43 (1992) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
1447734 | 29 | Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases. | J Med Chem 35: 4297-305 (1992) | University of Illinois | 2D 3D TSV |
1433225 | 18 | Analogs of CCK incorporating conformationally constrained replacements for Asp32. | J Med Chem 35: 4249-52 (1992) | Roche Research Center | 2D 3D TSV |
1433224 | 1 | Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake. | J Med Chem 35: 4238-48 (1992) | Warner-Lambert Company | 2D 3D TSV |
1433220 | 12 | Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine. | J Med Chem 35: 4180-4 (1992) | University of Rhode Island | 2D 3D TSV |
1433219 | 9 | Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors. | J Med Chem 35: 4165-74 (1992) | Virginia Polytechnic Institute and State University | 2D 3D TSV |
1433218 | 3 | Guanidinophenyl-substituted enol lactones as selective, mechanism-based inhibitors of trypsin-like serine proteases. | J Med Chem 35: 4150-9 (1992) | University of Illinois | 2D 3D TSV |
1433217 | 31 | Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists. | J Med Chem 35: 4143-9 (1992) | National Institute of Diabetes | 2D 3D TSV |
1433215 | 88 | (Pyridylcyanomethyl)piperazines as orally active PAF antagonists. | J Med Chem 35: 4118-34 (1992) | J. Uriach & C£a.S.A. | 2D 3D TSV |
1433214 | 7 | Inhibition of hog liver folylpolyglutamate synthetase by 5-substituted 5,8-dideaza analogues of folic acid bearing a terminal L-ornithine residue. | J Med Chem 35: 4078-85 (1992) | Medical University of South Carolina | 2D 3D TSV |
1433212 | 59 | Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis. | J Med Chem 35: 4061-8 (1992) | DuPont Pharmaceuticals Company | 2D 3D TSV |
1433210 | 35 | New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives. | J Med Chem 35: 4027-38 (1992) | ICI Pharmaceuticals Group | 2D 3D TSV |
1433209 | 58 | Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore. | J Med Chem 35: 4011-9 (1992) | Eli Lilly and Company | 2D 3D TSV |
1433207 | 22 | 6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists. | J Med Chem 35: 3984-90 (1992) | University of Göteborg | 2D 3D TSV |
1433205 | 8 | 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121). | J Med Chem 35: 3973-6 (1992) | Merck Research Laboratories | 2D 3D TSV |
1433204 | 10 | Design and synthesis of a C7 mimetic for the predicted gamma-turn conformation found in several constrained RGD antagonists. | J Med Chem 35: 3970-2 (1992) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1433203 | 20 | Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides. | J Med Chem 35: 3962-9 (1992) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1433199 | 12 | Stabilization of the N-terminal residues of luteinizing hormone-releasing hormone agonists and the effect on pharmacokinetics. | J Med Chem 35: 3890-4 (1992) | Abbott Laboratories | 2D 3D TSV |
1433195 | 55 | Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model. | J Med Chem 35: 3858-72 (1992) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
1433194 | 12 | 4-substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors. | J Med Chem 35: 3822-31 (1992) | Merck Research Laboratories | 2D 3D TSV |
1433193 | 7 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs. | J Med Chem 35: 3813-21 (1992) | Merck Research Laboratories | 2D 3D TSV |
1433192 | 27 | New hydroxyethylamine HIV protease inhibitors that suppress viral replication. | J Med Chem 35: 3803-12 (1992) | University of Wisconsin-Madison | 2D 3D TSV |
1433191 | 25 | Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29. | J Med Chem 35: 3774-83 (1992) | Roche Research Center | 2D 3D TSV |
1433190 | 43 | Highly potent, orally active diester macrocyclic human renin inhibitors. | J Med Chem 35: 3755-73 (1992) | Merck Research Laboratories | 2D 3D TSV |
1433188 | 7 | Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol. | J Med Chem 35: 3731-44 (1992) | Merck Research Laboratories | 2D 3D TSV |
1433184 | 7 | Discovery of a novel class of orally active, non-peptide angiotensin II antagonists. | J Med Chem 35: 3714-7 (1992) | Abbott Laboratories | 2D 3D TSV |
1433183 | 32 | Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors. | J Med Chem 35: 3705-13 (1992) | University of Saskatchewan | 2D 3D TSV |
1433182 | 11 | Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives. | J Med Chem 35: 3699-704 (1992) | Institute of Cancer Research | 2D 3D TSV |
1433181 | 39 | Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors. | J Med Chem 35: 3691-8 (1992) | Warner-Lambert Company | 2D 3D TSV |
1433179 | 13 | 5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities. | J Med Chem 35: 3678-85 (1992) | Duquesne University | 2D 3D TSV |
1433176 | 26 | Truncated, branched, and/or cyclic analogues of neuropeptide Y: importance of the pancreatic peptide fold in the design of specific Y2 receptor ligands. | J Med Chem 35: 3653-9 (1992) | Salk Institute | 2D 3D TSV |
1433175 | 2 | Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase. | J Med Chem 35: 3648-52 (1992) | University of Minnesota | 2D 3D TSV |
1433172 | 30 | 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. | J Med Chem 35: 3625-32 (1992) | Pfizer Inc | 2D 3D TSV |
1431946 | 28 | Displacement Activity of Bisbenzylisoquinoline Alkaloids at Striatal 3H-SCH 23390 and 3H-Raclopride Binding Sites | J Nat Prod 55: 1281-1286 (1992) | TBA | 2D 3D TSV |
1431940 | 6 | Brominated polyacetylenic acids from the marine sponge Xestospongia muta: inhibitors of HIV protease. | J Nat Prod 55: 1170-7 (1992) | SmithKline Beecham Pharmaceuticals | 2D 3D TSV |
1404239 | 8 | N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase. | J Med Chem 35: 3581-3 (1992) | Marion Merrell Dow Research Institute | 2D 3D TSV |
1404238 | 14 | 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist. | J Med Chem 35: 3578-81 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1404233 | 68 | Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'. | J Med Chem 35: 3525-36 (1992) | E. Merck Darmstadt | 2D 3D TSV |
1404229 | 15 | Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. | J Med Chem 35: 3474-82 (1992) | Merck Research Laboratories | 2D 3D TSV |
1397049 | 24 | NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists. | Eur J Pharmacol 219: 45-52 (1992) | Novo Nordisk | 2D 3D TSV |
1390689 | 13 | Inhibition of protein kinase C by cationic amphiphiles. | Biochemistry 31: 9025-30 (1992) | McMaster University | 2D 3D TSV |
1388208 | 45 | Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 2. | J Med Chem 35: 3402-13 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1388207 | 72 | Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1. | J Med Chem 35: 3394-402 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1382133 | 18 | Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones. | J Med Chem 35: 3319-24 (1992) | Eli Lilly and Company | 2D 3D TSV |
1378901 | 18 | The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst. | J Med Chem 35: 2591-600 (1992) | Pfizer Inc | 2D 3D TSV |
1377748 | 16 | Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. | J Med Chem 35: 2407-14 (1992) | Alter, S.A. | 2D 3D TSV |
1375965 | 47 | Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. | J Med Chem 35: 2015-25 (1992) | Fujisawa Pharmaceutical Co., Ltd | 2D 3D TSV |
1375964 | 112 | Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N epsilon)-amide residues. | J Med Chem 35: 2007-14 (1992) | Abbott Laboratories | 2D 3D TSV |
1375963 | 4 | Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine. | J Med Chem 35: 2002-6 (1992) | Medical University of South Carolina | 2D 3D TSV |
1375962 | 9 | New thymidine triphosphate analogue inhibitors of human immunodeficiency virus-1 reverse transcriptase. | J Med Chem 35: 1938-41 (1992) | University of California | 2D 3D TSV |
1375626 | 5 | Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds. | J Nat Prod 55: 340-6 (1992) | University of North Carolina | 2D 3D TSV |
1375293 | 42 | Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones. | J Med Chem 35: 1887-97 (1992) | Boehringer Ingelheim Pharmaceuticals Inc | 2D 3D TSV |
1373191 | 15 | Synthesis and substance P antagonist activity of naphthimidazolium derivatives. | J Med Chem 35: 1273-9 (1992) | Rochester | 2D 3D TSV |
1372359 | 3 | Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents. | J Med Chem 35: 958-65 (1992) | Warner-Lambert Company | 2D 3D TSV |
1372358 | 18 | Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates. | J Med Chem 35: 859-66 (1992) | Institute of Cancer Research | 2D 3D TSV |
1370696 | 6 | Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic. | J Med Chem 35: 389-97 (1992) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1370695 | 27 | Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles. | J Med Chem 35: 374-8 (1992) | Rochester | 2D 3D TSV |
1362243 | 4 | Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. | Mol Pharmacol 42: 939-46 (1992) | National Institute of Mental Health | 2D 3D TSV |
1361581 | 11 | Computer-aided mapping of the beta-adrenoceptor. 1. Explanation for effect of para substitution on blocking activity at the beta-1-adrenoceptor. | J Med Chem 35: 4676-82 (1993) | University of Melbourne | 2D 3D TSV |
1361580 | 25 | N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors. | J Med Chem 35: 4638-9 (1993) | Oregon State University | 2D 3D TSV |
1361578 | 99 | Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. | J Med Chem 35: 4516-25 (1993) | Bristol-Myers Squibb Co. | 2D 3D TSV |
1360027 | 16 | Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands. | J Med Chem 35: 4408-14 (1992) | University of Camerino | 2D 3D TSV |
1360026 | 350 | Novel piperidine sigma receptor ligands as potential antipsychotic drugs. | J Med Chem 35: 4344-61 (1992) | DuPont Pharmaceuticals Company | 2D 3D TSV |
1360025 | 27 | Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity. | J Med Chem 35: 4330-3 (1992) | Oregon State University | 2D 3D TSV |
1359142 | 40 | Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1-pyridylalkyl)indoles. A novel conformational model to explain structure-activity relationships. | J Med Chem 35: 4020-6 (1992) | E. Merck Darmstadt | 2D 3D TSV |
1359141 | 47 | Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. | J Med Chem 35: 3845-57 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1356154 | 26 | Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain. | J Pharmacol Exp Ther 262: 929-35 (1992) | DuPont Pharmaceuticals Company | 2D 3D TSV |
1354264 | 19 | Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. | J Med Chem 35: 3081-4 (1992) | American Cyanamid Company | 2D 3D TSV |
1354263 | 9 | Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine. | J Med Chem 35: 3045-9 (1992) | Universit£ di Bari | 2D 3D TSV |
1353796 | 17 | Synthesis and antihistaminic activity of some thiazolidin-4-ones. | J Med Chem 35: 2910-2 (1992) | Universit£ di Napoli Federico II | 2D 3D TSV |
1353247 | 71 | Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. | Mol Pharmacol 42: 1-5 (1992) | University of Nebraska | 2D 3D TSV |
1353116 | 10 | 3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia. | J Med Chem 35: 2712-5 (1992) | Hoechst-Roussel Pharmaceuticals Inc | 2D 3D TSV |
1352553 | 38 | Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. | J Pharmacol Exp Ther 262: 383-93 (1992) | University of North Carolina | 2D 3D TSV |
1352351 | 32 | Synthesis and antiulcer activity of N-substituted N'-[3-[3-(piperidinomethyl)phenoxy]propyl]ureas: histamine H2-receptor antagonists with a potent mucosal protective activity. | J Med Chem 35: 2446-51 (1992) | Kyorin Pharmaceutical Company Ltd | 2D 3D TSV |
1350797 | 21 | Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives. | J Med Chem 35: 2074-84 (1992) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
1348542 | 23 | Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation. | J Med Chem 35: 1259-66 (1992) | University of Paris | 2D 3D TSV |
1348090 | 64 | Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. | J Med Chem 35: 1092-101 (1992) | H. Lundbeck A/S | 2D 3D TSV |
1348089 | 71 | Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds. | J Med Chem 35: 1076-92 (1992) | Upjohn Laboratories | 2D 3D TSV |
1347791 | 35 | Analgesic dipeptide derivatives. 7. 3,7-Diamino-2-hydroxyheptanoic acid (DAHHA) containing dipeptide analogues of the analgesic compound H-Lys-Trp(Nps)-OMe. | J Med Chem 35: 889-95 (1992) | Instituto de Qu£mica M£dica | 2D 3D TSV |
1347569 | 52 | Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors. | J Pharmacol Exp Ther 260: 1361-5 (1992) | Stanford University | 2D 3D TSV |
1347319 | 15 | Synthesis and alpha-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogues. | J Med Chem 35: 750-5 (1992) | Ohio State University | 2D 3D TSV |
1347318 | 52 | Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents. | J Med Chem 35: 743-50 (1992) | Berlex Laboratories | 2D 3D TSV |
1346653 | 168 | Pyrrole mannich bases as potential antipsychotic agents. | J Med Chem 35: 552-8 (1992) | R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
1346651 | 29 | Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities. | J Med Chem 35: 466-79 (1992) | Ohio State University | 2D 3D TSV |
1346637 | 120 | Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. | J Pharmacol Exp Ther 260: 576-80 (1992) | Mayo Clinic | 2D 3D TSV |
1346276 | 25 | Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide. | J Med Chem 35: 223-33 (1992) | G.D. Searle and Co. | 2D 3D TSV |
1336055 | 22 | Novel cAMP PDE III inhibitors: 1,6-naphthyridin-2(1H)-ones. | J Med Chem 35: 4858-65 (1992) | Sterling Winthrop Pharmaceuticals Research Division | 2D 3D TSV |
1336054 | 63 | Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles. | J Med Chem 35: 4823-31 (1993) | H. Lundbeck A/S | 2D 3D TSV |
1336053 | 86 | Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles. | J Med Chem 35: 4813-22 (1993) | H. Lundbeck A/S | 2D 3D TSV |
1335080 | 20 | Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites. | J Med Chem 35: 4651-7 (1993) | University of Ferrara | 2D 3D TSV |
1335078 | 76 | O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay. | J Med Chem 35: 4589-94 (1993) | University of Washington | 2D 3D TSV |
1333014 | 12 | Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, delta opioid receptor selective tetrapeptide (JOM-13) enhances delta receptor binding affinity and selectivity. | J Med Chem 35: 4498-500 (1992) | University of Michigan | 2D 3D TSV |
1333013 | 29 | Opioid agonist and antagonist activities of morphindoles related to naltrindole. | J Med Chem 35: 4325-9 (1992) | University of Minnesota | 2D 3D TSV |
1333012 | 106 | omega-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists. | J Med Chem 35: 4315-24 (1992) | Centre de Recherche de Vitry-Alfortville | 2D 3D TSV |
1333011 | 29 | omega-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists. | J Med Chem 35: 4306-14 (1992) | Centre de Recherche de Vitry-Alfortville | 2D 3D TSV |
1331462 | 9 | 4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2- naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist. | J Med Chem 35: 4253-5 (1992) | Rhone-Poulenc Rorer Central Research | 2D 3D TSV |
1331461 | 1 | L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. | J Med Chem 35: 4214-20 (1992) | Istituto di Genetica Biochimica ed Evoluzionistica | 2D 3D TSV |
1331460 | 54 | Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. | J Med Chem 35: 4195-204 (1992) | Glaxo Group Research | 2D 3D TSV |
1331459 | 1 | The first mechanism-based inactivators for angiotensin-converting enzyme. | J Med Chem 35: 4175-9 (1992) | Baxter Diagnostics Inc. | 2D 3D TSV |
1331456 | 3 | Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists. | J Med Chem 35: 4092-7 (1992) | Centre de Neurochimie du CNRS | 2D 3D TSV |
1331455 | 9 | Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes. | J Med Chem 35: 4086-91 (1992) | University of Minnesota | 2D 3D TSV |
1331453 | 106 | Effects of alkyl substitutions of xanthine skeleton on bronchodilation. | J Med Chem 35: 4039-44 (1992) | Hokuriku University | 2D 3D TSV |
1331451 | 68 | Conformationally restricted deltorphin analogues. | J Med Chem 35: 3956-61 (1992) | Clinical Research Institute of Montreal | 2D 3D TSV |
1331450 | 21 | A new class of high affinity ligands for the neurokinin A NK2 receptor: psi (CH2NR) reduced peptide bond analogues of neurokinin A4-10. | J Med Chem 35: 3949-55 (1992) | Marion Merrell Dow Research Institute | 2D 3D TSV |
1331449 | 268 | Orally active, nonpeptide oxytocin antagonists. | J Med Chem 35: 3919-27 (1992) | Merck Research Laboratories | 2D 3D TSV |
1331448 | 101 | Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product. | J Med Chem 35: 3905-18 (1992) | Merck Research Laboratories | 2D 3D TSV |
1331447 | 32 | Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic | J Med Chem 35: 3832-44 (1992) | Merck Frosst Centre for Therapeutic Research | 2D 3D TSV |
1328199 | 8 | Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. | J Biol Chem 267: 20422-8 (1992) | University of Chicago | 2D 3D TSV |
1327769 | 12 | Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes. | Eur J Biochem 208: 815-9 (1992) | Université Libre de Bruxelles | 2D 3D TSV |
1326635 | 11 | 3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex. | J Med Chem 35: 3423-5 (1992) | Eli Lilly and Company | 2D 3D TSV |
1326634 | 38 | Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-substituted-4-(phenylamino)quinolines. | J Med Chem 35: 3413-22 (1992) | SmithKline Beecham Pharmaceuticals R&D | 2D 3D TSV |
1325033 | 19 | Receptor occupancy and adenylate cyclase activation in AR 4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21. | Mol Pharmacol 42: 347-55 (1992) | Universit´ Libre de Bruxelles | 2D 3D TSV |
1324981 | 3 | A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I | J Nat Prod 55: 401-413 (1992) | TBA | 2D 3D TSV |
1324321 | 20 | Design of a functional hexapeptide antagonist of endothelin. | J Med Chem 35: 3301-3 (1992) | Warner-Lambert Company | 2D 3D TSV |
1324317 | 21 | Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid. | J Med Chem 35: 3180-3 (1992) | R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
1324316 | 22 | Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists. | J Med Chem 35: 3170-9 (1992) | Centre de Recherche de Vitry-Alfortville | 2D 3D TSV |
1323682 | 61 | Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor. | J Med Chem 35: 3058-66 (1992) | Upjohn Company | 2D 3D TSV |
1323680 | 71 | Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases. | J Med Chem 35: 2979-83 (1992) | University of Massachusetts Medical School | 2D 3D TSV |
1323679 | 21 | Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors. | J Med Chem 35: 2970-8 (1992) | Zambeletti Research Laboratories | 2D 3D TSV |
1323677 | 18 | Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. | J Med Chem 35: 2928-38 (1992) | G.D. Searle and Co. | 2D 3D TSV |
1322988 | 60 | Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo | J Med Chem 35: 2826-35 (1992) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
1322987 | 34 | Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at sigma, PCP, and mu opioid receptors. | J Med Chem 35: 2812-8 (1992) | Research Triangle Institute | 2D 3D TSV |
1322986 | 13 | Inhibition of collagenase by aranciamycin and aranciamycin derivatives. | J Med Chem 35: 2768-71 (1992) | Technical University of Denmark | 2D 3D TSV |
1321911 | 59 | Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility. | J Med Chem 35: 2688-96 (1992) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1321910 | 237 | Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. | J Med Chem 35: 2672-87 (1992) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1321909 | 8 | Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives. | J Med Chem 35: 2652-8 (1992) | ICI Pharmaceuticals Group | 2D 3D TSV |
1321908 | 44 | Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. | J Med Chem 35: 2600-9 (1992) | ICI Pharmaceuticals Group | 2D 3D TSV |
1321744 | 14 | Multiple histamine receptors: properties and functional characteristics. | Biochem Soc Trans 20: 122-5 (1992) | Queen's Medical Centre | 2D 3D TSV |
1321043 | 17 | Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist. | Eur J Biochem 207: 239-46 (1992) | Université Libre de Bruxelles | 2D 3D TSV |
1320692 | 19 | Comparison of antagonist and agonist binding to the leukotriene B4 receptor intact human polymorphonuclear neutrophils (PMN). | J Pharmacol Exp Ther 262: 80-9 (1992) | Ciba-Geigy Corporation | 2D 3D TSV |
1320204 | 1 | Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285. | Naunyn Schmiedebergs Arch Pharmacol 345: 264-9 (1992) | Centre de pharmacologie-endocrinologie (Montpellier, France) | 2D 3D TSV |
1320122 | 55 | Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity. | J Med Chem 35: 2384-91 (1992) | University of Arizona | 2D 3D TSV |
1320121 | 48 | Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol. | J Med Chem 35: 2374-84 (1992) | University of Washington | 2D 3D TSV |
1319495 | 21 | Selective reversible and irreversible ligands for the kappa opioid receptor. | J Med Chem 35: 2243-7 (1992) | National Taiwan University | 2D 3D TSV |
1319493 | 31 | Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents. | J Med Chem 35: 2221-30 (1992) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
1319490 | 27 | Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist. | J Med Chem 35: 2163-8 (1992) | Université du Québec | 2D 3D TSV |
1317926 | 9 | Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications. | J Med Chem 35: 2139-42 (1992) | TBA | 2D 3D TSV |
1317925 | 6 | A novel probe for the cannabinoid receptor. | J Med Chem 35: 2065-9 (1992) | Hebrew University | 2D 3D TSV |
1317924 | 28 | Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists. | J Med Chem 35: 2055-61 (1992) | Abbott Laboratories | 2D 3D TSV |
1317923 | 48 | Spiropiperidines as high-affinity, selective sigma ligands. | J Med Chem 35: 2033-9 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1317922 | 48 | Benz[f]isoquinoline analogues as high-affinity sigma ligands. | J Med Chem 35: 2025-33 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1317407 | 7 | Akuammine and Dihydroakuammine, Two Indolomonoterpene Alkaloids Displaying Affinity for Opioid Receptors | J Nat Prod 55: 380-384 (1992) | TBA | 2D 3D TSV |
1316968 | 21 | Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent. | J Med Chem 35: 1845-52 (1992) | SmithKline Beecham Pharmaceuticals R&D | 2D 3D TSV |
1315870 | 39 | Substitution on the Phe3 aromatic ring in cyclic delta opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: electronic and lipophilic requirements for receptor affinity. | J Med Chem 35: 1535-41 (1992) | University of Michigan | 2D 3D TSV |
1315869 | 231 | (Aminoalkoxy)chromones. Selective sigma receptor ligands. | J Med Chem 35: 1526-35 (1992) | Nova Pharmaceutical Corporation | 2D 3D TSV |
1315868 | 44 | Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity. | J Med Chem 35: 1521-5 (1992) | Harvard Medical School | 2D 3D TSV |
1315867 | 31 | Endothelin: a new challenge. | J Med Chem 35: 1493-508 (1992) | Warner-Lambert Company | 2D 3D TSV |
1315531 | 17 | Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. | Biochem Biophys Res Commun 184: 752-9 (1992) | Veterans Affairs Medical Center | 2D 3D TSV |
1315395 | 18 | Novel naphthalenic ligands with high affinity for the melatonin receptor. | J Med Chem 35: 1484-6 (1992) | Universite de Lille | 2D 3D TSV |
1313879 | 21 | Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase. | J Med Chem 35: 1299-318 (1992) | Merck Frosst Centre for Therapeutic Research | 2D 3D TSV |
1313878 | 36 | Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors. | J Med Chem 35: 1222-7 (1992) | National Institute of Environmental Health Sciences | 2D 3D TSV |
1313110 | 26 | (H+,K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate. | J Med Chem 35: 1049-57 (1992) | Byk Gulden Pharmaceuticals | 2D 3D TSV |
1313109 | 40 | Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors. | J Med Chem 35: 1009-18 (1992) | Universit£ di Pisa | 2D 3D TSV |
1312602 | 18 | Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. | J Med Chem 35: 895-903 (1992) | Rh£ne-Poulenc Rorer Central Research | 2D 3D TSV |
1312599 | 28 | Novel inhibitors of prolyl 4-hydroxylase. 2. 5-Amide substituted pyridine-2-carboxylic acids. | J Med Chem 35: 804-7 (1992) | ICI Pharmaceuticals Group | 2D 3D TSV |
1312598 | 18 | Novel inhibitors of prolyl 4-hydroxylase. | J Med Chem 35: 800-4 (1992) | ICI Pharmaceuticals Group | 2D 3D TSV |
1311765 | 38 | Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site. | J Med Chem 35: 780-93 (1992) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
1311764 | 4 | Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin. | J Med Chem 35: 684-7 (1992) | Searle Research and Development | 2D 3D TSV |
1311763 | 14 | 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. | J Med Chem 35: 620-8 (1992) | Syntex Research | 2D 3D TSV |
1310743 | 38 | New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus. | J Med Chem 35: 490-501 (1992) | Glaxo Group Research Ltd. | 2D 3D TSV |
1310742 | 12 | 2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors. | J Med Chem 35: 438-50 (1992) | Hoechst AG | 2D 3D TSV |
1310135 | 23 | Pharmacological characterization of a novel muscarinic partial agonist, YM796, in transfected cells expressing the m1 or m2 muscarinic receptor gene. | Life Sci 50: 355-63 (1992) | University of Arizona | 2D 3D TSV |
1310120 | 33 | Structure-function studies of peptides inhibiting the ribonucleotide reductase activity of herpes simplex virus type I. | J Med Chem 35: 346-50 (1992) | Notre-Dame Hospital Research | 2D 3D TSV |
1310118 | 32 | Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding. | J Med Chem 35: 252-8 (1992) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
1310117 | 12 | Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor. | J Med Chem 35: 233-41 (1992) | Warner-Lambert Company | 2D 3D TSV |
1310116 | 8 | Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials. | J Med Chem 35: 94-9 (1992) | Kanebo Ltd. | 2D 3D TSV |
1310115 | 11 | Synthesis, antinociceptive activity, and opioid receptor profiles of substituted trans-3-(decahydro- and octahydro-4a-isoquinolinyl)phenols. | J Med Chem 35: 48-56 (1992) | Glaxo Group Research Ltd. | 2D 3D TSV |
1310114 | 30 | Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor. | J Med Chem 35: 38-47 (1992) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
1294695 | 3 | Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis. | J Nat Prod 55: 1748-55 (1992) | Toyama Medical and Pharmaceutical University | 2D 3D TSV |
1294693 | 5 | Phospholipase A2 inhibitors from marine organisms. | J Nat Prod 55: 1701-17 (1992) | University of California-San Diego | 2D 3D TSV |
1282570 | 6 | Discovery of a potent substance P antagonist: recognition of the key molecular determinant. | J Med Chem 35: 4911-3 (1993) | Pfizer Inc | 2D 3D TSV |
1282569 | 54 | Potential anti-AIDS naphthalenesulfonic acid derivatives. Synthesis and inhibition of HIV-1 induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities. | J Med Chem 35: 4846-53 (1992) | University of Illinois at Chicago | 2D 3D TSV |
1280300 | 7 | Gonadotropin-releasing hormone antagonists with N omega-triazolylornithine, -lysine, or -p-aminophenylalanine residues at positions 5 and 6. | J Med Chem 35: 4270-8 (1992) | Salk Institute | 2D 3D TSV |
1279173 | 72 | Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one. | J Med Chem 35: 3792-802 (1992) | Merck Research Laboratories | 2D 3D TSV |
1279172 | 22 | Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues. | J Med Chem 35: 3784-91 (1992) | Merck Research Laboratories | 2D 3D TSV |
1271416 | 10 | Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes. | J Med Chem 19: 725-7 (1976) | TBA | 2D 3D TSV |
1271404 | 55 | Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement. | J Med Chem 19: 634-9 (1976) | TBA | 2D 3D TSV |