Affinity Data by PubMed id=1973733

PubMed code 1973733

Found 17 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM82247 (8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50010707 (8-Chloro-3-methyl-5-m-tolyl-2,3,4,5-tetrahydro-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Mus musculus (Mouse))	BDBM82247 (8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50010717 (8-Chloro-3-methyl-5-o-tolyl-2,3,4,5-tetrahydro-1H-...) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1C Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50010716 (8-Chloro-3-methyl-5-p-tolyl-2,3,4,5-tetrahydro-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004823 ((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004822 ((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...) Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity against Dopamine receptor D1 in rat radioligand				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50010709 (5-Benzofuran-7-yl-8-chloro-3-methyl-2,3,4,5-tetrah...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004820 (3-Chloro-7-methyl-5,6,7,7a,8,12b-hexahydro-7-aza-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50010708 (6-Phenyl-2,6,7,8,9,9a-hexahydro-1H-8-aza-benzo[cd]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity against Dopamine receptor D1 in rat radioligand				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM55121 (3-HYDROXYTYRAMINE HYDROCHLORIDE \| 4-(2-aminoethyl)...) Show SMILES NCCc1ccc(O)c(O)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid PDB UniChem Similars	DrugBank PDB PubMed	192	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50010715 ((6aS,13bS)11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	513	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50010711 ((6aR,13bS )11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	531	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50010712 ((6aR,13bR)11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	898	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50010710 (6-Phenyl-2,6,7,8,9,9a-hexahydro-1H-8-aza-benzo[cd]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Binding affinity against Dopamine receptor D1 in rat radioligand				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 5 (Homo sapiens (Human))	BDBM50010714 (1-p-Tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,...) Show SMILES Cc1ccc(cc1)[C@H]1CNCCc2cc(O)c(O)cc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effective concentration required to stimulate Adenylate cyclase				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase type 5 (Homo sapiens (Human))	BDBM50004822 ((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...) Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effective concentration required to stimulate Adenylate cyclase				J Med Chem 33: 2197-204 (1990) BindingDB Entry DOI: 10.7270/Q2TD9XZB
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%