Found 46 hits Enz. Inhib. hit(s) with Target = 'D(1A) dopamine receptor' and Ligand = 'BDBM55121' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University
Curated by ChEMBL
| Assay Description Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 |
J Med Chem 43: 756-62 (2000)
BindingDB Entry DOI: 10.7270/Q27W6CXP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 11.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 800-12 (1976)
BindingDB Entry DOI: 10.7270/Q22B8WH6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 16.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 800-12 (1976)
BindingDB Entry DOI: 10.7270/Q22B8WH6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 17.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 800-12 (1976)
BindingDB Entry DOI: 10.7270/Q22B8WH6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University
Curated by ChEMBL
| Assay Description Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioliga... |
J Med Chem 43: 756-62 (2000)
BindingDB Entry DOI: 10.7270/Q27W6CXP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 51.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 253: 214-20 (1990)
BindingDB Entry DOI: 10.7270/Q2PN9447 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
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| 124 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tartu
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting |
Bioorg Med Chem 17: 4756-62 (2009)
Article DOI: 10.1016/j.bmc.2009.04.047 BindingDB Entry DOI: 10.7270/Q2KD1XZ4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells |
J Med Chem 38: 3445-7 (1995)
BindingDB Entry DOI: 10.7270/Q26M37G0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes |
J Med Chem 29: 1904-12 (1986)
BindingDB Entry DOI: 10.7270/Q2TQ623R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
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| 192 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1 |
J Med Chem 33: 2197-204 (1990)
BindingDB Entry DOI: 10.7270/Q2TD9XZB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by PDSP Ki Database
| |
Bioorg Med Chem 11: 1451-64 (2003)
Article DOI: 10.1016/S0968-0896(02)00561-8 BindingDB Entry DOI: 10.7270/Q2CV4G90 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
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| 243 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting |
J Med Chem 61: 11384-11397 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01622 BindingDB Entry DOI: 10.7270/Q20G3NT6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 309 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390 |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2930WC4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Catholique de Louvain
Curated by PDSP Ki Database
| |
Life Sci 37: 1971-83 (1985)
Article DOI: 10.1016/0024-3205(85)90028-1 BindingDB Entry DOI: 10.7270/Q2HX1B5B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 417 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Camerino
Curated by ChEMBL
| Assay Description Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand. |
J Med Chem 43: 599-608 (2000)
Article DOI: 10.1021/jm991034o BindingDB Entry DOI: 10.7270/Q2X35161 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum |
Bioorg Med Chem 21: 1680-4 (2013)
Article DOI: 10.1016/j.bmc.2013.01.065 BindingDB Entry DOI: 10.7270/Q21Z45SG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University
Curated by ChEMBL
| Assay Description Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at th... |
J Med Chem 43: 756-62 (2000)
BindingDB Entry DOI: 10.7270/Q27W6CXP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Camerino
Curated by ChEMBL
| Assay Description Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement. |
J Med Chem 39: 4238-46 (1996)
Article DOI: 10.1021/jm960318v BindingDB Entry DOI: 10.7270/Q2WQ04FD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by PDSP Ki Database
| |
Bioorg Med Chem 11: 1451-64 (2003)
Article DOI: 10.1016/S0968-0896(02)00561-8 BindingDB Entry DOI: 10.7270/Q2CV4G90 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by PDSP Ki Database
| |
Life Sci 35: 1885-93 (1984)
Article DOI: 10.1016/0024-3205(84)90540-x BindingDB Entry DOI: 10.7270/Q2JD4V9M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University
Curated by ChEMBL
| Assay Description Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1 |
J Med Chem 43: 756-62 (2000)
BindingDB Entry DOI: 10.7270/Q27W6CXP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Nature 350: 614-9 (1991)
Article DOI: 10.1038/350614a0 BindingDB Entry DOI: 10.7270/Q2NV9GQR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand |
J Med Chem 41: 4933-8 (1999)
Article DOI: 10.1021/jm9708700 BindingDB Entry DOI: 10.7270/Q2FJ2HGD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina |
Bioorg Med Chem Lett 11: 223-6 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89CZK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate. |
J Med Chem 29: 1889-95 (1986)
BindingDB Entry DOI: 10.7270/Q2ZC83F6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 4.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells |
J Med Chem 55: 10302-6 (2012)
Article DOI: 10.1021/jm301258w BindingDB Entry DOI: 10.7270/Q24X58ZX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
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Similars
| DrugBank PDB PubMed
| 4.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SRI International
Curated by PDSP Ki Database
| |
NIDA Res Monogr 178: 440-66 (1998)
BindingDB Entry DOI: 10.7270/Q23J3BH2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 253: 214-20 (1990)
BindingDB Entry DOI: 10.7270/Q2PN9447 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
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| DrugBank PDB Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
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Similars
| DrugBank PDB Article PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tartu
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells |
Eur J Med Chem 55: 255-61 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.025 BindingDB Entry DOI: 10.7270/Q2VT1T56 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
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| DrugBank PDB Article PubMed
| 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas at Austin
Curated by ChEMBL
| Assay Description Affinity towards Dopamine receptor D1 |
J Med Chem 41: 4385-99 (1998)
Article DOI: 10.1021/jm9800292 BindingDB Entry DOI: 10.7270/Q2R21227 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated in vitro for its binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand |
Bioorg Med Chem Lett 1: 403-406 (1991)
Article DOI: 10.1016/S0960-894X(00)80265-6 BindingDB Entry DOI: 10.7270/Q2M045B8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| PDB PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum |
J Med Chem 33: 1756-64 (1990)
BindingDB Entry DOI: 10.7270/Q23X877X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
UniProtKB/SwissProt
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Similars
| PDB PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes |
J Med Chem 33: 2408-12 (1990)
BindingDB Entry DOI: 10.7270/Q29G5NFT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
UniProtKB/SwissProt
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Similars
| PDB PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino
Curated by ChEMBL
| Assay Description Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane |
J Med Chem 35: 4408-14 (1992)
BindingDB Entry DOI: 10.7270/Q2WH2QMC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
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Similars
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| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1 |
J Med Chem 38: 3445-7 (1995)
BindingDB Entry DOI: 10.7270/Q26M37G0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
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Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
University Centre for Pharmacy
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production |
Bioorg Med Chem 16: 3438-44 (2008)
Article DOI: 10.1016/j.bmc.2007.06.036 BindingDB Entry DOI: 10.7270/Q2PK0H0W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production |
J Med Chem 49: 6848-57 (2006)
Article DOI: 10.1021/jm0604979 BindingDB Entry DOI: 10.7270/Q25T3M92 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ... |
ACS Med Chem Lett 10: 792-799 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00050 BindingDB Entry DOI: 10.7270/Q26W9FKV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins |
Bioorg Med Chem 19: 5420-31 (2011)
Article DOI: 10.1016/j.bmc.2011.07.057 BindingDB Entry DOI: 10.7270/Q2M9092X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
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Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a |
VA Medical Center
Curated by ChEMBL
| Assay Description Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells |
J Med Chem 39: 850-9 (1996)
Article DOI: 10.1021/jm950447w BindingDB Entry DOI: 10.7270/Q2XG9RT3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
UniProtKB/SwissProt
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
University of North Carolina
Curated by ChEMBL
| Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti... |
J Med Chem 39: 285-96 (1996)
Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 232 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay |
J Med Chem 61: 11384-11397 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01622 BindingDB Entry DOI: 10.7270/Q20G3NT6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
UniProtKB/SwissProt
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| PDB PubMed
| n/a | n/a | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes |
J Med Chem 30: 1166-76 (1987)
BindingDB Entry DOI: 10.7270/Q2028QJ6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
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Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec... |
ACS Med Chem Lett 10: 792-799 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00050 BindingDB Entry DOI: 10.7270/Q26W9FKV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Agonist activity at human D1 receptor assessed as cAMP accumulation |
Bioorg Med Chem 18: 6763-70 (2010)
Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |