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PubMed code 1431946

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292548
PNG
((+)-(1R,1'S)-thaligrisine hydrochloride | CHEMBL45...)
Show SMILES COc1cc2CCN(C)[C@@H](Cc3ccc(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(O)cc56)ccc4OC)cc3)c2cc1O |r|
Show InChI InChI=1S/C37H42N2O6/c1-38-14-12-25-19-35(43-4)32(40)21-28(25)30(38)16-23-6-9-27(10-7-23)45-37-18-24(8-11-34(37)42-3)17-31-29-22-33(41)36(44-5)20-26(29)13-15-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31+/m0/s1
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n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292549
PNG
((+)-(1R,1'S)-berbamunine hydrochloride | CHEMBL503...)
Show SMILES COc1cc2CCN(C)[C@@H](Cc3ccc(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(O)cc56)ccc4O)cc3)c2cc1O |r|
Show InChI InChI=1S/C36H40N2O6/c1-37-13-11-24-18-34(42-3)32(40)20-27(24)29(37)15-22-5-8-26(9-6-22)44-36-17-23(7-10-31(36)39)16-30-28-21-33(41)35(43-4)19-25(28)12-14-38(30)2/h5-10,17-21,29-30,39-41H,11-16H2,1-4H3/t29-,30+/m0/s1
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM85444
PNG
(CHEMBL506025 | Isotetrandrine (R,S) | Pheanthine (...)
Show SMILES COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34 |r|
Show InChI InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30+/m0/s1
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n/an/a 670n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292549
PNG
((+)-(1R,1'S)-berbamunine hydrochloride | CHEMBL503...)
Show SMILES COc1cc2CCN(C)[C@@H](Cc3ccc(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(O)cc56)ccc4O)cc3)c2cc1O |r|
Show InChI InChI=1S/C36H40N2O6/c1-37-13-11-24-18-34(42-3)32(40)20-27(24)29(37)15-22-5-8-26(9-6-22)44-36-17-23(7-10-31(36)39)16-30-28-21-33(41)35(43-4)19-25(28)12-14-38(30)2/h5-10,17-21,29-30,39-41H,11-16H2,1-4H3/t29-,30+/m0/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292466
PNG
(CHEMBL450147 | CHEMBL507970 | Dimethylgrisabine)
Show SMILES COc1ccc(C[C@@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1Oc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1 |r|
Show InChI InChI=1S/C39H46N2O6/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-8-11-29(12-9-25)47-39-20-26(10-13-34(39)42-3)19-33-31-24-38(46-7)36(44-5)22-28(31)15-17-41(33)2/h8-13,20-24,32-33H,14-19H2,1-7H3/t32-,33+/m1/s1
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n/an/a 1.45E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292556
PNG
((S,S)-oxandrine hydrochloride | CHEMBL445011)
Show SMILES COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(c4)-c4cc(ccc4O)C(=O)[C@H]4N(C)CCc5cc(OC)c(Oc(c1O)c23)cc45 |r|
Show InChI InChI=1S/C37H38N2O7/c1-38-12-11-22-18-32(45-5)36(42)37-33(22)27(38)15-20-6-9-29(43-3)26(14-20)25-16-23(7-8-28(25)40)35(41)34-24-19-31(46-37)30(44-4)17-21(24)10-13-39(34)2/h6-9,14,16-19,27,34,40,42H,10-13,15H2,1-5H3/t27-,34-/m0/s1
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n/an/a 2.76E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292467
PNG
(Antioquine | Antioquine (S,R) | CHEMBL446564 | CHE...)
Show SMILES COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(c4)-c4cc(C[C@H]5N(C)CCc6cc(OC)c(Oc(c1O)c23)cc56)ccc4O |r|
Show InChI InChI=1S/C37H40N2O6/c1-38-12-10-23-18-32(43-4)33-20-25(23)28(38)16-21-6-8-30(40)26(14-21)27-15-22(7-9-31(27)42-3)17-29-35-24(11-13-39(29)2)19-34(44-5)36(41)37(35)45-33/h6-9,14-15,18-20,28-29,40-41H,10-13,16-17H2,1-5H3/t28-,29+/m1/s1
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n/an/a 3.18E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292548
PNG
((+)-(1R,1'S)-thaligrisine hydrochloride | CHEMBL45...)
Show SMILES COc1cc2CCN(C)[C@@H](Cc3ccc(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(O)cc56)ccc4OC)cc3)c2cc1O |r|
Show InChI InChI=1S/C37H42N2O6/c1-38-14-12-25-19-35(43-4)32(40)21-28(25)30(38)16-23-6-9-27(10-7-23)45-37-18-24(8-11-34(37)42-3)17-31-29-22-33(41)36(44-5)20-26(29)13-15-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31+/m0/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292466
PNG
(CHEMBL450147 | CHEMBL507970 | Dimethylgrisabine)
Show SMILES COc1ccc(C[C@@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1Oc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1 |r|
Show InChI InChI=1S/C39H46N2O6/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-8-11-29(12-9-25)47-39-20-26(10-13-34(39)42-3)19-33-31-24-38(46-7)36(44-5)22-28(31)15-17-41(33)2/h8-13,20-24,32-33H,14-19H2,1-7H3/t32-,33+/m1/s1
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n/an/a 5.64E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292473
PNG
(CHEMBL450155 | CHEMBL506299 | Secantioquine)
Show SMILES COc1cc2CCN(C)[C@@H](Cc3ccc(OC)c(c3)-c3cc(C=O)ccc3O)c2c(Oc2cc3C(=O)N(C)CCc3cc2OC)c1O |r|
Show InChI InChI=1S/C37H38N2O8/c1-38-12-11-24-18-33(46-5)35(42)36(47-32-19-25-23(17-31(32)45-4)10-13-39(2)37(25)43)34(24)28(38)16-21-7-9-30(44-3)27(14-21)26-15-22(20-40)6-8-29(26)41/h6-9,14-15,17-20,28,41-42H,10-13,16H2,1-5H3/t28-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292556
PNG
((S,S)-oxandrine hydrochloride | CHEMBL445011)
Show SMILES COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(c4)-c4cc(ccc4O)C(=O)[C@H]4N(C)CCc5cc(OC)c(Oc(c1O)c23)cc45 |r|
Show InChI InChI=1S/C37H38N2O7/c1-38-12-11-22-18-32(45-5)36(42)37-33(22)27(38)15-20-6-9-29(43-3)26(14-20)25-16-23(7-8-28(25)40)35(41)34-24-19-31(46-37)30(44-4)17-21(24)10-13-39(34)2/h6-9,14,16-19,27,34,40,42H,10-13,15H2,1-5H3/t27-,34-/m0/s1
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n/an/a 1.11E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292553
PNG
((R,S)-homoaromaline hydrochloride | CHEMBL443953)
Show SMILES COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(Oc5c(O)c(OC)cc6CCN(C)[C@H](Cc7ccc(Oc1c2)cc7)c56)cc34 |r|
Show InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)17-23-8-11-30(41-3)32(18-23)44-26-9-6-22(7-10-26)16-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1
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n/an/a 1.54E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292557
PNG
((S,R)-pseudoxandrine hydrochloride | CHEMBL504303)
Show SMILES COc1cc2CCN(C)[C@H]3c2c(Oc2cc4[C@@H](Cc5ccc(OC)c(c5)-c5cc(ccc5O)C3=O)N(C)CCc4cc2OC)c1O |r|
Show InChI InChI=1S/C37H38N2O7/c1-38-12-10-21-17-30(44-4)31-19-24(21)27(38)15-20-6-9-29(43-3)26(14-20)25-16-23(7-8-28(25)40)35(41)34-33-22(11-13-39(34)2)18-32(45-5)36(42)37(33)46-31/h6-9,14,16-19,27,34,40,42H,10-13,15H2,1-5H3/t27-,34+/m1/s1
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n/an/a 1.62E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50241642
PNG
((+)-Obaberine | CHEMBL451211 | CHEMBL464525 | Obab...)
Show SMILES COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c(OC)c(OC)cc6CCN(C)[C@@H](Cc7ccc(Oc1c2)cc7)c56)cc34 |r|
Show InChI InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)18-24-9-12-31(41-3)33(19-24)45-27-10-7-23(8-11-27)17-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30+/m1/s1
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n/an/a 2.84E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292473
PNG
(CHEMBL450155 | CHEMBL506299 | Secantioquine)
Show SMILES COc1cc2CCN(C)[C@@H](Cc3ccc(OC)c(c3)-c3cc(C=O)ccc3O)c2c(Oc2cc3C(=O)N(C)CCc3cc2OC)c1O |r|
Show InChI InChI=1S/C37H38N2O8/c1-38-12-11-24-18-33(46-5)35(42)36(47-32-19-25-23(17-31(32)45-4)10-13-39(2)37(25)43)34(24)28(38)16-21-7-9-30(44-3)27(14-21)26-15-22(20-40)6-8-29(26)41/h6-9,14-15,17-20,28,41-42H,10-13,16H2,1-5H3/t28-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292559
PNG
((S)-secoobaberine hydrochloride | CHEMBL451463)
Show SMILES COc1ccc(C=O)cc1Oc1ccc(C[C@@H]2N(C)CCc3cc(OC)c(OC)c(Oc4cc5C(=O)N(C)CCc5cc4OC)c23)cc1 |r|
Show InChI InChI=1S/C38H40N2O8/c1-39-15-14-26-20-34(45-5)36(46-6)37(48-33-21-28-25(19-31(33)44-4)13-16-40(2)38(28)42)35(26)29(39)17-23-7-10-27(11-8-23)47-32-18-24(22-41)9-12-30(32)43-3/h7-12,18-22,29H,13-17H2,1-6H3/t29-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292559
PNG
((S)-secoobaberine hydrochloride | CHEMBL451463)
Show SMILES COc1ccc(C=O)cc1Oc1ccc(C[C@@H]2N(C)CCc3cc(OC)c(OC)c(Oc4cc5C(=O)N(C)CCc5cc4OC)c23)cc1 |r|
Show InChI InChI=1S/C38H40N2O8/c1-39-15-14-26-20-34(45-5)36(46-6)37(48-33-21-28-25(19-31(33)44-4)13-16-40(2)38(28)42)35(26)29(39)17-23-7-10-27(11-8-23)47-32-18-24(22-41)9-12-30(32)43-3/h7-12,18-22,29H,13-17H2,1-6H3/t29-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM85444
PNG
(CHEMBL506025 | Isotetrandrine (R,S) | Pheanthine (...)
Show SMILES COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34 |r|
Show InChI InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30+/m0/s1
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n/an/a 3.33E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50241642
PNG
((+)-Obaberine | CHEMBL451211 | CHEMBL464525 | Obab...)
Show SMILES COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c(OC)c(OC)cc6CCN(C)[C@@H](Cc7ccc(Oc1c2)cc7)c56)cc34 |r|
Show InChI InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)18-24-9-12-31(41-3)33(19-24)45-27-10-7-23(8-11-27)17-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30+/m1/s1
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n/an/a 3.91E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292553
PNG
((R,S)-homoaromaline hydrochloride | CHEMBL443953)
Show SMILES COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(Oc5c(O)c(OC)cc6CCN(C)[C@H](Cc7ccc(Oc1c2)cc7)c56)cc34 |r|
Show InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)17-23-8-11-30(41-3)32(18-23)44-26-9-6-22(7-10-26)16-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1
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n/an/a 6.64E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292472
PNG
(CHEMBL450834 | CHEMBL509530 | Secolucidine)
Show SMILES COc1ccc(C[C@@H]2N(C)CCc3cc(OC)c4Oc5cc6CCN(C)C(=O)c6cc5Oc4c23)cc1-c1cc(C=O)ccc1O |r|
Show InChI InChI=1S/C36H34N2O7/c1-37-11-10-23-17-32(43-4)34-35(45-31-18-24-22(16-30(31)44-34)9-12-38(2)36(24)41)33(23)27(37)15-20-6-8-29(42-3)26(13-20)25-14-21(19-39)5-7-28(25)40/h5-8,13-14,16-19,27,40H,9-12,15H2,1-4H3/t27-/m0/s1
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n/an/a 8.16E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292557
PNG
((S,R)-pseudoxandrine hydrochloride | CHEMBL504303)
Show SMILES COc1cc2CCN(C)[C@H]3c2c(Oc2cc4[C@@H](Cc5ccc(OC)c(c5)-c5cc(ccc5O)C3=O)N(C)CCc4cc2OC)c1O |r|
Show InChI InChI=1S/C37H38N2O7/c1-38-12-10-21-17-30(44-4)31-19-24(21)27(38)15-20-6-9-29(43-3)26(14-20)25-16-23(7-8-28(25)40)35(41)34-33-22(11-13-39(34)2)18-32(45-5)36(42)37(33)46-31/h6-9,14,16-19,27,34,40,42H,10-13,15H2,1-5H3/t27-,34+/m1/s1
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n/an/a 9.02E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292471
PNG
(CHEMBL449016 | CHEMBL504801 | Pampulhamine)
Show SMILES COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1Oc1ccc(C[C@H]2NCCc3cc(OC)c(OC)cc23)cc1 |r|
Show InChI InChI=1S/C38H44N2O6/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-9-12-33(41-2)38(19-25)46-28-10-7-24(8-11-28)17-31-29-22-36(44-5)34(42-3)20-26(29)13-15-39-31/h7-12,19-23,31-32,39H,13-18H2,1-6H3/t31-,32-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292472
PNG
(CHEMBL450834 | CHEMBL509530 | Secolucidine)
Show SMILES COc1ccc(C[C@@H]2N(C)CCc3cc(OC)c4Oc5cc6CCN(C)C(=O)c6cc5Oc4c23)cc1-c1cc(C=O)ccc1O |r|
Show InChI InChI=1S/C36H34N2O7/c1-37-11-10-23-17-32(43-4)34-35(45-31-18-24-22(16-30(31)44-34)9-12-38(2)36(24)41)33(23)27(37)15-20-6-8-29(42-3)26(13-20)25-14-21(19-39)5-7-28(25)40/h5-8,13-14,16-19,27,40H,9-12,15H2,1-4H3/t27-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50292469
PNG
(CHEMBL443081 | CHEMBL501861 | O-methyldauricine)
Show SMILES COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1Oc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1 |r|
Show InChI InChI=1S/C39H46N2O6/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-8-11-29(12-9-25)47-39-20-26(10-13-34(39)42-3)19-33-31-24-38(46-7)36(44-5)22-28(31)15-17-41(33)2/h8-13,20-24,32-33H,14-19H2,1-7H3/t32-,33-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292469
PNG
(CHEMBL443081 | CHEMBL501861 | O-methyldauricine)
Show SMILES COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1Oc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1 |r|
Show InChI InChI=1S/C39H46N2O6/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-8-11-29(12-9-25)47-39-20-26(10-13-34(39)42-3)19-33-31-24-38(46-7)36(44-5)22-28(31)15-17-41(33)2/h8-13,20-24,32-33H,14-19H2,1-7H3/t32-,33-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292471
PNG
(CHEMBL449016 | CHEMBL504801 | Pampulhamine)
Show SMILES COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(OC)cc23)cc1Oc1ccc(C[C@H]2NCCc3cc(OC)c(OC)cc23)cc1 |r|
Show InChI InChI=1S/C38H44N2O6/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-9-12-33(41-2)38(19-25)46-28-10-7-24(8-11-28)17-31-29-22-36(44-5)34(42-3)20-26(29)13-15-39-31/h7-12,19-23,31-32,39H,13-18H2,1-6H3/t31-,32-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50292467
PNG
(Antioquine | Antioquine (S,R) | CHEMBL446564 | CHE...)
Show SMILES COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(c4)-c4cc(C[C@H]5N(C)CCc6cc(OC)c(Oc(c1O)c23)cc56)ccc4O |r|
Show InChI InChI=1S/C37H40N2O6/c1-38-12-10-23-18-32(43-4)33-20-25(23)28(38)16-21-6-8-30(40)26(14-21)27-15-22(7-9-31(27)42-3)17-29-35-24(11-13-39(29)2)19-34(44-5)36(41)37(35)45-33/h6-9,14-15,18-20,28-29,40-41H,10-13,16-17H2,1-5H3/t28-,29+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting

J Nat Prod 55: 1281-1286 (1992)


Article DOI: 10.1021/np50087a016
BindingDB Entry DOI: 10.7270/Q2WM1DF2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%