Found 51 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229564
(CHEMBL98269)Show InChI InChI=1S/C12H11N3O3/c1-17-9-4-6-3-8-11(15-12(16)14-8)13-7(6)5-10(9)18-2/h3-5H,1-2H3,(H2,13,14,15,16) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229570
(CHEMBL98208)Show InChI InChI=1S/C12H10BrN3O/c1-5-3-8-7(6(2)10(5)13)4-9-11(14-8)16-12(17)15-9/h3-4H,1-2H3,(H2,14,15,16,17) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229568
(CHEMBL100676)Show InChI InChI=1S/C13H13N3O2/c1-7(2)18-9-3-4-10-8(5-9)6-11-12(14-10)16-13(17)15-11/h3-7H,1-2H3,(H2,14,15,16,17) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50000925
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229569
(CHEMBL97922)Show InChI InChI=1S/C11H9N3O/c1-6-3-2-4-8-7(6)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229572
(CHEMBL98812)Show InChI InChI=1S/C12H11N3O2/c1-2-17-8-3-4-9-7(5-8)6-10-11(13-9)15-12(16)14-10/h3-6H,2H2,1H3,(H2,13,14,15,16) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229566
(CHEMBL98268)Show InChI InChI=1S/C12H10ClN3O/c1-5-3-8-7(6(2)10(5)13)4-9-11(14-8)16-12(17)15-9/h3-4H,1-2H3,(H2,14,15,16,17) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007229
(7-Fluoro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)Show InChI InChI=1S/C10H8FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229557
(CHEMBL100784)Show InChI InChI=1S/C11H9N3O2/c1-16-7-2-3-8-6(4-7)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229558
(CHEMBL319947)Show InChI InChI=1S/C11H8ClN3O/c1-5-2-3-7-6(9(5)12)4-8-10(13-7)15-11(16)14-8/h2-4H,1H3,(H2,13,14,15,16) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007221
(7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C10H6ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50000334
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007216
(7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C11H9N3O/c1-6-2-3-8-7(4-6)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229563
(CHEMBL99760)Show InChI InChI=1S/C11H8ClN3O/c1-5-2-8-6(3-7(5)12)4-9-10(13-8)15-11(16)14-9/h2-4H,1H3,(H2,13,14,15,16) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229561
(CHEMBL317399)Show InChI InChI=1S/C12H11N3O/c1-6-3-8-5-10-11(15-12(16)14-10)13-9(8)4-7(6)2/h3-5H,1-2H3,(H2,13,14,15,16) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229556
(CHEMBL319551)Show InChI InChI=1S/C11H9N3O/c1-6-3-2-4-7-5-8-10(13-9(6)7)14-11(15)12-8/h2-5H,1H3,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007222
(1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one |...)Show InChI InChI=1S/C10H9N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-4,11H,5H2,(H2,12,13,14) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229562
(CHEMBL98164)Show InChI InChI=1S/C11H9N3O2/c1-16-9-4-2-3-7-6(9)5-8-10(12-7)14-11(15)13-8/h2-5H,1H3,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229567
(CHEMBL98687)Show InChI InChI=1S/C12H9N3O3/c1-6(16)18-8-2-3-9-7(4-8)5-10-11(13-9)15-12(17)14-10/h2-5H,1H3,(H2,13,14,15,17) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229559
(CHEMBL98373)Show InChI InChI=1S/C10H6ClN3O/c11-6-2-1-3-7-5(6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229560
(CHEMBL98024)Show InChI InChI=1S/C10H7N3O2/c14-6-1-2-7-5(3-6)4-8-9(11-7)13-10(15)12-8/h1-4,14H,(H2,11,12,13,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229565
(CHEMBL99996)Show InChI InChI=1S/C11H11N3O/c1-6-2-3-8-7(4-6)5-9-10(12-8)14-11(15)13-9/h2-4,9H,5H2,1H3,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007234
(7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C10H6FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007220
(1,3-Dihydro-imidazo[4,5-b]quinolin-2-one | CHEMBL9...)Show InChI InChI=1S/C10H7N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-5H,(H2,11,12,13,14) | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007247
(1,7,8-Trimethyl-1,3-dihydro-imidazo[4,5-b]quinolin...)Show InChI InChI=1S/C13H13N3O/c1-7-4-5-10-9(8(7)2)6-11-12(14-10)15-13(17)16(11)3/h4-6H,1-3H3,(H,14,15,17) | PDB
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| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229550
(CHEMBL98340)Show InChI InChI=1S/C13H13N3O4/c1-18-9-5-7-6(10(19-2)11(9)20-3)4-8-12(14-7)16-13(17)15-8/h4-5H,1-3H3,(H2,14,15,16,17) | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229555
(CHEMBL99507)Show InChI InChI=1S/C11H9N3O2/c1-16-8-4-2-3-6-5-7-10(13-9(6)8)14-11(15)12-7/h2-5H,1H3,(H2,12,13,14,15) | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007250
(7-Methoxy-1-methyl-1,3-dihydro-imidazo[4,5-b]quino...)Show InChI InChI=1S/C12H11N3O2/c1-15-10-6-7-5-8(17-2)3-4-9(7)13-11(10)14-12(15)16/h3-6H,1-2H3,(H,13,14,16) | PDB
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229551
(CHEMBL100365)Show InChI InChI=1S/C13H13N3O/c1-7-4-5-10-9(8(7)2)6-11-12(14-10)16(3)13(17)15-11/h4-6H,1-3H3,(H,15,17) | PDB
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007235
(1,7-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)Show InChI InChI=1S/C12H11N3O/c1-7-3-4-9-8(5-7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16) | PDB
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229553
(CHEMBL100030)Show InChI InChI=1S/C12H11N3O2/c1-15-11-10(14-12(15)16)6-7-5-8(17-2)3-4-9(7)13-11/h3-6H,1-2H3,(H,14,16) | PDB
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| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007236
(1,3-Dihydro-naphtho[2,3-d]imidazol-2-one | CHEMBL3...)Show InChI InChI=1S/C11H8N2O/c14-11-12-9-5-7-3-1-2-4-8(7)6-10(9)13-11/h1-6H,(H2,12,13,14) | PDB
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007248
(1,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)Show InChI InChI=1S/C12H11N3O/c1-7-4-3-5-9-8(7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16) | PDB
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007217
(7-Chloro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)Show InChI InChI=1S/C10H8ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15) | PDB
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| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50000925
(7,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)Show InChI InChI=1S/C12H11N3O/c1-6-3-4-9-8(7(6)2)5-10-11(13-9)15-12(16)14-10/h3-5H,1-2H3,(H2,13,14,15,16) | PDB
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| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50007227
(1-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C11H9N3O/c1-14-9-6-7-4-2-3-5-8(7)12-10(9)13-11(14)15/h2-6H,1H3,(H,12,13,15) | PDB
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| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007250
(7-Methoxy-1-methyl-1,3-dihydro-imidazo[4,5-b]quino...)Show InChI InChI=1S/C12H11N3O2/c1-15-10-6-7-5-8(17-2)3-4-9(7)13-11(10)14-12(15)16/h3-6H,1-2H3,(H,13,14,16) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50000334
(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)Show InChI InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16) | PDB
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| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007229
(7-Fluoro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)Show InChI InChI=1S/C10H8FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007227
(1-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C11H9N3O/c1-14-9-6-7-4-2-3-5-8(7)12-10(9)13-11(14)15/h2-6H,1H3,(H,12,13,15) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007248
(1,8-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)Show InChI InChI=1S/C12H11N3O/c1-7-4-3-5-9-8(7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007235
(1,7-Dimethyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-...)Show InChI InChI=1S/C12H11N3O/c1-7-3-4-9-8(5-7)6-10-11(13-9)14-12(16)15(10)2/h3-6H,1-2H3,(H,13,14,16) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50229554
(CHEMBL99441)Show InChI InChI=1S/C14H15N3O/c1-8-5-6-11-10(9(8)2)7-12-13(15-11)17(4)14(18)16(12)3/h5-7H,1-4H3 | PDB
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| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007220
(1,3-Dihydro-imidazo[4,5-b]quinolin-2-one | CHEMBL9...)Show InChI InChI=1S/C10H7N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-5H,(H2,11,12,13,14) | PDB
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| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007217
(7-Chloro-1,3,9,9a-tetrahydro-imidazo[4,5-b]quinoli...)Show InChI InChI=1S/C10H8ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-3,12H,4H2,(H2,13,14,15) | PDB
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| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007221
(7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C10H6ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15) | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007247
(1,7,8-Trimethyl-1,3-dihydro-imidazo[4,5-b]quinolin...)Show InChI InChI=1S/C13H13N3O/c1-7-4-5-10-9(8(7)2)6-11-12(14-10)15-13(17)16(11)3/h4-6H,1-3H3,(H,14,15,17) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007236
(1,3-Dihydro-naphtho[2,3-d]imidazol-2-one | CHEMBL3...)Show InChI InChI=1S/C11H8N2O/c14-11-12-9-5-7-3-1-2-4-8(7)6-10(9)13-11/h1-6H,(H2,12,13,14) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007216
(7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C11H9N3O/c1-6-2-3-8-7(4-6)5-9-10(12-8)14-11(15)13-9/h2-5H,1H3,(H2,12,13,14,15) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007222
(1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one |...)Show InChI InChI=1S/C10H9N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-4,11H,5H2,(H2,12,13,14) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50007234
(7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one ...)Show InChI InChI=1S/C10H6FN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15) | PDB
UniProtKB/SwissProt
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UniChem
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of cGMP hydrolysis by human platelet phosphodiesterase |
J Med Chem 34: 2906-16 (1991)
BindingDB Entry DOI: 10.7270/Q20P0Z03 |
More data for this
Ligand-Target Pair | |
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