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PubMed code 1578479

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005850
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@H]1OCC2(CN3CCC2CC3)O1 |wU:1.0,(13.51,6.12,;11.97,6.12,;12.74,4.77,;11.71,3.63,;10.3,4.26,;10.3,2.72,;8.96,1.95,;7.64,2.72,;7.64,4.26,;8.96,5.03,;8.44,3.84,;9.56,3.2,;10.46,5.8,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m0/s1
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 2.90E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005848
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@@H]1OCC2(CN3CCC2CC3)O1 |wD:1.0,(15.15,-4.25,;14.53,-5.65,;15.3,-6.97,;14.28,-8.13,;12.87,-7.51,;12.87,-9.05,;11.53,-9.82,;10.2,-9.05,;10.2,-7.51,;11.53,-6.74,;11,-7.9,;12.13,-8.54,;13.03,-5.97,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m1/s1
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 6.30E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005844
PNG
((2S,5'R)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@@H]1CC2(CO1)CN1CCC2CC1 |wU:1.0,(16.56,-.55,;15.01,-.56,;13.51,-.88,;13.35,-2.41,;14.76,-3.03,;15.79,-1.89,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,)|
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
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 6.30E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005845
PNG
((2S,5'S)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@H]1CC2(CO1)CN1CCC2CC1 |wD:1.0,(15.64,.86,;15.01,-.56,;13.51,-.88,;13.35,-2.41,;14.76,-3.03,;15.79,-1.89,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,)|
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
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 6.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005846
PNG
(2',2'-dimethylspiro[4-azabicyclo[2.2.2]octane-2,4'...)
Show SMILES CC1(C)OCC2(CN3CCC2CC3)O1 |(16.5,-.14,;15.01,-.56,;14.22,.79,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Show InChI InChI=1S/C11H19NO2/c1-10(2)13-8-11(14-10)7-12-5-3-9(11)4-6-12/h9H,3-8H2,1-2H3
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 9.30E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005850
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@H]1OCC2(CN3CCC2CC3)O1 |wU:1.0,(13.51,6.12,;11.97,6.12,;12.74,4.77,;11.71,3.63,;10.3,4.26,;10.3,2.72,;8.96,1.95,;7.64,2.72,;7.64,4.26,;8.96,5.03,;8.44,3.84,;9.56,3.2,;10.46,5.8,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m0/s1
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 9.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005850
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@H]1OCC2(CN3CCC2CC3)O1 |wU:1.0,(13.51,6.12,;11.97,6.12,;12.74,4.77,;11.71,3.63,;10.3,4.26,;10.3,2.72,;8.96,1.95,;7.64,2.72,;7.64,4.26,;8.96,5.03,;8.44,3.84,;9.56,3.2,;10.46,5.8,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m0/s1
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 1.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radiol...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005847
PNG
((2R,5'S)-5'-methyldihydro-3'H-spiro[4-azabicyclo[2...)
Show SMILES C[C@H]1CCC2(CN3CCC2CC3)O1 |wU:1.0,(16.07,-5.59,;14.53,-5.59,;15.3,-6.94,;14.28,-8.1,;12.87,-7.45,;12.87,-8.99,;11.52,-9.76,;10.2,-8.99,;10.2,-7.45,;11.52,-6.68,;11,-7.87,;12.13,-8.51,;13.03,-5.91,)|
Show InChI InChI=1S/C11H19NO/c1-9-2-5-11(13-9)8-12-6-3-10(11)4-7-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
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 1.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005847
PNG
((2R,5'S)-5'-methyldihydro-3'H-spiro[4-azabicyclo[2...)
Show SMILES C[C@H]1CCC2(CN3CCC2CC3)O1 |wU:1.0,(16.07,-5.59,;14.53,-5.59,;15.3,-6.94,;14.28,-8.1,;12.87,-7.45,;12.87,-8.99,;11.52,-9.76,;10.2,-8.99,;10.2,-7.45,;11.52,-6.68,;11,-7.87,;12.13,-8.51,;13.03,-5.91,)|
Show InChI InChI=1S/C11H19NO/c1-9-2-5-11(13-9)8-12-6-3-10(11)4-7-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
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 1.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005849
PNG
(CHEMBL290715 | spiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C1OCC2(CN3CCC2CC3)O1 |(15.01,-.56,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Show InChI InChI=1S/C9H15NO2/c1-3-10-4-2-8(1)9(5-10)6-11-7-12-9/h8H,1-7H2
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 1.90E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005844
PNG
((2S,5'R)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@@H]1CC2(CO1)CN1CCC2CC1 |wU:1.0,(16.56,-.55,;15.01,-.56,;13.51,-.88,;13.35,-2.41,;14.76,-3.03,;15.79,-1.89,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,)|
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
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>2.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50005843
PNG
((2R,5'R)-5'-methyldihydro-3'H-spiro[4-azabicyclo[2...)
Show SMILES C[C@@H]1CCC2(CN3CCC2CC3)O1 |wD:1.0,(8.15,-1.22,;7.52,-2.61,;8.29,-3.96,;7.26,-5.1,;5.85,-4.47,;5.85,-6.01,;4.5,-6.78,;3.19,-6.01,;3.19,-4.47,;4.5,-3.7,;3.99,-4.89,;5.11,-5.53,;6.01,-2.93,)|
Show InChI InChI=1S/C11H19NO/c1-9-2-5-11(13-9)8-12-6-3-10(11)4-7-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
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 2.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radi...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005845
PNG
((2S,5'S)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@H]1CC2(CO1)CN1CCC2CC1 |wD:1.0,(15.64,.86,;15.01,-.56,;13.51,-.88,;13.35,-2.41,;14.76,-3.03,;15.79,-1.89,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,)|
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
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>2.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005848
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@@H]1OCC2(CN3CCC2CC3)O1 |wD:1.0,(15.15,-4.25,;14.53,-5.65,;15.3,-6.97,;14.28,-8.13,;12.87,-7.51,;12.87,-9.05,;11.53,-9.82,;10.2,-9.05,;10.2,-7.51,;11.53,-6.74,;11,-7.9,;12.13,-8.54,;13.03,-5.97,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m1/s1
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>2.10E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005843
PNG
((2R,5'R)-5'-methyldihydro-3'H-spiro[4-azabicyclo[2...)
Show SMILES C[C@@H]1CCC2(CN3CCC2CC3)O1 |wD:1.0,(8.15,-1.22,;7.52,-2.61,;8.29,-3.96,;7.26,-5.1,;5.85,-4.47,;5.85,-6.01,;4.5,-6.78,;3.19,-6.01,;3.19,-4.47,;4.5,-3.7,;3.99,-4.89,;5.11,-5.53,;6.01,-2.93,)|
Show InChI InChI=1S/C11H19NO/c1-9-2-5-11(13-9)8-12-6-3-10(11)4-7-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
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>2.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005848
PNG
((2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C[C@@H]1OCC2(CN3CCC2CC3)O1 |wD:1.0,(15.15,-4.25,;14.53,-5.65,;15.3,-6.97,;14.28,-8.13,;12.87,-7.51,;12.87,-9.05,;11.53,-9.82,;10.2,-9.05,;10.2,-7.51,;11.53,-6.74,;11,-7.9,;12.13,-8.54,;13.03,-5.97,)|
Show InChI InChI=1S/C10H17NO2/c1-8-12-7-10(13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10?/m1/s1
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 2.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radio...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005845
PNG
((2S,5'S)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@H]1CC2(CO1)CN1CCC2CC1 |wD:1.0,(15.64,.86,;15.01,-.56,;13.51,-.88,;13.35,-2.41,;14.76,-3.03,;15.79,-1.89,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,)|
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
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 2.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radiol...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005846
PNG
(2',2'-dimethylspiro[4-azabicyclo[2.2.2]octane-2,4'...)
Show SMILES CC1(C)OCC2(CN3CCC2CC3)O1 |(16.5,-.14,;15.01,-.56,;14.22,.79,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Show InChI InChI=1S/C11H19NO2/c1-10(2)13-8-11(14-10)7-12-5-3-9(11)4-6-12/h9H,3-8H2,1-2H3
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 3.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005844
PNG
((2S,5'R)-5'-methyldihydrospiro[4-azabicyclo[2.2.2]...)
Show SMILES C[C@@H]1CC2(CO1)CN1CCC2CC1 |wU:1.0,(16.56,-.55,;15.01,-.56,;13.51,-.88,;13.35,-2.41,;14.76,-3.03,;15.79,-1.89,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,)|
Show InChI InChI=1S/C11H19NO/c1-9-6-11(8-13-9)7-12-4-2-10(11)3-5-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
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 3.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radio...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005847
PNG
((2R,5'S)-5'-methyldihydro-3'H-spiro[4-azabicyclo[2...)
Show SMILES C[C@H]1CCC2(CN3CCC2CC3)O1 |wU:1.0,(16.07,-5.59,;14.53,-5.59,;15.3,-6.94,;14.28,-8.1,;12.87,-7.45,;12.87,-8.99,;11.52,-9.76,;10.2,-8.99,;10.2,-7.45,;11.52,-6.68,;11,-7.87,;12.13,-8.51,;13.03,-5.91,)|
Show InChI InChI=1S/C11H19NO/c1-9-2-5-11(13-9)8-12-6-3-10(11)4-7-12/h9-10H,2-8H2,1H3/t9-,11?/m0/s1
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 3.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radio...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005846
PNG
(2',2'-dimethylspiro[4-azabicyclo[2.2.2]octane-2,4'...)
Show SMILES CC1(C)OCC2(CN3CCC2CC3)O1 |(16.5,-.14,;15.01,-.56,;14.22,.79,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Show InChI InChI=1S/C11H19NO2/c1-10(2)13-8-11(14-10)7-12-5-3-9(11)4-6-12/h9H,3-8H2,1-2H3
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 3.90E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M3 n guinea pig parotid gland using (-)-[3H]-QNB as radioli...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50005849
PNG
(CHEMBL290715 | spiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C1OCC2(CN3CCC2CC3)O1 |(15.01,-.56,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Show InChI InChI=1S/C9H15NO2/c1-3-10-4-2-8(1)9(5-10)6-11-7-12-9/h8H,1-7H2
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 5.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005843
PNG
((2R,5'R)-5'-methyldihydro-3'H-spiro[4-azabicyclo[2...)
Show SMILES C[C@@H]1CCC2(CN3CCC2CC3)O1 |wD:1.0,(8.15,-1.22,;7.52,-2.61,;8.29,-3.96,;7.26,-5.1,;5.85,-4.47,;5.85,-6.01,;4.5,-6.78,;3.19,-6.01,;3.19,-4.47,;4.5,-3.7,;3.99,-4.89,;5.11,-5.53,;6.01,-2.93,)|
Show InChI InChI=1S/C11H19NO/c1-9-2-5-11(13-9)8-12-6-3-10(11)4-7-12/h9-10H,2-8H2,1H3/t9-,11?/m1/s1
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 7.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against Muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radiol...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50005849
PNG
(CHEMBL290715 | spiro[4-azabicyclo[2.2.2]octane-2,4...)
Show SMILES C1OCC2(CN3CCC2CC3)O1 |(15.01,-.56,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Show InChI InChI=1S/C9H15NO2/c1-3-10-4-2-8(1)9(5-10)6-11-7-12-9/h8H,1-7H2
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 8.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M3 in guinea pig parotid gland using (-)-[3H]-QNB as radiol...

J Med Chem 35: 1541-50 (1992)


BindingDB Entry DOI: 10.7270/Q2R78D6J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%