The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27690435 |
20 |
Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions. |
China Pharmaceutical University |
| 27437072 |
6 |
Therapeutic Potential for Modulation of Nrf2-Keap-1 Signaling Pathway as Treatment for Diabetes and Other Disorders. |
Therachem Research Medilab (India) |
| 27031670 |
16 |
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. |
Astex Pharmaceuticals |
| 26363505 |
9 |
Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. |
University of Illinois At Chicago |
| 24512214 |
7 |
Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis. |
China Pharmaceutical University |
| 32046917 |
8 |
Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. |
The State University of New Jersey |
| 32324396 |
17 |
p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
China Pharmaceutical University |
| 32142281 |
24 |
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases. |
Genentech |
| 32435379 |
20 |
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction. |
Irbm |
| 31898999 |
42 |
Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators. |
Biogen |
| 32292559 |
15 |
Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors. |
University of Illinois At Chicago |
| 27409246 |
10 |
Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1. |
China Pharmaceutical University |
| 31735576 |
3 |
Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases. |
China Pharmaceutical University |
| 30973731 |
33 |
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. |
Astex Pharmaceuticals |
| 31411465 |
52 |
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity. |
University of Copenhagen |
| 31283229 |
41 |
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. |
China Pharmaceutical University |
| 31531189 |
12 |
Modulators of KEAP-1 Activity as Potential Therapies for the Treatment of Neurodegenerative Disorders. |
Temple University |
| 23647822 |
3 |
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. |
Biogen Idec |
| 23562243 |
11 |
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. |
The State University of New Jersey |
| 29534931 |
7 |
Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction. |
University of East Anglia |
| 30122040 |
23 |
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. |
University of Illinois At Chicago |
| 29750408 |
16 |
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases. |
University of Copenhagen |
| 29407955 |
2 |
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway. |
China Pharmaceutical University |
| 29117896 |
7 |
Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency. |
China Pharmaceutical University |
| 29037947 |
8 |
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor. |
Keio University |
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