The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
24405703 |
72 |
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.![EBI](/images/logo_chembl.png) |
Janssen Research and Development |
24153205 |
21 |
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.![EBI](/images/logo_chembl.png) |
Janssen Research and Development |
23395660 |
48 |
Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization.![EBI](/images/logo_chembl.png) |
Sanofi-Aventis Deutschland |
23265904 |
54 |
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).![EBI](/images/logo_chembl.png) |
Merck Research Laboratories |
21661758 |
39 |
Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
22101133 |
26 |
Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
22047692 |
50 |
Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
22209206 |
35 |
Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
21924609 |
28 |
Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
21871798 |
39 |
Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
21324691 |
24 |
N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors.![EBI](/images/logo_chembl.png) |
Pfizer |
20933412 |
83 |
2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
20137926 |
43 |
SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
20004097 |
36 |
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
19632834 |
16 |
Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.![EBI](/images/logo_chembl.png) |
Merck Frosst Centre For Therapeutic Research |
19577469 |
30 |
Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.![EBI](/images/logo_chembl.png) |
Gilead Sciences |
19394219 |
40 |
Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.![EBI](/images/logo_chembl.png) |
Cv Therapeutics |
27660693 |
11 |
T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
30248655 |
64 |
Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity.![EBI](/images/logo_chembl.png) |
Japan Tobacco |