The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27369451 |
37 |
Discovery of a novel small molecule agonist scaffold for the APJ receptor. |
Rti International |
| 26986036 |
73 |
Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. |
Universit£ |
| 25668242 |
94 |
C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. |
Universit£ |
| 25241924 |
47 |
The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor. |
Novartis Institutes For Biomedical Research |
| 24755525 |
33 |
Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity. |
Rti International |
| 23010269 |
145 |
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. |
Sanford-Burnham Medical Research Institute |
| 31948845 |
126 |
Identification of potent pyrazole based APELIN receptor (APJ) agonists. |
Rti International |
| 32035698 |
40 |
Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ. |
Bristol-Myers Squibb Research and Development |
| 30690406 |
10 |
Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents. |
University of Alberta |
| 29939744 |
179 |
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. |
Shanghaitech University |
| 31724863 |
29 |
Biphenyl Acid Derivatives as APJ Receptor Agonists. |
Bristol-Myers Squibb |
| 29461833 |
71 |
A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects. |
Universit£ |
| 25379648 |
6 |
Quinone reductase 2 is an adventitious target of protein kinase CK2 inhibitors TBBz (TBI) and DMAT. |
University of Western Ontario |
| 21111404 |
19 |
Preparation of triazole-linked glycosylated ??????-ketocarboxylic acid derivatives as new PTP1B inhibitors. |
East China University of Science and Technology |
| 17378546 |
325 |
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
St. Jude Research Hospital |
| 16112862 |
9 |
Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency. |
Schering-Plough Research Institute |
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