The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
27997164 |
18 |
Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting thea |
Universit£ |
27774126 |
95 |
Exploring |
University of California San Francisco |
26753814 |
7 |
Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dualaVß3 anda5ß1 integrin ligands. |
University of Florence |
24949551 |
22 |
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. |
Philipps-Universit£T Marburg |
24973662 |
8 |
Targeting integrinsavß3 anda5ß1 with newß-lactam derivatives. |
University of Bologna |
24654918 |
19 |
Pharmacophoric modifications lead to superpotentavß3 integrin ligands with suppresseda5ß1 activity. |
Technische Universit£T M£Nchen |
24900800 |
46 |
Small Macrocycles As Highly Active Integrin?2?1 Antagonists. |
Sanofi R & D |
24095096 |
3 |
Synthesis and in vitro evaluation of a novel radioligand foravß3 integrin receptor imaging: [18F]FPPA-c(RGDfK). |
University Hospital of Geneva |
23811088 |
26 |
Modulation ofavß3- anda5ß1-integrin-mediated adhesion by dehydro-ß-amino acids containing peptidomimetics. |
University of Bologna |
23562062 |
4 |
Arylsulfonamide pyrimidines as VLA-4 antagonists. |
Elan Pharmaceuticals |
23362923 |
59 |
Biselectivity of isoDGR peptides for fibronectin binding integrin subtypesa5ß1 andavß6: conformational control through flanking amino acids. |
Technische Universit£T M£Nchen |
19959360 |
50 |
SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists. |
Jerini |
19910191 |
46 |
Discovery of orally available integrin alpha5beta1 antagonists. |
Jerini |
7650686 |
3 |
Non-peptide fibrinogen receptor antagonists. 7. Design and synthesis of a potent, orally active fibrinogen receptor antagonist. |
Merck Research Laboratories |
22575869 |
61 |
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targetinga5ß1: part 1. |
Astrazeneca |
22572578 |
124 |
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targetinga5ß1: part 2. |
Astrazeneca |
20055426 |
30 |
Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics. |
Universita Degli Studi Di Bologna |
18331794 |
20 |
Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors. |
Millennium Pharmaceuticals |
18303826 |
48 |
Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. |
Universit£ |
15357991 |
20 |
Design, synthesis, and biochemical evaluation of novel alpha V beta 3 integrin ligands. |
3-Dimensional Pharmaceuticals |
12139455 |
78 |
Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents. |
Genentech |
9191954 |
9 |
Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. |
Merck Research Laboratories |
20172716 |
3 |
Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation. |
Universit£ |
17973471 |
24 |
Multiple N-methylation by a designed approach enhances receptor selectivity. |
Technische UniversitäT MüNchen |
17869121 |
32 |
Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds. |
Università |
17616113 |
63 |
Design and synthesis of a new class of selective integrin alpha5beta1 antagonists. |
Jerini |
15974570 |
30 |
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists. |
Università |
15715463 |
16 |
Design, synthesis, and biological evaluation of novel potent and selective alphavbeta3/alphavbeta5 integrin dual inhibitors with improved bioavailability. Selection of the molecular core. |
Johnson and Johnson Pharmaceutical Research & Development |
15109641 |
4 |
Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents. |
Riken Discovery Research Institute |
14741263 |
67 |
Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin alphaVbeta3. |
Nerviano |
14698164 |
39 |
Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds. |
Pharmaceutical Research Institute |
12852971 |
8 |
Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide. |
Kyowa Hakko Kogyo |
12699755 |
4 |
Nonpeptide RGD antagonists: a novel class of mimetics, the 5,8-disubstituted 1-azabicyclo[5.2.0]nonan-2-one lactam. |
University of Montpellier |
12565960 |
33 |
Thiophene-based vitronectin receptor antagonists. |
Shire Biochem |
11677134 |
42 |
Design and synthesis of potent and selective inhibitors of integrin VLA-4. |
Novartis Institute For Biomedical Research |
32094009 |
36 |
Novel cilengitide-based cyclic RGD peptides as ?v? |
Division of Organic Chemistry Csir-National Chemical Laboratory (Ncl) |
11327582 |
23 |
2-Acylimino-3H-thiazoline derivatives: a novel template for platelet GPIIb/IIIa receptor antagonists. |
Taisho Pharmaceutical |
10853677 |
34 |
Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists. |
Celltech Chiroscience |
30657681 |
262 |
Selective Targeting of Integrin ?v?8 by a Highly Active Cyclic Peptide. |
Technische Universit£T M£Nchen |
10072689 |
39 |
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
Biogen |
31306009 |
64 |
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling. |
Bielefeld University |
31670514 |
45 |
Could Dissecting the Molecular Framework of ?-Lactam Integrin Ligands Enhance Selectivity? |
University of Bologna |
9016328 |
19 |
Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists. |
Dupont Pharmaceuticals |
26101577 |
15 |
Dehydro-?-proline Containing ?4?1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay. |
University of Bologna |
24568695 |
76 |
Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists. |
University of Bradford |
8057299 |
66 |
Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp. |
Merck Research Laboratories |
7507165 |
139 |
Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin alpha IIb beta 3 antagonists. |
Telios Pharmaceuticals |
30215258 |
228 |
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic ? |
University of Strathclyde |
29775303 |
60 |
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme. |
Universit£ |
28135089 |
9 |
Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins. |
University of Strathclyde |
1469694 |
22 |
Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. |
Merck Research Laboratories |
17915848 |
48 |
Small molecule inhibitors of integrin alpha2beta1. |
University of Pennsylvania |