The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
8393112 |
12 |
Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains. |
Warner-Lambert |
3346869 |
16 |
7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
Warner-Lambert |
15125947 |
38 |
Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity. |
Dainippon Pharmaceutical |
11378377 |
11 |
Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues. |
Aventis Pharma |
9871636 |
17 |
DNA gyrase inhibitory activity of ellagic acid derivatives. |
R. W. Johnson Pharmaceutical Research Institute |
27569197 |
30 |
Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB. |
R. C. Patel Institute of Pharmaceutical Education and Research |
27541007 |
45 |
Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors. |
University of Ljubljana |
26363871 |
7 |
Discovery of WQ-3810: Design, synthesis, and evaluation of 7-(3-alkylaminoazetidin-1-yl)fluoro-quinolones as orally active antibacterial agents. |
Wakunaga Pharmaceutical |
25286019 |
18 |
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
Astrazeneca |
26098163 |
66 |
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site. |
University of Ljubljana |
25951434 |
4 |
Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids. |
Medical University |
25238443 |
11 |
Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
University of Hawaii At Hilo |
15715489 |
4 |
Chiral DNA gyrase inhibitors. 3. Probing the chiral preference of the active site of DNA gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9-piperazinyl- 2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues. |
University of Kansas |
18347114 |
56 |
Biological activities of novel gyrase inhibitors of the aminocoumarin class. |
UniversitäT TüBingen |
18268084 |
2 |
DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties. |
The University of Queensland |
17064062 |
4 |
3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. |
Pfizer |
16392790 |
12 |
Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. |
Achillion Pharmaceuticals |
16337791 |
34 |
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells. |
Achillion Pharmaceuticals |
14623007 |
5 |
Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. |
Morphochem |
32234278 |
11 |
Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase. |
University of Iowa |
32634310 |
8 |
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria. |
Novartis Institutes For Biomedical Research |
30846404 |
34 |
Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase. |
Nanjing University |
31789518 |
11 |
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. |
Purdue University |
31279292 |
3 |
Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. |
Medical University of Gdansk |
31276392 |
176 |
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens. |
Angelini |
31015103 |
2 |
1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents. |
Henan University of Chinese Medicine |
30962087 |
21 |
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase. |
Glaxosmithkline |
25317480 |
4 |
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability. |
Vertex Pharmaceuticals |
24882676 |
6 |
Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: design, synthesis and evaluation as antibacterial agent. |
Jishou University |
16087337 |
6 |
Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles. |
Dainippon Pharmaceutical |
15214796 |
5 |
Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivatives. |
Dainippon Pharmaceutical |
12904069 |
24 |
Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens. |
Procter & Gamble Pharmaceuticals |
8960555 |
13 |
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy. |
Universit£ |
8385225 |
16 |
Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
Warner-Lambert |
30125722 |
34 |
Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. |
Experimental Therapeutics Centre |
29529504 |
2 |
Synthesis and antimycobacterial activity of 1-(?-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole. |
University of Delhi |
29596745 |
13 |
Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. |
Sanofi R&D |
29778894 |
30 |
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity. |
University of Ljubljana |
29661533 |
7 |
Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase. |
University of Iowa |
27689732 |
30 |
Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B. |
University of Ljubljana |
18022567 |
34 |
Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. |
Vanderbilt University |
18690678 |
66 |
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. |
Vertex Pharmaceuticals |