47 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
8393112	12	Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains.	Warner-Lambert
3346869	16	7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.	Warner-Lambert
15125947	38	Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.	Dainippon Pharmaceutical
11378377	11	Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues.	Aventis Pharma
9871636	17	DNA gyrase inhibitory activity of ellagic acid derivatives.	R. W. Johnson Pharmaceutical Research Institute
26363871	7	Discovery of WQ-3810: Design, synthesis, and evaluation of 7-(3-alkylaminoazetidin-1-yl)fluoro-quinolones as orally active antibacterial agents.	Wakunaga Pharmaceutical
25286019	18	Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization.	Astrazeneca
26098163	66	Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.	University of Ljubljana
25951434	4	Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.	Medical University
25238443	11	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.	University of Hawaii At Hilo
15715489	4	Chiral DNA gyrase inhibitors. 3. Probing the chiral preference of the active site of DNA gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9-piperazinyl- 2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues.	University of Kansas
18268084	2	DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties.	The University of Queensland
17064062	4	3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.	Pfizer
16392790	12	Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents.	Achillion Pharmaceuticals
16337791	34	Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.	Achillion Pharmaceuticals
14623007	5	Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.	Morphochem
32234278	11	Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase.	University of Iowa
32634310	8	Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.	Novartis Institutes For Biomedical Research
32027491	4	Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs).	National Institute of Chemistry
30846404	34	Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase.	Nanjing University
31279292	3	Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents.	Medical University of Gdansk
31276392	176	Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.	Angelini
31015103	2	1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents.	Henan University of Chinese Medicine
30962087	21	Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.	Glaxosmithkline
25317480	4	Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.	Vertex Pharmaceuticals
24882676	6	Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: design, synthesis and evaluation as antibacterial agent.	Jishou University
20404126	20	Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.	University of Minnesota Medical School
16087337	6	Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles.	Dainippon Pharmaceutical
15214796	5	Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivatives.	Dainippon Pharmaceutical
12904069	24	Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.	Procter & Gamble Pharmaceuticals
8960555	13	Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.	Universit£
8385225	16	Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.	Warner-Lambert
29727185	2	Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.	Ptc Therapeutics
29596745	13	Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.	Sanofi R&D
29661533	7	Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.	University of Iowa
18690678	66	Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.	Vertex Pharmaceuticals