18 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28237763	43	Continued optimization of the M	Vanderbilt University School of Medicine
27939174	84	Challenges in the development of an M	Vanderbilt University Medical Center
25542588	80	Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges.	Vanderbilt University Medical Center
25147929	105	Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).	Vanderbilt University Medical Center
24164599	9	Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).	Vanderbilt University
23562060	9	Discovery of ML326: The first sub-micromolar, selective M5 PAM.	Vanderbilt University Medical Center
23379472	187	Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.	University of Arkansas For Medical Sciences
23200253	67	Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism.	Vanderbilt University Medical Center
23177787	59	Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.	Vanderbilt University Medical Center
18178088	64	Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.	Vanderbilt Institute of Chemical Biology
21930376	92	Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.	Vanderbilt University Medical Center
18059262	9	An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.	Dvanderbilt Program In Drug Discovery
6747997	23	cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-phenyl-2H-pyrazino[2,1-a] isoquinoline: a new atypical antidepressant.	TBA
29652494	18	Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand.	University of Shizuoka
28633897	73	Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.	Vanderbilt University School of Medicine
28442253	68	Optimization of M	Vanderbilt University Medical Center