21 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28122186	2	Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway.	Sapienza University of Rome
27736063	34	Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists.	University of Chinese Academy of Sciences
27429255	22	Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives.	Universit£
26119500	22	Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors.	Soochow University
23063522	8	Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.	Duke University Medical Center
23036954	27	Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists.	Genomics Institute of The Novartis Research Foundation
23074541	38	Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.	TBA
24900436	18	Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.	TBA
19091559	59	Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.	Novartis Institutes For Biomedical Research
21840217	22	Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.	Amgen
20594845	30	Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.	Amgen
20493695	36	Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.	Amgen
19469545	140	1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.	Novartis Institutes For Biomedical Research
31862310	57	Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).	Astrazeneca
31408335	36	Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor.	Shanghaitech University
30939349	39	Structural optimization on a virtual screening hit of smoothened receptor.	Soochow University
30896941	31	Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors.	University of Connecticut
30025349	25	Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.	Sapienza University of Rome
29499483	10	Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor.	Soochow University
29857275	50	Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.	Soochow University