The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 15887951 |
29 |
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. |
Monash University (Parkville Campus) |
| 16913726 |
33 |
Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction. |
Università |
| 15006407 |
15 |
Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 12668004 |
76 |
Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors. |
Pfizer |
| 32171616 |
32 |
Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease. |
Changzhou University |
| 31235264 |
13 |
Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. |
Mitsubishi Tanabe Pharma |
| 30986068 |
112 |
Structure Overhaul Affords a Potent Purine PI3K? Inhibitor with Improved Tolerability. |
TBA |
| 25062128 |
16 |
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). |
Amgen |
| 23867165 |
21 |
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. |
Chinese Academy of Sciences |
Search and Browse
