The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
15887966 |
58 |
Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring. |
Central Pharmaceutical Research Institute |
12904065 |
30 |
Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide. |
Lg Life Sciences |
11170646 |
106 |
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa. |
Dupont Pharmaceuticals |
10794696 |
233 |
Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1. |
Universit£ |
9836616 |
92 |
Tetrahydro-isoquinoline-based factor Xa inhibitors. |
Boehringer Mannheim |
16137886 |
88 |
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization. |
Merck Research Laboratories |
15501047 |
75 |
Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa. |
Merck |
11960487 |
30 |
Structure-based design of novel potent nonpeptide thrombin inhibitors. |
Boehringer Ingelheim Pharma |
11689072 |
49 |
Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator. |
Axys Pharmaceuticals |
9822554 |
14 |
1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
9484495 |
74 |
Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa. |
Collegeville |