The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
15771450 |
42 |
Synthesis of new benzoxazinone derivatives as neuropeptide Y5 antagonists for the treatment of obesity. |
Laboratorios Dr. Esteve |
21924902 |
43 |
5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists. |
Lundbeck Research Usa |
21782428 |
61 |
Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder. |
Lundbeck Research Usa |
19720539 |
32 |
Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. |
Tsukuba Research Institute |
19464889 |
43 |
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists. |
Tsukuba Research Institute |
15109631 |
86 |
Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. |
Novartis Pharma |
12593645 |
2 |
In vitro and in vivo characterization of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt, a potent and selective NPY5 receptor antagonist. |
Pfizer |
12139462 |
34 |
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. |
Astrazeneca |
12067557 |
24 |
Discovery of potent and selective small molecule NPY Y5 receptor antagonists. |
Lundbeck Research Usa |
10866375 |
50 |
Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. |
Novartis Pharma |
9925722 |
18 |
Pharmacological treatment of obesity: therapeutic strategies. |
The R. W. Johnson Pharmaceutical Research Institute |