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The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
16854068 59 Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.EBI Wyeth Research