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The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
21550809 44 Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.EBI Duquesne University