The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28111141 |
58 |
The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics. |
Merck |
| 27017115 |
77 |
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation. |
Merck Research Laboratories |
| 26191360 |
99 |
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. |
Merck Research Laboratories |
| 24075732 |
43 |
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one. |
Merck Research Laboratories |
| 24900480 |
75 |
Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics. |
TBA |
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