Entries for Covid-19

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PMID	Data	Article Title	Citation	Organization	Files Download
32935104	0	Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19.	NA	Pfizer Inc.
32803196	0	Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening.	NA	National Institutes of Health
32747425	0	3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.	NA	Wichita State University
32428392	0	Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease.	NA	University of Georgia
32321856	0	Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.	NA	Shanghai Institute of Materia Medica
32272481	0	Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors	NA	ShanghaiTech University
32198291	0	Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved ?-ketoamide inhibitors.	NA	TBA
29544147	0	Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.	NA	Wichita State University
27240464	24	Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.	Bioorg Med Chem 24: 3035-3042 (2016)	Academia Sinica
25746232	16	Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.	ACS Chem Biol 10: 1456-65 (2015)	University of Illinois at Chicago	2D 3D
24332657	0	Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.	NA	University of Illinois at Chicago
24316352	0	Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.	NA	Tianjin University of Science and Technology
24125888	0	Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.	NA	Kansas State University
23647823	0	Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.	NA	Korea Research Institute of Bioscience and Biotechnology
23323951	10	Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.	J Enzyme Inhib Med Chem 29: 59-63 (2014)	Gyeongsang National University
23202846	0	Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases.	NA	The Chinese University of Hong Kong
22884354	36	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.	Bioorg Med Chem 20: 5928-35 (2012)	Korea Research Institute of Bioscience and Biotechnology	2D 3D
21470860	9	Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation.	Bioorg Med Chem Lett 21: 3088-91 (2011)	Chonnam National University	2D 3D
20947359	0	Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors.	NA	Academia Sinica
20934345	0	Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.	NA	Korea Research Institute of Bioscience and Biotechnology
20167482	0	SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.	NA	Korea Research Institute of Bioscience and Biotechnology
19645480	24	Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease.	J Med Chem 52: 5228-40 (2009)	Purdue University	2D 3D
19625187	22	Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.	Bioorg Med Chem Lett 19: 4538-41 (2009)	Konkuk University	2D 3D
19540764	0	Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.	NA	National Human Genome Research Institute
19362479	0	New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.	NA	Kyoto Pharmaceutical University
19233643	16	Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.	Bioorg Med Chem Lett 19: 1636-8 (2009)	Konkuk University	2D 3D
19144641	8	Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds.	J Biol Chem 284: 7646-55 (2009)	National Yang-Ming University	2D 3D
18343121	2	Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits.	Bioorg Med Chem 16: 4138-49 (2008)	University of Mississippi	2D 3D
17855091	0	Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.	NA	Purdue University
17709464	0	Novel small-molecule inhibitors of transmissible gastroenteritis virus.	NA	National Health Research Institute
17381079	8	Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.	J Med Chem 50: 1850-64 (2007)	University of Alberta	2D 3D
16913704	21	Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.	J Med Chem 49: 5154-61 (2006)	National Defense Medical Center	2D 3D
16884309	5	Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.	J Med Chem 49: 4971-80 (2006)	TaiGen Biotechnology Co.	2D 3D
16759091	28	Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies.	J Med Chem 49: 3485-95 (2006)	National Tsing Hua University	2D 3D
16759084	12	Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.	J Med Chem 49: 3440-3 (2006)	Peking University	2D 3D
16638531	16	Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.	Chem Biol 13: 261-8 (2006)	Academia Sinica	2D 3D
16250632	2	Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.	J Med Chem 48: 6767-71 (2005)	Purdue University	2D 3D
15994085	21	Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.	Bioorg Med Chem 13: 5240-52 (2005)	National Taiwan University	2D 3D
15974598	9	Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease.	J Med Chem 48: 4469-73 (2005)	National Taiwan University	2D 3D
15950190	0	Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease.	NA	National Taiwan University
15896959	14	Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors.	Bioorg Med Chem Lett 15: 3058-62 (2005)	Development Center for Biotechnology	2D 3D
	0	Discovery of potent inhibitors of PLproCoV2 by screening a library of selenium-containing compounds	NA	University ofAmsterdam
US9975885	0	Broad-spectrum non-covalent coronavirus protease inhibitors	NA	PURDUE RESEARCH FOUNDATION

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