BDBM50038178 (+)-4-Amino-3-isoxazolidinone::(4R)-4-aminoisoxazolidin-3-one::(R)-4-AMINO-ISOXAZOLIDIN-3-ONE::CHEMBL771::D-CYCLOSERINE::alpha-Cycloserine::cycloserine

SMILES: N[C@@H]1CON=C1O

InChI Key: InChIKey=DYDCUQKUCUHJBH-UWTATZPHSA-N

Data: 1 KI  2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038178   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proton-coupled amino acid transporter 1 (Homo sapiens (Human))	BDBM50038178 ((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...) Show SMILES N[C@@H]1CON=C1O |r,c:4| Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	4.40E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting				Bioorg Med Chem 19: 6409-18 (2011) Checked by Author Article DOI: 10.1016/j.bmc.2011.08.058 BindingDB Entry DOI: 10.7270/Q2NZ882D
					More data for this Ligand-Target Pair
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (Staphylococcus epidermidis (strain ATCC 35984 / RP...)	BDBM50038178 ((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...) Show SMILES N[C@@H]1CON=C1O |r,c:4| Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Antibacterial activity against D-alanyl-D-alanine ligase from Streptococcus faecalis (ATCC 8043)				J Med Chem 31: 1772-8 (1988) BindingDB Entry DOI: 10.7270/Q24B31XZ
					More data for this Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C) (Rattus norvegicus (Rat))	BDBM50038178 ((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...) Show SMILES N[C@@H]1CON=C1O |r,c:4| Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.81E+4	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for in vitro inhibition of [3H]-TCP at NMDA receptor.				J Med Chem 37: 4053-67 (1995) BindingDB Entry DOI: 10.7270/Q2JM28PT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50038178 ((+)-4-Amino-3-isoxazolidinone | (4R)-4-aminoisoxaz...) Show SMILES N[C@@H]1CON=C1O |r,c:4| Show InChI InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor				Bioorg Med Chem Lett 9: 1409-14 (1999) BindingDB Entry DOI: 10.7270/Q2W0954Z
					More data for this Ligand-Target Pair