Found 16 hits for monomerid = 50056445 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn
Curated by ChEMBL
| Assay Description Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT. |
J Med Chem 40: 639-46 (1997)
Article DOI: 10.1021/jm960360q BindingDB Entry DOI: 10.7270/Q29P30R9 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn
Curated by ChEMBL
| Assay Description Binding affinity towards Dopamine receptor D2 by displacement of [3H]-U-86,170. |
J Med Chem 40: 639-46 (1997)
Article DOI: 10.1021/jm960360q BindingDB Entry DOI: 10.7270/Q29P30R9 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [125]iodosulpride from human recombinant dopamine D2L receptor expressed in CHO cells after 30 mins |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
Reactome pathway KEGG
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| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas at Austin
Curated by ChEMBL
| Assay Description Affinity towards Dopamine receptor D2 |
J Med Chem 41: 4385-99 (1998)
Article DOI: 10.1021/jm9800292 BindingDB Entry DOI: 10.7270/Q2R21227 |
More data for this Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
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| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn
Curated by ChEMBL
| Assay Description Binding affinity towards Dopamine receptor D3 by displacement of [3H]-(+)-7-OH-DPAT. |
J Med Chem 40: 639-46 (1997)
Article DOI: 10.1021/jm960360q BindingDB Entry DOI: 10.7270/Q29P30R9 |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
KEGG
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| DrugBank Article PubMed
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas at Austin
Curated by ChEMBL
| Assay Description Affinity towards Dopamine receptor D1 |
J Med Chem 41: 4385-99 (1998)
Article DOI: 10.1021/jm9800292 BindingDB Entry DOI: 10.7270/Q2R21227 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 6.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cerebrus Ltd
Curated by PDSP Ki Database
| |
Br J Pharmacol 128: 13-20 (1999)
Article DOI: 10.1038/sj.bjp.0702751 BindingDB Entry DOI: 10.7270/Q2GH9GH2 |
More data for this Ligand-Target Pair | |
Serotonin 1d (5-HT1d) receptor
(Sus scrofa) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity for 5-hydroxytryptamine 1D receptor in piglet caudate using [3H]5-HT |
J Med Chem 36: 1918-9 (1993)
Article DOI: 10.1021/jm00065a015 BindingDB Entry DOI: 10.7270/Q2JS9SNZ |
More data for this Ligand-Target Pair | |
Serotonin 2 (5-HT2) receptor
(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | >5.01E+3 | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity for 5-hydroxytryptamine 2 receptor in rat cortex using [3H]- ketanserin |
J Med Chem 36: 1918-9 (1993)
Article DOI: 10.1021/jm00065a015 BindingDB Entry DOI: 10.7270/Q2JS9SNZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | n/a | 5.01E+4 | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity for 5-hydroxytryptamine 1C receptor in piglet choroid plexus using [3H]5-HT |
J Med Chem 36: 1918-9 (1993)
Article DOI: 10.1021/jm00065a015 BindingDB Entry DOI: 10.7270/Q2JS9SNZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity for 5-hydroxytryptamine 1A receptor in piglet hippocampus using [3H]8-OH-DPAT |
J Med Chem 36: 1918-9 (1993)
Article DOI: 10.1021/jm00065a015 BindingDB Entry DOI: 10.7270/Q2JS9SNZ |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
Reactome pathway KEGG
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| n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a |
University of Texas
Curated by ChEMBL
| Assay Description In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes. |
J Med Chem 43: 3005-19 (2000)
BindingDB Entry DOI: 10.7270/Q24J0FS2 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
Reactome pathway KEGG
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| n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a |
University of Texas
Curated by ChEMBL
| Assay Description In vitro affinity at mutant D2 receptor (S197A) in C6 (glioma) cell membranes. |
J Med Chem 43: 3005-19 (2000)
BindingDB Entry DOI: 10.7270/Q24J0FS2 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
Reactome pathway KEGG
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| n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a |
University of Texas
Curated by ChEMBL
| Assay Description In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes. |
J Med Chem 43: 3005-19 (2000)
BindingDB Entry DOI: 10.7270/Q24J0FS2 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | Reactome pathway KEGG
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| n/a | n/a | n/a | n/a | 89 | n/a | n/a | n/a | n/a |
University of Pennsylvania
Curated by ChEMBL
| Assay Description Agonist activity at recombinant human D4 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins... |
J Med Chem 62: 5132-5147 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00412 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
Reactome pathway KEGG
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| n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a |
University of Texas
Curated by ChEMBL
| Assay Description In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes. |
J Med Chem 43: 3005-19 (2000)
BindingDB Entry DOI: 10.7270/Q24J0FS2 |
More data for this Ligand-Target Pair | |