BindingDB PrimarySearch

BDBM50209218 4',5,6,7,8-pentamethoxyflavone::5,6,7,8,4'-Pentamethoxyflavone::5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one::CHEMBL73930::Tangeretin

SMILES: COc1ccc(cc1)-c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1

InChI Key: InChIKey=ULSUXBXHSYSGDT-UHFFFAOYSA-N

Data: 2 KI 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50209218
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Delta-type opioid receptor (MOUSE)	BDBM50209218 (4',5,6,7,8-pentamethoxyflavone \| 5,6,7,8,4'-Pentam...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Research Council Curated by ChEMBL					Assay Description Displacement of [3H]DPDPE from delta opioid receptor in CD1 mouse whole brain minus cerebellum membranes by liquid scintillation counting				J Nat Prod 78: 69-76 (2015) Article DOI: 10.1021/np500671v BindingDB Entry DOI: 10.7270/Q2Q52R9R
National Research Council Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (MOUSE)	BDBM50209218 (4',5,6,7,8-pentamethoxyflavone \| 5,6,7,8,4'-Pentam...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.63E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Research Council Curated by ChEMBL					Assay Description Displacement of [3H]DAMGO from mu opioid receptor in CD1 mouse whole brain minus cerebellum membranes by liquid scintillation counting				J Nat Prod 78: 69-76 (2015) Article DOI: 10.1021/np500671v BindingDB Entry DOI: 10.7270/Q2Q52R9R
National Research Council Curated by ChEMBL					More data for this Ligand-Target Pair
P-glycoprotein 1 (Homo sapiens (Human))	BDBM50209218 (4',5,6,7,8-pentamethoxyflavone \| 5,6,7,8,4'-Pentam...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometry				Bioorg Med Chem 19: 2090-102 (2011) Article DOI: 10.1016/j.bmc.2010.12.043 BindingDB Entry DOI: 10.7270/Q2PZ593F
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Homo sapiens (Human))	BDBM50209218 (4',5,6,7,8-pentamethoxyflavone \| 5,6,7,8,4'-Pentam...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry				J Nat Prod 61: 71-6 (1998) Article DOI: 10.1021/np970237h BindingDB Entry DOI: 10.7270/Q29C6Z93
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50209218 (4',5,6,7,8-pentamethoxyflavone \| 5,6,7,8,4'-Pentam...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.63E+6	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease-mediated ammonia production preincubated for 1.5 hrs by indophenol method				Eur J Med Chem 63: 685-95 (2013) Article DOI: 10.1016/j.ejmech.2013.03.016 BindingDB Entry DOI: 10.7270/Q2D79FB1
Jishou University Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family G member 2 (Homo sapiens (Human))	BDBM50209218 (4',5,6,7,8-pentamethoxyflavone \| 5,6,7,8,4'-Pentam...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining				Bioorg Med Chem 19: 2090-102 (2011) Article DOI: 10.1016/j.bmc.2010.12.043 BindingDB Entry DOI: 10.7270/Q2PZ593F
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family G member 2 (Homo sapiens (Human))	BDBM50209218 (4',5,6,7,8-pentamethoxyflavone \| 5,6,7,8,4'-Pentam...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining				Bioorg Med Chem 19: 2090-102 (2011) Article DOI: 10.1016/j.bmc.2010.12.043 BindingDB Entry DOI: 10.7270/Q2PZ593F
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair