BindingDB PrimarySearch

BDBM50004852 AMAA::Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-acetic acid::Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-acetic acid (D-AMAA)::CHEMBL280585

SMILES: Cc1o[nH]c(=O)c1C(N)C(O)=O

InChI Key: InChIKey=XIHYCWZNHQMZSX-UHFFFAOYSA-N

Data: 6 KI 6 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50004852
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 189: 381-91 (1990) Article DOI: 10.1016/0922-4106(90)90035-v BindingDB Entry DOI: 10.7270/Q2MW2FNT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 189: 381-91 (1990) Article DOI: 10.1016/0922-4106(90)90035-v BindingDB Entry DOI: 10.7270/Q2MW2FNT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 189: 381-91 (1990) Article DOI: 10.1016/0922-4106(90)90035-v BindingDB Entry DOI: 10.7270/Q2MW2FNT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 189: 381-91 (1990) Article DOI: 10.1016/0922-4106(90)90035-v BindingDB Entry DOI: 10.7270/Q2MW2FNT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 189: 381-91 (1990) Article DOI: 10.1016/0922-4106(90)90035-v BindingDB Entry DOI: 10.7270/Q2MW2FNT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 189: 381-91 (1990) Article DOI: 10.1016/0922-4106(90)90035-v BindingDB Entry DOI: 10.7270/Q2MW2FNT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha				J Med Chem 39: 3188-94 (1996) Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6				J Med Chem 39: 3188-94 (1996) Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for agonistic activity against mGluR2 alpha metabotropic receptor subtype in rat cortical slice model				Bioorg Med Chem Lett 8: 1563-8 (1999) BindingDB Entry DOI: 10.7270/Q27P8XJ2
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for agonistic activity against mGluR4a alpha metabotropic receptor subtype in rat cortical slice model				Bioorg Med Chem Lett 8: 1563-8 (1999) BindingDB Entry DOI: 10.7270/Q27P8XJ2
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2				J Med Chem 39: 3188-94 (1996) Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50004852 (AMAA \| Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...) Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for agonistic activity against mGluR1 alpha metabotropic receptor subtype in rat cortical slice model				Bioorg Med Chem Lett 8: 1563-8 (1999) BindingDB Entry DOI: 10.7270/Q27P8XJ2
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair