BDBM102175 US9695165, 11

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2CCN(C(=O)C=C)c2c1

InChI Key: InChIKey=MVPPFNHYNCOQCT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 102175   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102175 (US9695165, 11) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2CCN(C(=O)C=C)c2c1 Show InChI InChI=1S/C27H21Cl2N3O3/c1-4-23(33)32-10-9-15-5-6-17(12-20(15)32)27-30-14-18-11-16(7-8-19(18)31-27)24-25(28)21(34-2)13-22(35-3)26(24)29/h4-8,11-14H,1,9-10H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair