BDBM102226 US9695165, 22

SMILES: CCN1C(=O)N(Cc2cnc(cc12)-c1cccc(NC(=O)C=C)c1)c1c(Cl)c(OC)cc(OC)c1Cl

InChI Key: InChIKey=PGKOVECYHRNFSL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102226   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102226 (US9695165, 22) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cccc(NC(=O)C=C)c1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H24Cl2N4O4/c1-5-22(33)30-17-9-7-8-15(10-17)18-11-19-16(13-29-18)14-32(26(34)31(19)6-2)25-23(27)20(35-3)12-21(36-4)24(25)28/h5,7-13H,1,6,14H2,2-4H3,(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102226 (US9695165, 22) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cccc(NC(=O)C=C)c1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H24Cl2N4O4/c1-5-22(33)30-17-9-7-8-15(10-17)18-11-19-16(13-29-18)14-32(26(34)31(19)6-2)25-23(27)20(35-3)12-21(36-4)24(25)28/h5,7-13H,1,6,14H2,2-4H3,(H,30,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair