BDBM102277 US9695165, 25

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C

InChI Key: InChIKey=PXZAJVXHFXMMSO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102277 (US9695165, 25) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C |(-4,8.09,;-4,6.54,;-2.67,5.77,;-1.33,6.54,;,5.77,;1.33,6.55,;2.67,5.78,;,4.23,;1.33,3.47,;-1.33,3.46,;-2.67,4.23,;-4,3.46,;-1.33,1.92,;-2.67,1.15,;-2.67,-.39,;-4,-1.16,;-4,-2.7,;-2.67,-3.47,;-1.33,-2.7,;-1.33,-1.16,;,-.39,;1.33,-1.16,;2.67,-.38,;1.33,-2.69,;,1.15,;1.33,1.92,;-2.67,-5.01,;-4,-5.78,;-4,-7.32,;-2.67,-8.09,;-1.33,-7.32,;-1.33,-5.78,;,-5,;1.33,-5.77,;1.33,-7.31,;2.67,-5,;4,-5.77,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-19-10-8-7-9-17(19)20-12-21-16(14-31-20)11-18(28(35)33(21)15(2)3)25-26(29)22(36-4)13-23(37-5)27(25)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102277 (US9695165, 25) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C |(-4,8.09,;-4,6.54,;-2.67,5.77,;-1.33,6.54,;,5.77,;1.33,6.55,;2.67,5.78,;,4.23,;1.33,3.47,;-1.33,3.46,;-2.67,4.23,;-4,3.46,;-1.33,1.92,;-2.67,1.15,;-2.67,-.39,;-4,-1.16,;-4,-2.7,;-2.67,-3.47,;-1.33,-2.7,;-1.33,-1.16,;,-.39,;1.33,-1.16,;2.67,-.38,;1.33,-2.69,;,1.15,;1.33,1.92,;-2.67,-5.01,;-4,-5.78,;-4,-7.32,;-2.67,-8.09,;-1.33,-7.32,;-1.33,-5.78,;,-5,;1.33,-5.77,;1.33,-7.31,;2.67,-5,;4,-5.77,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-19-10-8-7-9-17(19)20-12-21-16(14-31-20)11-18(28(35)33(21)15(2)3)25-26(29)22(36-4)13-23(37-5)27(25)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair