null

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCNCC3)cn2)c2ncccc12

InChI Key: InChIKey=UFQIIMKAJNPQOV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102545   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102545 (US8536175, 167) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCNCC3)cn2)c2ncccc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.34,;8.85,-0,;8.08,1.33,;8.85,2.66,;8.08,4,;6.54,1.33,;5.77,2.66,;5.77,-0,;6.54,-1.34,;5.77,-2.67,;4.23,-0,;3.46,1.33,;1.92,1.33,;1.15,-0,;-.39,-0,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-0,;-5.01,-0,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-0,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,1.33,;-9.63,-0,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)| Show InChI InChI=1S/C28H27Cl2N5O3/c1-37-21-14-22(38-2)26(30)24(25(21)29)18-6-7-20(27-19(18)4-3-9-32-27)28(36)34-23-8-5-17(15-33-23)16-35-12-10-31-11-13-35/h3-9,14-15,31H,10-13,16H2,1-2H3,(H,33,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102545 (US8536175, 167) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCNCC3)cn2)c2ncccc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.34,;8.85,-0,;8.08,1.33,;8.85,2.66,;8.08,4,;6.54,1.33,;5.77,2.66,;5.77,-0,;6.54,-1.34,;5.77,-2.67,;4.23,-0,;3.46,1.33,;1.92,1.33,;1.15,-0,;-.39,-0,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-0,;-5.01,-0,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-0,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,1.33,;-9.63,-0,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)| Show InChI InChI=1S/C28H27Cl2N5O3/c1-37-21-14-22(38-2)26(30)24(25(21)29)18-6-7-20(27-19(18)4-3-9-32-27)28(36)34-23-8-5-17(15-33-23)16-35-12-10-31-11-13-35/h3-9,14-15,31H,10-13,16H2,1-2H3,(H,33,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair