BDBM10257 2-chloro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide::Isoquinoline-1,3,4-trione 6d::N-(1,3,4-Trioxo-1,2,3,4-tetrahydro-isoquinolin-5-yl)-2-chlorobenzamide

SMILES: Clc1ccccc1C(=O)Nc1cccc2C(=O)NC(=O)C(=O)c12

InChI Key: InChIKey=CKKFQWOWQVJSIP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 10257   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Caspase-3 (Homo sapiens (Human))	BDBM10257 (2-chloro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquin...) Show SMILES Clc1ccccc1C(=O)Nc1cccc2C(=O)NC(=O)C(=O)c12 Show InChI InChI=1S/C16H9ClN2O4/c17-10-6-2-1-4-8(10)14(21)18-11-7-3-5-9-12(11)13(20)16(23)19-15(9)22/h1-7H,(H,18,21)(H,19,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	35
Shanghai Institutes for Biological Sciences					Assay Description The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...				J Med Chem 49: 1613-23 (2006) Article DOI: 10.1021/jm050896o BindingDB Entry DOI: 10.7270/Q23N21MB
					More data for this Ligand-Target Pair