null

SMILES: COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1

InChI Key: InChIKey=YSSONUCZBHLAKQ-ROJLCIKYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 102977   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Growth hormone secretagogue receptor type 1 (Homo sapiens (Human))	BDBM102977 (US8546435, 5) Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 |r| Show InChI InChI=1S/C35H33N7O3/c1-45-27-16-14-25(15-17-27)22-42-33(31(38-23-43)19-24-9-3-2-4-10-24)40-41-34(42)32(39-35(44)30-13-7-8-18-36-30)20-26-21-37-29-12-6-5-11-28(26)29/h2-18,21,23,31-32,37H,19-20,22H2,1H3,(H,38,43)(H,39,44)/t31-,32-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Montpellier Curated by ChEMBL					Assay Description Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method				Bioorg Med Chem Lett 26: 2408-12 (2016) Article DOI: 10.1016/j.bmcl.2016.04.003 BindingDB Entry DOI: 10.7270/Q2J9688V
					More data for this Ligand-Target Pair
Growth hormone secretagogue receptor type 1 (Homo sapiens (Human))	BDBM102977 (US8546435, 5) Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 |r| Show InChI InChI=1S/C35H33N7O3/c1-45-27-16-14-25(15-17-27)22-42-33(31(38-23-43)19-24-9-3-2-4-10-24)40-41-34(42)32(39-35(44)30-13-7-8-18-36-30)20-26-21-37-29-12-6-5-11-28(26)29/h2-18,21,23,31-32,37H,19-20,22H2,1H3,(H,38,43)(H,39,44)/t31-,32-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Montpellier Curated by ChEMBL					Assay Description Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured o...				Bioorg Med Chem Lett 26: 2408-12 (2016) Article DOI: 10.1016/j.bmcl.2016.04.003 BindingDB Entry DOI: 10.7270/Q2J9688V
					More data for this Ligand-Target Pair
Growth hormone secretagogue receptor type 1 (Homo sapiens (Human))	BDBM102977 (US8546435, 5) Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 |r| Show InChI InChI=1S/C35H33N7O3/c1-45-27-16-14-25(15-17-27)22-42-33(31(38-23-43)19-24-9-3-2-4-10-24)40-41-34(42)32(39-35(44)30-13-7-8-18-36-30)20-26-21-37-29-12-6-5-11-28(26)29/h2-18,21,23,31-32,37H,19-20,22H2,1H3,(H,38,43)(H,39,44)/t31-,32-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
AEterna Zentaris GmbH; Centre National de la Recherche Scientifique; University of Montpellier I; University of Montpellier II US Patent					Assay Description Competitive binding assay using ghrelin receptor.				US Patent US8546435 (2013) BindingDB Entry DOI: 10.7270/Q22N50XS
					More data for this Ligand-Target Pair
Growth hormone secretagogue receptor type 1 (Homo sapiens (Human))	BDBM102977 (US8546435, 5) Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 |r| Show InChI InChI=1S/C35H33N7O3/c1-45-27-16-14-25(15-17-27)22-42-33(31(38-23-43)19-24-9-3-2-4-10-24)40-41-34(42)32(39-35(44)30-13-7-8-18-36-30)20-26-21-37-29-12-6-5-11-28(26)29/h2-18,21,23,31-32,37H,19-20,22H2,1H3,(H,38,43)(H,39,44)/t31-,32-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Montpellier Curated by ChEMBL					Assay Description Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and roli...				Bioorg Med Chem Lett 26: 2408-12 (2016) Article DOI: 10.1016/j.bmcl.2016.04.003 BindingDB Entry DOI: 10.7270/Q2J9688V
					More data for this Ligand-Target Pair